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Fusion gene ID: 31020 |
FusionGeneSummary for RFC1_PDS5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RFC1_PDS5A | Fusion gene ID: 31020 | Hgene | Tgene | Gene symbol | RFC1 | PDS5A | Gene ID | 6573 | 23244 |
| Gene name | solute carrier family 19 member 1 | PDS5 cohesin associated factor A | |
| Synonyms | CHMD|FOLT|IFC-1|IFC1|REFC|RFC|RFC1 | PIG54|SCC-112|SCC112 | |
| Cytomap | 21q22.3 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | folate transporter 1intestinal folate carrier 1placental folate transporterreduced folate carrier 1reduced folate carrier proteinsolute carrier family 19 (folate transporter), member 1 | sister chromatid cohesion protein PDS5 homolog APDS5, regulator of cohesion maintenance, homolog Acell proliferation-inducing gene 54 proteinsister chromatid cohesion protein 112 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P35251 | Q29RF7 | |
| Ensembl transtripts involved in fusion gene | ENST00000349703, ENST00000381897, ENST00000418436, | ENST00000303538, ENST00000503396, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 6 X 7 X 4=168 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RFC1 [Title/Abstract] AND PDS5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RFC1 | GO:0098838 | folate transmembrane transport | 14609557 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | DLBC | TCGA-GS-A9TV-01A | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000349703 | ENST00000303538 | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
| 5CDS-intron | ENST00000349703 | ENST00000503396 | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
| In-frame | ENST00000381897 | ENST00000303538 | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
| 5CDS-intron | ENST00000381897 | ENST00000503396 | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
| 5UTR-3CDS | ENST00000418436 | ENST00000303538 | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
| 5UTR-intron | ENST00000418436 | ENST00000503396 | RFC1 | chr4 | 39328183 | - | PDS5A | chr4 | 39827108 | - |
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FusionProtFeatures for RFC1_PDS5A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RFC1 | PDS5A |
| The elongation of primed DNA templates by DNA polymerasedelta and epsilon requires the action of the accessory proteinsPCNA and activator 1. This subunit binds to the primer-templatejunction. Binds the PO-B transcription element as well as other GArich DNA sequences. Could play a role in DNA transcriptionregulation as well as DNA replication and/or repair. Can bindsingle- or double-stranded DNA. {ECO:0000269|PubMed:8999859}. Interacts with C-terminus of PCNA. 5' phosphate residueis required for binding of the N-terminal DNA-binding domain toduplex DNA, suggesting a role in recognition of non-primertemplate DNA structures during replication and/or repair.