![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 30928 |
FusionGeneSummary for REG3G_CEL |
![]() |
Fusion gene information | Fusion gene name: REG3G_CEL | Fusion gene ID: 30928 | Hgene | Tgene | Gene symbol | REG3G | CEL | Gene ID | 130120 | 1056 |
Gene name | regenerating family member 3 gamma | carboxyl ester lipase | |
Synonyms | LPPM429|PAP IB|PAP-1B|PAP1B|PAPIB|REG III|REG-III|UNQ429 | BAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8 | |
Cytomap | 2p12 | 9q34.13 | |
Type of gene | protein-coding | protein-coding | |
Description | regenerating islet-derived protein 3-gammaREG-3-gammapancreatitis-associated protein 1Bpancreatitis-associated protein IBreg III-gammaregenerating gene IIIregenerating islet-derived 3 gammaregenerating islet-derived protein III-gamma | bile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera | |
Modification date | 20180523 | 20180528 | |
UniProtAcc | Q6UW15 | P19835 | |
Ensembl transtripts involved in fusion gene | ENST00000393897, ENST00000272324, ENST00000409471, | ENST00000351304, ENST00000372080, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/9*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: REG3G [Title/Abstract] AND CEL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | REG3G | GO:0044278 | cell wall disruption in other organism | 16931762 |
Hgene | REG3G | GO:0051715 | cytolysis in other organism | 16931762 |
Hgene | REG3G | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 16931762 |
Tgene | CEL | GO:0006707 | cholesterol catabolic process | 12031288 |
Tgene | CEL | GO:0030157 | pancreatic juice secretion | 1854805 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PAAD | TCGA-F2-7273-01A | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000393897 | ENST00000351304 | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
Frame-shift | ENST00000393897 | ENST00000372080 | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
Frame-shift | ENST00000272324 | ENST00000351304 | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
Frame-shift | ENST00000272324 | ENST00000372080 | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
intron-3CDS | ENST00000409471 | ENST00000351304 | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
intron-3CDS | ENST00000409471 | ENST00000372080 | REG3G | chr2 | 79254281 | + | CEL | chr9 | 135941983 | + |
Top |
FusionProtFeatures for REG3G_CEL |
![]() |
Hgene | Tgene |
REG3G | CEL |
Bactericidal C-type lectin which acts exclusivelyagainst Gram-positive bacteria and mediates bacterial killing bybinding to surface-exposed carbohydrate moieties of peptidoglycan.Restricts bacterial colonization of the intestinal epithelialsurface and consequently limits activation of adaptive immuneresponses by the microbiota. The uncleaved form has bacteriostaticactivity, whereas the cleaved form has bactericidal activityagainst L.monocytogenes and methicillin-resistant S.aureus.Regulates keratinocyte proliferation and differentiation afterskin injury. {ECO:0000269|PubMed:19095652}. | Catalyzes fat and vitamin absorption. Acts in concertwith pancreatic lipase and colipase for the complete digestion ofdietary triglycerides. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for REG3G_CEL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for REG3G_CEL |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
REG3G | CEL | BPGM, OLR1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for REG3G_CEL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for REG3G_CEL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CEL | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |