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Fusion gene ID: 31026 |
FusionGeneSummary for RFC4_EHHADH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RFC4_EHHADH | Fusion gene ID: 31026 | Hgene | Tgene | Gene symbol | RFC4 | EHHADH | Gene ID | 5984 | 1962 |
| Gene name | replication factor C subunit 4 | enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase | |
| Synonyms | A1|RFC37 | ECHD|FRTS3|L-PBE|LBFP|LBP|PBFE | |
| Cytomap | 3q27.3 | 3q27.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | replication factor C subunit 4A1 37 kDa subunitRF-C 37 kDa subunitRFC 37 kDa subunitactivator 1 37 kDa subunitactivator 1 subunit 4replication factor C (activator 1) 4, 37kDareplication factor C 37 kDa subunit | peroxisomal bifunctional enzyme3,2-trans-enoyl-CoA isomeraseL-3-hydroxyacyl-CoA dehydrogenaseL-bifunctional protein, peroxisomalPBEenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenaseenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P35249 | Q08426 | |
| Ensembl transtripts involved in fusion gene | ENST00000433496, ENST00000392481, ENST00000296273, | ENST00000231887, ENST00000456310, ENST00000475987, ENST00000440662, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 4 X 5=120 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RFC4 [Title/Abstract] AND EHHADH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RFC4 | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity | 12930902 |
| Tgene | EHHADH | GO:0006475 | internal protein amino acid acetylation | 20167786 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4306-01A | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000433496 | ENST00000231887 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000433496 | ENST00000456310 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000433496 | ENST00000475987 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000433496 | ENST00000440662 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| Frame-shift | ENST00000392481 | ENST00000231887 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000392481 | ENST00000456310 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000392481 | ENST00000475987 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000392481 | ENST00000440662 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| Frame-shift | ENST00000296273 | ENST00000231887 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000296273 | ENST00000456310 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000296273 | ENST00000475987 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
| 5CDS-5UTR | ENST00000296273 | ENST00000440662 | RFC4 | chr3 | 186510593 | - | EHHADH | chr3 | 184966305 | - |
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FusionProtFeatures for RFC4_EHHADH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RFC4 | EHHADH |