{ECO:0000269|PubMed:8999859}. | Probable regulator of sister chromatid cohesion inmitosis which may stabilize cohesin complex association withchromatin. May couple sister chromatid cohesion during mitosis toDNA replication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. {ECO:0000269|PubMed:15855230,ECO:0000269|PubMed:19907496}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PDS5A | chr4:39328183 | chr4:39827108 | ENST00000503396 | - | 0 | 16 | 393_429 | -180 | 601 | Repeat | HEAT |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RFC1 | chr4:39328183 | chr4:39827108 | ENST00000349703 | - | 6 | 25 | 402_492 | 214 | 1148 | Domain | BRCT |
| Hgene | >RFC1 | chr4:39328183 | chr4:39827108 | ENST00000381897 | - | 6 | 25 | 402_492 | 214 | 1149 | Domain | BRCT |
| Hgene | >RFC1 | chr4:39328183 | chr4:39827108 | ENST00000349703 | - | 6 | 25 | 1120_1124 | 214 | 1148 | Motif | Nuclear localization signal |
| Hgene | >RFC1 | chr4:39328183 | chr4:39827108 | ENST00000381897 | - | 6 | 25 | 1120_1124 | 214 | 1149 | Motif | Nuclear localization signal |
| Hgene | >RFC1 | chr4:39328183 | chr4:39827108 | ENST00000349703 | - | 6 | 25 | 650_657 | 214 | 1148 | Nucleotide binding | ATP |
| Hgene | >RFC1 | chr4:39328183 | chr4:39827108 | ENST00000381897 | - | 6 | 25 | 650_657 | 214 | 1149 | Nucleotide binding | ATP |
| Tgene | PDS5A | chr4:39328183 | chr4:39827108 | ENST00000303538 | - | 31 | 33 | 393_429 | 1336 | 1338 | Repeat | HEAT |
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FusionGeneSequence for RFC1_PDS5A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RFC1_ENST00000349703_chr4_39328183_-_PDS5A_ENST00000303538_chr4_39827108_-_215aa MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP VSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK >In-frame_RFC1_ENST00000381897_chr4_39328183_-_PDS5A_ENST00000303538_chr4_39827108_-_215aa MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLP VSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKLTPTSVLDYFGTGSVQRSNKK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RFC1_ENST00000349703_chr4_39328183_-_PDS5A_ENST00000303538_chr4_39827108_-_646nt ATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAACTTGTAAGTGAAACAGTAAAGAAGAATGAGAAAACAAAGTCTGAT GAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAAATAGCTCCCGTAAAGAGGATGACTTCAAACAAAAGCAACCAAGC AAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGACGTTGCAGGTAAAAAATGCCAAAAAGCCACCAGAAAAACTGCCA GTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACATACATTTCAGAAACAGATGAAGAAGATGACTTTATGTGTAAGAAG GCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATCTTGGAACATCAAACATGAAAAAGAATGAAGAAAACACTAAGACC AAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTACTTGATTATTTTGGAACTGGAAGTGTCCAAAGATCTAATAAGAAG ATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGTCTGGATTAAATGATGAAGCCATCGCCAAGCAATTACAGCTTGAT >In-frame_RFC1_ENST00000381897_chr4_39328183_-_PDS5A_ENST00000303538_chr4_39827108_-_646nt ATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAACTTGTAAGTGAAACAGTAAAGAAGAATGAGAAAACAAAGTCTGAT GAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAAATAGCTCCCGTAAAGAGGATGACTTCAAACAAAAGCAACCAAGC AAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGACGTTGCAGGTAAAAAATGCCAAAAAGCCACCAGAAAAACTGCCA GTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACATACATTTCAGAAACAGATGAAGAAGATGACTTTATGTGTAAGAAG GCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATCTTGGAACATCAAACATGAAAAAGAATGAAGAAAACACTAAGACC AAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTACTTGATTATTTTGGAACTGGAAGTGTCCAAAGATCTAATAAGAAG ATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGTCTGGATTAAATGATGAAGCCATCGCCAAGCAATTACAGCTTGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RFC1_ENST00000349703_chr4_39328183_-_PDS5A_ENST00000303538_chr4_39827108_-_3378nt CTTGCACTTCGCGGGAGAAGTTGTTGGCGCGAATGGATCCTGAGCCTCGATAACAGATTCCTCAACCGGCCCACCCGCCAGCCAGCCAGC GCCTTCATCCTGGGGCTGCGATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAACTTGTAAGTGAAACAGTAAAGAAGA ATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAAATAGCTCCCGTAAAGAGGATGACT TCAAACAAAAGCAACCAAGCAAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGACGTTGCAGGTAAAAAATGCCAAAA AGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACATACATTTCAGAAACAGATGAAGAAG ATGACTTTATGTGTAAGAAGGCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATCTTGGAACATCAAACATGAAAAAGA ATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTACTTGATTATTTTGGAACTGGAAGTG TCCAAAGATCTAATAAGAAGATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGTCTGGATTAAATGATGAAGCCATCG CCAAGCAATTACAGCTTGATGAAGATGCGGAGGTAAAAATGCATTTGCAAAGGGAGAAAATGAAGGCCAAACAGAAGCAGGCTCCAGCTT CTGCAAAAACTTGGATTCACAAATGTCCCTGAACAGAAAATGAAGCTCACTTCAGAACACACACTCTCTGCCTTGAAAACTAAAGAGACT ATTACTTCCTTTTCACATGACCACAAGTCCTCTGATGGAAATGTACAGCAGAAACTCTTGAGAGAGAGGCTAAAAGCAACTCTGTTCTCC CCCTTCCCCTAGACTTTTCTTACGAAAAGTCAATAATTAAGCAAATTGCTTAACACTTGGTTCCAGTTCCTGCCTATCTGGAGTTTAAAT GCGTAATACACCATTAATTTCCACGCTGCAGTTTTTATTTTAAAGAAAGTAACAAGATGTCTTTACACTGACACTGAAAATTCATCCATT TTAGAGCCAGGAATTCCCATGTTACACAGGAAAAAATAGAAGTCTACTGAATTAATTTTTTAAAAGAAAAGAGATCAGATTAAATATTTC TTTGTTTTTCCTTTTGGAAACTTTTATGTATAATTCTTTCTGCCTGCCTACTTTTCTGCAAAAATGAGATGTACAGATTTCGGTTCCCTG CTATGAAAAGTGATGTGGTAGCAATTTTATAAATGTTGCTTTCTGATTTTTATCAGAGTGAGAAAATTAAAATTATTGATTTGCAAGTAG TAAACAGTTCATATTTTGATTTCCCCTCATTTTAGTTTAATATAATTTGCAATAAATGTACATATTGTTGTTTGTTTCATAAAGCATATC ACTTTAAAATGGTTTTTACTCCTGTGATTATGTTGGAATATTTGGAATTTTAAAGGAGTAAAGACTGTCCAGCATTTGGTTTTATAATGT TTGTCACCAGATTTTTATTAATGTAAAAAAAATCAATTTTTAAAAAATAGTTGGACTTTGGCAGCTTTTAAGGAAAGTTGGAGGTGTTTT AGGATTGCTATCAATTTTCAGCATTGTGCTATTTGGAAATAAGTGTTTTGCTTTTGTCTGATGGTCTGGGCTCATTTTTATGTTTATTTT AGAAAACTGTTGCATCAATATATTATGTTTCTTGGCATTGTTCAGCATAGGTAATGTGTGCACTTTATGTGTACACATAATCATATTTAA GTTTTTTGCATAAAATAAATGCTTCTAGATGTCATGGCAGTCTTTTTAATCTTTTTATCATATGCTTTCTTGTGAATTTTTTCATGTTAA AGAGCTAAAGTCATAACATGATTACAGTCAACTCTCCATTATCTATATAAAATAGTGACTAAGCCTCAGGTTTTTAATTTTGTGATAACA AAATAACGAAGGCATGTAAGACCTGATTCTGGAGGAACATGAAATTTGTCTTTTCTCATGTCCAGAGTTCTATCCTGCCCCCACTGTCCA CTGTAGGGTCATCCGCAAAGCCCTAGCAGAATGTGCTCACTCCATTTCCTTACACGTTTCTAGCATGGGTCAGAGGAAACAACATTTGTG TTATAACTTCGTCTTGATAGGCTGTAGTGTACATGGGATGTAAAACAAACAAGTGTATCAAAGGTGGATGATTCTGTTAGAGTGAAGTTT GAGAGTAAATGTCACTTACGTTTCTCATAGATAATCAAGAGTTGGCTGTGTATTGACTGAAAGATGGGTAATTATTTTAAATATGCATTT ACACACATTTAGGTATCAGAAGATGCTTAGGGAACAATGGATACCAATGATAGAAAATGATACCTTTACAGGGGCAGAAAAATCCCCACT CTTCCTTATTGCCTCTTCAGAACCCTTTAGAAAGTATAAAATATTGCCTCCAACATGCTGAAAAAGAGTATCTATGCATAAGTATCAGAG AAGTCCCTCAAGCAATCAGTAGGTGTGTTCTATTTAGAGAGAGTTTAAAGTTCTCTTAGCATCAGACAACTTGATTCCTAAGGTTTCCAG TGTGTCACCAACAAAAAGTGCATTGATAGGGACCTTTGTCTCTTCCTCCCTTTGATTAATTGCCCGGCATCACAGTTTACTAGATTACCA AGTGTTACATCATATTAAATAAAATGTAGCAGAACCATCTGCATCAATATATTCCTGTTTAGATTTTTGCAGGAGAGAAGTTAAAAGGAT TTGCTCCTTGTATGATGTAAGTGGCCCACCCCAATTTTGTAACATGATGCAAGTGTCTGGCACTAAGGGAAGCAAGAGTAGGGTTGTGGA AAGACCAAGCTGATGGGGAGGGACTTGTTTACGGGAATTTTTTTAGTTTTCCTTTTCAAAGGAAAACATTAAAATCCCTTAGGAATTTGG TATTCACATCTCAGAGAACTACAACACAAAAGTGCAGACTTATATTTGAGAATTAATGTTAACCCTTTGTGTCTAGTTTGAAGCTTCTTG TATTTGTCTAAAACAACAAGCCAGAATTTTGTATCTCCTTTGATAAAAAGTGTGTATAATGTAAAGTAGTTTTGCATATTCTTGTGCTGC ACATGGGCTGAATTTTTAAATTTTTTTTAAAAACTTGAAGCAGAACCTTGTAATTTGTGTAAATGACAAGTGTAAAATCCTACCATAAAA >In-frame_RFC1_ENST00000381897_chr4_39328183_-_PDS5A_ENST00000303538_chr4_39827108_-_3402nt ACCGCGCGCCACTGTCTTCGCCTTCTTGCACTTCGCGGGAGAAGTTGTTGGCGCGAATGGATCCTGAGCCTCGATAACAGATTCCTCAAC CGGCCCACCCGCCAGCCAGCCAGCGCCTTCATCCTGGGGCTGCGATGGACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAAC TTGTAAGTGAAACAGTAAAGAAGAATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATAAAGGAAATCAAGGTAA ATAGCTCCCGTAAAGAGGATGACTTCAAACAAAAGCAACCAAGCAAGAAAAAGAGGATCATCTATGATTCAGATTCAGAGTCAGAGGAGA CGTTGCAGGTAAAAAATGCCAAAAAGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGGCAGGATCCTGTTACAT ACATTTCAGAAACAGATGAAGAAGATGACTTTATGTGTAAGAAGGCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATC TTGGAACATCAAACATGAAAAAGAATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTTACACCCACATCAGTAC TTGATTATTTTGGAACTGGAAGTGTCCAAAGATCTAATAAGAAGATGGTGGCAAGCAAAAGAAAAGAGCTTTCACAAAATACAGATGAGT CTGGATTAAATGATGAAGCCATCGCCAAGCAATTACAGCTTGATGAAGATGCGGAGGTAAAAATGCATTTGCAAAGGGAGAAAATGAAGG CCAAACAGAAGCAGGCTCCAGCTTCTGCAAAAACTTGGATTCACAAATGTCCCTGAACAGAAAATGAAGCTCACTTCAGAACACACACTC TCTGCCTTGAAAACTAAAGAGACTATTACTTCCTTTTCACATGACCACAAGTCCTCTGATGGAAATGTACAGCAGAAACTCTTGAGAGAG AGGCTAAAAGCAACTCTGTTCTCCCCCTTCCCCTAGACTTTTCTTACGAAAAGTCAATAATTAAGCAAATTGCTTAACACTTGGTTCCAG TTCCTGCCTATCTGGAGTTTAAATGCGTAATACACCATTAATTTCCACGCTGCAGTTTTTATTTTAAAGAAAGTAACAAGATGTCTTTAC ACTGACACTGAAAATTCATCCATTTTAGAGCCAGGAATTCCCATGTTACACAGGAAAAAATAGAAGTCTACTGAATTAATTTTTTAAAAG AAAAGAGATCAGATTAAATATTTCTTTGTTTTTCCTTTTGGAAACTTTTATGTATAATTCTTTCTGCCTGCCTACTTTTCTGCAAAAATG AGATGTACAGATTTCGGTTCCCTGCTATGAAAAGTGATGTGGTAGCAATTTTATAAATGTTGCTTTCTGATTTTTATCAGAGTGAGAAAA TTAAAATTATTGATTTGCAAGTAGTAAACAGTTCATATTTTGATTTCCCCTCATTTTAGTTTAATATAATTTGCAATAAATGTACATATT GTTGTTTGTTTCATAAAGCATATCACTTTAAAATGGTTTTTACTCCTGTGATTATGTTGGAATATTTGGAATTTTAAAGGAGTAAAGACT GTCCAGCATTTGGTTTTATAATGTTTGTCACCAGATTTTTATTAATGTAAAAAAAATCAATTTTTAAAAAATAGTTGGACTTTGGCAGCT TTTAAGGAAAGTTGGAGGTGTTTTAGGATTGCTATCAATTTTCAGCATTGTGCTATTTGGAAATAAGTGTTTTGCTTTTGTCTGATGGTC TGGGCTCATTTTTATGTTTATTTTAGAAAACTGTTGCATCAATATATTATGTTTCTTGGCATTGTTCAGCATAGGTAATGTGTGCACTTT ATGTGTACACATAATCATATTTAAGTTTTTTGCATAAAATAAATGCTTCTAGATGTCATGGCAGTCTTTTTAATCTTTTTATCATATGCT TTCTTGTGAATTTTTTCATGTTAAAGAGCTAAAGTCATAACATGATTACAGTCAACTCTCCATTATCTATATAAAATAGTGACTAAGCCT CAGGTTTTTAATTTTGTGATAACAAAATAACGAAGGCATGTAAGACCTGATTCTGGAGGAACATGAAATTTGTCTTTTCTCATGTCCAGA GTTCTATCCTGCCCCCACTGTCCACTGTAGGGTCATCCGCAAAGCCCTAGCAGAATGTGCTCACTCCATTTCCTTACACGTTTCTAGCAT GGGTCAGAGGAAACAACATTTGTGTTATAACTTCGTCTTGATAGGCTGTAGTGTACATGGGATGTAAAACAAACAAGTGTATCAAAGGTG GATGATTCTGTTAGAGTGAAGTTTGAGAGTAAATGTCACTTACGTTTCTCATAGATAATCAAGAGTTGGCTGTGTATTGACTGAAAGATG GGTAATTATTTTAAATATGCATTTACACACATTTAGGTATCAGAAGATGCTTAGGGAACAATGGATACCAATGATAGAAAATGATACCTT TACAGGGGCAGAAAAATCCCCACTCTTCCTTATTGCCTCTTCAGAACCCTTTAGAAAGTATAAAATATTGCCTCCAACATGCTGAAAAAG AGTATCTATGCATAAGTATCAGAGAAGTCCCTCAAGCAATCAGTAGGTGTGTTCTATTTAGAGAGAGTTTAAAGTTCTCTTAGCATCAGA CAACTTGATTCCTAAGGTTTCCAGTGTGTCACCAACAAAAAGTGCATTGATAGGGACCTTTGTCTCTTCCTCCCTTTGATTAATTGCCCG GCATCACAGTTTACTAGATTACCAAGTGTTACATCATATTAAATAAAATGTAGCAGAACCATCTGCATCAATATATTCCTGTTTAGATTT TTGCAGGAGAGAAGTTAAAAGGATTTGCTCCTTGTATGATGTAAGTGGCCCACCCCAATTTTGTAACATGATGCAAGTGTCTGGCACTAA GGGAAGCAAGAGTAGGGTTGTGGAAAGACCAAGCTGATGGGGAGGGACTTGTTTACGGGAATTTTTTTAGTTTTCCTTTTCAAAGGAAAA CATTAAAATCCCTTAGGAATTTGGTATTCACATCTCAGAGAACTACAACACAAAAGTGCAGACTTATATTTGAGAATTAATGTTAACCCT TTGTGTCTAGTTTGAAGCTTCTTGTATTTGTCTAAAACAACAAGCCAGAATTTTGTATCTCCTTTGATAAAAAGTGTGTATAATGTAAAG TAGTTTTGCATATTCTTGTGCTGCACATGGGCTGAATTTTTAAATTTTTTTTAAAAACTTGAAGCAGAACCTTGTAATTTGTGTAAATGA |
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FusionGenePPI for RFC1_PDS5A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RFC1 | ATM, BLM, BRCA1, MLH1, MRE11A, MSH2, MSH6, NBN, RAD50, HDAC1, BRD4, PCNA, TP53, RELA, CDK4, CCND1, RB1, XRCC5, RFC3, RAD17, CHTF18, RFC2, RFC4, RFC5, PMS1, SSBP3, ZSCAN1, SAP25, CSNK2B, HDGF, SIRT7, MYOC, LAMP2, RBM14, WDR18, NOTCH1, SMC1A, YWHAQ, RPA1, RPA2, RPA3, SPRTN, NIFK, THBS3, NTRK1, GLYR1, PDS5A, RACGAP1, CDC45, SMC2, SMC4, XRCC6, MUS81, HIST1H2BG, HIST1H3A, DAXX, HNRNPU, EMC2, NOP56, IBTK, C10orf12, NF2, H2AFY2, TEAD2, RRP8, RPL18A, FGF3, UBC, CHEK2, CHEK1 | PDS5A | AKTIP, MYC, STAG1, STAG2, SMC3, CDCA5, SRRM1, RAD21, SMC1A, WFDC5, PDS5B, WAPAL, TIRAP, MAVS, CSNK2B, SIRT7, NSMCE2, DDX21, NOTCH1, UBC, RPA1, RPA2, RPA3, EZH2, EED, EGFR, SIRT6, BCL2L1, BSG, NT5E, LYPD3, RP2, DLK1, SLC30A4, SCN2B, RFC1, NTRK1, SCARNA22, CCNB2, JUN, NFATC1, TEAD2, FOXB1, FOXE1, FOXG1, FOXH1, FOXI1, FOXI2, FOXL1, FOXL2, FOXQ1, MDM2, GYPB, VIPR2, CD70, MAS1, APLNR, SIGLECL1, LAMP3, SLC15A1, CD83, LPAR4, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RFC1_PDS5A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RFC1_PDS5A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RFC1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | RFC1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | RFC1 | C0029463 | Osteosarcoma | 1 | CTD_human |
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