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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30898

FusionGeneSummary for RDH13_RUSC1

check button Fusion gene summary
Fusion gene informationFusion gene name: RDH13_RUSC1
Fusion gene ID: 30898
HgeneTgene
Gene symbol

RDH13

RUSC1

Gene ID

112724

23623

Gene nameretinol dehydrogenase 13RUN and SH3 domain containing 1
SynonymsSDR7C3NESCA
Cytomap

19q13.42

1q22

Type of geneprotein-codingprotein-coding
Descriptionretinol dehydrogenase 13retinol dehydrogenase 13 (all-trans and 9-cis)retinol dehydrogenase 13 (all-trans/9-cis)short chain dehydrogenase/reductase family 7C member 3RUN and SH3 domain-containing protein 1new molecule containing SH3 at the carboxy-terminus
Modification date2018051920180519
UniProtAcc

Q8NBN7

Q9BVN2

Ensembl transtripts involved in fusion geneENST00000415061, ENST00000396247, 
ENST00000592423, 
ENST00000368354, 
ENST00000368352, ENST00000368347, 
ENST00000462780, ENST00000368349, 
ENST00000292254, 
Fusion gene scores* DoF score4 X 3 X 4=483 X 3 X 3=27
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RDH13 [Title/Abstract] AND RUSC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRUSC1

GO:0000209

protein polyubiquitination

19365808


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A08F-01ARDH13chr19

55568021

-RUSC1chr1

155297941

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000415061ENST00000368354RDH13chr19

55568021

-RUSC1chr1

155297941

+
Frame-shitENST00000415061ENST00000368352RDH13chr19

55568021

-RUSC1chr1

155297941

+
Frame-shitENST00000415061ENST00000368347RDH13chr19

55568021

-RUSC1chr1

155297941

+
5CDS-3UTRENST00000415061ENST00000462780RDH13chr19

55568021

-RUSC1chr1

155297941

+
5CDS-3UTRENST00000415061ENST00000368349RDH13chr19

55568021

-RUSC1chr1

155297941

+
5CDS-3UTRENST00000415061ENST00000292254RDH13chr19

55568021

-RUSC1chr1

155297941

+
Frame-shitENST00000396247ENST00000368354RDH13chr19

55568021

-RUSC1chr1

155297941

+
Frame-shitENST00000396247ENST00000368352RDH13chr19

55568021

-RUSC1chr1

155297941

+
Frame-shitENST00000396247ENST00000368347RDH13chr19

55568021

-RUSC1chr1

155297941

+
5CDS-3UTRENST00000396247ENST00000462780RDH13chr19

55568021

-RUSC1chr1

155297941

+
5CDS-3UTRENST00000396247ENST00000368349RDH13chr19

55568021

-RUSC1chr1

155297941

+
5CDS-3UTRENST00000396247ENST00000292254RDH13chr19

55568021

-RUSC1chr1

155297941

+
intron-3CDSENST00000592423ENST00000368354RDH13chr19

55568021

-RUSC1chr1

155297941

+
intron-3CDSENST00000592423ENST00000368352RDH13chr19

55568021

-RUSC1chr1

155297941

+
intron-3CDSENST00000592423ENST00000368347RDH13chr19

55568021

-RUSC1chr1

155297941

+
intron-3UTRENST00000592423ENST00000462780RDH13chr19

55568021

-RUSC1chr1

155297941

+
intron-3UTRENST00000592423ENST00000368349RDH13chr19

55568021

-RUSC1chr1

155297941

+
intron-3UTRENST00000592423ENST00000292254RDH13chr19

55568021

-RUSC1chr1

155297941

+

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FusionProtFeatures for RDH13_RUSC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RDH13

Q8NBN7

RUSC1

Q9BVN2

Does not exhibit retinol dehydrogenase (RDH) activity invitro. Putative signaling adapter which may play a role inneuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronalvesicular trafficking, specifically involving pre-synapticmembrane proteins. Seems to be involved in signaling pathways thatare regulated by the prolonged activation of MAPK. Can regulatethe polyubiquitination of IKBKG and thus may be involved inregulation of the NF-kappa-B pathway.{ECO:0000269|PubMed:19365808}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RDH13_RUSC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RDH13_RUSC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RDH13MINOS1, GADD45G, CYP3A5, PSKH1, TP53, IDH3A, NT5E, GNAI3, L3HYPDH, NAPSA, OLFM4, DDOST, KDSR, ETFA, RAB1A, RAB1B, RPN1, RPN2, COQ9, NDUFA4, PROSER2, EMILIN1, ZNF44, PCDHGA5, LSM5, PON1, SLC39A12, PCDHB5, ALPI, DEFA5, SLC15A1, ATP6V0D1RUSC1IKBKG, TRAF6, APP, PNMA1, STUB1, RBPMS, WWP2, FAM9B, DVL2, HNRNPH2, UBE2S, FAM83H


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RDH13_RUSC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRDH13Q8NBN7DB00162Vitamin ARetinol dehydrogenase 13small moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for RDH13_RUSC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource