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Fusion gene ID: 31036 |
FusionGeneSummary for RFT1_TKT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RFT1_TKT | Fusion gene ID: 31036 | Hgene | Tgene | Gene symbol | RFT1 | TKT | Gene ID | 91869 | 7086 |
| Gene name | RFT1 homolog | transketolase | |
| Synonyms | CDG1N | HEL-S-48|HEL107|SDDHD|TK|TKT1 | |
| Cytomap | 3p21.1 | 3p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein RFT1 homologRFT1, requiring fifty three 1 homologcongenital disorder of glycosylation 1Nputative endoplasmic reticulum multispan transmembrane protein | transketolaseepididymis luminal protein 107epididymis secretory protein Li 48 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96AA3 | P29401 | |
| Ensembl transtripts involved in fusion gene | ENST00000296292, ENST00000394738, | ENST00000462138, ENST00000423525, ENST00000461139, ENST00000423516, ENST00000296289, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 8 X 6=384 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/384*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RFT1 [Title/Abstract] AND TKT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TKT | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process | 9611778 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-B5-A5OD-01A | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000296292 | ENST00000462138 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| Frame-shift | ENST00000296292 | ENST00000423525 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| 5CDS-intron | ENST00000296292 | ENST00000461139 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| 5CDS-intron | ENST00000296292 | ENST00000423516 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| 5CDS-5UTR | ENST00000296292 | ENST00000296289 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| In-frame | ENST00000394738 | ENST00000462138 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| Frame-shift | ENST00000394738 | ENST00000423525 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| 5CDS-intron | ENST00000394738 | ENST00000461139 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| 5CDS-intron | ENST00000394738 | ENST00000423516 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
| 5CDS-5UTR | ENST00000394738 | ENST00000296289 | RFT1 | chr3 | 53159925 | - | TKT | chr3 | 53276258 | - |
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FusionProtFeatures for RFT1_TKT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RFT1 | TKT |
| May be involved in N-linked oligosaccharide assembly.May participate in the translocation of oligosaccharide from thecytoplasmic side to the lumenal side of the endoplasmic reticulummembrane. {ECO:0000269|PubMed:18313027}. | Catalyzes the transfer of a two-carbon ketol group froma ketose donor to an aldose acceptor, via a covalent intermediatewith the cofactor thiamine pyrophosphate.{ECO:0000269|PubMed:27259054}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 16_36 | 49 | 542 | Transmembrane | Helical |
| Tgene | >TKT | chr3:53159925 | chr3:53276258 | ENST00000423516 | - | 0 | 15 | 123_125 | 35 | 632 | Nucleotide binding | Note=Thiamine pyrophosphate |
| Tgene | >TKT | chr3:53159925 | chr3:53276258 | ENST00000423525 | - | 0 | 15 | 123_125 | 35 | 888 | Nucleotide binding | Note=Thiamine pyrophosphate |
| Tgene | >TKT | chr3:53159925 | chr3:53276258 | ENST00000462138 | - | 0 | 14 | 123_125 | 35 | 624 | Nucleotide binding | Note=Thiamine pyrophosphate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 123_143 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 155_174 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 187_207 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 335_355 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 376_396 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 404_423 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 428_450 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 42_62 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 470_490 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 499_519 | 49 | 542 | Transmembrane | Helical |
| Hgene | >RFT1 | chr3:53159925 | chr3:53276258 | ENST00000296292 | - | 2 | 13 | 85_105 | 49 | 542 | Transmembrane | Helical |
