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Fusion gene ID: 3103 |
FusionGeneSummary for ATAD5_PTP4A1 |
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Fusion gene information | Fusion gene name: ATAD5_PTP4A1 | Fusion gene ID: 3103 | Hgene | Tgene | Gene symbol | ATAD5 | PTP4A1 | Gene ID | 79915 | 7803 |
Gene name | ATPase family, AAA domain containing 5 | protein tyrosine phosphatase type IVA, member 1 | |
Synonyms | C17orf41|ELG1|FRAG1 | HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1 | |
Cytomap | 17q11.2 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | ATPase family AAA domain-containing protein 5chromosome fragility associated gene 1chromosome fragility-associated gene 1 proteinenhanced level of genomic instability 1 homolog | protein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96QE3 | Q93096 | |
Ensembl transtripts involved in fusion gene | ENST00000321990, | ENST00000370651, ENST00000370650, ENST00000578299, ENST00000473334, | |
Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 4 X 2 X 3=24 |
# samples | 7 | 4 | |
** MAII score | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ATAD5 [Title/Abstract] AND PTP4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-GC-A3RB-01A | ATAD5 | chr17 | 29187630 | + | PTP4A1 | chr6 | 64286341 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000321990 | ENST00000370651 | ATAD5 | chr17 | 29187630 | + | PTP4A1 | chr6 | 64286341 | + |
5CDS-5UTR | ENST00000321990 | ENST00000370650 | ATAD5 | chr17 | 29187630 | + | PTP4A1 | chr6 | 64286341 | + |
5CDS-5UTR | ENST00000321990 | ENST00000578299 | ATAD5 | chr17 | 29187630 | + | PTP4A1 | chr6 | 64286341 | + |
5CDS-3UTR | ENST00000321990 | ENST00000473334 | ATAD5 | chr17 | 29187630 | + | PTP4A1 | chr6 | 64286341 | + |
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FusionProtFeatures for ATAD5_PTP4A1 |
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Hgene | Tgene |
ATAD5 | PTP4A1 |
Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important indetermining whether DNA damage is compatible with cell survival orwhether it requires cell elimination by apoptosis. Modulates theRAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. {ECO:0000269|PubMed:15983387}. | Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATAD5_PTP4A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATAD5_PTP4A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATAD5 | USP1, WDR48, RFC4, PCNA, BRD4, CPVL, BAZ1B, HIST1H2BG, HIST1H3A, BAX, NOP56, MIS12, CDC14B, RFC5, CHEK2, CHEK1, CSNK2A1, ALDH2, WEE1, MAP2K1, RABGGTB, FNTA, TUBA1A | PTP4A1 | TNFAIP8, PTP4A2, ATF7, ELAVL1, APP, LAMP1, GNL1, CREB3L2, ZNF212, RABGGTB, LRRC39, PDHB, AUP1, ISLR, FNTB, BLMH, CNNM1, CNNM3, CNNM4, FDFT1, NUDT12, CDC25A, PTP4A1, MACROD1, RPS12, POLDIP2, CMSS1, EIF3M, MRTO4, RPS19BP1, SSB, RPS10P5, PA2G4, NUDT16, RPL36AL, GRSF1, GADD45GIP1, ACOT8, MRPS28, NIFK, RPL3L, SND1, MBLAC2, EIF3L, PTPRE |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATAD5_PTP4A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATAD5_PTP4A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ATAD5 | C0677886 | Epithelial ovarian cancer | 1 | CTD_human |
Tgene | PTP4A1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |