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Fusion gene ID: 30885 |
FusionGeneSummary for RCOR1_PPP2R5C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RCOR1_PPP2R5C | Fusion gene ID: 30885 | Hgene | Tgene | Gene symbol | RCOR1 | PPP2R5C | Gene ID | 23186 | 5527 |
| Gene name | REST corepressor 1 | protein phosphatase 2 regulatory subunit B'gamma | |
| Synonyms | COREST|RCOR | B56G|B56gamma|PR61G | |
| Cytomap | 14q32.31-q32.32 | 14q32.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | REST corepressor 1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKL0 | Q13362 | |
| Ensembl transtripts involved in fusion gene | ENST00000262241, ENST00000570597, | ENST00000422945, ENST00000556068, ENST00000554442, ENST00000328724, ENST00000350249, ENST00000445439, ENST00000334743, ENST00000557095, ENST00000556260, ENST00000556946, ENST00000557714, | |
| Fusion gene scores | * DoF score | 8 X 8 X 10=640 | 10 X 9 X 8=720 |
| # samples | 12 | 13 | |
| ** MAII score | log2(12/640*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RCOR1 [Title/Abstract] AND PPP2R5C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RCOR1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10449787 |
| Hgene | RCOR1 | GO:0070933 | histone H4 deacetylation | 17555596 |
| Tgene | PPP2R5C | GO:0008285 | negative regulation of cell proliferation | 17245430 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-OR-A5J7-01A | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| TCGA | RV | OV | TCGA-13-1410-01A | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262241 | ENST00000422945 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000556068 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000554442 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000328724 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000350249 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000445439 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000334743 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000557095 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000556260 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000556946 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000262241 | ENST00000557714 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| In-frame | ENST00000570597 | ENST00000422945 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000556068 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000554442 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000328724 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000350249 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000445439 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000334743 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000557095 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000556260 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000556946 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| 5CDS-intron | ENST00000570597 | ENST00000557714 | RCOR1 | chr14 | 103148315 | + | PPP2R5C | chr14 | 102323023 | + |
| In-frame | ENST00000262241 | ENST00000422945 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000556068 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000554442 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000328724 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000350249 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000445439 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000334743 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000557095 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000556260 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000556946 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000262241 | ENST00000557714 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| In-frame | ENST00000570597 | ENST00000422945 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000556068 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000554442 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000328724 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000350249 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000445439 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000334743 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000557095 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000556260 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000556946 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
| 5CDS-intron | ENST00000570597 | ENST00000557714 | RCOR1 | chr14 | 103059662 | + | PPP2R5C | chr14 | 102391478 | + |
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FusionProtFeatures for RCOR1_PPP2R5C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RCOR1 | PPP2R5C |
| Essential component of the BHC complex, a corepressorcomplex that represses transcription of neuron-specific genes innon-neuronal cells. The BHC complex is recruited at RE1/NRSE sitesby REST and acts by deacetylating and demethylating specific siteson histones, thereby acting as a chromatin modifier. In the BHCcomplex, it serves as a molecular beacon for the recruitment ofmolecular machinery, including MeCP2 and SUV39H1, that imposessilencing across a chromosomal interval. Plays a central role indemethylation of Lys-4 of histone H3 by promoting demethylaseactivity of KDM1A on core histones and nucleosomal substrates. Italso protects KDM1A from the proteasome. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development and controls hematopoieticdifferentiation. {ECO:0000269|PubMed:11171972,ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298,ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763,ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. | The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The PP2A-PPP2R5C holoenzyme may specificallydephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may alsoregulate the ERK signaling pathway through ERK dephosphorylation.{ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 21_77 | 117 | 483 | Compositional bias | Note=Ala-rich |
| Hgene | RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 21_77 | 145 | 483 | Compositional bias | Note=Ala-rich |
| Tgene | >PPP2R5C | chr14:103059662 | chr14:102391478 | ENST00000445439 | + | 0 | 12 | 416_422 | -16 | 450 | Motif | Nuclear localization signal |
| Tgene | >PPP2R5C | chr14:103148315 | chr14:102323023 | ENST00000328724 | + | 2 | 15 | 416_422 | 86 | 541 | Motif | Nuclear localization signal |
| Tgene | >PPP2R5C | chr14:103148315 | chr14:102323023 | ENST00000334743 | + | 0 | 14 | 416_422 | 31 | 525 | Motif | Nuclear localization signal |
| Tgene | >PPP2R5C | chr14:103148315 | chr14:102323023 | ENST00000350249 | + | 0 | 13 | 416_422 | 31 | 486 | Motif | Nuclear localization signal |
| Tgene | >PPP2R5C | chr14:103148315 | chr14:102323023 | ENST00000422945 | + | 2 | 16 | 416_422 | 62 | 556 | Motif | Nuclear localization signal |
| Tgene | >PPP2R5C | chr14:103148315 | chr14:102323023 | ENST00000445439 | + | 0 | 12 | 416_422 | 31 | 450 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 244_273 | 117 | 483 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 334_369 | 117 | 483 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 244_273 | 145 | 483 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 334_369 | 145 | 483 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 103_189 | 117 | 483 | Domain | ELM2 |
| Hgene | >RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 190_241 | 117 | 483 | Domain | SANT 1 |
| Hgene | >RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 381_432 | 117 | 483 | Domain | SANT 2 |
| Hgene | >RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 103_189 | 145 | 483 | Domain | ELM2 |
| Hgene | >RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 190_241 | 145 | 483 | Domain | SANT 1 |
| Hgene | >RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 381_432 | 145 | 483 | Domain | SANT 2 |
| Tgene | PPP2R5C | chr14:103059662 | chr14:102391478 | ENST00000328724 | + | 13 | 15 | 416_422 | 497 | 541 | Motif | Nuclear localization signal |
| Tgene | PPP2R5C | chr14:103059662 | chr14:102391478 | ENST00000334743 | + | 12 | 14 | 416_422 | 481 | 525 | Motif | Nuclear localization signal |
| Tgene | PPP2R5C | chr14:103059662 | chr14:102391478 | ENST00000350249 | + | 11 | 13 | 416_422 | 442 | 486 | Motif | Nuclear localization signal |
| Tgene | PPP2R5C | chr14:103059662 | chr14:102391478 | ENST00000422945 | + | 14 | 16 | 416_422 | 512 | 556 | Motif | Nuclear localization signal |
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FusionGeneSequence for RCOR1_PPP2R5C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RCOR1_ENST00000262241_chr14_103148315_+_PPP2R5C_ENST00000422945_chr14_102323023_+_642aa MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEG SSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKYVPPADQEKLFIQKLRQCCVLFDFVSDPLSDL KWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPN IAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEH KIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAK CVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKM KEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHC >In-frame_RCOR1_ENST00000570597_chr14_103148315_+_PPP2R5C_ENST00000422945_chr14_102323023_+_639aa MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSG SSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKYVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWK EVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAK KYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIF LLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVS SPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKER EEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRAD >In-frame_RCOR1_ENST00000262241_chr14_103059662_+_PPP2R5C_ENST00000422945_chr14_102391478_+_164aa MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEG >In-frame_RCOR1_ENST00000570597_chr14_103059662_+_PPP2R5C_ENST00000422945_chr14_102391478_+_161aa MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RCOR1_ENST00000262241_chr14_103148315_+_PPP2R5C_ENST00000422945_chr14_102323023_+_1926nt ATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCC TCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCA GCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGC AGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCC GCCAAACTGGCAAGACGCAGTCAAGAACGGGACAATCTTGGCATGTTGGTCTGGTCACCCAATCAAAATCTGTCAGAAGCAAAGTATGTT CCTCCTGCTGATCAAGAGAAGCTTTTTATCCAGAAGTTACGTCAGTGTTGCGTCCTCTTTGACTTTGTTTCTGATCCACTAAGTGACCTA AAGTGGAAGGAAGTAAAACGAGCTGCTTTAAGTGAAATGGTAGAATATATCACCCATAATCGGAATGTGATCACAGAGCCTATTTACCCA GAAGTAGTCCATATGTTTGCAGTTAACATGTTTCGAACATTACCACCTTCCTCCAATCCTACGGGAGCGGAATTTGACCCGGAGGAAGAT GAACCAACGTTAGAAGCAGCCTGGCCTCATCTACAGCTTGTTTATGAATTTTTCTTAAGATTTTTAGAGTCTCCAGATTTCCAACCTAAT ATAGCGAAGAAATATATTGATCAGAAGTTTGTATTGCAGCTTTTAGAGCTCTTTGACAGTGAAGATCCTCGGGAGAGAGATTTTCTTAAA ACCACCCTTCACAGAATCTATGGGAAATTCCTAGGCTTGAGAGCTTACATCAGAAAACAGATAAATAATATATTTTATAGGTTTATTTAT GAAACAGAGCATCATAATGGCATAGCAGAGTTACTGGAAATATTGGGAAGTATAATTAATGGATTTGCCTTACCACTAAAAGAAGAGCAC AAGATTTTCTTATTGAAGGTGTTACTACCTTTGCACAAAGTGAAATCTCTGAGTGTCTACCATCCCCAGCTGGCATACTGTGTAGTGCAG TTTTTAGAAAAGGACAGCACCCTCACGGAACCAGTGGTGATGGCACTTCTCAAATACTGGCCAAAGACTCACAGTCCAAAAGAAGTAATG TTCTTAAACGAATTAGAAGAGATTTTAGATGTCATTGAACCATCAGAATTTGTGAAGATCATGGAACCCCTCTTCCGGCAGTTGGCCAAA TGTGTCTCCAGCCCACACTTCCAGGTGGCAGAGCGAGCTCTCTATTACTGGAATAATGAATACATCATGAGTTTAATCAGTGACAACGCA GCGAAGATTCTGCCCATCATGTTTCCTTCCTTGTACCGCAACTCAAAGACCCATTGGAACAAGACAATACATGGCTTGATATACAACGCC CTGAAGCTCTTCATGGAGATGAACCAAAAGCTATTTGATGACTGTACACAACAGTTCAAAGCAGAGAAACTAAAAGAGAAGCTAAAAATG AAAGAACGGGAAGAAGCATGGGTTAAAATAGAAAATCTAGCCAAAGCCAATCCCCAGTACACAGTGTATAGTCAAGCCAGCACCATGAGC ATTCCGGTTGCAATGGAGACAGATGGGCCTTTATTTGAAGATGTGCAGATGCTGAGAAAGACAGTGAAGGACGAGGCTCATCAGGCACAG AAAGATCCGAAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGC >In-frame_RCOR1_ENST00000570597_chr14_103148315_+_PPP2R5C_ENST00000422945_chr14_102323023_+_1917nt ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCCAAACTG GCAAGACGCAGTCAAGAACGGGACAATCTTGGCATGTTGGTCTGGTCACCCAATCAAAATCTGTCAGAAGCAAAGTATGTTCCTCCTGCT GATCAAGAGAAGCTTTTTATCCAGAAGTTACGTCAGTGTTGCGTCCTCTTTGACTTTGTTTCTGATCCACTAAGTGACCTAAAGTGGAAG GAAGTAAAACGAGCTGCTTTAAGTGAAATGGTAGAATATATCACCCATAATCGGAATGTGATCACAGAGCCTATTTACCCAGAAGTAGTC CATATGTTTGCAGTTAACATGTTTCGAACATTACCACCTTCCTCCAATCCTACGGGAGCGGAATTTGACCCGGAGGAAGATGAACCAACG TTAGAAGCAGCCTGGCCTCATCTACAGCTTGTTTATGAATTTTTCTTAAGATTTTTAGAGTCTCCAGATTTCCAACCTAATATAGCGAAG AAATATATTGATCAGAAGTTTGTATTGCAGCTTTTAGAGCTCTTTGACAGTGAAGATCCTCGGGAGAGAGATTTTCTTAAAACCACCCTT CACAGAATCTATGGGAAATTCCTAGGCTTGAGAGCTTACATCAGAAAACAGATAAATAATATATTTTATAGGTTTATTTATGAAACAGAG CATCATAATGGCATAGCAGAGTTACTGGAAATATTGGGAAGTATAATTAATGGATTTGCCTTACCACTAAAAGAAGAGCACAAGATTTTC TTATTGAAGGTGTTACTACCTTTGCACAAAGTGAAATCTCTGAGTGTCTACCATCCCCAGCTGGCATACTGTGTAGTGCAGTTTTTAGAA AAGGACAGCACCCTCACGGAACCAGTGGTGATGGCACTTCTCAAATACTGGCCAAAGACTCACAGTCCAAAAGAAGTAATGTTCTTAAAC GAATTAGAAGAGATTTTAGATGTCATTGAACCATCAGAATTTGTGAAGATCATGGAACCCCTCTTCCGGCAGTTGGCCAAATGTGTCTCC AGCCCACACTTCCAGGTGGCAGAGCGAGCTCTCTATTACTGGAATAATGAATACATCATGAGTTTAATCAGTGACAACGCAGCGAAGATT CTGCCCATCATGTTTCCTTCCTTGTACCGCAACTCAAAGACCCATTGGAACAAGACAATACATGGCTTGATATACAACGCCCTGAAGCTC TTCATGGAGATGAACCAAAAGCTATTTGATGACTGTACACAACAGTTCAAAGCAGAGAAACTAAAAGAGAAGCTAAAAATGAAAGAACGG GAAGAAGCATGGGTTAAAATAGAAAATCTAGCCAAAGCCAATCCCCAGTACACAGTGTATAGTCAAGCCAGCACCATGAGCATTCCGGTT GCAATGGAGACAGATGGGCCTTTATTTGAAGATGTGCAGATGCTGAGAAAGACAGTGAAGGACGAGGCTCATCAGGCACAGAAAGATCCG AAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGCAGGGCCGAT >In-frame_RCOR1_ENST00000262241_chr14_103059662_+_PPP2R5C_ENST00000422945_chr14_102391478_+_493nt ATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCC TCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCA GCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGC AGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCC GGCACAGAAAGATCCGAAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGC >In-frame_RCOR1_ENST00000570597_chr14_103059662_+_PPP2R5C_ENST00000422945_chr14_102391478_+_484nt ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGGCACAGAA AGATCCGAAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RCOR1_ENST00000262241_chr14_103148315_+_PPP2R5C_ENST00000422945_chr14_102323023_+_4869nt GTGAGGGCGGCGATGAGAGCGAAAGTTGCGCTCGGCTCGTCGCTGGGGGCTTGAAGCGGCTCCGCGCTCTGCCCGTTTGGGCCTCCCCCG ACTCGGACTCGCGCCCGTGGGCTCCCGCCGCGCCCGCCCGGCCCCGCGCCGGCCCCGCGCCCCCTCCCCCGTCTCGGCGCCCCCTCCTCA GGAGCCGCGGGTCCCCGCCACTTTCGCACGGCCCCGGCCCCCGCCGATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCG GAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGC CGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGC GGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCAT GAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCCAAACTGGCAAGACGCAGTCAAGAACGGGACAATCTTGGCAT GTTGGTCTGGTCACCCAATCAAAATCTGTCAGAAGCAAAGTATGTTCCTCCTGCTGATCAAGAGAAGCTTTTTATCCAGAAGTTACGTCA GTGTTGCGTCCTCTTTGACTTTGTTTCTGATCCACTAAGTGACCTAAAGTGGAAGGAAGTAAAACGAGCTGCTTTAAGTGAAATGGTAGA ATATATCACCCATAATCGGAATGTGATCACAGAGCCTATTTACCCAGAAGTAGTCCATATGTTTGCAGTTAACATGTTTCGAACATTACC ACCTTCCTCCAATCCTACGGGAGCGGAATTTGACCCGGAGGAAGATGAACCAACGTTAGAAGCAGCCTGGCCTCATCTACAGCTTGTTTA TGAATTTTTCTTAAGATTTTTAGAGTCTCCAGATTTCCAACCTAATATAGCGAAGAAATATATTGATCAGAAGTTTGTATTGCAGCTTTT AGAGCTCTTTGACAGTGAAGATCCTCGGGAGAGAGATTTTCTTAAAACCACCCTTCACAGAATCTATGGGAAATTCCTAGGCTTGAGAGC TTACATCAGAAAACAGATAAATAATATATTTTATAGGTTTATTTATGAAACAGAGCATCATAATGGCATAGCAGAGTTACTGGAAATATT GGGAAGTATAATTAATGGATTTGCCTTACCACTAAAAGAAGAGCACAAGATTTTCTTATTGAAGGTGTTACTACCTTTGCACAAAGTGAA ATCTCTGAGTGTCTACCATCCCCAGCTGGCATACTGTGTAGTGCAGTTTTTAGAAAAGGACAGCACCCTCACGGAACCAGTGGTGATGGC ACTTCTCAAATACTGGCCAAAGACTCACAGTCCAAAAGAAGTAATGTTCTTAAACGAATTAGAAGAGATTTTAGATGTCATTGAACCATC AGAATTTGTGAAGATCATGGAACCCCTCTTCCGGCAGTTGGCCAAATGTGTCTCCAGCCCACACTTCCAGGTGGCAGAGCGAGCTCTCTA TTACTGGAATAATGAATACATCATGAGTTTAATCAGTGACAACGCAGCGAAGATTCTGCCCATCATGTTTCCTTCCTTGTACCGCAACTC AAAGACCCATTGGAACAAGACAATACATGGCTTGATATACAACGCCCTGAAGCTCTTCATGGAGATGAACCAAAAGCTATTTGATGACTG TACACAACAGTTCAAAGCAGAGAAACTAAAAGAGAAGCTAAAAATGAAAGAACGGGAAGAAGCATGGGTTAAAATAGAAAATCTAGCCAA AGCCAATCCCCAGTACACAGTGTATAGTCAAGCCAGCACCATGAGCATTCCGGTTGCAATGGAGACAGATGGGCCTTTATTTGAAGATGT GCAGATGCTGAGAAAGACAGTGAAGGACGAGGCTCATCAGGCACAGAAAGATCCGAAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGA GCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGCAGGGCCGATGAGCTGGCCTCCCAGGACGGCCGCTAGCCTCCGGG GCGCCGCGTCGGGGCCGGGCCCGCCAGTTCTTTTCCGGATTCTGTAGAAAATACATACTTCCTGTGCCATACCAATCAGTTACACTCAAA GCTTTCTTGGACCCCGTTCCGTAGGCAATAACGTGCGTCCGCCTCAGCGCGAGATTAGGAGTTCAAACAATGGTGACTTCCCAGAGCCCG CTGGCAGAGCCGCGGGTTGACGACGGTGTCCTCGCAGTGTCGCCGCCACCCCAGCGTAGTCCAAGTCAGACTATTTCACAAAGTCAGAGC GATAGGAAAGCACCCTGCCCTTCATCTTCATGTTCTCCCAAATGGAACTTAGGATCTTTTAACATAGGTGGTTCTGTGATAACATCAGTG TTTTCCAAATCAAAGGAACGCTTTAAAAAATAGGACCTATTTTTTAAGACTTTACAGCCTTTGAAATGGTTTCCACGTGATTGTTACGCC AGCAGTTCTCGTTTTGTTTGTTTTTCAATCTCAGTGAAATGGCTCTTTGCTTTCGAGTTCTCACGCAACGTACTGGGCAAATGACAATCC TCAGCCGCTGGTATTTTCTAAGGGGTCTCTTCACTTTGATGAGTGACATGAACACCGTGTCTCCTTCTCTTGTGTGTACCTAAAGCCATA TTTCCAAGTCTGTGGTACTCCAGGATTCCAGGAGTAAGCCTGTAGAAGAGATTTATTTTAAAAGAGATTGCTCTGAAATTTATCTTAAAA GAGCTTGCTCTGTCTACCTTGACAGAAATTGGAGTTTTAAAATTATGTGTTAATATTTTTATTTGCAGATTTCGTTTCCGTCAACTTAAA CATTGTTGCCCTTCAACAAGGCTCTTGAATTAATAAAATTATAGTCTCTAAGAATTCCACATTTTATGGAAAGTTAGAGCAAAATCATTT TGAGTTAAGCCAGTTCTTAGCCTAATGCAAACTGCAGCGCCTTTAAGCATAAAGTAACACAACAGCATTGCACGGGGCCGGCACTGCCGC TGCCTTCACTGAAGGCTGCAGTGCTGTTCTGAGAGCTTGGAGGAGGCACCAGCGAGGATGACGTTTAGTGGAGCTCTTTCTGTTGAAAAG AGCTCACGTTATCAACACCTTGTAAGGAAAATACAGTGTCTGAGTTTTCATCGGTCTTCACATGCTGCTATATATTCCACAGAGTTCCTT GCATGTACTGAGCTTTTGTTTTAGATGGAATAGCACAAGGAGAAAAATCTTTAAACTTAGTGCTTTGTCTATTCTTTATTTCTCTCAGGG TGGCCAGTATTTTGACTTATTTATCCTGCTTGAAAGCTACTTGAGATGTGTACTGCTATTCTAAACACGTGATCTAGTTTCTTTCATCTC TGGCATAAGATTATATAACTTAATGTTAAGTGTCTTGAGGCATAAAAGACAAAATGTGGCTTATTTTAGGATCTGTTTTTTCATCGAGGT CTCGGGTATCCTTTCAAAGATAGTGAGAAGCAGACACTGCTCCTTGTGCAGCTCTGGTACCTCCTGCCCACTGCTGTCACTTCAAGCCAC TGGCAATGCTTCTGTCCTCGTGTCTTGGAGGAAAATCACCTGGGGGGAGGGGACTTCTTGTGGTAAGAGCAAGTGCAGGTATGAAATGCG AAGATTGCCCCAGCTAAAAGTGGACAAGTCCGCTTTGTGAGATGAATACTTCCTGAGAAACTTGACAAGTATCTCTCCATTTTACCATTA TGAAAACTATCATTAAAAAAAACAGTTTAGATGCCTTCTCCTTTTGAGGGAAAAAGGGTGCTTTTTATTGTATAAAGCAGCGTCTTATGT ATTTTGATATACCATTGTTTGAACTTCCGTCTTTAGCTGATAGATTCTCAAATATCCTTGATTTTGGATGTTCAGTATGTTTGTGAGAGA GGTTTCTGGGAAGACTCTCTTTTTGCCCTCGGGAAAAAGCAAAATATCAATGTTTGGGTGACTGTGTAAAGCTCAGTGTGTAAGAACATC TTTTTGTCTAGGTTTTCTTTCTGCTCTTTATTGAAGACAAACACTCACCAAAAAGAAAAATAAAAGTTTTCAGAGAAACTAATTTTCTTT GGCAAGAGTATTACTTAATATTTTGGCCTCCTAAAGTTTCCCTAGTTAGTACTCGGACTCCTGTGCTAATTGTCAGCTTACATATCATTG TATAGAGACTGTTTATTCTGTACCAAACTGATTTCAAAAGTACTACATTGAAAATAAACCGGTGACTGTTTTTCTTCATAAAGTTCTGCG TTTGGCATCTTCACTCTTTCCAAAATGTATCTGTACATCAGAAATGTCACTATTCCAAGTGTCTTTTTAGTGTGGCTTTAGTATGGCTTC CTTTTAATATTGTACATACATTGTATCTTTGTTTTATGGTAATAAGTAATAAAAATGTAGACTTCATATTTTGTACAAAATGTCCTATGT ACAGAATAAAAAAGTTCATAGAAACAGCAAATATAGGTAAGTGGCACAATTATTTTTCTTTAGAAAATATCTGTAACTTTATGCATTAGT GAAATGTTAAGTACCGACATATTTTTTAACATTTTGTAATTCAAAACTTTTTGTTTTGACATTGTTTATGAAGAGAAACTTCATACACTT GCCATTTAATATGCTCTTTTATCTAATTTTCAAAAACTCTAAAAAACGGTGTATCATATGGACTAAATAAAGAACATGTGAATTTTATTG >In-frame_RCOR1_ENST00000570597_chr14_103148315_+_PPP2R5C_ENST00000422945_chr14_102323023_+_4634nt ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCCAAACTG GCAAGACGCAGTCAAGAACGGGACAATCTTGGCATGTTGGTCTGGTCACCCAATCAAAATCTGTCAGAAGCAAAGTATGTTCCTCCTGCT GATCAAGAGAAGCTTTTTATCCAGAAGTTACGTCAGTGTTGCGTCCTCTTTGACTTTGTTTCTGATCCACTAAGTGACCTAAAGTGGAAG GAAGTAAAACGAGCTGCTTTAAGTGAAATGGTAGAATATATCACCCATAATCGGAATGTGATCACAGAGCCTATTTACCCAGAAGTAGTC CATATGTTTGCAGTTAACATGTTTCGAACATTACCACCTTCCTCCAATCCTACGGGAGCGGAATTTGACCCGGAGGAAGATGAACCAACG TTAGAAGCAGCCTGGCCTCATCTACAGCTTGTTTATGAATTTTTCTTAAGATTTTTAGAGTCTCCAGATTTCCAACCTAATATAGCGAAG AAATATATTGATCAGAAGTTTGTATTGCAGCTTTTAGAGCTCTTTGACAGTGAAGATCCTCGGGAGAGAGATTTTCTTAAAACCACCCTT CACAGAATCTATGGGAAATTCCTAGGCTTGAGAGCTTACATCAGAAAACAGATAAATAATATATTTTATAGGTTTATTTATGAAACAGAG