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FusionGeneSequence for RFT1_TKT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RFT1_ENST00000296292_chr3_53159925_-_TKT_ENST00000462138_chr3_53276258_-_638aa MGSQEVLGHAARLASSGLLLQVLFRLITFVLNAFILRFLSKEIVGVVNVSHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDRFVLSKG HAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEA MAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGVEDKES WHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNST FSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAM FRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEK INIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDRDAIAQAV >In-frame_RFT1_ENST00000394738_chr3_53159925_-_TKT_ENST00000462138_chr3_53276258_-_638aa MGSQEVLGHAARLASSGLLLQVLFRLITFVLNAFILRFLSKEIVGVVNVSHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDRFVLSKG HAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEA MAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGVEDKES WHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNST FSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAM FRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEK INIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDRDAIAQAV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RFT1_ENST00000296292_chr3_53159925_-_TKT_ENST00000462138_chr3_53276258_-_1914nt ATGGGCAGCCAGGAGGTGCTGGGCCACGCGGCCCGGCTGGCCTCCTCCGGTCTCCTCCTGCAGGTGTTGTTTCGGTTGATCACCTTTGTC TTGAATGCATTTATTCTTCGCTTCCTGTCAAAGGAAATCGTTGGCGTAGTAAATGTAAGCCACCCCACGTCATGCTGCAGCGCCGCAGAG ATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCCCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGC CATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGAC TTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTGGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCC TACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCC ATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCCATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAG CACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAG GCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCCAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCT TGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCA ACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAACATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCC ACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACC TTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGT GCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCC GAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCCATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATG TTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGT ATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTG AAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAG ATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATC CTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCAC CTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGAGCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTG >In-frame_RFT1_ENST00000394738_chr3_53159925_-_TKT_ENST00000462138_chr3_53276258_-_1914nt ATGGGCAGCCAGGAGGTGCTGGGCCACGCGGCCCGGCTGGCCTCCTCCGGTCTCCTCCTGCAGGTGTTGTTTCGGTTGATCACCTTTGTC TTGAATGCATTTATTCTTCGCTTCCTGTCAAAGGAAATCGTTGGCGTAGTAAATGTAAGCCACCCCACGTCATGCTGCAGCGCCGCAGAG ATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCCCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGC CATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGAC TTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTGGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCC TACACCGGCAAATACTTCGACAAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCC ATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCCATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAG CACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAG GCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCCAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCT TGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCA ACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAACATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCC ACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACC TTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGT GCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCC GAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCCATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATG TTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGT ATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTG AAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAG ATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATC CTCACCGTGGAGGACCATTATTATGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCAC CTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGGCTGAGCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RFT1_ENST00000296292_chr3_53159925_-_TKT_ENST00000462138_chr3_53276258_-_3025nt CTTATCGCGACTAAACGGAGTGGCGGCGGCATTTCCTGGTGTCTGAGCCTGGCGCGGAGGCTATGGGCAGCCAGGAGGTGCTGGGCCACG CGGCCCGGCTGGCCTCCTCCGGTCTCCTCCTGCAGGTGTTGTTTCGGTTGATCACCTTTGTCTTGAATGCATTTATTCTTCGCTTCCTGT CAAAGGAAATCGTTGGCGTAGTAAATGTAAGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCA TGCGCTACAAGTCCCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCT GGGCTGAAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAG CTTTCACCGACGTGGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCA GCTACCGAGTCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGG ACAACCTTGTGGCCATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGT GCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAA CAGCCATCATTGCCAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACA TGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAG TGGACATTGCCAACATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGG CCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACC CGGACCGCTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCT GCAGCACTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCC ACTGCGGCGTTTCCATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCT TTTACCCAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAG AAAATGCCATCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTA TCGGGGCTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCA CCATCAAGCCCCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAG GTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTG GGAAGCCGGCTGAGCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCG GGTATGAAGTGTGGGGCGGGGGTCTATACATTCCTGAGATTCTGGGAAAGGTGCTCAAAGATGTACTGAGAGGAGGGGTAAATATATGTT TTGAGAAAAATGAATTGGCCCTGAAATGTTTTCTTTTTTGATGTGTTTGCAGCCAGTGCAGGTTCTGGGGAAGAAGCGTGGAGGGTGCGC TAGGGAGGCTGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCACCTGCAACTGCCCTCAACCTCCAGAAC TATCGCTGCCTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGCTGAGACCTACATCCCTCATTGTGACC TCAGTCCACCTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCTCAGGGCCGCCCCACCTCCCCCAAGTC CCCACAGCCTTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCTTGTCATATCCTTTTAACTAGGCATCT CAGAGAAGCAGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGAGGTCCTCAATCCCAAGTGTGGAACTG TCCCCCTCAACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTGACAACTGGCCCAGGAGCTTCTGATGT CACACAGAATTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCCCTCACACTGCTGACCACAGTGGATTT CTCCCCCTGCTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCTTATACTGGCCAAGAACAAACTAGTGC TGGGGGAGGAGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTGCGAGGATGAGACACATTTGTGGACAC >In-frame_RFT1_ENST00000394738_chr3_53159925_-_TKT_ENST00000462138_chr3_53276258_-_3016nt ACTAAACGGAGTGGCGGCGGCATTTCCTGGTGTCTGAGCCTGGCGCGGAGGCTATGGGCAGCCAGGAGGTGCTGGGCCACGCGGCCCGGC TGGCCTCCTCCGGTCTCCTCCTGCAGGTGTTGTTTCGGTTGATCACCTTTGTCTTGAATGCATTTATTCTTCGCTTCCTGTCAAAGGAAA TCGTTGGCGTAGTAAATGTAAGCCACCCCACGTCATGCTGCAGCGCCGCAGAGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACA AGTCCCAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCCTCTACGCGGTCTGGGCTGAAG CTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTGAGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCG ACGTGGCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAATACTTCGACAAGGCCAGCTACCGAG TCTATTGCTTGCTGGGAGACGGGGAGCTGTCAGAGGGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTG TGGCCATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCACTGCAGCACCAGATGGACATCTACCAGAAGCGGTGCGAGGCCT TCGGTTGGCATGCCATCATCGTGGATGGACACAGCGTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCA TTGCCAAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGC AGATCATCCAGGAGATCTACAGCCAGATCCAGAGCAAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTG CCAACATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCCTACGGGCAGGCACTGGCCAAGCTGG GCCATGCCAGTGACCGCATCATCGCCCTGGATGGGGACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCT TCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAACAGGACGGTGCCCTTCTGCAGCACTT TTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATTCGCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCG TTTCCATCGGGGAAGACGGGCCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTCCCCACATCAACTGTCTTTTACCCAA GTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTAGCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCA TCATCTATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGATGACCAGGTGACCGTTATCGGGGCTG GGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAACTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGC CCCTGGACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAGGACCATTATTATGAAGGTGGCATTG GTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCTGGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCGG CTGAGCTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATCACCAAGGCCTAGGGCGGGTATGAAG TGTGGGGCGGGGGTCTATACATTCCTGAGATTCTGGGAAAGGTGCTCAAAGATGTACTGAGAGGAGGGGTAAATATATGTTTTGAGAAAA ATGAATTGGCCCTGAAATGTTTTCTTTTTTGATGTGTTTGCAGCCAGTGCAGGTTCTGGGGAAGAAGCGTGGAGGGTGCGCTAGGGAGGC TGGTGTCCTTGGTCCTGGGCCAGGACCTGGGTGTCCCAAGTCCCCTTGGAATCACCTGCAACTGCCCTCAACCTCCAGAACTATCGCTGC CTCCCATTCATCACCAGGTGACATTTGACTGCAACCTGCCTTCTAGCTGAGAGGCTGAGACCTACATCCCTCATTGTGACCTCAGTCCAC CTGGCCCTGAGCGGGCTGGGGAACTGCCTCAGTCTGGAAGCTGACCAGGCACTCTCAGGGCCGCCCCACCTCCCCCAAGTCCCCACAGCC TTGCAGTCAGGTCTCCTGGGATAGGGAGGTTCACTTGCTTGTTGTCCCTCGTCCTTGTCATATCCTTTTAACTAGGCATCTCAGAGAAGC AGAGACAGGGCAGCCTTCGTCCTGGGGGAAAAGGGACCCTCAGGATGGCATGAGAGGTCCTCAATCCCAAGTGTGGAACTGTCCCCCTCA ACTTGTTAAAATGCAGATTTCTGGGTCTTGCCAATGGGGCCTGGGACTCCATGTGACAACTGGCCCAGGAGCTTCTGATGTCACACAGAA TTCTGCAGTCCCAAGCTCCAGCCCCGACCTGCTCTGCTGTTCCTAGGTGACTGCCCTCACACTGCTGACCACAGTGGATTTCTCCCCCTG CTGCTCGGGCTCAGCTGGGGTCAGCCCTGCTTATAAGGTCAACTGTGCAAAACCTTATACTGGCCAAGAACAAACTAGTGCTGGGGGAGG AGGGCTGGGTGCCCCGGCCACTGGTGGAGTCCCCAGGAAATCCTCAGAGCTGTTGCGAGGATGAGACACATTTGTGGACACGTCCACCTG |
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FusionGenePPI for RFT1_TKT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RFT1 | NEDD4, PSMA3, TSPAN5, GPM6A, ASGR2, TMEM171, GPR52, P2RY12, LYPD3, ZACN, LTBR, SCN2B, VAPB, TENC1, TCTN2, TCTN3, FYCO1, SKA1, GPR114, STOM | TKT | TKT, ATG5, PIK3C2A, H2AFX, HDAC5, ISG15, TERF1, CUL3, CDK2, MYOC, TPI1, TALDO1, AHCYL1, IGBP1, UBE2I, UFC1, PKM, VDAC3, UGDH, UFM1, SSSCA1, PRDX1, UBE2D1, DYNC1LI1, MYC, FN1, SQSTM1, FBXO6, FUS, MAPK8, ACAA2, ACP1, AKR1A1, AKR1B1, AKR1B15, LOC101930400, AKR1C2, ALDH4A1, ALDOA, CALR, COX17, DUT, ENO1, ENO2, ENO3, ESD, FABP5, FABP7, FH, GAPDH, GLRX, GPI, GPX4, HINT1, HSPA4L, HSPE1, IDH1, ITPA, LDHA, LDHAL6B, LDHB, LYPLA2, MIF, NANS, NEDD8, NME1-NME2, NME2, P4HB, PCBP1, PCMT1, PDCD6, PDCD6IP, PGK1, PGM2, PITPNB, PLS3, PMP2, RAB10, RPE, SCYL2, SF1, SOD2, STAT4, STIP1, ABHD14B, AK2, ANXA7, ASS1, C11orf54, CALU, CAPG, CFL1, COTL1, DAZAP1, EZR, FKBP7, FSCN1, GLO1, GLOD4, HSD17B10, HSPA9, HSPB1, LAP3, MSN, PAICS, PIR, PTGES3, RDX, RPIA, RSU1, SLC2A9, SOD1, SPR, SRI, TAGLN2, TAGLN3, C12orf5, VAPA, WDR1, YKT6, VCP, XRCC6, NTRK1, IFI16, PPME1, EXOSC9, PRKCD, MCM2, BCOR, U2AF2, SERPINB5, KHNYN, GREB1, SMG8, DMWD, ATG2B, FIGNL1, POLA2, WDR54, C5orf34, WDR19, MOCOS, POTEF, WDR41, STIL, GOLGA4, MED20, EIF2AK4, TBL1X, CAMK2B, TRIM32, KDM5C, SPC25, MED17, LCMT2, TUBA4A, PLEC, DPP9, EML4, HTT, TRAPPC8, AASDH, TBC1D4, COQ2, DNM1L, SDHA, SOAT1, VDAC1, BRCA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RFT1_TKT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RFT1_TKT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RFT1 | C2677590 | Congenital Disorder Of Glycosylation, Type In | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TKT | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Tgene | TKT | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | TKT | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | TKT | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | TKT | C0043121 | Wernicke Encephalopathy | 1 | CTD_human |
| Tgene | TKT | C0242184 | Hypoxia | 1 | CTD_human |
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