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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30880

FusionGeneSummary for RCOR1_AMN

check button Fusion gene summary
Fusion gene informationFusion gene name: RCOR1_AMN
Fusion gene ID: 30880
HgeneTgene
Gene symbol

RCOR1

AMN

Gene ID

23186

81693

Gene nameREST corepressor 1amnion associated transmembrane protein
SynonymsCOREST|RCORPRO1028|amnionless
Cytomap

14q32.31-q32.32

14q32.32

Type of geneprotein-codingprotein-coding
DescriptionREST corepressor 1protein amnionlessamnionless homologvisceral endoderm-specific type 1 transmembrane protein
Modification date2018052320180519
UniProtAcc

Q9UKL0

Q9BXJ7

Ensembl transtripts involved in fusion geneENST00000262241, ENST00000570597, 
ENST00000299155, 
Fusion gene scores* DoF score8 X 8 X 10=6402 X 2 X 2=8
# samples 122
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: RCOR1 [Title/Abstract] AND AMN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRCOR1

GO:0045892

negative regulation of transcription, DNA-templated

10449787

HgeneRCOR1

GO:0070933

histone H4 deacetylation

17555596

TgeneAMN

GO:0006898

receptor-mediated endocytosis

14576052

TgeneAMN

GO:0015889

cobalamin transport

14576052

TgeneAMN

GO:0043001

Golgi to plasma membrane protein transport

14576052


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A928-01ARCOR1chr14

103059662

+AMNchr14

103390048

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262241ENST00000299155RCOR1chr14

103059662

+AMNchr14

103390048

+
In-frameENST00000570597ENST00000299155RCOR1chr14

103059662

+AMNchr14

103390048

+

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FusionProtFeatures for RCOR1_AMN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RCOR1

Q9UKL0

AMN

Q9BXJ7

Essential component of the BHC complex, a corepressorcomplex that represses transcription of neuron-specific genes innon-neuronal cells. The BHC complex is recruited at RE1/NRSE sitesby REST and acts by deacetylating and demethylating specific siteson histones, thereby acting as a chromatin modifier. In the BHCcomplex, it serves as a molecular beacon for the recruitment ofmolecular machinery, including MeCP2 and SUV39H1, that imposessilencing across a chromosomal interval. Plays a central role indemethylation of Lys-4 of histone H3 by promoting demethylaseactivity of KDM1A on core histones and nucleosomal substrates. Italso protects KDM1A from the proteasome. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development and controls hematopoieticdifferentiation. {ECO:0000269|PubMed:11171972,ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298,ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763,ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. Necessary for efficient absorption of vitamin B12(PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct theproduction of trunk mesoderm during development by modulating abone morphogenetic protein (BMP) signaling pathway in theunderlying visceral endoderm (By similarity).{ECO:0000250|UniProtKB:Q99JB7, ECO:0000269|PubMed:14576052,ECO:0000305|PubMed:12590260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+21221_77117483Compositional biasNote=Ala-rich
TgeneAMNchr14:103059662chr14:103390048ENST00000299155+012202_25414454DomainNote=VWFC
TgeneAMNchr14:103059662chr14:103390048ENST00000299155+01220_35714454Topological domainExtracellular
TgeneAMNchr14:103059662chr14:103390048ENST00000299155+012379_45314454Topological domainCytoplasmic
TgeneAMNchr14:103059662chr14:103390048ENST00000299155+012358_37814454TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+212244_273117483Coiled coilOntology_term=ECO:0000255
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+212334_369117483Coiled coilOntology_term=ECO:0000255
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+212103_189117483DomainELM2
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+212190_241117483DomainSANT 1
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+212381_432117483DomainSANT 2


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FusionGeneSequence for RCOR1_AMN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RCOR1_ENST00000262241_chr14_103059662_+_AMN_ENST00000299155_chr14_103390048_+_560aa
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEG
SSGSSSDEEHGGGGMRVGPQYQAVVPDFDPALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLD
GELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVR
SISALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCG
AVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEA
TMRESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAAD

>In-frame_RCOR1_ENST00000570597_chr14_103059662_+_AMN_ENST00000299155_chr14_103390048_+_557aa
MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSG
SSSDEEHGGGGMRVGPQYQAVVPDFDPALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGEL
VLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSIS
ALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVV
LLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMR
ESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAADSTS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RCOR1_ENST00000262241_chr14_103059662_+_AMN_ENST00000299155_chr14_103390048_+_1680nt
ATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCC
TCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCA
GCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGC
AGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCC
GCACTGACCCAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGACTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCC
GGCGGCGCCGTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCTGGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGAT
GGGGAACTCGTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGACGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTC
CGCGACTCTGACCGCTTCTCCTGGCATGACCCGCACCTGTGGCGCTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGC
GTGCCCTGCCGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTCCTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGC
AGCATCTCGGCTCTGGGCCGGACGTTCACGCGCGACGAGGACCTGGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGG
CCGGGCGCGCTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTCGGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCG
GCCCTGCTCCAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTGCCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGA
GCCGTTGTGTTGCTGACCCACGGCCCCGCATTTGACCTGGAGCGGTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTAC
CACGGGCTGCAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCGGCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAAT
GGGCCCGAGACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCTGGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCG
ACCATGCGGGAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGCTGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTG
GTCCTGCTGGTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCTCAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTC
GGCTTCCGCAACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCTGCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGAC

>In-frame_RCOR1_ENST00000570597_chr14_103059662_+_AMN_ENST00000299155_chr14_103390048_+_1671nt
ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC
GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC
GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC
TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACC
CAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGACTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCC
GTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCTGGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTC
GTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGACGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCT
GACCGCTTCTCCTGGCATGACCCGCACCTGTGGCGCTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGC
CGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTCCTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCG
GCTCTGGGCCGGACGTTCACGCGCGACGAGGACCTGGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCG
CTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTCGGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTC
CAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTGCCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTG
TTGCTGACCCACGGCCCCGCATTTGACCTGGAGCGGTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTG
CAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCGGCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAG
ACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCTGGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGG
GAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGCTGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTG
GTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCTCAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGC
AACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCTGCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RCOR1_ENST00000262241_chr14_103059662_+_AMN_ENST00000299155_chr14_103390048_+_2418nt
GTGAGGGCGGCGATGAGAGCGAAAGTTGCGCTCGGCTCGTCGCTGGGGGCTTGAAGCGGCTCCGCGCTCTGCCCGTTTGGGCCTCCCCCG
ACTCGGACTCGCGCCCGTGGGCTCCCGCCGCGCCCGCCCGGCCCCGCGCCGGCCCCGCGCCCCCTCCCCCGTCTCGGCGCCCCCTCCTCA
GGAGCCGCGGGTCCCCGCCACTTTCGCACGGCCCCGGCCCCCGCCGATGCCGGCCATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCG
GAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCCGCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGC
CGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCCGCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGC
GGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGCTCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCAT
GAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACCCAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGA
CTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCCGTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCT
GGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTCGTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGA
CGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCTGACCGCTTCTCCTGGCATGACCCGCACCTGTGGCG
CTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGCCGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTC
CTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCGGCTCTGGGCCGGACGTTCACGCGCGACGAGGACCT
GGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCGCTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTC
GGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTCCAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTG
CCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTGTTGCTGACCCACGGCCCCGCATTTGACCTGGAGCG
GTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTGCAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCG
GCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAGACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCT
GGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGGGAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGC
TGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTGGTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCT
CAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGCAACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCT
GCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGCCACAGTTACTTCGTCAACCCTCTGTTCGCCGGGGC
CGAGGCCGAGGCCTGAGCGGCCGCCTGACCGTCGACCTTGGGGCTCTCCACCCGCTCTGGCCCCAGTCGAACTGGGGGCTAGCCACCTCC
TCGTCCAGCCCCCAAACCTCCCCTTCCTTTCCCCCTCCTCCGGGGGCCAAGGACAGGGTGGCCTTACTCAGTAAAGGTGTTTCCTGCACC
TGCTGTCAGCCTGGCTATGCCGCCACCGGCCCCGCCCATGAGGACTAGGAGCCCAGCCTTGCGCCGCATTCGCACTGGGGGACATGGGAG
GGGTCTAGCTGGCCACTGCTGGAGGCAGCGCTGGTCGTCACCTGGGCGGCCAGAGGCTGGGATCTGCGAAGTTGAACCCAGAACTAGGAG
TGGGGCTTCCCCCGCCTTCCGGTGAGGGGAGGGTGAGGAGCTGGAGGGAGGGGCGGGAGAGAGGCAAGGGGTGGACGGAGCCAAAGGCCG

>In-frame_RCOR1_ENST00000570597_chr14_103059662_+_AMN_ENST00000299155_chr14_103390048_+_2183nt
ATGGTGGAGAAGGGCCCCGAGGTCTCAGGGAAGCGGAGAGGGAGGAACAACGCGGCCGCCTCCGCCTCCGCCGCCGCCGCCTCCGCCGCC
GCCTCGGCCGCCTGCGCCTCGCCAGCCGCCACTGCCGCCTCGGGCGCCGCCGCCTCCTCAGCCTCGGCCGCCGCCGCCTCAGCCGCCGCC
GCCCCCAATAATGGCCAGAATAAAAGTTTGGCGGCGGCGGCGCCCAATGGCAACAGCAGCAGCAACTCCTGGGAGGAAGGCAGCTCGGGC
TCGTCCAGCGACGAGGAGCACGGTGGCGGTGGCATGAGGGTCGGACCCCAGTACCAGGCGGTGGTGCCCGACTTCGACCCCGCACTGACC
CAGGCGGTCTCCAAACTCTGGGTCCCCAACACGGACTTCGACGTCGCAGCCAACTGGAGCCAGAACCGGACCCCGTGCGCCGGCGGCGCC
GTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCTGGTGCAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTC
GTCCTGGCTTCAGGAGCCGGATTCGGCGTCTCAGACGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAACCTGCCGTCTTCCGCGACTCT
GACCGCTTCTCCTGGCATGACCCGCACCTGTGGCGCTCTGGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGC
CGCCACGACGACGTCTTCTTTCCGCCTAGTGCCTCCTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCCGTGCGTGTCCGCAGCATCTCG
GCTCTGGGCCGGACGTTCACGCGCGACGAGGACCTGGCTGTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCG
CTGAGCGTGGGCCCCGAGGACTGCGCGGACCCGTCGGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCGTGGATCTGCGCGGCCCTGCTC
CAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTGCCACAGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTG
TTGCTGACCCACGGCCCCGCATTTGACCTGGAGCGGTACCGGGCGCGGATACTGGACACCTTCCTGGGTCTGCCTCAGTACCACGGGCTG
CAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCGGCTCCGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAG
ACAGGCGGAGCGGGGCGGCTGGCCCGGGCCCTCCTGGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGCGTCCTGGAGGCGACCATGCGG
GAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGCTGGGCTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTG
GTGGCGCCGCCGCTGCTGCGCCGCGCGGGGAGGCTCAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCTGGAGCGCCCCTCGGCTTCCGC
AACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCTGCCCCTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGC
CACAGTTACTTCGTCAACCCTCTGTTCGCCGGGGCCGAGGCCGAGGCCTGAGCGGCCGCCTGACCGTCGACCTTGGGGCTCTCCACCCGC
TCTGGCCCCAGTCGAACTGGGGGCTAGCCACCTCCTCGTCCAGCCCCCAAACCTCCCCTTCCTTTCCCCCTCCTCCGGGGGCCAAGGACA
GGGTGGCCTTACTCAGTAAAGGTGTTTCCTGCACCTGCTGTCAGCCTGGCTATGCCGCCACCGGCCCCGCCCATGAGGACTAGGAGCCCA
GCCTTGCGCCGCATTCGCACTGGGGGACATGGGAGGGGTCTAGCTGGCCACTGCTGGAGGCAGCGCTGGTCGTCACCTGGGCGGCCAGAG
GCTGGGATCTGCGAAGTTGAACCCAGAACTAGGAGTGGGGCTTCCCCCGCCTTCCGGTGAGGGGAGGGTGAGGAGCTGGAGGGAGGGGCG
GGAGAGAGGCAAGGGGTGGACGGAGCCAAAGGCCGTGCCTGGTGGGGCGGACGGAAAAGGGGTGGGCATCCCTCCTGGTACCAAGCTGCT


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FusionGenePPI for RCOR1_AMN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RCOR1HDAC1, KDM1A, HMG20B, PHF21A, HDAC2, ZNF217, REST, MECP2, ZMYM2, CTBP1, KDM5B, CTBP2, HSPA4, SUMO2, ESCO2, SMARCE1, SMARCA4, SMARCC2, HIST1H3A, NR2E1, EMD, SERPINH1, SNAI1, MED12, MED28, TRIP4, OBFC1, BCL3, SUB1, GFI1B, GFI1, TAL1, HIST3H3, RCOR1, TCF3, NR2C1, TP53BP1, MTA3, NPM1, HDAC3, ECE2, FGF1, DOK4, ARRDC1, DDX46, MED23, B9D2, CEP135, NINL, SCLT1, HMG20A, FBXW7, NFATC2, DCAF12L2, ZSCAN5A, LLGL2, NR3C1, AR, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, CCDC132, CCDC93, OIP5, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, GIT2, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, TRIM25, UHRF2AMNSTAMBP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+21278_257117483HDAC1
HgeneRCOR1chr14:103059662chr14:103390048ENST00000570597+212296_384117483KDM1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RCOR1_AMN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAMNQ9BXJ7DB00200HydroxocobalaminProtein amnionlesssmall moleculeapproved

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RelatedDiseases for RCOR1_AMN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRCOR1C0009375Colonic Neoplasms1CTD_human
TgeneAMNC0600467Neurogenic Inflammation2CTD_human
TgeneAMNC0013604Edema1CTD_human
TgeneAMNC0015379Extravasation of Diagnostic and Therapeutic Materials1CTD_human
TgeneAMNC1306856Megaloblastic anemia due to inborn errors of metabolism1CTD_human;ORPHANET;UNIPROT
TgeneAMNC2609414Acute kidney injury1CTD_human