| The elongation of primed DNA templates by DNA polymerasedelta and epsilon requires the action of the accessory proteinsproliferating cell nuclear antigen (PCNA) and activator 1. Thissubunit may be involved in the elongation of the multiprimed DNAtemplate. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RFC4 | chr3:186510593 | chr3:184966305 | ENST00000296273 | - | 6 | 11 | 78_85 | 184 | 364 | Nucleotide binding | ATP |
| Hgene | RFC4 | chr3:186510593 | chr3:184966305 | ENST00000392481 | - | 6 | 11 | 78_85 | 184 | 364 | Nucleotide binding | ATP |
| Tgene | >EHHADH | chr3:186510593 | chr3:184966305 | ENST00000231887 | - | 0 | 7 | 721_723 | 24 | 724 | Motif | Note=Microbody targeting signal |
| Tgene | >EHHADH | chr3:186510593 | chr3:184966305 | ENST00000456310 | - | 0 | 7 | 721_723 | -72 | 628 | Motif | Note=Microbody targeting signal |
| Tgene | >EHHADH | chr3:186510593 | chr3:184966305 | ENST00000231887 | - | 0 | 7 | 283_572 | 24 | 724 | Region | Note=3-hydroxyacyl-CoA dehydrogenase |
| Tgene | >EHHADH | chr3:186510593 | chr3:184966305 | ENST00000456310 | - | 0 | 7 | 1_282 | -72 | 628 | Region | Note=Enoyl-CoA hydratase / isomerase |
| Tgene | >EHHADH | chr3:186510593 | chr3:184966305 | ENST00000456310 | - | 0 | 7 | 283_572 | -72 | 628 | Region | Note=3-hydroxyacyl-CoA dehydrogenase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EHHADH | chr3:186510593 | chr3:184966305 | ENST00000231887 | - | 0 | 7 | 1_282 | 24 | 724 | Region | Note=Enoyl-CoA hydratase / isomerase |
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FusionGeneSequence for RFC4_EHHADH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RFC4_ENST00000433496_chr3_186510593_-_EHHADH_ENST00000231887_chr3_184966305_-_884aa MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILA AARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLIC NYVSRTTLLRDIKEGLQKAVIDHTIKAIVICGAEGKFSAGADIRGFSAPRTFGLTLGHVVDEIQRNEKPVVAAIQGMAFGGGLELALGCH YRIAHAEAQVGLPEVTLGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNSDPVEEAIRFAQRVSDQPLESRRLCN KPIQSLPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAERKANKWSTPSGASWK TASARPVSSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSGPKPRLTSSVKELGGVDLVIE AVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIG VVVGNCFGFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKGQGLTGPTLLPGTPARKRGNRRYCP IPDVLCELGRFGQKTGKGWYQYDKPLGRIHKPDPWLSKFLSRYRKTHHIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RFC4_ENST00000433496_chr3_186510593_-_EHHADH_ENST00000231887_chr3_184966305_-_2652nt ATGCAAGCATTTCTTAAAGGTACATCCATCAGTACTAAACCCCCGCTGACCAAGGATCGAGGAGTAGCTGCCAGTGCGGGAAGTAGCGGA GAGAACAAGAAAGCCAAACCCGTTCCCTGGGTGGAAAAATATCGCCCAAAATGTGTGGATGAAGTTGCTTTCCAGGAAGAAGTGGTTGCA