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Fusion gene ID: 31001 |
FusionGeneSummary for REV1_ZNF385A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REV1_ZNF385A | Fusion gene ID: 31001 | Hgene | Tgene | Gene symbol | REV1 | ZNF385A | Gene ID | 51455 | 25946 |
| Gene name | REV1, DNA directed polymerase | zinc finger protein 385A | |
| Synonyms | AIBP80|REV1L | HZF|RZF|ZFP385|ZNF385 | |
| Cytomap | 2q11.2 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferase | zinc finger protein 385Ahematopoietic zinc finger proteinretinal zinc finger proteinzinc finger protein 385 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UBZ9 | Q96PM9 | |
| Ensembl transtripts involved in fusion gene | ENST00000393445, ENST00000258428, ENST00000465835, | ENST00000551109, ENST00000352268, ENST00000394313, ENST00000338010, ENST00000546970, ENST00000552382, ENST00000551771, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 3 X 3 X 2=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: REV1 [Title/Abstract] AND ZNF385A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | REV1 | GO:0009411 | response to UV | 11485998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA465008 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000393445 | ENST00000551109 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000393445 | ENST00000352268 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-5UTR | ENST00000393445 | ENST00000394313 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000393445 | ENST00000338010 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000393445 | ENST00000546970 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000393445 | ENST00000552382 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000393445 | ENST00000551771 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000258428 | ENST00000551109 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000258428 | ENST00000352268 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-5UTR | ENST00000258428 | ENST00000394313 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000258428 | ENST00000338010 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000258428 | ENST00000546970 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000258428 | ENST00000552382 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000258428 | ENST00000551771 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000465835 | ENST00000551109 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000465835 | ENST00000352268 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-5UTR | ENST00000465835 | ENST00000394313 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000465835 | ENST00000338010 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000465835 | ENST00000546970 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000465835 | ENST00000552382 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
| intron-intron | ENST00000465835 | ENST00000551771 | REV1 | chr2 | 100093851 | - | ZNF385A | chr12 | 54778479 | - |
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FusionProtFeatures for REV1_ZNF385A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REV1 | ZNF385A |
| Deoxycytidyl transferase involved in DNA repair.Transfers a dCMP residue from dCTP to the 3'-end of a DNA primerin a template-dependent reaction. May assist in the first step inthe bypass of abasic lesions by the insertion of a nucleotideopposite the lesion. Required for normal induction of mutations byphysical and chemical agents. {ECO:0000269|PubMed:10536157,ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384,ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. | RNA-binding protein that affects the localization andthe translation of a subset of mRNA. May play a role inadipogenesis through binding to the 3'-UTR of CEBPA mRNA andregulation of its translation. Targets ITPR1 mRNA to dendrites inPurkinje cells, and may regulate its activity-dependenttranslation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs tocontrol their nuclear export induced by CDKN2A. Hence, mayregulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively,may also regulate p53/TP53 activity through direct protein-proteininteraction. Interacts with p53/TP53 and promotes cell-cyclearrest over apoptosis enhancing preferentially the DNA binding andtransactivation of p53/TP53 on cell-cycle arrest target genes overproapoptotic target genes. May also regulate the ubiquitinationand stability of CDKN1A promoting DNA damage-induced cell cyclearrest. Also plays a role in megakaryocytes differentiation.{ECO:0000269|PubMed:17719541}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REV1_ZNF385A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REV1_ZNF385A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REV1_ZNF385A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REV1_ZNF385A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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