CATCATAATGGCATAGCAGAGTTACTGGAAATATTGGGAAGTATAATTAATGGATTTGCCTTACCACTAAAAGAAGAGCACAAGATTTTC TTATTGAAGGTGTTACTACCTTTGCACAAAGTGAAATCTCTGAGTGTCTACCATCCCCAGCTGGCATACTGTGTAGTGCAGTTTTTAGAA AAGGACAGCACCCTCACGGAACCAGTGGTGATGGCACTTCTCAAATACTGGCCAAAGACTCACAGTCCAAAAGAAGTAATGTTCTTAAAC GAATTAGAAGAGATTTTAGATGTCATTGAACCATCAGAATTTGTGAAGATCATGGAACCCCTCTTCCGGCAGTTGGCCAAATGTGTCTCC AGCCCACACTTCCAGGTGGCAGAGCGAGCTCTCTATTACTGGAATAATGAATACATCATGAGTTTAATCAGTGACAACGCAGCGAAGATT CTGCCCATCATGTTTCCTTCCTTGTACCGCAACTCAAAGACCCATTGGAACAAGACAATACATGGCTTGATATACAACGCCCTGAAGCTC TTCATGGAGATGAACCAAAAGCTATTTGATGACTGTACACAACAGTTCAAAGCAGAGAAACTAAAAGAGAAGCTAAAAATGAAAGAACGG GAAGAAGCATGGGTTAAAATAGAAAATCTAGCCAAAGCCAATCCCCAGTACACAGTGTATAGTCAAGCCAGCACCATGAGCATTCCGGTT GCAATGGAGACAGATGGGCCTTTATTTGAAGATGTGCAGATGCTGAGAAAGACAGTGAAGGACGAGGCTCATCAGGCACAGAAAGATCCG AAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGCAGGGCCGAT GAGCTGGCCTCCCAGGACGGCCGCTAGCCTCCGGGGCGCCGCGTCGGGGCCGGGCCCGCCAGTTCTTTTCCGGATTCTGTAGAAAATACA TACTTCCTGTGCCATACCAATCAGTTACACTCAAAGCTTTCTTGGACCCCGTTCCGTAGGCAATAACGTGCGTCCGCCTCAGCGCGAGAT TAGGAGTTCAAACAATGGTGACTTCCCAGAGCCCGCTGGCAGAGCCGCGGGTTGACGACGGTGTCCTCGCAGTGTCGCCGCCACCCCAGC GTAGTCCAAGTCAGACTATTTCACAAAGTCAGAGCGATAGGAAAGCACCCTGCCCTTCATCTTCATGTTCTCCCAAATGGAACTTAGGAT CTTTTAACATAGGTGGTTCTGTGATAACATCAGTGTTTTCCAAATCAAAGGAACGCTTTAAAAAATAGGACCTATTTTTTAAGACTTTAC AGCCTTTGAAATGGTTTCCACGTGATTGTTACGCCAGCAGTTCTCGTTTTGTTTGTTTTTCAATCTCAGTGAAATGGCTCTTTGCTTTCG AGTTCTCACGCAACGTACTGGGCAAATGACAATCCTCAGCCGCTGGTATTTTCTAAGGGGTCTCTTCACTTTGATGAGTGACATGAACAC CGTGTCTCCTTCTCTTGTGTGTACCTAAAGCCATATTTCCAAGTCTGTGGTACTCCAGGATTCCAGGAGTAAGCCTGTAGAAGAGATTTA TTTTAAAAGAGATTGCTCTGAAATTTATCTTAAAAGAGCTTGCTCTGTCTACCTTGACAGAAATTGGAGTTTTAAAATTATGTGTTAATA TTTTTATTTGCAGATTTCGTTTCCGTCAACTTAAACATTGTTGCCCTTCAACAAGGCTCTTGAATTAATAAAATTATAGTCTCTAAGAAT TCCACATTTTATGGAAAGTTAGAGCAAAATCATTTTGAGTTAAGCCAGTTCTTAGCCTAATGCAAACTGCAGCGCCTTTAAGCATAAAGT AACACAACAGCATTGCACGGGGCCGGCACTGCCGCTGCCTTCACTGAAGGCTGCAGTGCTGTTCTGAGAGCTTGGAGGAGGCACCAGCGA GGATGACGTTTAGTGGAGCTCTTTCTGTTGAAAAGAGCTCACGTTATCAACACCTTGTAAGGAAAATACAGTGTCTGAGTTTTCATCGGT CTTCACATGCTGCTATATATTCCACAGAGTTCCTTGCATGTACTGAGCTTTTGTTTTAGATGGAATAGCACAAGGAGAAAAATCTTTAAA CTTAGTGCTTTGTCTATTCTTTATTTCTCTCAGGGTGGCCAGTATTTTGACTTATTTATCCTGCTTGAAAGCTACTTGAGATGTGTACTG CTATTCTAAACACGTGATCTAGTTTCTTTCATCTCTGGCATAAGATTATATAACTTAATGTTAAGTGTCTTGAGGCATAAAAGACAAAAT GTGGCTTATTTTAGGATCTGTTTTTTCATCGAGGTCTCGGGTATCCTTTCAAAGATAGTGAGAAGCAGACACTGCTCCTTGTGCAGCTCT GGTACCTCCTGCCCACTGCTGTCACTTCAAGCCACTGGCAATGCTTCTGTCCTCGTGTCTTGGAGGAAAATCACCTGGGGGGAGGGGACT TCTTGTGGTAAGAGCAAGTGCAGGTATGAAATGCGAAGATTGCCCCAGCTAAAAGTGGACAAGTCCGCTTTGTGAGATGAATACTTCCTG AGAAACTTGACAAGTATCTCTCCATTTTACCATTATGAAAACTATCATTAAAAAAAACAGTTTAGATGCCTTCTCCTTTTGAGGGAAAAA GGGTGCTTTTTATTGTATAAAGCAGCGTCTTATGTATTTTGATATACCATTGTTTGAACTTCCGTCTTTAGCTGATAGATTCTCAAATAT CCTTGATTTTGGATGTTCAGTATGTTTGTGAGAGAGGTTTCTGGGAAGACTCTCTTTTTGCCCTCGGGAAAAAGCAAAATATCAATGTTT GGGTGACTGTGTAAAGCTCAGTGTGTAAGAACATCTTTTTGTCTAGGTTTTCTTTCTGCTCTTTATTGAAGACAAACACTCACCAAAAAG AAAAATAAAAGTTTTCAGAGAAACTAATTTTCTTTGGCAAGAGTATTACTTAATATTTTGGCCTCCTAAAGTTTCCCTAGTTAGTACTCG GACTCCTGTGCTAATTGTCAGCTTACATATCATTGTATAGAGACTGTTTATTCTGTACCAAACTGATTTCAAAAGTACTACATTGAAAAT AAACCGGTGACTGTTTTTCTTCATAAAGTTCTGCGTTTGGCATCTTCACTCTTTCCAAAATGTATCTGTACATCAGAAATGTCACTATTC CAAGTGTCTTTTTAGTGTGGCTTTAGTATGGCTTCCTTTTAATATTGTACATACATTGTATCTTTGTTTTATGGTAATAAGTAATAAAAA TGTAGACTTCATATTTTGTACAAAATGTCCTATGTACAGAATAAAAAAGTTCATAGAAACAGCAAATATAGGTAAGTGGCACAATTATTT TTCTTTAGAAAATATCTGTAACTTTATGCATTAGTGAAATGTTAAGTACCGACATATTTTTTAACATTTTGTAATTCAAAACTTTTTGTT TTGACATTGTTTATGAAGAGAAACTTCATACACTTGCCATTTAATATGCTCTTTTATCTAATTTTCAAAAACTCTAAAAAACGGTGTATC >In-frame_RCOR1_ENST00000262241_chr14_103059662_+_PPP2R5C_ENST00000422945_chr14_102391478_+_3436nt GTGAGGGCGGCGATGAGAGCGAAAGTTGCGCTCGGCTCGTCGCTGGGGGCTTGAAGCGGCTCCGCGCTCTGCCCGTTTGGGCCTCCCCCG ACTCGGACTCGCGCCCGTGGGCTCCCGCCGCGCCCGCCCGGCCCCGCGCCGGCCCCGCGCCCCCTCCCCCGTCTCGGCGCCCCCTCCTCA GGAGCCGCGGGTCCCCGCCACTTTCGCACGGCCCCGGCCCCCGCCGATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCG GAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGC CGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGC GGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCAT GAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGGCACAGAAAGATCCGAAGAAGGACCGTCCTCTTGCACGCCGCA AGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGCAGGGCCGATGAGCTGGCCTCCCAGGACGGCCGCTAGC CTCCGGGGCGCCGCGTCGGGGCCGGGCCCGCCAGTTCTTTTCCGGATTCTGTAGAAAATACATACTTCCTGTGCCATACCAATCAGTTAC ACTCAAAGCTTTCTTGGACCCCGTTCCGTAGGCAATAACGTGCGTCCGCCTCAGCGCGAGATTAGGAGTTCAAACAATGGTGACTTCCCA GAGCCCGCTGGCAGAGCCGCGGGTTGACGACGGTGTCCTCGCAGTGTCGCCGCCACCCCAGCGTAGTCCAAGTCAGACTATTTCACAAAG TCAGAGCGATAGGAAAGCACCCTGCCCTTCATCTTCATGTTCTCCCAAATGGAACTTAGGATCTTTTAACATAGGTGGTTCTGTGATAAC ATCAGTGTTTTCCAAATCAAAGGAACGCTTTAAAAAATAGGACCTATTTTTTAAGACTTTACAGCCTTTGAAATGGTTTCCACGTGATTG TTACGCCAGCAGTTCTCGTTTTGTTTGTTTTTCAATCTCAGTGAAATGGCTCTTTGCTTTCGAGTTCTCACGCAACGTACTGGGCAAATG ACAATCCTCAGCCGCTGGTATTTTCTAAGGGGTCTCTTCACTTTGATGAGTGACATGAACACCGTGTCTCCTTCTCTTGTGTGTACCTAA AGCCATATTTCCAAGTCTGTGGTACTCCAGGATTCCAGGAGTAAGCCTGTAGAAGAGATTTATTTTAAAAGAGATTGCTCTGAAATTTAT CTTAAAAGAGCTTGCTCTGTCTACCTTGACAGAAATTGGAGTTTTAAAATTATGTGTTAATATTTTTATTTGCAGATTTCGTTTCCGTCA ACTTAAACATTGTTGCCCTTCAACAAGGCTCTTGAATTAATAAAATTATAGTCTCTAAGAATTCCACATTTTATGGAAAGTTAGAGCAAA ATCATTTTGAGTTAAGCCAGTTCTTAGCCTAATGCAAACTGCAGCGCCTTTAAGCATAAAGTAACACAACAGCATTGCACGGGGCCGGCA CTGCCGCTGCCTTCACTGAAGGCTGCAGTGCTGTTCTGAGAGCTTGGAGGAGGCACCAGCGAGGATGACGTTTAGTGGAGCTCTTTCTGT TGAAAAGAGCTCACGTTATCAACACCTTGTAAGGAAAATACAGTGTCTGAGTTTTCATCGGTCTTCACATGCTGCTATATATTCCACAGA GTTCCTTGCATGTACTGAGCTTTTGTTTTAGATGGAATAGCACAAGGAGAAAAATCTTTAAACTTAGTGCTTTGTCTATTCTTTATTTCT CTCAGGGTGGCCAGTATTTTGACTTATTTATCCTGCTTGAAAGCTACTTGAGATGTGTACTGCTATTCTAAACACGTGATCTAGTTTCTT TCATCTCTGGCATAAGATTATATAACTTAATGTTAAGTGTCTTGAGGCATAAAAGACAAAATGTGGCTTATTTTAGGATCTGTTTTTTCA TCGAGGTCTCGGGTATCCTTTCAAAGATAGTGAGAAGCAGACACTGCTCCTTGTGCAGCTCTGGTACCTCCTGCCCACTGCTGTCACTTC AAGCCACTGGCAATGCTTCTGTCCTCGTGTCTTGGAGGAAAATCACCTGGGGGGAGGGGACTTCTTGTGGTAAGAGCAAGTGCAGGTATG AAATGCGAAGATTGCCCCAGCTAAAAGTGGACAAGTCCGCTTTGTGAGATGAATACTTCCTGAGAAACTTGACAAGTATCTCTCCATTTT ACCATTATGAAAACTATCATTAAAAAAAACAGTTTAGATGCCTTCTCCTTTTGAGGGAAAAAGGGTGCTTTTTATTGTATAAAGCAGCGT CTTATGTATTTTGATATACCATTGTTTGAACTTCCGTCTTTAGCTGATAGATTCTCAAATATCCTTGATTTTGGATGTTCAGTATGTTTG TGAGAGAGGTTTCTGGGAAGACTCTCTTTTTGCCCTCGGGAAAAAGCAAAATATCAATGTTTGGGTGACTGTGTAAAGCTCAGTGTGTAA GAACATCTTTTTGTCTAGGTTTTCTTTCTGCTCTTTATTGAAGACAAACACTCACCAAAAAGAAAAATAAAAGTTTTCAGAGAAACTAAT TTTCTTTGGCAAGAGTATTACTTAATATTTTGGCCTCCTAAAGTTTCCCTAGTTAGTACTCGGACTCCTGTGCTAATTGTCAGCTTACAT ATCATTGTATAGAGACTGTTTATTCTGTACCAAACTGATTTCAAAAGTACTACATTGAAAATAAACCGGTGACTGTTTTTCTTCATAAAG TTCTGCGTTTGGCATCTTCACTCTTTCCAAAATGTATCTGTACATCAGAAATGTCACTATTCCAAGTGTCTTTTTAGTGTGGCTTTAGTA TGGCTTCCTTTTAATATTGTACATACATTGTATCTTTGTTTTATGGTAATAAGTAATAAAAATGTAGACTTCATATTTTGTACAAAATGT CCTATGTACAGAATAAAAAAGTTCATAGAAACAGCAAATATAGGTAAGTGGCACAATTATTTTTCTTTAGAAAATATCTGTAACTTTATG CATTAGTGAAATGTTAAGTACCGACATATTTTTTAACATTTTGTAATTCAAAACTTTTTGTTTTGACATTGTTTATGAAGAGAAACTTCA TACACTTGCCATTTAATATGCTCTTTTATCTAATTTTCAAAAACTCTAAAAAACGGTGTATCATATGGACTAAATAAAGAACATGTGAAT >In-frame_RCOR1_ENST00000570597_chr14_103059662_+_PPP2R5C_ENST00000422945_chr14_102391478_+_3201nt ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGGCACAGAA AGATCCGAAGAAGGACCGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTGGAAGCTCACTGCAG GGCCGATGAGCTGGCCTCCCAGGACGGCCGCTAGCCTCCGGGGCGCCGCGTCGGGGCCGGGCCCGCCAGTTCTTTTCCGGATTCTGTAGA AAATACATACTTCCTGTGCCATACCAATCAGTTACACTCAAAGCTTTCTTGGACCCCGTTCCGTAGGCAATAACGTGCGTCCGCCTCAGC GCGAGATTAGGAGTTCAAACAATGGTGACTTCCCAGAGCCCGCTGGCAGAGCCGCGGGTTGACGACGGTGTCCTCGCAGTGTCGCCGCCA CCCCAGCGTAGTCCAAGTCAGACTATTTCACAAAGTCAGAGCGATAGGAAAGCACCCTGCCCTTCATCTTCATGTTCTCCCAAATGGAAC TTAGGATCTTTTAACATAGGTGGTTCTGTGATAACATCAGTGTTTTCCAAATCAAAGGAACGCTTTAAAAAATAGGACCTATTTTTTAAG ACTTTACAGCCTTTGAAATGGTTTCCACGTGATTGTTACGCCAGCAGTTCTCGTTTTGTTTGTTTTTCAATCTCAGTGAAATGGCTCTTT GCTTTCGAGTTCTCACGCAACGTACTGGGCAAATGACAATCCTCAGCCGCTGGTATTTTCTAAGGGGTCTCTTCACTTTGATGAGTGACA TGAACACCGTGTCTCCTTCTCTTGTGTGTACCTAAAGCCATATTTCCAAGTCTGTGGTACTCCAGGATTCCAGGAGTAAGCCTGTAGAAG AGATTTATTTTAAAAGAGATTGCTCTGAAATTTATCTTAAAAGAGCTTGCTCTGTCTACCTTGACAGAAATTGGAGTTTTAAAATTATGT GTTAATATTTTTATTTGCAGATTTCGTTTCCGTCAACTTAAACATTGTTGCCCTTCAACAAGGCTCTTGAATTAATAAAATTATAGTCTC TAAGAATTCCACATTTTATGGAAAGTTAGAGCAAAATCATTTTGAGTTAAGCCAGTTCTTAGCCTAATGCAAACTGCAGCGCCTTTAAGC ATAAAGTAACACAACAGCATTGCACGGGGCCGGCACTGCCGCTGCCTTCACTGAAGGCTGCAGTGCTGTTCTGAGAGCTTGGAGGAGGCA CCAGCGAGGATGACGTTTAGTGGAGCTCTTTCTGTTGAAAAGAGCTCACGTTATCAACACCTTGTAAGGAAAATACAGTGTCTGAGTTTT CATCGGTCTTCACATGCTGCTATATATTCCACAGAGTTCCTTGCATGTACTGAGCTTTTGTTTTAGATGGAATAGCACAAGGAGAAAAAT CTTTAAACTTAGTGCTTTGTCTATTCTTTATTTCTCTCAGGGTGGCCAGTATTTTGACTTATTTATCCTGCTTGAAAGCTACTTGAGATG TGTACTGCTATTCTAAACACGTGATCTAGTTTCTTTCATCTCTGGCATAAGATTATATAACTTAATGTTAAGTGTCTTGAGGCATAAAAG ACAAAATGTGGCTTATTTTAGGATCTGTTTTTTCATCGAGGTCTCGGGTATCCTTTCAAAGATAGTGAGAAGCAGACACTGCTCCTTGTG CAGCTCTGGTACCTCCTGCCCACTGCTGTCACTTCAAGCCACTGGCAATGCTTCTGTCCTCGTGTCTTGGAGGAAAATCACCTGGGGGGA GGGGACTTCTTGTGGTAAGAGCAAGTGCAGGTATGAAATGCGAAGATTGCCCCAGCTAAAAGTGGACAAGTCCGCTTTGTGAGATGAATA CTTCCTGAGAAACTTGACAAGTATCTCTCCATTTTACCATTATGAAAACTATCATTAAAAAAAACAGTTTAGATGCCTTCTCCTTTTGAG GGAAAAAGGGTGCTTTTTATTGTATAAAGCAGCGTCTTATGTATTTTGATATACCATTGTTTGAACTTCCGTCTTTAGCTGATAGATTCT CAAATATCCTTGATTTTGGATGTTCAGTATGTTTGTGAGAGAGGTTTCTGGGAAGACTCTCTTTTTGCCCTCGGGAAAAAGCAAAATATC AATGTTTGGGTGACTGTGTAAAGCTCAGTGTGTAAGAACATCTTTTTGTCTAGGTTTTCTTTCTGCTCTTTATTGAAGACAAACACTCAC CAAAAAGAAAAATAAAAGTTTTCAGAGAAACTAATTTTCTTTGGCAAGAGTATTACTTAATATTTTGGCCTCCTAAAGTTTCCCTAGTTA GTACTCGGACTCCTGTGCTAATTGTCAGCTTACATATCATTGTATAGAGACTGTTTATTCTGTACCAAACTGATTTCAAAAGTACTACAT TGAAAATAAACCGGTGACTGTTTTTCTTCATAAAGTTCTGCGTTTGGCATCTTCACTCTTTCCAAAATGTATCTGTACATCAGAAATGTC ACTATTCCAAGTGTCTTTTTAGTGTGGCTTTAGTATGGCTTCCTTTTAATATTGTACATACATTGTATCTTTGTTTTATGGTAATAAGTA ATAAAAATGTAGACTTCATATTTTGTACAAAATGTCCTATGTACAGAATAAAAAAGTTCATAGAAACAGCAAATATAGGTAAGTGGCACA ATTATTTTTCTTTAGAAAATATCTGTAACTTTATGCATTAGTGAAATGTTAAGTACCGACATATTTTTTAACATTTTGTAATTCAAAACT TTTTGTTTTGACATTGTTTATGAAGAGAAACTTCATACACTTGCCATTTAATATGCTCTTTTATCTAATTTTCAAAAACTCTAAAAAACG 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FusionGenePPI for RCOR1_PPP2R5C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RCOR1 | HDAC1, KDM1A, HMG20B, PHF21A, HDAC2, ZNF217, REST, MECP2, ZMYM2, CTBP1, KDM5B, CTBP2, HSPA4, SUMO2, ESCO2, SMARCE1, SMARCA4, SMARCC2, HIST1H3A, NR2E1, EMD, SERPINH1, SNAI1, MED12, MED28, TRIP4, OBFC1, BCL3, SUB1, GFI1B, GFI1, TAL1, HIST3H3, RCOR1, TCF3, NR2C1, TP53BP1, MTA3, NPM1, HDAC3, ECE2, FGF1, DOK4, ARRDC1, DDX46, MED23, B9D2, CEP135, NINL, SCLT1, HMG20A, FBXW7, NFATC2, DCAF12L2, ZSCAN5A, LLGL2, NR3C1, AR, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, CCDC132, CCDC93, OIP5, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, GIT2, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, TRIM25, UHRF2 | PPP2R5C | CCNG2, PPP2CA, PPP2R5A, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, MBP, TBC1D3, APP, BRCA1, PAXIP1, IER3, MAPK1, SOX2, COL4A3BP, FAF1, JMJD6, PACSIN2, UGP2, PSMG3, SWAP70, EGFR, EP300, FAM43A, CCNG1, API5, LSM6, LSM7, PPP2R2A, POLD1, PPP2R5E, RQCD1, TP53, PRR14, PPP1CA, PPP1CB, PPP1CC, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 78_257 | 117 | 483 | HDAC1 |
| Hgene | RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 78_257 | 145 | 483 | HDAC1 |
| Hgene | RCOR1 | chr14:103059662 | chr14:102391478 | ENST00000570597 | + | 2 | 12 | 296_384 | 117 | 483 | KDM1A |
| Hgene | RCOR1 | chr14:103148315 | chr14:102323023 | ENST00000570597 | + | 3 | 12 | 296_384 | 145 | 483 | KDM1A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RCOR1_PPP2R5C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RCOR1_PPP2R5C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RCOR1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | PPP2R5C | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
| Tgene | PPP2R5C | C1257806 | Chromosomal Instability | 1 | CTD_human |
| Tgene | PPP2R5C | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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