GTGCTGAAAAAATCTTTAGAAGGAGCAGATCTTCCTAATCTCTTGTTTTACGGACCACCTGGAACTGGAAAAACATCCACTATTTTGGCA GCAGCTAGAGAACTCTTTGGGCCTGAACTTTTCCGATTAAGAGTTCTTGAGTTAAATGCATCTGATGAACGTGGAATACAAGTAGTTCGA GAGAAAGTGAAAAATTTTGCTCAATTAACTGTGTCAGGAAGTCGCTCAGATGGGAAGCCGTGTCCGCCTTTTAAGATTGTGATTCTGGAT GAAGCAGATTCTATGACCTCAGCTGCTCAGGCAGCTTTAAGACGTACCATGGAGAAGGAGTCGAAAACCACCCGATTCTGTCTTATCTGT AACTATGTCAGTCGTACGACTTTACTCCGTGACATAAAAGAAGGACTACAGAAAGCTGTAATAGACCATACAATAAAAGCCATTGTGATT TGTGGAGCAGAGGGCAAATTTTCTGCAGGTGCTGATATTCGTGGCTTCAGTGCTCCTAGGACATTTGGCCTTACACTGGGACATGTAGTA GATGAAATACAGAGAAATGAGAAGCCCGTGGTGGCAGCAATCCAAGGCATGGCTTTCGGAGGGGGACTAGAGCTGGCCCTGGGCTGTCAC TATAGGATTGCCCACGCAGAGGCTCAAGTTGGCTTACCAGAAGTTACACTGGGACTTCTCCCTGGTGCAAGAGGAACCCAGCTTCTCCCC AGACTCACTGGAGTTCCTGCTGCACTTGACTTAATTACCTCAGGAAGACGTATTTTAGCAGATGAAGCACTCAAGCTGGGCATTCTAGAT AAAGTTGTAAACTCAGACCCGGTTGAAGAAGCAATCAGATTTGCTCAGAGAGTTTCAGATCAACCTCTAGAATCCCGTAGACTCTGCAAC AAGCCAATTCAGAGCTTGCCCAACATGGACAGCATTTTTAGTGAGGCCCTCTTGAAGATGCGGAGGCAGCACCCTGGGTGTCTTGCACAG GAGGCTTGTGTCCGTGCAGTCCAGGCTGCTGTGCAGTATCCCTATGAAGTGGGCATCAAGAAGGAGGAGGAGCTGTTTCTATATCTTTTG CAATCAGGGCAGGCTAGAGCCCTGCAATATGCTTTCTTCGCTGAAAGGAAAGCAAATAAGTGGTCAACTCCCTCCGGAGCATCGTGGAAA ACAGCATCAGCGCGGCCTGTCTCCTCAGTTGGTGTTGTTGGCTTGGGAACAATGGGCCGAGGCATTGTCATTTCTTTTGCAAGGGCCAGG ATTCCTGTGATTGCTGTAGACTCGGACAAAAACCAGCTAGCAACTGCAAACAAGATGATAACCTCTGTCTTGGAAAAAGAAGCCTCCAAA ATGCAACAGAGCGGCCACCCTTGGTCAGGACCAAAACCCAGGTTAACTTCATCTGTGAAGGAGCTTGGTGGTGTAGATTTAGTCATTGAA GCAGTATTTGAGGAAATGAGCCTGAAGAAGCAGGTCTTTGCTGAACTCTCAGCTGTGTGCAAACCAGAAGCATTTTTGTGCACTAATACT TCAGCCCTGGATGTTGATGAGATTGCTTCTTCCACTGATCGTCCTCACTTGGTCATTGGCACCCACTTCTTTTCGCCAGCTCATGTCATG AAGTTGTTAGAGGTTATTCCCAGCCAATACTCTTCCCCCACTACCATTGCCACTGTTATGAACTTATCAAAAAAGATTAAAAAGATTGGA GTCGTTGTAGGCAACTGTTTTGGATTTGTGGGGAATCGAATGTTGAATCCTTACTACAATCAGGCATATTTCTTGTTAGAAGAAGGCAGC AAACCAGAGGAGGTAGATCAGGTGCTGGAAGAGTTTGGTTTTAAAATGGGACCTTTTAGAGTGTCTGATCTTGCTGGGTTGGATGTGGGC TGGAAATCTAGAAAGGGGCAAGGTCTTACTGGACCTACATTGCTTCCAGGAACTCCTGCCCGAAAAAGGGGTAATAGGAGGTACTGCCCA ATTCCTGATGTGCTCTGTGAATTAGGACGATTTGGCCAGAAGACAGGTAAGGGTTGGTATCAATATGACAAGCCATTGGGTAGGATTCAC AAACCTGATCCCTGGCTTTCCAAATTCCTATCACGGTATAGAAAAACCCATCACATTGAACCACGTACCATTAGCCAGGATGAGATCCTT GAACGCTGCTTATATTCACTTATCAATGAAGCATTCCGTATCTTGGGAGAAGGGATAGCTGCTAGCCCAGAGCACATTGATGTTGTCTAT TTACATGGATATGGATGGCCAAGGCACAAGGGCGGGCCCATGTTCTATGCTTCCACAGTTGGGTTGCCCACAGTTCTAGAGAAATTGCAG AAATATTACAGGCAGAACCCTGATATTCCCCAACTGGAGCCAAGTGACTATCTAAAAAAACTGGCTTCTCAGGGAAACCCTCCCCTGAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RFC4_ENST00000433496_chr3_186510593_-_EHHADH_ENST00000231887_chr3_184966305_-_4265nt GGTGAAGTACCATGCAAGCATTTCTTAAAGGTACATCCATCAGTACTAAACCCCCGCTGACCAAGGATCGAGGAGTAGCTGCCAGTGCGG GAAGTAGCGGAGAGAACAAGAAAGCCAAACCCGTTCCCTGGGTGGAAAAATATCGCCCAAAATGTGTGGATGAAGTTGCTTTCCAGGAAG AAGTGGTTGCAGTGCTGAAAAAATCTTTAGAAGGAGCAGATCTTCCTAATCTCTTGTTTTACGGACCACCTGGAACTGGAAAAACATCCA CTATTTTGGCAGCAGCTAGAGAACTCTTTGGGCCTGAACTTTTCCGATTAAGAGTTCTTGAGTTAAATGCATCTGATGAACGTGGAATAC AAGTAGTTCGAGAGAAAGTGAAAAATTTTGCTCAATTAACTGTGTCAGGAAGTCGCTCAGATGGGAAGCCGTGTCCGCCTTTTAAGATTG TGATTCTGGATGAAGCAGATTCTATGACCTCAGCTGCTCAGGCAGCTTTAAGACGTACCATGGAGAAGGAGTCGAAAACCACCCGATTCT GTCTTATCTGTAACTATGTCAGTCGTACGACTTTACTCCGTGACATAAAAGAAGGACTACAGAAAGCTGTAATAGACCATACAATAAAAG CCATTGTGATTTGTGGAGCAGAGGGCAAATTTTCTGCAGGTGCTGATATTCGTGGCTTCAGTGCTCCTAGGACATTTGGCCTTACACTGG GACATGTAGTAGATGAAATACAGAGAAATGAGAAGCCCGTGGTGGCAGCAATCCAAGGCATGGCTTTCGGAGGGGGACTAGAGCTGGCCC TGGGCTGTCACTATAGGATTGCCCACGCAGAGGCTCAAGTTGGCTTACCAGAAGTTACACTGGGACTTCTCCCTGGTGCAAGAGGAACCC AGCTTCTCCCCAGACTCACTGGAGTTCCTGCTGCACTTGACTTAATTACCTCAGGAAGACGTATTTTAGCAGATGAAGCACTCAAGCTGG GCATTCTAGATAAAGTTGTAAACTCAGACCCGGTTGAAGAAGCAATCAGATTTGCTCAGAGAGTTTCAGATCAACCTCTAGAATCCCGTA GACTCTGCAACAAGCCAATTCAGAGCTTGCCCAACATGGACAGCATTTTTAGTGAGGCCCTCTTGAAGATGCGGAGGCAGCACCCTGGGT GTCTTGCACAGGAGGCTTGTGTCCGTGCAGTCCAGGCTGCTGTGCAGTATCCCTATGAAGTGGGCATCAAGAAGGAGGAGGAGCTGTTTC TATATCTTTTGCAATCAGGGCAGGCTAGAGCCCTGCAATATGCTTTCTTCGCTGAAAGGAAAGCAAATAAGTGGTCAACTCCCTCCGGAG CATCGTGGAAAACAGCATCAGCGCGGCCTGTCTCCTCAGTTGGTGTTGTTGGCTTGGGAACAATGGGCCGAGGCATTGTCATTTCTTTTG CAAGGGCCAGGATTCCTGTGATTGCTGTAGACTCGGACAAAAACCAGCTAGCAACTGCAAACAAGATGATAACCTCTGTCTTGGAAAAAG AAGCCTCCAAAATGCAACAGAGCGGCCACCCTTGGTCAGGACCAAAACCCAGGTTAACTTCATCTGTGAAGGAGCTTGGTGGTGTAGATT TAGTCATTGAAGCAGTATTTGAGGAAATGAGCCTGAAGAAGCAGGTCTTTGCTGAACTCTCAGCTGTGTGCAAACCAGAAGCATTTTTGT GCACTAATACTTCAGCCCTGGATGTTGATGAGATTGCTTCTTCCACTGATCGTCCTCACTTGGTCATTGGCACCCACTTCTTTTCGCCAG CTCATGTCATGAAGTTGTTAGAGGTTATTCCCAGCCAATACTCTTCCCCCACTACCATTGCCACTGTTATGAACTTATCAAAAAAGATTA AAAAGATTGGAGTCGTTGTAGGCAACTGTTTTGGATTTGTGGGGAATCGAATGTTGAATCCTTACTACAATCAGGCATATTTCTTGTTAG AAGAAGGCAGCAAACCAGAGGAGGTAGATCAGGTGCTGGAAGAGTTTGGTTTTAAAATGGGACCTTTTAGAGTGTCTGATCTTGCTGGGT TGGATGTGGGCTGGAAATCTAGAAAGGGGCAAGGTCTTACTGGACCTACATTGCTTCCAGGAACTCCTGCCCGAAAAAGGGGTAATAGGA GGTACTGCCCAATTCCTGATGTGCTCTGTGAATTAGGACGATTTGGCCAGAAGACAGGTAAGGGTTGGTATCAATATGACAAGCCATTGG GTAGGATTCACAAACCTGATCCCTGGCTTTCCAAATTCCTATCACGGTATAGAAAAACCCATCACATTGAACCACGTACCATTAGCCAGG ATGAGATCCTTGAACGCTGCTTATATTCACTTATCAATGAAGCATTCCGTATCTTGGGAGAAGGGATAGCTGCTAGCCCAGAGCACATTG ATGTTGTCTATTTACATGGATATGGATGGCCAAGGCACAAGGGCGGGCCCATGTTCTATGCTTCCACAGTTGGGTTGCCCACAGTTCTAG AGAAATTGCAGAAATATTACAGGCAGAACCCTGATATTCCCCAACTGGAGCCAAGTGACTATCTAAAAAAACTGGCTTCTCAGGGAAACC CTCCCCTGAAAGAATGGCAAAGCTTGGCAGGCTCCCCTAGCAGTAAATTGTGATTCAGTCTTCCAGATTATGCCTCACATGCTAGCATCA GGTAATGCTGACTGAATTTCAGTGAAATTAAATCAAAAATCCAAAGTAAGATTGTTCTGAAATACAAAGCAAAATAAATAATCATTAGAA TCTTCTGTGTAACGACTCTAATGGTCAAATCTTTAGGAATGTGCTTCCTATGCCTCTGAATCTGTCCTTATCAGATAAATTCAATGCATG