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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30923

FusionGeneSummary for REG1B_CPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: REG1B_CPA1
Fusion gene ID: 30923
HgeneTgene
Gene symbol

REG1B

CPA1

Gene ID

5968

1357

Gene nameregenerating family member 1 betacarboxypeptidase A1
SynonymsPSPS2|REGH|REGI-BETA|REGLCPA
Cytomap

2p12

7q32.2

Type of geneprotein-codingprotein-coding
Descriptionlithostathine-1-betaPSP-2REG-1-betapancreatic stone protein 2regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)regenerating islet-derived protein 1-betaregenerating protein I betasecretory pancreatic stone protecarboxypeptidase A1carboxypeptidase A1 (pancreatic)pancreatic carboxypeptidase A
Modification date2018052320180523
UniProtAcc

P48304

P15085

Ensembl transtripts involved in fusion geneENST00000305089, ENST00000011292, 
ENST00000484324, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 6 X 2=60
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: REG1B [Title/Abstract] AND CPA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-F2-6880-01AREG1Bchr2

79312341

-CPA1chr7

130025743

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000305089ENST00000011292REG1Bchr2

79312341

-CPA1chr7

130025743

+
intron-3CDSENST00000305089ENST00000484324REG1Bchr2

79312341

-CPA1chr7

130025743

+

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FusionProtFeatures for REG1B_CPA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
REG1B

P48304

CPA1

P15085

Might act as an inhibitor of spontaneous calciumcarbonate precipitation. May be associated with neuronal sproutingin brain, and with brain and pancreas regeneration. Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu,-Arg, -Lys or -Pro. {ECO:0000269|PubMed:8806703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for REG1B_CPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for REG1B_CPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
REG1BBAG6, REG1A, NUP155CPA1ARRB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for REG1B_CPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for REG1B_CPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPA1C0149521Pancreatitis, Chronic1CTD_human