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Fusion gene ID: 30921 |
FusionGeneSummary for REG1A_PLEKHB2 |
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Fusion gene information | Fusion gene name: REG1A_PLEKHB2 | Fusion gene ID: 30921 | Hgene | Tgene | Gene symbol | REG1A | PLEKHB2 | Gene ID | 5967 | 55041 |
Gene name | regenerating family member 1 alpha | pleckstrin homology domain containing B2 | |
Synonyms | ICRF|P19|PSP|PSPS|PSPS1|PTP|REG | EVT2 | |
Cytomap | 2p12 | 2q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lithostathine-1-alphaREG-1-alphaislet cells regeneration factorislet of langerhans regenerating proteinpancreatic stone protein, secretorypancreatic thread proteinprotein-Xregenerating islet-derived protein 1-alpharegenerating protein I alpha | pleckstrin homology domain-containing family B member 2PH domain-containing family B member 2evectin-2pleckstrin homology domain containing, family B (evectins) member 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P05451 | Q96CS7 | |
Ensembl transtripts involved in fusion gene | ENST00000233735, | ENST00000404460, ENST00000303908, ENST00000409158, ENST00000403716, ENST00000234115, ENST00000439822, ENST00000487980, ENST00000438882, ENST00000538982, ENST00000409612, ENST00000409279, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 13 X 3 X 10=390 |
# samples | 4 | 15 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/390*10)=-1.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: REG1A [Title/Abstract] AND PLEKHB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PAAD | TCGA-F2-A44H-01A | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000233735 | ENST00000404460 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000303908 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000409158 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000403716 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000234115 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000439822 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000487980 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000438882 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000538982 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000409612 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
5CDS-intron | ENST00000233735 | ENST00000409279 | REG1A | chr2 | 79350545 | + | PLEKHB2 | chr2 | 131876464 | + |
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FusionProtFeatures for REG1A_PLEKHB2 |
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Hgene | Tgene |
REG1A | PLEKHB2 |
Might act as an inhibitor of spontaneous calciumcarbonate precipitation. May be associated with neuronal sproutingin brain, and with brain and pancreas regeneration. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for REG1A_PLEKHB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for REG1A_PLEKHB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
REG1A | APP, RFWD2, REG1B | PLEKHB2 | KRT85, KRT31, KRT82, KRT34, UPF1, CDA, BHLHE40, DAZAP2, STAM2, EPN1, C1orf94, MAP3K1, TMEM231, CST6, ITCH, NCCRP1, ALOXE3, CGRRF1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REG1A_PLEKHB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REG1A_PLEKHB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |