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Fusion gene ID: 30900 |
FusionGeneSummary for RDX_FOXD1 |
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Fusion gene information | Fusion gene name: RDX_FOXD1 | Fusion gene ID: 30900 | Hgene | Tgene | Gene symbol | RDX | FOXD1 | Gene ID | 5962 | 2297 |
Gene name | radixin | forkhead box D1 | |
Synonyms | DFNB24 | FKHL8|FREAC-4|FREAC4 | |
Cytomap | 11q22.3 | 5q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | radixin | forkhead box protein D1Forkhead, drosophila, homolog-like 8forkhead-like 8forkhead-related activator 4forkhead-related protein FKHL8forkhead-related transcription factor 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P35241 | ||
Ensembl transtripts involved in fusion gene | ENST00000528498, ENST00000528900, ENST00000405097, ENST00000530301, ENST00000343115, ENST00000544551, | ENST00000513595, ENST00000499003, | |
Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RDX [Title/Abstract] AND FOXD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG108039 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000528498 | ENST00000513595 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-3UTR | ENST00000528498 | ENST00000499003 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-intron | ENST00000528900 | ENST00000513595 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-3UTR | ENST00000528900 | ENST00000499003 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-intron | ENST00000405097 | ENST00000513595 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-3UTR | ENST00000405097 | ENST00000499003 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-intron | ENST00000530301 | ENST00000513595 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-3UTR | ENST00000530301 | ENST00000499003 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-intron | ENST00000343115 | ENST00000513595 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-3UTR | ENST00000343115 | ENST00000499003 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-intron | ENST00000544551 | ENST00000513595 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
intron-3UTR | ENST00000544551 | ENST00000499003 | RDX | chr5 | 148875348 | - | FOXD1 | chr5 | 72742530 | - |
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FusionProtFeatures for RDX_FOXD1 |
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Hgene | Tgene |
RDX | FOXD1 |
Probably plays a crucial role in the binding of thebarbed end of actin filaments to the plasma membrane. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RDX_FOXD1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RDX_FOXD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RDX_FOXD1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RDX_FOXD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RDX | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | RDX | C1970239 | DEAFNESS, AUTOSOMAL RECESSIVE, 24 | 1 | CTD_human;UNIPROT |