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Fusion gene ID: 30989 |
FusionGeneSummary for REST_UFD1L |
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Fusion gene information | Fusion gene name: REST_UFD1L | Fusion gene ID: 30989 | Hgene | Tgene | Gene symbol | REST | UFD1L | Gene ID | 5978 |
Gene name | RE1 silencing transcription factor | ||
Synonyms | GINGF5|HGF5|NRSF|WT6|XBR | ||
Cytomap | 4q12 | ||
Type of gene | protein-coding | ||
Description | RE1-silencing transcription factorneural-restrictive silencer factorneuron restrictive silencer factorrepressor binding to the X2 box | ||
Modification date | 20180523 | ||
UniProtAcc | Q13127 | ||
Ensembl transtripts involved in fusion gene | ENST00000309042, ENST00000514063, | ENST00000263202, ENST00000360834, ENST00000399523, ENST00000484101, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: REST [Title/Abstract] AND UFD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | REST | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8568247|21284946 |
Hgene | REST | GO:0043922 | negative regulation by host of viral transcription | 17555596 |
Hgene | REST | GO:0045892 | negative regulation of transcription, DNA-templated | 7697725|10449787|10734093|17984088|19342457 |
Hgene | REST | GO:0045893 | positive regulation of transcription, DNA-templated | 17984088 |
Hgene | REST | GO:0070933 | histone H4 deacetylation | 17555596 |
Hgene | REST | GO:0071385 | cellular response to glucocorticoid stimulus | 17984088 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE813696 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000309042 | ENST00000263202 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
5CDS-intron | ENST00000309042 | ENST00000360834 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
5CDS-intron | ENST00000309042 | ENST00000399523 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
5CDS-intron | ENST00000309042 | ENST00000484101 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
intron-intron | ENST00000514063 | ENST00000263202 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
intron-intron | ENST00000514063 | ENST00000360834 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
intron-intron | ENST00000514063 | ENST00000399523 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
intron-intron | ENST00000514063 | ENST00000484101 | REST | chr4 | 57796393 | + | UFD1L | chr22 | 19450787 | - |
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FusionProtFeatures for REST_UFD1L |
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Hgene | Tgene |
REST | UFD1L |
Transcriptional repressor which binds neuron-restrictivesilencer element (NRSE) and represses neuronal gene transcriptionin non-neuronal cells. Restricts the expression of neuronal genesby associating with two distinct corepressors, mSin3 and CoREST,which in turn recruit histone deacetylase to the promoters ofREST-regulated genes. Mediates repression by recruiting the BHCcomplex at RE1/NRSE sites which acts by deacetylating anddemethylating specific sites on histones, thereby acting as achromatin modifier. Transcriptional repression by REST-CDYL viathe recruitment of histone methyltransferase EHMT2 may beimportant in transformation suppression.{ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646,ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:7697725,ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REST_UFD1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REST_UFD1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REST_UFD1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REST_UFD1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | REST | C0015923 | Fetal Alcohol Syndrome | 1 | PSYGENET |
Hgene | REST | C0027708 | Nephroblastoma | 1 | CTD_human;HPO;ORPHANET |
Hgene | REST | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | REST | C0036572 | Seizures | 1 | CTD_human |
Hgene | REST | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | REST | C3891301 | WILMS TUMOR, SUSCEPTIBILITY TO | 1 | UNIPROT |