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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30903

FusionGeneSummary for RECK_ACER3

check button Fusion gene summary
Fusion gene informationFusion gene name: RECK_ACER3
Fusion gene ID: 30903
HgeneTgene
Gene symbol

RECK

ACER3

Gene ID

8434

55331

Gene namereversion inducing cysteine rich protein with kazal motifsalkaline ceramidase 3
SynonymsST15APHC|PHCA|PLDECO
Cytomap

9p13.3

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionreversion-inducing cysteine-rich protein with Kazal motifsmembrane-anchored glycoprotein (metastasis and invasion)suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)suppression of tumorigenicity 5 (reversion-inalkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline
Modification date2018052320180519
UniProtAcc

O95980

Q9NUN7

Ensembl transtripts involved in fusion geneENST00000377966, ENST00000479053, 
ENST00000532485, ENST00000530182, 
ENST00000526597, ENST00000533873, 
ENST00000538157, ENST00000544113, 
Fusion gene scores* DoF score2 X 1 X 2=47 X 5 X 4=140
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RECK [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

TgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-DA-A3F3-06ARECKchr9

36052320

+ACER3chr11

76687333

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377966ENST00000532485RECKchr9

36052320

+ACER3chr11

76687333

+
5CDS-3UTRENST00000377966ENST00000530182RECKchr9

36052320

+ACER3chr11

76687333

+
5CDS-5UTRENST00000377966ENST00000526597RECKchr9

36052320

+ACER3chr11

76687333

+
5CDS-5UTRENST00000377966ENST00000533873RECKchr9

36052320

+ACER3chr11

76687333

+
5CDS-5UTRENST00000377966ENST00000538157RECKchr9

36052320

+ACER3chr11

76687333

+
5CDS-intronENST00000377966ENST00000544113RECKchr9

36052320

+ACER3chr11

76687333

+
3UTR-3CDSENST00000479053ENST00000532485RECKchr9

36052320

+ACER3chr11

76687333

+
3UTR-3UTRENST00000479053ENST00000530182RECKchr9

36052320

+ACER3chr11

76687333

+
3UTR-5UTRENST00000479053ENST00000526597RECKchr9

36052320

+ACER3chr11

76687333

+
3UTR-5UTRENST00000479053ENST00000533873RECKchr9

36052320

+ACER3chr11

76687333

+
3UTR-5UTRENST00000479053ENST00000538157RECKchr9

36052320

+ACER3chr11

76687333

+
3UTR-intronENST00000479053ENST00000544113RECKchr9

36052320

+ACER3chr11

76687333

+

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FusionProtFeatures for RECK_ACER3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RECK

O95980

ACER3

Q9NUN7

Negatively regulates matrix metalloproteinase-9 (MMP-9)by suppressing MMP-9 secretion and by direct inhibition of itsenzymatic activity. RECK down-regulation by oncogenic signals mayfacilitate tumor invasion and metastasis. Appears to also regulateMMP-2 and MT1-MMP, which are involved in cancer progression. Hydrolyzes only phytoceramide into phytosphingosine andfree fatty acid. Does not have reverse activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+211118_13789268TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+211147_16989268TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+211174_19689268TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+211216_23889268TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+21194_11189268TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+06118_1370135TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+06147_1690135TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+06174_1960135TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+06216_2380135TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+0629_510135TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+0663_840135TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000544113+0694_1110135TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221627_67353972DomainKazal-like 1
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221698_75253972DomainKazal-like 2
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221753_78953972DomainKazal-like 3
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+22137_33853972RegionNote=5 X Knot repeats
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221104_14153972RepeatNote=Knot 2
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221151_19753972RepeatNote=Knot 3
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221216_26353972RepeatNote=Knot 4
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+221292_33853972RepeatNote=Knot 5
HgeneRECKchr9:36052320chr11:76687333ENST00000377966+22137_8453972RepeatNote=Knot 1
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+21129_5189268TransmembraneHelical
TgeneACER3chr9:36052320chr11:76687333ENST00000532485+21163_8489268TransmembraneHelical


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FusionGeneSequence for RECK_ACER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RECK_ENST00000377966_chr9_36052320_+_ACER3_ENST00000532485_chr11_76687333_+_232aa
MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLV
LFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RECK_ENST00000377966_chr9_36052320_+_ACER3_ENST00000532485_chr11_76687333_+_696nt
ATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCGCGGAGGTGGCAGGGGGCCTGGCTCCG
GGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTGAACAGCTATTGGATGAACTCCCAATG
ATATACAGCTGTTGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAAACTACCATCTGCTTTTTACCTTAGTT
CTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAAGAGCCGATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTA
GTACTTCGATCTATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGTTATACATCATTGGGTATATTTTTATTGGGATTT
TTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGGAACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTT
CATGCATGGTGGCATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATACAAGAACACTTTACCTGAGATATAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RECK_ENST00000377966_chr9_36052320_+_ACER3_ENST00000532485_chr11_76687333_+_7732nt
GATGAACCCTTGTCAGGGGGCCGTGTCTGCGGGAGGCCGAAGGATCCCGGGTGACATGCTTTCTTTGGGTGCGAGGCAGCGTCTCGGCAG
AAAGAATATTGCGAGTATTACTGAGGGTACATGAAGGAGAGAAGCCCCTTTGGTTCGGCCTTGGACTAAGCCCTTGTTCTCAGGTGAACT
TGCAGTGTGATCTTGAGTAAGGTCAGTCTCCTCTCTCACCTCAGTGGCCCGAAACCTCAGGAGGTGGCAGAGGTTTTCTAATGACTCTCC
CAGCTCTGACATCCTCTGACTTCACTCTGGGAGAACGTGGGCTGGTGGACTCCTGGCAGAAGCCGACACACAGTTGGGCCATAACAAAGA
GCCCTGGTACGGGGCACGTTCCCGCCCCCGGGAGGTTTTGGAAACACTGTGAGGCAGGGGGCGGGGCTTGAGCGGGCCGCAGCCAGTCAC
CAAAGGGCCGGGCGCTGGGGGCGGGGCCTCGCGCGAGCGGCGGCGGTAGCGGCGGCAGCGGCTGCGGCCAAGCTGGGTCCGAGCATCCCG
CGGCTCTGGAGCCGCCCGGCCCGGACATGGCGACCGTCCGGGCCTCTCTGCGAGGTGCGCTGCTCCTTCTGCTGGCCGTGGCGGGGGTCG
CGGAGGTGGCAGGGGGCCTGGCTCCGGGCAGTGCGGGTGCATTGTGTTGTAATCATTCAAAGGATAACCAAATGTGCCGTGATGTATGTG
AACAGCTATTGGATGAACTCCCAATGATATACAGCTGTTGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAA
ACTACCATCTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAAGAGCCGATATTCCATCAGGTCA
TGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCTATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGTTATACAT
CATTGGGTATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGGAACTTTCGAAAGAAGGTACCAC
CTATCATAGGTATTACCACACAATTTCATGCATGGTGGCATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATA
CAAGAACACTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGATCCTGTTTGAGCCTCTCAGGAAGCATT
GATGAATCATTCCACCAAGAAAACAAACAAGCACCTACCATAGACCTGGCAGAATAAATAAGGAAATCCTTAAAGATCTACAAGTTCAAA
TATGTCATGACCATCACAGCAGAGGAGTGACTTTCTGACTAATGCTGCCACCCACACAGAGAATAAGGAGTAGGGCCTGCTGGGTGTTTA
GCTCATGGCTTTATCTTATTTGTCCCCCTCCTCCTTTCACGCTCCAGTTTATAAAGAAACAGAGATGATGTGTGTGTATGCCTCAAATGC
AGAAACAGTTGGGCTTTTCTTAACAGGTTAACAGTTTGTGCTGGTTATAAGAAATTAACCTTCTTTTCTTTTTGCCAAGGGTTGCATGTG
AATTATACCTTTCTTAATATTTGATTAAATAATGCAGTCAGCTAAGAGCCAACAAAACCCCATATCCAGATAGTTAGCTGTGAGCCAGCA
CTCAGCTGTGTCAGATTTGATTAATATTGTATTAATCTCATGGATGGTTCTCAAAGGTAAAAAAAGAGAGAGAAAGAGAGAGAGCTAGCT
GTGGGATTCTGTGTAGTTCTTCACTATCTGTTCCAGGGCTAGTCGGAGGATCATAAGCAAGCTCAGACCTGCCCCCAGTTCAGTACTTGA
CCACATCCCAGGATTTATGGTGTCTGTCTATGGCCACAGCCAACCAGAATGAGTGGGTCATCTTATAACCTTTCTGAAGCTCCATGAGGA
CATGTATAGAATGCTGCACCTTCAGCCAGCTCTGCTCTGATCTTTGCAGATCTTTAAGTTGTCACTGTTTCTACGGCTAGACAAATATGA
CTGGTGGTCTAGACTACCCATAGTTCATCCTCCTCACATAACTTATTTGAAGTTGTCAGGGAATGTCATTACACTCTGATTTTTAAAATT
ATGCAGTATTTTCCAGTTCTCAGAGAGGTCATGGTTGTGCCCAGGGAAGTGTGTTGCATTAACTAAAGCTAAAATTATCAGAATCCTATT
TACATAAAGCATATTAAAATATCTGCTCCTTAATTTTCTGAAGGAAATAGATGTAAGTTTCTGCTACTTGAAACCTACAGAACCGACAAA
AATTAGGGTGCTAAAAAAATGACAGTGAAATCTCATCGTAAGGCAGCTAGTTCTAATTTGCATTTGAATGTATAACAAATTGCATCACTT
TTCACAAACTTAACACCTGCCTGGAGTAAAAATCTGATTTGACCCCTCTGCTCATGTTTCATCATATTTGTAGCTCTGCATCATTTAGCA
TTTTTATGACTTTTTTTGCTTTATATAAATTATTGTAAAATCCAGATTGTTTTTACCACATGATGACGTGACTCAGGATTAAATCCTGAG
CTACAGTTTCAAAAGGAAAATCATTTTTTTCTTATGCAAAGATGGTAAAACACTGTTGTCATTTTTTCCAGTATTCAATAAGTAGCCTTT
GTACAAATTTAAAACCAAAAACTATTCTGTTGTTTTTCTTCACCTACTAGCCTTAGTTTTTAACCAAGTATCCAAGGATGTCAACTTGAC
ATCCTTCCCTTAGCATGCCAACAAGCCATTAGACTGATTCTTCCACCTATTTTTATGAACCTCCAGGAAGAAAAACACTTGCCAAAACAT
TAAGAGAACTTTGATTCTGCCTTAAGAGGGTATAAAACTAAACCATTTGAAGGCACAGCCCATAAGACTATACTTGATTTTGCCCCAAGA
TTCTGACTTCTGGCTACATTTCACCTGCAGTTACCTGGGCTATCGGCCGTGATACATTTTTTAATTCATTTGTTTTCCACCATTATATTT
TTATACTTTTCAGTTAGATATACTTCTGCATAAAGAGTATATATACAGTGTAGGATAAAGGCATATCGTACATGGCAATGCTGTTAAACA
TGGTAAGACTGAGGTTCTGCAGGATTAAAGTCAGATTAAGGGTACAGAAAGCACACCTTGATACTGAGGCCATTTAGAGCAATTTGTTTA
ATGAGTGGTTCAGCCATCACCACCAGTGGCCACCTGTTCAATAAAATTGCCTAGCACCACAGTGGAGAGTCATCTACACCCCAAGGTGAG
CTGTAAGACTGGCCAATTCTTTGAAGACCTTTTTTTCTGTTGGGAGAATGGAAAGCAGAAAGGGAAGCCAGGCTCTTTAATGTTCCAAGT
CAGCTGTGCCTCACACAAGGCTCTCTTTTTAGCTACTAAGTAACATACTCAAGACTTTGTATCTGTGCAGCATTTTATGGAAATCACTGG
TGACCTATAGGATATTACTAAATTATTTCAATAGCTTTATTTTTTTCCTACTTGGATTCTAGGTGGACATTACAGAGTTGAATTCCTCAC
