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Fusion gene ID: 30948 |
FusionGeneSummary for REL_RAB1A |
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Fusion gene information | Fusion gene name: REL_RAB1A | Fusion gene ID: 30948 | Hgene | Tgene | Gene symbol | REL | RAB1A | Gene ID | 5966 | 5861 |
Gene name | REL proto-oncogene, NF-kB subunit | RAB1A, member RAS oncogene family | |
Synonyms | C-Rel | RAB1|YPT1 | |
Cytomap | 2p16.1 | 2p14 | |
Type of gene | protein-coding | protein-coding | |
Description | proto-oncogene c-Reloncogene REL, avian reticuloendotheliosisv-rel avian reticuloendotheliosis viral oncogene homolog | ras-related protein Rab-1AGTP binding protein Rab1aRAB1, member RAS oncogene familyRab GTPase YPT1 homologYPT1-related protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q04864 | P62820 | |
Ensembl transtripts involved in fusion gene | ENST00000295025, ENST00000394479, | ENST00000494188, ENST00000409892, ENST00000409784, ENST00000398529, ENST00000409751, ENST00000260638, ENST00000356214, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 6 X 4 X 6=144 |
# samples | 5 | 7 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: REL [Title/Abstract] AND RAB1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | REL | GO:0010629 | negative regulation of gene expression | 22065573 |
Hgene | REL | GO:0032688 | negative regulation of interferon-beta production | 22065573 |
Hgene | REL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1406630 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-77-8009-01A | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000295025 | ENST00000494188 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000295025 | ENST00000409892 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000295025 | ENST00000409784 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000295025 | ENST00000398529 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000295025 | ENST00000409751 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000295025 | ENST00000260638 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000295025 | ENST00000356214 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000494188 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000409892 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000409784 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000398529 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000409751 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000260638 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
5CDS-5UTR | ENST00000394479 | ENST00000356214 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
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FusionProtFeatures for REL_RAB1A |
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Hgene | Tgene |
REL | RAB1A |
Proto-oncogene that may play a role in differentiationand lymphopoiesis. NF-kappa-B is a pleiotropic transcriptionfactor which is present in almost all cell types and is involvedin many biological processed such as inflammation, immunity,differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-likedomain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA oftheir target genes and the individual dimers have distinctpreferences for different kappa-B sites that they can bind withdistinguishable affinity and specificity. Different dimercombinations act as transcriptional activators or repressors,respectively. NF-kappa-B is controlled by various mechanisms ofpost-translational modification and subcellularcompartmentalization as well as by interactions with othercofactors or corepressors. NF-kappa-B complexes are held in thecytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activationpathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)in response to different activators, subsequently degraded thusliberating the active NF-kappa-B complex which translocates to thenucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is atranscriptional activator. | The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. RAB1A regulates vesicular protein transportfrom the endoplasmic reticulum (ER) to the Golgi compartment andon to the cell surface, and plays a role in IL-8 and growthhormone secretion. Regulates the level of CASR present at the cellmembrane. Plays a role in cell adhesion and cell migration, viaits role in protein trafficking. Plays a role in autophagosomeassembly and cellular defense reactions against pathogenicbacteria. Plays a role in microtubule-dependent protein transportby early endosomes and in anterograde melanosome transport.{ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236,ECO:0000269|PubMed:21303926, ECO:0000269|PubMed:22939626}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REL_RAB1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REL_RAB1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
REL | PPP4C, MAP3K8, PAPOLA, RELA, NFKB1, NFKB2, TBK1, TNIP2, NFKBIE, ELF1, SRF, TBP, GTF2B, SP1, NKRF, MTPN, MAPK8, NFKBIA, NFKBIB, CDK2, CREBBP, EP300, FOXP3, DPF2, HSPA4, COMMD1, SOCS3, CXCL14, AAAS, CLIC4, TMEM165, C9orf91, AR, ADRB2, ADSL, ARNT2, BZRAP1, DGCR6, FHIT, MVP, NDE1, PARK2, PRKAB2, TDO2, ACTN3, AES, ALOX5, BID, SEPT7, CDKN2C, CKS1B, COL8A1, DHPS, DNTT, EIF4EBP1, EIF5A, EPHB6, FHL2, FKBP1B, FLNA, GRB2, HIP1, UBE2K, HLA-DOA, LASP1, LMO1, LMO2, LNPEP, FOXO4, NEDD9, NUCB1, PLCB4, POLE2, POLR2L, PSMA1, PTGER3, PTK6, RABIF, SAT1, ATXN1, SDCBP, SLC6A12, RECK, NCK2, HAT1, CGGBP1, STK16, EIF3A, EIF3D, EIF4E2, RBM39, KIAA0100, EPM2AIP1, ACOT8, CHAF1A, TSSC4, ARIH2, MAD2L2, GADD45G, MORF4L1, EXOSC8, R3HDM2, SEC31A, SZT2, TENC1, DAAM2, EML2, POLR1A, NDUFAF3, NECAP1, IL36RN, OSTF1, HSPB7, RSPH14, CPSF1, NME7, OSGIN1, A1CF, NEUROG3, EXOSC1, MEMO1, CHCHD2, DYNC1LI1, POP5, CINP, HDAC7, OAZ3, TRAPPC2L, UBASH3A, OTUD4, TTC19, SLC41A3, C1orf109, TXNL4B, MAGOHB, NAGK, ASAP3, NXT2, CABP5, EIF5A2, LGALS14, AGPAT4, MAP3K7CL, EXOSC5, PRDM10, CTNNBIP1, COL20A1, RNF213, LSM2, NGB, DMRT3, TMEM8A, PARVG, UBE2Z, OTUB2, C20orf195, ATG9A, CCNJL, SNRNP25, NOL9, FLAD1, TSSK3, RASSF5, C11orf68, PLEKHN1, MIEN1, VPS25, CEP19, KRTAP9-4, BMF, SLC39A13, ATPAF2, ZNF765, RIPPLY1, EGLN3, EFHC1, KLHL32, CIB3, PIH1D2, MRPL10, NR2C2AP, KLHL40, GLYCTK, ZNF572, ZNF417, TSTD2, PATE1, ZNF550, ZNF564, FUT11, TTC21A, STRA13, C9orf72, CPNE2, NEIL2, ZDHHC24, NUDT14, SEC14L4, BARHL2, RAB41, TRIM74, C12orf75, REXO1L6P, BTRC, RELB, TSR3, AURKA, XPO1, BIRC3, RGS3, HIF1AN, NFKBID | RAB1A | RABAC1, GOLGA2, MICAL1, RABIF, GOLGA5, CAPNS1, CREB1, FSCN1, HIVEP1, SLC16A8, TBC1D17, CDKN1A, RFK, CHML, USO1, CHM, RABEP1, ELAVL1, ARRB1, RAB11B, RAB7A, GDI1, GDI2, RAB11A, RAB31, HNRNPA1L2, RAP1A, PTBP1, HNRNPA3, IQCB1, UBL4A, BAG3, ATP4A, ATP6V1A, MTPN, PCYT2, PDIA3, ENO2, GMPS, MTAP, PNP, TUBB4B, RPA1, RPA2, RPA3, ASB5, ASB9, SART3, RUSC2, CUL7, CCDC8, OCRL, ULK1, RAB1B, UNK, ATP1A1, ATP1A2, ATP1A3, ATP1B1, ATP5H, BCAP31, CCDC47, CYC1, DNAJA3, ETFA, HNRNPA1, HSD17B12, IPO9, KDSR, LDHA, LDHAL6B, LDHB, LDHC, LRPPRC, NDUFB8, NDUFB9, PHB, PHPT1, AHSA1, ARF1, ATP1B3, CANX, CDC42, CLGN, DUT, FUBP1, ILVBL, MTCH2, NDUFS8, PLIN3, PRRC1, RAB5A, RAB5B, RAB5C, RANBP1, RAP2C, SLC25A3, SSRP1, STMN1, TECR, TM9SF4, TOMM70A, TXN, RAB2A, RAB6A, RAB6B, RDH13, RER1, RPN1, RPN2, STOML2, STX12, STX7, TMCO1, TMED2, UBE2K, UQCRC2, UQCRQ, VAPA, VDAC2, TCTN2, TCTN3, CAPZA2, DBN1, ATL3, LIMA1, GTSE1, MTOR, RPTOR, CSNK1D, TRAPPC2L, VPS51, TMED10, TSSC1, PTAR1, SEC23IP, COG5, RAB18, VPS52, TRAPPC12, JTB, COG8, RIC1, COG3, COG7, VPS53, TRAPPC13, VPS54, CDC73, CDH1, EGFR, RAB8A, VPS13C, EEF1A2, RABGGTA, RAB2B, DLD, DLST, PARK7, PDHA1, G3BP1, HEY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REL_RAB1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REL_RAB1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | REL | C0003873 | Rheumatoid Arthritis | 3 | CTD_human |
Hgene | REL | C0018843 | Heat Stroke | 1 | CTD_human |
Hgene | REL | C0019829 | Hodgkin Disease | 1 | CTD_human |
Hgene | REL | C0025261 | Memory Disorders | 1 | CTD_human |
Hgene | REL | C0033860 | Psoriasis | 1 | CTD_human |