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Fusion gene ID: 30929 |
FusionGeneSummary for REG3G_CPA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REG3G_CPA1 | Fusion gene ID: 30929 | Hgene | Tgene | Gene symbol | REG3G | CPA1 | Gene ID | 130120 | 1357 |
| Gene name | regenerating family member 3 gamma | carboxypeptidase A1 | |
| Synonyms | LPPM429|PAP IB|PAP-1B|PAP1B|PAPIB|REG III|REG-III|UNQ429 | CPA | |
| Cytomap | 2p12 | 7q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | regenerating islet-derived protein 3-gammaREG-3-gammapancreatitis-associated protein 1Bpancreatitis-associated protein IBreg III-gammaregenerating gene IIIregenerating islet-derived 3 gammaregenerating islet-derived protein III-gamma | carboxypeptidase A1carboxypeptidase A1 (pancreatic)pancreatic carboxypeptidase A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6UW15 | P15085 | |
| Ensembl transtripts involved in fusion gene | ENST00000393897, ENST00000272324, ENST00000409471, | ENST00000011292, ENST00000484324, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 5 X 6 X 2=60 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/9*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: REG3G [Title/Abstract] AND CPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | REG3G | GO:0044278 | cell wall disruption in other organism | 16931762 |
| Hgene | REG3G | GO:0051715 | cytolysis in other organism | 16931762 |
| Hgene | REG3G | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 16931762 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-HZ-8003-01A | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000393897 | ENST00000011292 | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
| 3UTR-3CDS | ENST00000393897 | ENST00000484324 | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
| 3UTR-3CDS | ENST00000272324 | ENST00000011292 | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
| 3UTR-3CDS | ENST00000272324 | ENST00000484324 | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
| intron-3CDS | ENST00000409471 | ENST00000011292 | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
| intron-3CDS | ENST00000409471 | ENST00000484324 | REG3G | chr2 | 79255554 | + | CPA1 | chr7 | 130021954 | + |
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FusionProtFeatures for REG3G_CPA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REG3G | CPA1 |
| Bactericidal C-type lectin which acts exclusivelyagainst Gram-positive bacteria and mediates bacterial killing bybinding to surface-exposed carbohydrate moieties of peptidoglycan.Restricts bacterial colonization of the intestinal epithelialsurface and consequently limits activation of adaptive immuneresponses by the microbiota. The uncleaved form has bacteriostaticactivity, whereas the cleaved form has bactericidal activityagainst L.monocytogenes and methicillin-resistant S.aureus.Regulates keratinocyte proliferation and differentiation afterskin injury. {ECO:0000269|PubMed:19095652}. | Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu,-Arg, -Lys or -Pro. {ECO:0000269|PubMed:8806703}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REG3G_CPA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REG3G_CPA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| REG3G | CPA1 | ARRB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REG3G_CPA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REG3G_CPA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CPA1 | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |
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