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Fusion gene ID: 3101 |
FusionGeneSummary for ATAD5_MN1 |
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Fusion gene information | Fusion gene name: ATAD5_MN1 | Fusion gene ID: 3101 | Hgene | Tgene | Gene symbol | ATAD5 | MN1 | Gene ID | 79915 | 4330 |
Gene name | ATPase family, AAA domain containing 5 | MN1 proto-oncogene, transcriptional regulator | |
Synonyms | C17orf41|ELG1|FRAG1 | MGCR|MGCR1|MGCR1-PEN|dJ353E16.2 | |
Cytomap | 17q11.2 | 22q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ATPase family AAA domain-containing protein 5chromosome fragility associated gene 1chromosome fragility-associated gene 1 proteinenhanced level of genomic instability 1 homolog | transcriptional activator MN1meningioma (disrupted in balanced translocation) 1meningioma (translocation balanced)meningioma chromosome region 1probable tumor suppressor protein MN1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96QE3 | Q10571 | |
Ensembl transtripts involved in fusion gene | ENST00000321990, | ENST00000302326, ENST00000497225, | |
Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ATAD5 [Title/Abstract] AND MN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI024583 | ATAD5 | chr17 | 29160560 | + | MN1 | chr22 | 28156876 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000321990 | ENST00000302326 | ATAD5 | chr17 | 29160560 | + | MN1 | chr22 | 28156876 | + |
intron-intron | ENST00000321990 | ENST00000497225 | ATAD5 | chr17 | 29160560 | + | MN1 | chr22 | 28156876 | + |
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FusionProtFeatures for ATAD5_MN1 |
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Hgene | Tgene |
ATAD5 | MN1 |
Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important indetermining whether DNA damage is compatible with cell survival orwhether it requires cell elimination by apoptosis. Modulates theRAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. {ECO:0000269|PubMed:15983387}. | Transcriptional activator which specifically regulatesexpression of TBX22 in the posterior region of the developingpalate. Required during later stages of palate development forgrowth and medial fusion of the palatal shelves. Promotesmaturation and normal function of calvarial osteoblasts, includingexpression of the osteoclastogenic cytokine TNFSF11/RANKL.Necessary for normal development of the membranous bones of theskull (By similarity). May play a role in tumor suppression(Probable). {ECO:0000250|UniProtKB:D3YWE6,ECO:0000305|PubMed:7731706}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATAD5_MN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATAD5_MN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATAD5_MN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATAD5_MN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ATAD5 | C0677886 | Epithelial ovarian cancer | 1 | CTD_human |
Tgene | MN1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |