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Fusion gene ID: 30927 |
FusionGeneSummary for REG3A_SERPINA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REG3A_SERPINA1 | Fusion gene ID: 30927 | Hgene | Tgene | Gene symbol | REG3A | SERPINA1 | Gene ID | 5068 | 5265 |
| Gene name | regenerating family member 3 alpha | serpin family A member 1 | |
| Synonyms | HIP|HIP/PAP|INGAP|PAP|PAP-H|PAP1|PBCGF|REG-III|REG3 | A1A|A1AT|AAT|PI|PI1|PRO2275|alpha1AT|nNIF | |
| Cytomap | 2p12 | 14q32.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | regenerating islet-derived protein 3-alphaPAP homologous proteinREG-3-alphahepatocarcinoma-intestine-pancreashepatointestinal pancreatic proteinhuman proislet peptidepancreatic beta cell growth factorpancreatitis-associated protein 1proliferation- | alpha-1-antitrypsinalpha-1 antitrypsinalpha-1 protease inhibitoralpha-1-antiproteinasealpha-1-antitrypsin nullalpha-1-antitrypsin short transcript variant 1C4alpha-1-antitrypsin short transcript variant 1C5protease inhibitor 1 (anti-elastase), alph | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q06141 | P01009 | |
| Ensembl transtripts involved in fusion gene | ENST00000409839, ENST00000393878, ENST00000305165, | ENST00000440909, ENST00000448921, ENST00000437397, ENST00000355814, ENST00000393087, ENST00000393088, ENST00000404814, ENST00000449399, ENST00000402629, ENST00000555289, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 9 X 9 X 3=243 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/18*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/243*10)=-0.902444690577326 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: REG3A [Title/Abstract] AND SERPINA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-D5-6536-01A | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409839 | ENST00000440909 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000448921 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000437397 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000355814 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000393087 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000393088 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000404814 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000449399 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| In-frame | ENST00000409839 | ENST00000402629 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| 5CDS-intron | ENST00000409839 | ENST00000555289 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000440909 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000448921 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000437397 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000355814 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000393087 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000393088 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000404814 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000449399 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000393878 | ENST00000402629 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| 5CDS-intron | ENST00000393878 | ENST00000555289 