AACTTGTGTGAATATAATACCATAATAGCTAATGAAAGAGGCTCAGGCATAAGTTGAGATTCTCAAATGCTTTTATCATTGGATAAATGT GTCATCAATTAATAAATGATAAATGCAGCTAAGTCATACATTCATTTTGACTCCTTTCAATGTCACACACATAGTATTGATCAGAAATCT TATGAATCATACATACACTCAACAAACATTAAAGTTGTAGGAAAAAGACAGTTGGAAATTGGTAAGGGAACTGAGTACTTCAAACCAGCA CAGGGAACTTAGGTTAGTGTGGCAAGCCTTTCCTCTTCTGGTCTTTCCTCTTCTGTTTATGGAGAAATAATAGAAAGTAGTAAGTCGTTA ACTTAGTGTAAGAAGGGTCTTAGAGAACATCTAACCTTCTAGGATTTCCCAATTCTGTGATAGAGTAATGACACCAGTTTTCCTGTCATG ACAAGCCTCTGTGATGTTACATATGGAAATGGTTGAATCTTGAAAAATCTAAAATTGTTGCAAAACATATTTTGTATGATTTTGTTGTAA GAGTTCTTCTCTTTTTACTTTTTGCCTTGTGTAGTTAAAAATTAAGGGGCTGGTCAATACAAAAACTTGTACACAAATATTTATAGCAGA ATTATTCATAATGGCCAAAAGCTGAATACAACCCAAATGTCTATGAACTAATGAATAGATAAACCAAATCTGGTATATCCATACAATGGA CTATATTATTCAGCCATAAAAAGAAATAAAGGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGAGG ATTGTTTGAGGCCAGAAATTTGAGACCAGCCTGGGCAACATAGCAAAACCCTGTCTCTACAAAAAATACTTTCCGTACATTAGTGGTTGC CTAAGGCTAGAATTGGGGGTGATGAATGGGGAGTACAGGATTCATCTAATGGGTACAGGATTTCTTTATGGTTCATGAAAATGGTCTAAA CTTATTGTGGTAATGGTCACATAACAATATATTAAAAACCATTGAGTTGTATATTTTAAGTGGGTGAATTATATGGTATGTGAATTATAT CTCAATAAAGTTGTTAGTAAATAAATGGGGCTGAAGATGTTATCCTTCATTGTGGTGTAAATGAACTTTCACAATATTTTCACCTGTGAA CCCAAATAAAATGATTAAAGTTCTGATGGAAAAATCTTGAATGGAGTATAAGTTTTCCGTTGTTAAAAAGCAAACAAAAAACCAACAAAA AATCCAAGTGTGCCTTGAATTGTACAGAGCACAATTATTATGTTTGAAATGTGTACTACTTAATTTTATATAATTTGGTTTGTGAAATTA |
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FusionGenePPI for RFC4_EHHADH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RFC4 | RFC5, RAD17, CHTF18, BRD4, RFC2, PCNA, RFC3, RFC1, USP20, UIMC1, RUVBL2, MEPCE, CDK9, RPAP2, PMS1, PML, RARA, FAN1, ATAD5, PIDD1, SMARCAD1, HDGF, PRAME, NCSTN, HNRNPU, MCM3, MDC1, PAXIP1, NOTCH1, MYC, FN1, MPG, TARDBP, PARK2, ABCF1, HNRNPM, IGF2BP3, ILF2, MRE11A, NMT1, QARS, C14orf166, RTCB, NELFB, YBX3, DDX1, DHX9, DIMT1, EDC4, EIF2B2, EIF2B3, EPRS, FKBP3, FLII, RPL26L1, RPA3, RPA2, RPA1, TP53, RNF41, BRCA1, RNF2, EGFR, ABCE1, SETD3, DSCC1, TRIM33, NTRK1, EWSR1, RPL10, NOP56, IBTK, SNW1, CDC5L, NFATC1, NFATC2, ZNF746, CHTF8, RAD1, TAF12, EPHA4, TAF2, TAF9B, TAF6, IL13RA2, CD58, NEURL4, FBXO45, G3BP1, TES, MCM9 | EHHADH | PEX5, CAT, TRIM63, TRIM55, ACTB, ACTG1, CBS, DES, MID1, TRIM27, TPP2, TRAF1, BHLHE40, SSNA1, PNMA1, TNIP1, NECAB2, KCTD9, TRIM54, CCDC102B, LZTS2, TRIM41, SSX2IP, FUNDC1, KCTD6, ZBTB9, KRTAP10-7, NTRK1, DHRS4, NCDN, SLC7A6OS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RFC4_EHHADH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RFC4_EHHADH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EHHADH | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | EHHADH | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | EHHADH | C3810100 | FANCONI RENOTUBULAR SYNDROME 3 | 1 | UNIPROT |
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