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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30928

FusionGeneSummary for REG3G_CEL

check button Fusion gene summary
Fusion gene informationFusion gene name: REG3G_CEL
Fusion gene ID: 30928
HgeneTgene
Gene symbol

REG3G

CEL

Gene ID

130120

1056

Gene nameregenerating family member 3 gammacarboxyl ester lipase
SynonymsLPPM429|PAP IB|PAP-1B|PAP1B|PAPIB|REG III|REG-III|UNQ429BAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8
Cytomap

2p12

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionregenerating islet-derived protein 3-gammaREG-3-gammapancreatitis-associated protein 1Bpancreatitis-associated protein IBreg III-gammaregenerating gene IIIregenerating islet-derived 3 gammaregenerating islet-derived protein III-gammabile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera
Modification date2018052320180528
UniProtAcc

Q6UW15

P19835

Ensembl transtripts involved in fusion geneENST00000393897, ENST00000272324, 
ENST00000409471, 
ENST00000351304, 
ENST00000372080, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 3=27
# samples 23
** MAII scorelog2(2/9*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: REG3G [Title/Abstract] AND CEL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneREG3G

GO:0044278

cell wall disruption in other organism

16931762

HgeneREG3G

GO:0051715

cytolysis in other organism

16931762

HgeneREG3G

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

16931762

TgeneCEL

GO:0006707

cholesterol catabolic process

12031288

TgeneCEL

GO:0030157

pancreatic juice secretion

1854805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-F2-7273-01AREG3Gchr2

79254281

+CELchr9

135941983

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000393897ENST00000351304REG3Gchr2

79254281

+CELchr9

135941983

+
Frame-shiftENST00000393897ENST00000372080REG3Gchr2

79254281

+CELchr9

135941983

+
Frame-shiftENST00000272324ENST00000351304REG3Gchr2

79254281

+CELchr9

135941983

+
Frame-shiftENST00000272324ENST00000372080REG3Gchr2

79254281

+CELchr9

135941983

+
intron-3CDSENST00000409471ENST00000351304REG3Gchr2

79254281

+CELchr9

135941983

+
intron-3CDSENST00000409471ENST00000372080REG3Gchr2

79254281

+CELchr9

135941983

+

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FusionProtFeatures for REG3G_CEL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
REG3G

Q6UW15

CEL

P19835

Bactericidal C-type lectin which acts exclusivelyagainst Gram-positive bacteria and mediates bacterial killing bybinding to surface-exposed carbohydrate moieties of peptidoglycan.Restricts bacterial colonization of the intestinal epithelialsurface and consequently limits activation of adaptive immuneresponses by the microbiota. The uncleaved form has bacteriostaticactivity, whereas the cleaved form has bactericidal activityagainst L.monocytogenes and methicillin-resistant S.aureus.Regulates keratinocyte proliferation and differentiation afterskin injury. {ECO:0000269|PubMed:19095652}. Catalyzes fat and vitamin absorption. Acts in concertwith pancreatic lipase and colipase for the complete digestion ofdietary triglycerides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for REG3G_CEL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for REG3G_CEL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
REG3GCELBPGM, OLR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for REG3G_CEL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for REG3G_CEL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCELC0149521Pancreatitis, Chronic1CTD_human