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Fusion gene ID: 30924 |
FusionGeneSummary for REG1B_IGF2 |
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Fusion gene information | Fusion gene name: REG1B_IGF2 | Fusion gene ID: 30924 | Hgene | Tgene | Gene symbol | REG1B | IGF2 | Gene ID | 5968 | 3481 |
Gene name | regenerating family member 1 beta | insulin like growth factor 2 | |
Synonyms | PSPS2|REGH|REGI-BETA|REGL | C11orf43|GRDF|IGF-II|PP9974 | |
Cytomap | 2p12 | 11p15.5 | |
Type of gene | protein-coding | protein-coding | |
Description | lithostathine-1-betaPSP-2REG-1-betapancreatic stone protein 2regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)regenerating islet-derived protein 1-betaregenerating protein I betasecretory pancreatic stone prote | insulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptin | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P48304 | P01344 | |
Ensembl transtripts involved in fusion gene | ENST00000305089, | ENST00000381395, ENST00000381406, ENST00000416167, ENST00000300632, ENST00000434045, ENST00000381392, ENST00000381389, ENST00000418738, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 23 X 24 X 8=4416 |
# samples | 2 | 20 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(20/4416*10)=-4.46466826700344 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: REG1B [Title/Abstract] AND IGF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IGF2 | GO:0008284 | positive regulation of cell proliferation | 28873464 |
Tgene | IGF2 | GO:0042104 | positive regulation of activated T cell proliferation | 15694994 |
Tgene | IGF2 | GO:0043410 | positive regulation of MAPK cascade | 11500939 |
Tgene | IGF2 | GO:0045840 | positive regulation of mitotic nuclear division | 11500939 |
Tgene | IGF2 | GO:0046628 | positive regulation of insulin receptor signaling pathway | 11500939 |
Tgene | IGF2 | GO:0051897 | positive regulation of protein kinase B signaling | 11500939 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PAAD | TCGA-LB-A8F3-01A | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000305089 | ENST00000381395 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-3UTR | ENST00000305089 | ENST00000381406 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-3UTR | ENST00000305089 | ENST00000416167 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-3UTR | ENST00000305089 | ENST00000300632 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-intron | ENST00000305089 | ENST00000434045 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-intron | ENST00000305089 | ENST00000381392 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-intron | ENST00000305089 | ENST00000381389 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
intron-intron | ENST00000305089 | ENST00000418738 | REG1B | chr2 | 79312176 | - | IGF2 | chr11 | 2152897 | - |
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FusionProtFeatures for REG1B_IGF2 |
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Hgene | Tgene |
REG1B | IGF2 |
Might act as an inhibitor of spontaneous calciumcarbonate precipitation. May be associated with neuronal sproutingin brain, and with brain and pancreas regeneration. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REG1B_IGF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REG1B_IGF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
REG1B | BAG6, REG1A, NUP155 | IGF2 | NOV, IGFBP7, IGFBP1, TF, IGFBP3, VTN, IDE, IGFBP6, IGFBP4, IGFBP5, BAG6, NMRK2, FAF1, PCSK4, RBPMS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REG1B_IGF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REG1B_IGF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IGF2 | C0004903 | Beckwith-Wiedemann Syndrome | 2 | CTD_human |
Tgene | IGF2 | C0015934 | Fetal Growth Retardation | 2 | CTD_human;HPO |
Tgene | IGF2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | IGF2 | C0206686 | Adrenocortical carcinoma | 2 | CTD_human;HPO |
Tgene | IGF2 | C2239176 | Liver carcinoma | 2 | CTD_human;HPO |
Tgene | IGF2 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | IGF2 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Tgene | IGF2 | C0002871 | Anemia | 1 | CTD_human |
Tgene | IGF2 | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | IGF2 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | IGF2 | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
Tgene | IGF2 | C0009241 | Cognition Disorders | 1 | CTD_human |
Tgene | IGF2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | IGF2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | IGF2 | C0018273 | Growth Disorders | 1 | CTD_human |
Tgene | IGF2 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Tgene | IGF2 | C0020224 | Polyhydramnios | 1 | CTD_human |
Tgene | IGF2 | C0020615 | Hypoglycemia | 1 | CTD_human |
Tgene | IGF2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | IGF2 | C0025261 | Memory Disorders | 1 | CTD_human |
Tgene | IGF2 | C0027708 | Nephroblastoma | 1 | CTD_human;HPO |
Tgene | IGF2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | IGF2 | C0028754 | Obesity | 1 | CTD_human |
Tgene | IGF2 | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | IGF2 | C0032045 | Placenta Disorders | 1 | CTD_human |
Tgene | IGF2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | IGF2 | C0035412 | Rhabdomyosarcoma | 1 | CTD_human |
Tgene | IGF2 | C0175693 | Russell-Silver syndrome | 1 | CTD_human |
Tgene | IGF2 | C0206624 | Hepatoblastoma | 1 | CTD_human;HPO |
Tgene | IGF2 | C0678807 | prenatal alcohol exposure | 1 | PSYGENET |
Tgene | IGF2 | C0752347 | Lewy Body Disease | 1 | CTD_human |