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000440909 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000448921 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000437397 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000355814 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000393087 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000393088 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000404814 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000449399 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| Frame-shift | ENST00000305165 | ENST00000402629 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
| 5CDS-intron | ENST00000305165 | ENST00000555289 | REG3A | chr2 | 79385774 | - | SERPINA1 | chr14 | 94847478 | - |
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FusionProtFeatures for REG3A_SERPINA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REG3A | SERPINA1 |
| Bactericidal C-type lectin which acts exclusivelyagainst Gram-positive bacteria and mediates bacterial killing bybinding to surface-exposed carbohydrate moieties of peptidoglycan.Regulates keratinocyte proliferation and differentiation afterskin injury via activation of EXTL3-PI3K-AKT signaling pathway.{ECO:0000269|PubMed:16931762}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000355814 | - | 1 | 5 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000393087 | - | 1 | 5 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000393088 | - | 3 | 7 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000402629 | - | 1 | 4 | 368_392 | 215 | 360 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000404814 | - | 2 | 6 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000437397 | - | 2 | 6 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000440909 | - | 1 | 5 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000448921 | - | 3 | 7 | 368_392 | 215 | 419 | Region | Note=RCL |
| Tgene | >SERPINA1 | chr2:79385774 | chr14:94847478 | ENST00000449399 | - | 2 | 6 | 368_392 | 215 | 419 | Region | Note=RCL |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >REG3A | chr2:79385774 | chr14:94847478 | ENST00000305165 | - | 3 | 6 | 47_172 | 65 | 176 | Domain | C-type lectin |
| Hgene | >REG3A | chr2:79385774 | chr14:94847478 | ENST00000393878 | - | 2 | 5 | 47_172 | 65 | 176 | Domain | C-type lectin |
| Hgene | >REG3A | chr2:79385774 | chr14:94847478 | ENST00000409839 | - | 3 | 6 | 47_172 | 65 | 176 | Domain | C-type lectin |
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FusionGeneSequence for REG3A_SERPINA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000440909_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000448921_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000437397_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000355814_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000393087_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000393088_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000404814_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000449399_chr14_94847478_-_268aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000402629_chr14_94847478_-_209aa MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADANGRDPLKSRTPRKRTSTWTRXPPX RCLXXSVXACLTSSTVRSCPAGCCXXNTWAMPPPSSSCLMRGNYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEPMIXRASWVNW |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000440909_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000448921_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000437397_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000355814_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000393087_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000393088_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000404814_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000449399_chr14_94847478_-_806nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG GCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTG TGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCA >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000402629_chr14_94847478_-_629nt ATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCTCATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAG AGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGGCTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCC TGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGA AGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCA ATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGG AAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000440909_chr14_94847478_-_2545nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT TAAAGAAGGGTTGAGCTGGTCCCTGCCTGCATGTGACTGTAAATCCCTCCCATGTTTTCTCTGAGTCTCCCTTTGCCTGCTGAGGCTGTA TGTGGGCTCCAGGTAACAGTGCTGTCTTCGGGCCCCCTGAACTGTGTTCATGGAGCATCTGGCTGGGTAGGCACATGCTGGGCTTGAATC CAGGGGGGACTGAATCCTCAGCTTACGGACCTGGGCCCATCTGTTTCTGGAGGGCTCCAGTCTTCCTTGTCCTGTCTTGGAGTCCCCAAG AAGGAATCACAGGGGAGGAACCAGATACCAGCCATGACCCCAGGCTCCACCAAGCATCTTCATGTCCCCCTGCTCATCCCCCACTCCCCC CCACCCAGAGTTGCTCATCCTGCCAGGGCTGGCTGTGCCCACCCCAAGGCTGCCCTCCTGGGGGCCCCAGAACTGCCTGATCGTGCCGTG GCCCAGTTTTGTGGCATCTGCAGCAACACAAGAGAGAGGACAATGTCCTCCTCTTGACCCGCTGTCACCTAACCAGACTCGGGCCCTGCA CCTCTCAGGCACTTCTGGAAAATGACTGAGGCAGATTCTTCCTGAAGCCCATTCTCCATGGGGCAACAAGGACACCTATTCTGTCCTTGT CCTTCCATCGCTGCCCCAGAAAGCCTCACATATCTCCGTTTAGAATCAGGTCCCTTCTCCCCAGATGAAGAGGAGGGTCTCTGCTTTGTT TTCTCTATCTCCTCCTCAGACTTGACCAGGCCCAGCAGGCCCCAGAAGACCATTACCCTATATCCCTTCTCCTCCCTAGTCACATGGCCA TAGGCCTGCTGATGGCTCAGGAAGGCCATTGCAAGGACTCCTCAGCTATGGGAGAGGAAGCACATCACCCATTGACCCCCGCAACCCCTC CCTTTCCTCCTCTGAGTCCCGACTGGGGCCACATGCAGCCTGACTTCTTTGTGCCTGTTGCTGTCCCTGCAGTCTTCAGAGGGCCACCGC AGCTCCAGTGCCACGGCAGGAGGCTGTTCCTGAATAGCCCCTGTGGTAAGGGCCAGGAGAGTCCTTCCATCCTCCAAGGCCCTGCTAAAG GACACAGCAGCCAGGAAGTCCCCTGGGCCCCTAGCTGAAGGACAGCCTGCTCCCTCCGTCTCTACCAGGAATGGCCTTGTCCTATGGAAG GCACTGCCCCATCCCAAACTAATCTAGGAATCACTGTCTAACCACTCACTGTCATGAATGTGTACTTAAAGGATGAGGTTGAGTCATACC AAATAGTGATTTCGATAGTTCAAAATGGTGAAATTAGCAATTCTACATGATTCAGTCTAATCAATGGATACCGACTGTTTCCCACACAAG TCTCCTGTTCTCTTAAGCTTACTCACTGACAGCCTTTCACTCTCCACAAATACATTAAAGATATGGCCATCACCAAGCCCCCTAGGATGA CACCAGACCTGAGAGTCTGAAGACCTGGATCCAAGTTCTGACTTTTCCCCCTGACAGCTGTGTGACCTTCGTGAAGTCGCCAAACCTCTC TGAGCCCCAGTCATTGCTAGTAAGACCTGCCTTTGAGTTGGTATGATGTTCAAGTTAGATAACAAAATGTTTATACCCATTAGAACAGAG >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000448921_chr14_94847478_-_2545nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT TAAAGAAGGGTTGAGCTGGTCCCTGCCTGCATGTGACTGTAAATCCCTCCCATGTTTTCTCTGAGTCTCCCTTTGCCTGCTGAGGCTGTA TGTGGGCTCCAGGTAACAGTGCTGTCTTCGGGCCCCCTGAACTGTGTTCATGGAGCATCTGGCTGGGTAGGCACATGCTGGGCTTGAATC CAGGGGGGACTGAATCCTCAGCTTACGGACCTGGGCCCATCTGTTTCTGGAGGGCTCCAGTCTTCCTTGTCCTGTCTTGGAGTCCCCAAG AAGGAATCACAGGGGAGGAACCAGATACCAGCCATGACCCCAGGCTCCACCAAGCATCTTCATGTCCCCCTGCTCATCCCCCACTCCCCC CCACCCAGAGTTGCTCATCCTGCCAGGGCTGGCTGTGCCCACCCCAAGGCTGCCCTCCTGGGGGCCCCAGAACTGCCTGATCGTGCCGTG GCCCAGTTTTGTGGCATCTGCAGCAACACAAGAGAGAGGACAATGTCCTCCTCTTGACCCGCTGTCACCTAACCAGACTCGGGCCCTGCA CCTCTCAGGCACTTCTGGAAAATGACTGAGGCAGATTCTTCCTGAAGCCCATTCTCCATGGGGCAACAAGGACACCTATTCTGTCCTTGT CCTTCCATCGCTGCCCCAGAAAGCCTCACATATCTCCGTTTAGAATCAGGTCCCTTCTCCCCAGATGAAGAGGAGGGTCTCTGCTTTGTT TTCTCTATCTCCTCCTCAGACTTGACCAGGCCCAGCAGGCCCCAGAAGACCATTACCCTATATCCCTTCTCCTCCCTAGTCACATGGCCA TAGGCCTGCTGATGGCTCAGGAAGGCCATTGCAAGGACTCCTCAGCTATGGGAGAGGAAGCACATCACCCATTGACCCCCGCAACCCCTC CCTTTCCTCCTCTGAGTCCCGACTGGGGCCACATGCAGCCTGACTTCTTTGTGCCTGTTGCTGTCCCTGCAGTCTTCAGAGGGCCACCGC AGCTCCAGTGCCACGGCAGGAGGCTGTTCCTGAATAGCCCCTGTGGTAAGGGCCAGGAGAGTCCTTCCATCCTCCAAGGCCCTGCTAAAG GACACAGCAGCCAGGAAGTCCCCTGGGCCCCTAGCTGAAGGACAGCCTGCTCCCTCCGTCTCTACCAGGAATGGCCTTGTCCTATGGAAG GCACTGCCCCATCCCAAACTAATCTAGGAATCACTGTCTAACCACTCACTGTCATGAATGTGTACTTAAAGGATGAGGTTGAGTCATACC AAATAGTGATTTCGATAGTTCAAAATGGTGAAATTAGCAATTCTACATGATTCAGTCTAATCAATGGATACCGACTGTTTCCCACACAAG TCTCCTGTTCTCTTAAGCTTACTCACTGACAGCCTTTCACTCTCCACAAATACATTAAAGATATGGCCATCACCAAGCCCCCTAGGATGA CACCAGACCTGAGAGTCTGAAGACCTGGATCCAAGTTCTGACTTTTCCCCCTGACAGCTGTGTGACCTTCGTGAAGTCGCCAAACCTCTC TGAGCCCCAGTCATTGCTAGTAAGACCTGCCTTTGAGTTGGTATGATGTTCAAGTTAGATAACAAAATGTTTATACCCATTAGAACAGAG >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000437397_chr14_94847478_-_2545nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT TAAAGAAGGGTTGAGCTGGTCCCTGCCTGCATGTGACTGTAAATCCCTCCCATGTTTTCTCTGAGTCTCCCTTTGCCTGCTGAGGCTGTA TGTGGGCTCCAGGTAACAGTGCTGTCTTCGGGCCCCCTGAACTGTGTTCATGGAGCATCTGGCTGGGTAGGCACATGCTGGGCTTGAATC CAGGGGGGACTGAATCCTCAGCTTACGGACCTGGGCCCATCTGTTTCTGGAGGGCTCCAGTCTTCCTTGTCCTGTCTTGGAGTCCCCAAG AAGGAATCACAGGGGAGGAACCAGATACCAGCCATGACCCCAGGCTCCACCAAGCATCTTCATGTCCCCCTGCTCATCCCCCACTCCCCC CCACCCAGAGTTGCTCATCCTGCCAGGGCTGGCTGTGCCCACCCCAAGGCTGCCCTCCTGGGGGCCCCAGAACTGCCTGATCGTGCCGTG GCCCAGTTTTGTGGCATCTGCAGCAACACAAGAGAGAGGACAATGTCCTCCTCTTGACCCGCTGTCACCTAACCAGACTCGGGCCCTGCA CCTCTCAGGCACTTCTGGAAAATGACTGAGGCAGATTCTTCCTGAAGCCCATTCTCCATGGGGCAACAAGGACACCTATTCTGTCCTTGT CCTTCCATCGCTGCCCCAGAAAGCCTCACATATCTCCGTTTAGAATCAGGTCCCTTCTCCCCAGATGAAGAGGAGGGTCTCTGCTTTGTT TTCTCTATCTCCTCCTCAGACTTGACCAGGCCCAGCAGGCCCCAGAAGACCATTACCCTATATCCCTTCTCCTCCCTAGTCACATGGCCA TAGGCCTGCTGATGGCTCAGGAAGGCCATTGCAAGGACTCCTCAGCTATGGGAGAGGAAGCACATCACCCATTGACCCCCGCAACCCCTC CCTTTCCTCCTCTGAGTCCCGACTGGGGCCACATGCAGCCTGACTTCTTTGTGCCTGTTGCTGTCCCTGCAGTCTTCAGAGGGCCACCGC AGCTCCAGTGCCACGGCAGGAGGCTGTTCCTGAATAGCCCCTGTGGTAAGGGCCAGGAGAGTCCTTCCATCCTCCAAGGCCCTGCTAAAG GACACAGCAGCCAGGAAGTCCCCTGGGCCCCTAGCTGAAGGACAGCCTGCTCCCTCCGTCTCTACCAGGAATGGCCTTGTCCTATGGAAG GCACTGCCCCATCCCAAACTAATCTAGGAATCACTGTCTAACCACTCACTGTCATGAATGTGTACTTAAAGGATGAGGTTGAGTCATACC AAATAGTGATTTCGATAGTTCAAAATGGTGAAATTAGCAATTCTACATGATTCAGTCTAATCAATGGATACCGACTGTTTCCCACACAAG TCTCCTGTTCTCTTAAGCTTACTCACTGACAGCCTTTCACTCTCCACAAATACATTAAAGATATGGCCATCACCAAGCCCCCTAGGATGA CACCAGACCTGAGAGTCTGAAGACCTGGATCCAAGTTCTGACTTTTCCCCCTGACAGCTGTGTGACCTTCGTGAAGTCGCCAAACCTCTC TGAGCCCCAGTCATTGCTAGTAAGACCTGCCTTTGAGTTGGTATGATGTTCAAGTTAGATAACAAAATGTTTATACCCATTAGAACAGAG >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000355814_chr14_94847478_-_2545nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT TAAAGAAGGGTTGAGCTGGTCCCTGCCTGCATGTGACTGTAAATCCCTCCCATGTTTTCTCTGAGTCTCCCTTTGCCTGCTGAGGCTGTA TGTGGGCTCCAGGTAACAGTGCTGTCTTCGGGCCCCCTGAACTGTGTTCATGGAGCATCTGGCTGGGTAGGCACATGCTGGGCTTGAATC CAGGGGGGACTGAATCCTCAGCTTACGGACCTGGGCCCATCTGTTTCTGGAGGGCTCCAGTCTTCCTTGTCCTGTCTTGGAGTCCCCAAG AAGGAATCACAGGGGAGGAACCAGATACCAGCCATGACCCCAGGCTCCACCAAGCATCTTCATGTCCCCCTGCTCATCCCCCACTCCCCC CCACCCAGAGTTGCTCATCCTGCCAGGGCTGGCTGTGCCCACCCCAAGGCTGCCCTCCTGGGGGCCCCAGAACTGCCTGATCGTGCCGTG GCCCAGTTTTGTGGCATCTGCAGCAACACAAGAGAGAGGACAATGTCCTCCTCTTGACCCGCTGTCACCTAACCAGACTCGGGCCCTGCA CCTCTCAGGCACTTCTGGAAAATGACTGAGGCAGATTCTTCCTGAAGCCCATTCTCCATGGGGCAACAAGGACACCTATTCTGTCCTTGT CCTTCCATCGCTGCCCCAGAAAGCCTCACATATCTCCGTTTAGAATCAGGTCCCTTCTCCCCAGATGAAGAGGAGGGTCTCTGCTTTGTT TTCTCTATCTCCTCCTCAGACTTGACCAGGCCCAGCAGGCCCCAGAAGACCATTACCCTATATCCCTTCTCCTCCCTAGTCACATGGCCA TAGGCCTGCTGATGGCTCAGGAAGGCCATTGCAAGGACTCCTCAGCTATGGGAGAGGAAGCACATCACCCATTGACCCCCGCAACCCCTC CCTTTCCTCCTCTGAGTCCCGACTGGGGCCACATGCAGCCTGACTTCTTTGTGCCTGTTGCTGTCCCTGCAGTCTTCAGAGGGCCACCGC AGCTCCAGTGCCACGGCAGGAGGCTGTTCCTGAATAGCCCCTGTGGTAAGGGCCAGGAGAGTCCTTCCATCCTCCAAGGCCCTGCTAAAG GACACAGCAGCCAGGAAGTCCCCTGGGCCCCTAGCTGAAGGACAGCCTGCTCCCTCCGTCTCTACCAGGAATGGCCTTGTCCTATGGAAG GCACTGCCCCATCCCAAACTAATCTAGGAATCACTGTCTAACCACTCACTGTCATGAATGTGTACTTAAAGGATGAGGTTGAGTCATACC AAATAGTGATTTCGATAGTTCAAAATGGTGAAATTAGCAATTCTACATGATTCAGTCTAATCAATGGATACCGACTGTTTCCCACACAAG TCTCCTGTTCTCTTAAGCTTACTCACTGACAGCCTTTCACTCTCCACAAATACATTAAAGATATGGCCATCACCAAGCCCCCTAGGATGA CACCAGACCTGAGAGTCTGAAGACCTGGATCCAAGTTCTGACTTTTCCCCCTGACAGCTGTGTGACCTTCGTGAAGTCGCCAAACCTCTC TGAGCCCCAGTCATTGCTAGTAAGACCTGCCTTTGAGTTGGTATGATGTTCAAGTTAGATAACAAAATGTTTATACCCATTAGAACAGAG >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000393087_chr14_94847478_-_943nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000393088_chr14_94847478_-_916nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000404814_chr14_94847478_-_903nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC ATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACAT >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000449399_chr14_94847478_-_843nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAG GCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTC >In-frame_REG3A_ENST00000409839_chr2_79385774_-_SERPINA1_ENST00000402629_chr14_94847478_-_1002nt AAACCATACCATATCCCACCAGAGAGTCGCAGACACTATGCTGCCTCCCATGGCCCTGCCCAGTGTATCTTGGATGCTGCTTTCCTGCCT CATGCTGCTGTCTCAGGTTCAAGGTGAAGAACCCCAGAGGGAACTGCCCTCTGCACGGATCCGCTGTCCCAAAGGCTCCAAGGCCTATGG CTCCCACTGCTATGCCTTGTTTTTGTCACCAAAATCCTGGACAGATGCAGATGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAG GAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAG CTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAA AATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACT GGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAG GCACCCCTGAAGCTCTCCAAGGTGAGATCACCCTGACGACCTTGTTGCACCCTGGTATCTGTAGGGAAGAATGTGTGGGGGCTGCAGCTC TGTCCTGAGGCTGAGGAAGGGGCCGAGGGAAACAAATGAAGACCCAGGCTGAGCTCCTGAAGATGCCCGTGATTCACTGACACGGGACGT GGTCAAACAGCAAAGCCAGGCAGGGGACTGCTGTGCAGCTGGCACTTTCGGGGCCTCCCTTGAGGTTGTGTCACTGACCCTGAATTTCAA CTTTGCCCAAGACCTTCTAGACATTGGGCCTTGATTTATCCATACTGACACAGAAAGGTTTGGGCTAAGTTGTTTCAAAGGAATTTCTGA |
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FusionGenePPI for REG3A_SERPINA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| REG3A | SDC2, FN1, MDFI, ACTB, ACTA2, ACTBL2 | SERPINA1 | KLK3, ELANE, PRTN3, MIS12, RAP2A, DERL2, DERL1, VCP, OS9, ERLEC1, VKORC1, SSR1, CANX, FN1, ATP5C1, GSDMB, SMAD4, ECHS1, SDC2, RCHY1, LAMTOR5, CA8, GDPD1, DDX19B, ZNF558, ICE2, ALDH2, PLK2, HSPA5, FBXO2, SYVN1, SQSTM1, DDX31, MAPK6, SNX27, GOT1L1, HSPA8, UPF3A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REG3A_SERPINA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SERPINA1 | P01009 | DB01593 | Zinc | Alpha-1-antitrypsin | small molecule | approved|investigational |
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RelatedDiseases for REG3A_SERPINA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SERPINA1 | C0023895 | Liver diseases | 6 | CTD_human |
| Tgene | SERPINA1 | C0023890 | Liver Cirrhosis | 3 | CTD_human |
| Tgene | SERPINA1 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
| Tgene | SERPINA1 | C0024117 | Chronic Obstructive Airway Disease | 2 | CTD_human;HPO |
| Tgene | SERPINA1 | C0030328 | Panniculitis, Nodular Nonsuppurative | 2 | CTD_human |
| Tgene | SERPINA1 | C0221757 | alpha 1-Antitrypsin Deficiency | 2 | CTD_human;ORPHANET |
| Tgene | SERPINA1 | C0525045 | Mood Disorders | 2 | PSYGENET |
| Tgene | SERPINA1 | C2239176 | Liver carcinoma | 2 | CTD_human;HPO |
| Tgene | SERPINA1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | SERPINA1 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Tgene | SERPINA1 | C0003850 | Arteriosclerosis | 1 | CTD_human |
| Tgene | SERPINA1 | C0003949 | Asbestosis | 1 | CTD_human |
| Tgene | SERPINA1 | C0006267 | Bronchiectasis | 1 | CTD_human |
| Tgene | SERPINA1 | C0008370 | Cholestasis | 1 | CTD_human |
| Tgene | SERPINA1 | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
| Tgene | SERPINA1 | C0019080 | Hemorrhage | 1 | CTD_human |
| Tgene | SERPINA1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | SERPINA1 | C0020615 | Hypoglycemia | 1 | CTD_human |
| Tgene | SERPINA1 | C0024115 | Lung diseases | 1 | CTD_human |
| Tgene | SERPINA1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | SERPINA1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | SERPINA1 | C0034067 | Pulmonary Emphysema | 1 | CTD_human;HPO |
| Tgene | SERPINA1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | SERPINA1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | SERPINA1 | C0039841 | Thiamine Deficiency | 1 | CTD_human |
| Tgene | SERPINA1 | C0042384 | Vasculitis | 1 | CTD_human |
| Tgene | SERPINA1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
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