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Fusion gene ID: 30923 |
FusionGeneSummary for REG1B_CPA1 |
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Fusion gene information | Fusion gene name: REG1B_CPA1 | Fusion gene ID: 30923 | Hgene | Tgene | Gene symbol | REG1B | CPA1 | Gene ID | 5968 | 1357 |
Gene name | regenerating family member 1 beta | carboxypeptidase A1 | |
Synonyms | PSPS2|REGH|REGI-BETA|REGL | CPA | |
Cytomap | 2p12 | 7q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lithostathine-1-betaPSP-2REG-1-betapancreatic stone protein 2regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)regenerating islet-derived protein 1-betaregenerating protein I betasecretory pancreatic stone prote | carboxypeptidase A1carboxypeptidase A1 (pancreatic)pancreatic carboxypeptidase A | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P48304 | P15085 | |
Ensembl transtripts involved in fusion gene | ENST00000305089, | ENST00000011292, ENST00000484324, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 6 X 2=60 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: REG1B [Title/Abstract] AND CPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PAAD | TCGA-F2-6880-01A | REG1B | chr2 | 79312341 | - | CPA1 | chr7 | 130025743 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000305089 | ENST00000011292 | REG1B | chr2 | 79312341 | - | CPA1 | chr7 | 130025743 | + |
intron-3CDS | ENST00000305089 | ENST00000484324 | REG1B | chr2 | 79312341 | - | CPA1 | chr7 | 130025743 | + |
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FusionProtFeatures for REG1B_CPA1 |
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Hgene | Tgene |
REG1B | CPA1 |
Might act as an inhibitor of spontaneous calciumcarbonate precipitation. May be associated with neuronal sproutingin brain, and with brain and pancreas regeneration. | Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu,-Arg, -Lys or -Pro. {ECO:0000269|PubMed:8806703}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REG1B_CPA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REG1B_CPA1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
REG1B | BAG6, REG1A, NUP155 | CPA1 | ARRB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REG1B_CPA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REG1B_CPA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CPA1 | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |