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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30907

FusionGeneSummary for RECQL5_CACNA1G

check button Fusion gene summary
Fusion gene informationFusion gene name: RECQL5_CACNA1G
Fusion gene ID: 30907
HgeneTgene
Gene symbol

RECQL5

CACNA1G

Gene ID

9400

8913

Gene nameRecQ like helicase 5calcium voltage-gated channel subunit alpha1 G
SynonymsRECQ5Ca(V)T.1|Cav3.1|NBR13|SCA42
Cytomap

17q25.1

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent DNA helicase Q5DNA helicase, RecQ-like type 5RecQ helicase-like 5RecQ protein-like 5voltage-dependent T-type calcium channel subunit alpha-1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitcav3.1cvoltage-dependent T-type calcium channel alpha 1G subunitvoltage-dependent calcium channel alpha 1G subunitvoltage-gated calci
Modification date2018052320180523
UniProtAcc

O94762

O43497

Ensembl transtripts involved in fusion geneENST00000423245, ENST00000317905, 
ENST00000420326, ENST00000340830, 
ENST00000584999, ENST00000443199, 
ENST00000360761, ENST00000354983, 
ENST00000352832, ENST00000442258, 
ENST00000416767, ENST00000502264, 
ENST00000515411, ENST00000510115, 
ENST00000503485, ENST00000515165, 
ENST00000507510, ENST00000514181, 
ENST00000515765, ENST00000507336, 
ENST00000514079, ENST00000507896, 
ENST00000512389, ENST00000513689, 
ENST00000513964, ENST00000505165, 
ENST00000507609, ENST00000514717, 
ENST00000510366, ENST00000429973, 
ENST00000359106, ENST00000358244, 
Fusion gene scores* DoF score8 X 7 X 5=2805 X 3 X 4=60
# samples 94
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RECQL5 [Title/Abstract] AND CACNA1G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRECQL5

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

23748380

TgeneCACNA1G

GO:0042391

regulation of membrane potential

21084288

TgeneCACNA1G

GO:0070509

calcium ion import

21084288

TgeneCACNA1G

GO:0070588

calcium ion transmembrane transport

26456284|26715324


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5JP-01ARECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000423245ENST00000360761RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000354983RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000352832RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000442258RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000416767RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000502264RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000515411RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000510115RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000503485RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000515165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000507510RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000514181RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000515765RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000507336RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000514079RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000507896RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000512389RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000513689RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000513964RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000505165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000507609RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000514717RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000510366RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000429973RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000359106RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000423245ENST00000358244RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000360761RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000354983RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000352832RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000442258RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000416767RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000502264RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000515411RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000510115RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000503485RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000515165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000507510RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000514181RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000515765RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000507336RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000514079RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000507896RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000512389RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000513689RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000513964RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000505165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000507609RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000514717RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000510366RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000429973RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000359106RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000317905ENST00000358244RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000360761RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000354983RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000352832RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000442258RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000416767RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000502264RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000515411RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000510115RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000503485RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000515165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000507510RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000514181RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000515765RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000507336RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000514079RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000507896RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000512389RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000513689RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000513964RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000505165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000507609RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000514717RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000510366RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000429973RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000359106RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000420326ENST00000358244RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000360761RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000354983RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000352832RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000442258RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000416767RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000502264RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000515411RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000510115RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000503485RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000515165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000507510RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000514181RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000515765RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000507336RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000514079RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000507896RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000512389RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000513689RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000513964RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000505165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000507609RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000514717RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000510366RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000429973RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000359106RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000340830ENST00000358244RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000360761RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000354983RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000352832RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000442258RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000416767RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000502264RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000515411RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000510115RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000503485RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000515165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000507510RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000514181RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000515765RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000507336RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000514079RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000507896RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000512389RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000513689RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000513964RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000505165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000507609RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000514717RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000510366RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000429973RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000359106RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
Frame-shitENST00000584999ENST00000358244RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000360761RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000354983RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000352832RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000442258RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000416767RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000502264RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000515411RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000510115RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000503485RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000515165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000507510RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000514181RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000515765RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000507336RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000514079RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000507896RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000512389RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000513689RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000513964RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000505165RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000507609RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000514717RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000510366RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000429973RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000359106RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+
intron-3CDSENST00000443199ENST00000358244RECQL5chr17

73654378

-CACNA1Gchr17

48667832

+

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FusionProtFeatures for RECQL5_CACNA1G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RECQL5

O94762

CACNA1G

O43497

Isoform beta is a DNA helicase that plays an importantrole in DNA replication, transcription and repair. Inhibitselongation of stalled transcripts at DNA damage sites by bindingto the RNA polymerase II subunit POLR2A and blocking the TCEA1binding site. Required for mitotic chromosome separation aftercross-over events and cell cycle progress. Required for efficientDNA repair, including repair of inter-strand cross-links.Stimulates DNA decatenation mediated by TOP2A. Prevents sisterchromatid exchange and homologous recombination.{ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101,ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166,ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498,ECO:0000269|PubMed:23748380}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RECQL5_CACNA1G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RECQL5_CACNA1G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RECQL5CUX1, DDX42, ITGB3BP, MAPK8IP1, MTSS1, CREB1, PLK1, TIMP1, EEF1G, TOP3A, TOP3B, MRE11A, RAD50, NBN, PRKDC, RECQL4, MCM7, POLR2A, POLR2B, NCL, UBR5, CUL5, DHX29, BRCA1, MDC1, POLR2C, RAD51, PCNA, POLR2E, POLR2G, POLR2D, POLR2I, BNIPL, RPRD1B, POLR2M, DXO, DHX36, EIF2D, KIN, TP53, HIST1H2BG, HIST1H3A, FOSL2, POLR2F, PARD6B, POLR1A, WWP2, LMO2, PITHD1, FANCC, BRCA2CACNA1GUBQLN4, RANBP9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RECQL5_CACNA1G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCACNA1GO43497DB00347TrimethadioneVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved
TgeneCACNA1GO43497DB00593EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved
TgeneCACNA1GO43497DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved
TgeneCACNA1GO43497DB04841FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved
TgeneCACNA1GO43497DB05246MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved
TgeneCACNA1GO43497DB09089TrimebutineVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved
TgeneCACNA1GO43497DB00568CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved|investigational
TgeneCACNA1GO43497DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved|investigational
TgeneCACNA1GO43497DB09231BenidipineVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved|investigational
TgeneCACNA1GO43497DB09238ManidipineVoltage-dependent T-type calcium channel subunit alpha-1Gsmall moleculeapproved|investigational

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RelatedDiseases for RECQL5_CACNA1G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCACNA1GC3714756Intellectual Disability1CTD_human
TgeneCACNA1GC4225205SPINOCEREBELLAR ATAXIA 421ORPHANET;UNIPROT