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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30900

FusionGeneSummary for RDX_FOXD1

check button Fusion gene summary
Fusion gene informationFusion gene name: RDX_FOXD1
Fusion gene ID: 30900
HgeneTgene
Gene symbol

RDX

FOXD1

Gene ID

5962

2297

Gene nameradixinforkhead box D1
SynonymsDFNB24FKHL8|FREAC-4|FREAC4
Cytomap

11q22.3

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionradixinforkhead box protein D1Forkhead, drosophila, homolog-like 8forkhead-like 8forkhead-related activator 4forkhead-related protein FKHL8forkhead-related transcription factor 4
Modification date2018052320180523
UniProtAcc

P35241

Ensembl transtripts involved in fusion geneENST00000528498, ENST00000528900, 
ENST00000405097, ENST00000530301, 
ENST00000343115, ENST00000544551, 
ENST00000513595, ENST00000499003, 
Fusion gene scores* DoF score4 X 5 X 1=201 X 1 X 1=1
# samples 51
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: RDX [Title/Abstract] AND FOXD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG108039RDXchr5

148875348

-FOXD1chr5

72742530

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000528498ENST00000513595RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-3UTRENST00000528498ENST00000499003RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-intronENST00000528900ENST00000513595RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-3UTRENST00000528900ENST00000499003RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-intronENST00000405097ENST00000513595RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-3UTRENST00000405097ENST00000499003RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-intronENST00000530301ENST00000513595RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-3UTRENST00000530301ENST00000499003RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-intronENST00000343115ENST00000513595RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-3UTRENST00000343115ENST00000499003RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-intronENST00000544551ENST00000513595RDXchr5

148875348

-FOXD1chr5

72742530

-
intron-3UTRENST00000544551ENST00000499003RDXchr5

148875348

-FOXD1chr5

72742530

-

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FusionProtFeatures for RDX_FOXD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RDX

P35241

FOXD1

Probably plays a crucial role in the binding of thebarbed end of actin filaments to the plasma membrane. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RDX_FOXD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RDX_FOXD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RDX_FOXD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RDX_FOXD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRDXC0008370Cholestasis1CTD_human
HgeneRDXC1970239DEAFNESS, AUTOSOMAL RECESSIVE, 241CTD_human;UNIPROT