TACCCCCTCCCGCTGTCATTTGTTTTATTGGAAAACTTCATGTTAACTAGAGTGTACAAAAAGTCTGTTTCCTGCTGAGCCAATAGTGAT
TTGTTTGCATATCACCTAATGTGAAAAGTGCTCATCTGTGAACTCTACAGCAAATTATATTTTAGAAAATACTTTGTGAGGCCGGGCATG
GTGGCAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAGAAAATATAAGGATGTAAAAGAAGCAATTTGCT
TGCACATCTGAATATCCTTCTTGTGCCTCCATTTTCACTCTTGAAAACTGAAAGCAATTTGACTTTTATTTTTGTTTTTCTAAAGAACAG
CTAGGTGAAAGGAGGTTAAGCTGATTGTCACTCTGCCTGCCCACTACCTACTCCCCACCATGGTGTTTCATGAAACATCCCCACCACCTG
AAGTGATCTTTTTAATCCTTGTGATAGTAAATGCATTGATAATTAACAGGAAAAACATGTTTTTAAATAATCTACAAATGAGAACCCAAA
TAGTAGTGTTTTGTTTGACAGAAGTAAATCAAATATTATGGTTTAAATATAATGCAAAATTTCAGGACAGTTAATTTGGACTTCCCTTAC
CCTAAGAGGGTTTTTCTTATAATAAGGAGAAGAGGTGTGGTTCAAAGAAAATTAAGAGACAAAACCTTCAGGTACATAATGCATGAAAAT
CTTTAAATGCCTGCAAAAATTAAGTTCTGTTATAATACCAGCCAATTCTGAATTAGCCAATGCCCTAAAAGCATCTAACAATTTAAGGTT
ATCTTATGAGTCCTATGAAAACAATTATTTGTTGCTAAATTTGAGTTTTAGCTACCAACGCCATGTTTACGTGACAAGAAATTGTTTTGG
CCCTGTGGTTTATGACGTGCTGCTGGATAAGCATTTATGTAAAACTGAGTATTTCAAAGAGAACCATTTACAATTGGAATTTCCACCTGT
GTGGCTGTTTGCAGACCTACCTCTGTCTTCCATTTTGCATCCTGTCAGTGCTATAATTAGTTTGATCACTTTGTCTTGTTTTTCAGTGTC
TACAATTATAGCTTATTCACTATGTTCTAACTATTTAAAAATAATGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGGTGAGCAGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAT
TAGTCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCAGAGCTTGCA
GTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGACT
AAAATTTGATTTAAAGTAGTTAAACCCCTTTATGGAAGGAGCTGCAAAATGAAAAAAAAAAAAAAAAGGAATCATGTCATCTTGACCCAG
CTGACTGGAAATTTTCAATACTGTCTTTTAACTGTTGTACTCCAGCCAGCCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAGAATTAGGAAATACTTGTTAAAATATCTAACTACGTAATTGCTACATGGGGGAGCTGCTGGTGTTGTTGAGGTC
CTTGGGAGCATTCCACTGGACTTCACCATTTCTCCAAAATTATCAGCCCAGTCAGCTTCATATACCCAGATATGGACACTTCTACACGTG
AAATTCAAACTGAAGATAAAACTCTGACTTTGGAGTATAAACTTTTGCCTTGAGTATGAAACCTTGACATTGCTGAAAGAAAAGTGGAAA
CTGTAAGGGACAACAAGTTTCACCAAGGCACAGTCTTCTCTGATAGGCCAGCAGAGCAGCTAAGGAGAAGACAGATCATTCAAGAACTTA
AGTCGTTTGTTAGCTACAGCATTTCCATTGCTGTGATACACATTCAGCCATTTTGGAGGAAAGCTAAGCAGGTTCTGACCACCCATTTTC
ATGTACTTTAAATAACAAATATTATTTCTCAAGGTCTTCATTTTATCATTAAATTCAGCTAATTACTACCTGATTTCAAAGGCAGCTAGT
GTAGAAGACTGGTCACAAGAATTTTTTTTTAAATAGAAAACCCTAAAATGCAAATCAAGAAATTCAGTTACAGGCTGCAAGTGACCTAAA
ATTCCCCTACTCTAGCTCAGCAGCCATCAGTCAGTATAGCATCAGCCACAGGTCACTGCTCTGCATACAGTTCCTTTTCAACCCTTACAA
GACCTGCTTCATTGCTTTAAAAATGTAGTGTTGATACTTGAACTGAATTTAGTCATTGGTAACTTAAATATTCACAAAATTGTCATAAAG
CTTCTGAAACATCTGGCAATGCCAGATCTGTAATCATCACTTTTAAATTGAATTTGCAGAATTAACTCTAAAGTTGCAGCAACCATATTT
ATTAGAGAAATCTTTAAGCATATACATATGGTTCCCTATAAGCATTCATTCAGAGATCATCTGTGCCTAAAAGAAAATGATAAAAATGTG
TCATAATATCAAAGGGGTCTAGATCAGGGGTTGGTAAACTACAACCCATGGGCCAAATTCAGGCTGCGTTGTATGGCCTGCAAGGTAAGA
ATGGTTATTTTATTTTATTTTATTCTTTATATATATATATATATATTTATTTATTTTTTTGAGACAGAGTCTCTCTCTGTCACCCACGCT
GGAGTGCAGTGGCAGGATCTCAACTCATTGCAACCTCCGCCTCCCAAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGA
CTACAGGCACATGCCACCATGCCACCATGCCTGGCTGATTTTTGTATTTTTAGTAGAGCTGGGTTGGCCAGGCTGGTCTTGAACTCCTGA
CCTCAAGTGATTCACCTGCCTTGGCCTCCCAAAGTCCTGGAATTACAGGCGTGAGCTACCGTGCCCAGCTGGTTTTTACATTTTAAAAAC
GTTTAGAGAAAGAAGAATATGCAACAGAAACTGTATGTAGCCTGCAAAGCCTAAAATGTTTACTCTCTGGCTTGGGAGTTTGTCTCCCCT
GCTCTAGACTGTCAGCAAGTGGTACAGTGGTACAGTACAGTGGTACTGCCCAACTGCACTTCTCTGCAAGGTGATTCTAGTGTGCACTTG
TCAGAATGAAAATATGTTATTCATTTAAGACATCTCATGTCTTTGAATGTAATCACATGATTTGTATTTAATATTTACATGACCTAATTA
TTTTTTCACGTCAGTTTTTCTAGATTGGCAATAGCCTGTTGCAAAGTGCCTAAACCTTTGAGAAAAATTACTATGAGCAAGGTCCATGAT
TTAGTTTTCAATATAAAGGGAATTCCATTCTATACTGTAAAATCCAAAAATGCTAGTTGCCCTCAGCTTTTGAGTTGACTTCCAGAAAGT
TGAGATCTTTTGACCATTTTTTCTCATGTCATATAAAATGTGCCACATGGTAGTTGTCAAGCTGTGGTAGTCATGTACACTTTTTTTCTT
TTTTTTAACTTTCTAAAAGGAAAAGTTCAAAGTCCTTTCCACAGTTAGTCTTCGCTTCTTTTGGATTTTTCTTTTTAGAGCTAAATTATT
CATACCAATGAATAAGTGAGTCTGTTCTAAGATATAGGGGCCATTATCTATTTTTGCTTAATGGACTCATGTGGCATTGTTCACTATCAT
GCCTTTCCATACTTGTAATATTTCTGAGTCACTTATTAATGTGACCAACAGATAAACTGTTCAAGCTAATACAGCATTTCCTAACTTCAT
AGTTGTCGCAGATGTTTGTTCTAGTAGCGATTATTTAATAAACATACATTGTACTGAATCTTACTAGCAACTAACTATTTTCAGGTAATC
TCAGTCTGCTTATTCACTTTTTCCATTTGATTTGCTAATGCCACAATCATTTTTCTAGAAAATAGTAGGATAATGTATTTTTTCCTGTCT


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FusionGenePPI for RECK_ACER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RECKCTH, MEOX2, REL, TCF4, KEAP1, TRIM39, USHBP1, KRT40, TRIM69, TEKT4, NOTCH2NL, CEP44, MCCC2, IFNA4, ACOX1, MTNR1BACER3ELAVL1, MLH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RECK_ACER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RECK_ACER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRECKC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneRECKC0009171Cocaine Abuse1PSYGENET
HgeneRECKC0009375Colonic Neoplasms1CTD_human
HgeneRECKC0017636Glioblastoma1CTD_human
HgeneRECKC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneRECKC0027626Neoplasm Invasiveness1CTD_human
HgeneRECKC0027627Neoplasm Metastasis1CTD_human
TgeneACER3C0025202melanoma1CTD_human