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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3103

FusionGeneSummary for ATAD5_PTP4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD5_PTP4A1
Fusion gene ID: 3103
HgeneTgene
Gene symbol

ATAD5

PTP4A1

Gene ID

79915

7803

Gene nameATPase family, AAA domain containing 5protein tyrosine phosphatase type IVA, member 1
SynonymsC17orf41|ELG1|FRAG1HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1
Cytomap

17q11.2

6q12

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 5chromosome fragility associated gene 1chromosome fragility-associated gene 1 proteinenhanced level of genomic instability 1 homologprotein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1
Modification date2018052320180523
UniProtAcc

Q96QE3

Q93096

Ensembl transtripts involved in fusion geneENST00000321990, ENST00000370651, 
ENST00000370650, ENST00000578299, 
ENST00000473334, 
Fusion gene scores* DoF score7 X 7 X 6=2944 X 2 X 3=24
# samples 74
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATAD5 [Title/Abstract] AND PTP4A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GC-A3RB-01AATAD5chr17

29187630

+PTP4A1chr6

64286341

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000321990ENST00000370651ATAD5chr17

29187630

+PTP4A1chr6

64286341

+
5CDS-5UTRENST00000321990ENST00000370650ATAD5chr17

29187630

+PTP4A1chr6

64286341

+
5CDS-5UTRENST00000321990ENST00000578299ATAD5chr17

29187630

+PTP4A1chr6

64286341

+
5CDS-3UTRENST00000321990ENST00000473334ATAD5chr17

29187630

+PTP4A1chr6

64286341

+

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FusionProtFeatures for ATAD5_PTP4A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATAD5

Q96QE3

PTP4A1

Q93096

Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important indetermining whether DNA damage is compatible with cell survival orwhether it requires cell elimination by apoptosis. Modulates theRAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. {ECO:0000269|PubMed:15983387}. Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATAD5_PTP4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATAD5_PTP4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATAD5USP1, WDR48, RFC4, PCNA, BRD4, CPVL, BAZ1B, HIST1H2BG, HIST1H3A, BAX, NOP56, MIS12, CDC14B, RFC5, CHEK2, CHEK1, CSNK2A1, ALDH2, WEE1, MAP2K1, RABGGTB, FNTA, TUBA1APTP4A1TNFAIP8, PTP4A2, ATF7, ELAVL1, APP, LAMP1, GNL1, CREB3L2, ZNF212, RABGGTB, LRRC39, PDHB, AUP1, ISLR, FNTB, BLMH, CNNM1, CNNM3, CNNM4, FDFT1, NUDT12, CDC25A, PTP4A1, MACROD1, RPS12, POLDIP2, CMSS1, EIF3M, MRTO4, RPS19BP1, SSB, RPS10P5, PA2G4, NUDT16, RPL36AL, GRSF1, GADD45GIP1, ACOT8, MRPS28, NIFK, RPL3L, SND1, MBLAC2, EIF3L, PTPRE


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATAD5_PTP4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATAD5_PTP4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATAD5C0677886Epithelial ovarian cancer1CTD_human
TgenePTP4A1C0001973Alcoholic Intoxication, Chronic2PSYGENET