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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3094

FusionGeneSummary for ATAD2_WDYHV1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD2_WDYHV1
Fusion gene ID: 3094
HgeneTgene
Gene symbol

ATAD2

WDYHV1

Gene ID

29028

55093

Gene nameATPase family, AAA domain containing 2WDYHV motif containing 1
SynonymsANCCA|CT137|PRO2000C8orf32
Cytomap

8q24.13

8q24.13

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 2AAA nuclear coregulator cancer-associated proteinprotein N-terminal glutamine amidohydrolaseN-terminal Gln amidaseWDYHV motif-containing protein 1nt(Q)-amidaseprotein NH2-terminal glutamine deamidase
Modification date2018052320180522
UniProtAcc

Q6PL18

Q96HA8

Ensembl transtripts involved in fusion geneENST00000287394, ENST00000521903, 
ENST00000534257, 		ENST00000287387, 
ENST00000523984, ENST00000517609, 
ENST00000523356, ENST00000518125, 
Fusion gene scores* DoF score10 X 8 X 7=5603 X 3 X 4=36
# samples 125
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATAD2 [Title/Abstract] AND WDYHV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATAD2

GO:0045893

positive regulation of transcription, DNA-templated

17998543


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-05-4422-01AATAD2chr8

124392769

-WDYHV1chr8

124440164

+
TCGARVSARCTCGA-DX-AB2V-01AATAD2chr8

124384877

-WDYHV1chr8

124448693

+
TCGARVUCECTCGA-AX-A3GI-01AATAD2chr8

124408427

-WDYHV1chr8

124440164

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000287394ENST00000287387ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-5UTRENST00000287394ENST00000523984ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000517609ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000523356ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5CDS-intronENST00000287394ENST00000518125ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-3CDSENST00000521903ENST00000287387ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-5UTRENST00000521903ENST00000523984ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-3UTRENST00000521903ENST00000517609ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-3UTRENST00000521903ENST00000523356ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
5UTR-intronENST00000521903ENST00000518125ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3CDSENST00000534257ENST00000287387ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-5UTRENST00000534257ENST00000523984ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000517609ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000523356ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
intron-intronENST00000534257ENST00000518125ATAD2chr8

124392769

-WDYHV1chr8

124440164

+
Frame-shiftENST00000287394ENST00000287387ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
Frame-shiftENST00000287394ENST00000523984ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5CDS-3UTRENST00000287394ENST00000517609ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5CDS-3UTRENST00000287394ENST00000523356ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5CDS-intronENST00000287394ENST00000518125ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3CDSENST00000521903ENST00000287387ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3CDSENST00000521903ENST00000523984ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3UTRENST00000521903ENST00000517609ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-3UTRENST00000521903ENST00000523356ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
5UTR-intronENST00000521903ENST00000518125ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3CDSENST00000534257ENST00000287387ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3CDSENST00000534257ENST00000523984ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3UTRENST00000534257ENST00000517609ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-3UTRENST00000534257ENST00000523356ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
intron-intronENST00000534257ENST00000518125ATAD2chr8

124384877

-WDYHV1chr8

124448693

+
Frame-shiftENST00000287394ENST00000287387ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-5UTRENST00000287394ENST00000523984ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000517609ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-3UTRENST00000287394ENST00000523356ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
5CDS-intronENST00000287394ENST00000518125ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3CDSENST00000521903ENST00000287387ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-5UTRENST00000521903ENST00000523984ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000521903ENST00000517609ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000521903ENST00000523356ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-intronENST00000521903ENST00000518125ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3CDSENST00000534257ENST00000287387ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-5UTRENST00000534257ENST00000523984ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000517609ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-3UTRENST00000534257ENST00000523356ATAD2chr8

124408427

-WDYHV1chr8

124440164

+
intron-intronENST00000534257ENST00000518125ATAD2chr8

124408427

-WDYHV1chr8

124440164

+

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FusionProtFeatures for ATAD2_WDYHV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATAD2

Q6PL18

WDYHV1

Q96HA8

May be a transcriptional coactivator of the nuclearreceptor ESR1 required to induce the expression of a subset ofestradiol target genes, such as CCND1, MYC and E2F1. May play arole in the recruitment or occupancy of CREBBP at some ESR1 targetgene promoters. May be required for histone hyperacetylation.Involved in the estrogen-induced cell proliferation and cell cycleprogression of breast cancer cells. {ECO:0000269|PubMed:17998543}. Mediates the side-chain deamidation of N-terminalglutamine residues to glutamate, an important step in N-end rulepathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible toarginylation, polyubiquitination and degradation as specified bythe N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues inany position. Does not deaminate acetylated N-terminal glutamine.With the exception of proline, all tested second-position residueson substrate peptides do not greatly influence the activity. Incontrast, a proline at position 2, virtually abolishes deamidationof N-terminal glutamine. {ECO:0000250|UniProtKB:Q80WB5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-2281086_11121061391Coiled coilOntology_term=ECO:0000255
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228970_9941061391Coiled coilOntology_term=ECO:0000255
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228250_2851061391Compositional biasNote=Asp-rich
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228357_3661061391Compositional biasNote=Poly-Ser
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-2281001_10711061391DomainBromo
HgeneATAD2chr8:124392769chr8:124440164ENST00000287394-228467_4741061391Nucleotide bindingATP


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FusionGeneSequence for ATAD2_WDYHV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATAD2_WDYHV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATAD2MYC, NCOA3, ESR1, E2F1, E2F3, E2F4, E2F2, HIST3H3, HIST2H4A, SIRT7, HDAC11, NXF1, POLE3, IFI16, BAG4, BCAR3, CASP8, HIST1H2BG, HIST1H3A, SPTBN2, TRIM25, G3BP1WDYHV1NME1, DCTPP1, HSD17B14, XIAP, NECAB2, JUP, RPIA, SFN, MDFI, HPRT1, CBFA2T2, BLOC1S6, TRIP13, RABAC1, PCBD1, RBBP8, SMN1, COIL, PTS, ACTB, ACTG1, BIRC2, ASL, BLMH, CAPN3, CDA, CDR2, CRYAA, CTH, DAB1, DHPS, EIF2B1, ETV6, FTH1, GMDS, GOLGA2, PRMT1, KCNH1, KRTAP5-9, KRT31, MAGEA11, MIF, PRPS2, PYGM, TRIM27, SIAH1, TNR, VCP, RAD54L, GAS7, STX11, TSC22D1, PNMA1, RBPMS, MTUS2, GNMT, APIP, AMOTL2, TOLLIP, LZTFL1, THAP1, VAC14, SEPT3, TRIM54, NCOA5, KLHL12, PPCDC, C1orf50, CCDC102B, NPL, KRTAP9-2, LZTS2, NT5C1A, ZNF341, KRTAP9-4, KRTAP4-2, LONRF1, PNMA5, EDARADD, AMOT, MARCH10, NUDT14, KCTD1, KRTAP10-7, KRTAP10-5, CCDC184, ZBTB8A, TMEM239, ARFGAP3, SBNO1, TRIM33, ERN1, SHB, NFATC2IP, INPP4A, MTG2, ZNF639, RPS6KA3, PRADC1, TRIM24, ZHX3, PLA2G10, LPP, TRAF2, ZBTB2, NET1, TRMT1, SIX4, EIF4G3, ASPH, NDC80, CEP85, CRTC2, SRRT, HMGCL, HTRA2, KIF2C, R3HDM1, GNPTG, DMXL2, FAM122B, PKP2, NUP35, MTMR4, GFER, QRICH1, PINX1, RIOK1, INPP5K, NUF2, PCCA, AXIN1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATAD2_WDYHV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATAD2_WDYHV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource