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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30872

FusionGeneSummary for RCHY1_YWHAG

check button Fusion gene summary
Fusion gene informationFusion gene name: RCHY1_YWHAG
Fusion gene ID: 30872
HgeneTgene
Gene symbol

RCHY1

YWHAG

Gene ID

25898

7532

Gene namering finger and CHY zinc finger domain containing 1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
SynonymsARNIP|CHIMP|PIRH2|PRO1996|RNF199|ZCHY|ZNF36314-3-3GAMMA|EIEE56|PPP1R170
Cytomap

4q21.1

7q11.23

Type of geneprotein-codingprotein-coding
DescriptionRING finger and CHY zinc finger domain-containing protein 1CH-rich interacting match with PLAG1E3 ubiquitin-protein ligase Pirh2RING finger protein 199RING-type E3 ubiquitin transferase RCHY1androgen-receptor N-terminal-interacting proteinp53-induce14-3-3 protein gammaKCIP-1protein kinase C inhibitor protein 1protein phosphatase 1, regulatory subunit 170tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Modification date2018052220180522
UniProtAcc

Q96PM5

P61981

Ensembl transtripts involved in fusion geneENST00000324439, ENST00000451788, 
ENST00000380840, ENST00000512706, 
ENST00000513257, ENST00000514021, 
ENST00000307630, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 2=98
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RCHY1 [Title/Abstract] AND YWHAG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRCHY1

GO:0006511

ubiquitin-dependent protein catabolic process

19483087

HgeneRCHY1

GO:0016567

protein ubiquitination

19043414|19483087

HgeneRCHY1

GO:0031398

positive regulation of protein ubiquitination

19483087

HgeneRCHY1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19483087


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ376661RCHY1chr4

76407481

+YWHAGchr7

75956368

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000324439ENST00000307630RCHY1chr4

76407481

+YWHAGchr7

75956368

-
intron-3UTRENST00000451788ENST00000307630RCHY1chr4

76407481

+YWHAGchr7

75956368

-
intron-3UTRENST00000380840ENST00000307630RCHY1chr4

76407481

+YWHAGchr7

75956368

-
intron-3UTRENST00000512706ENST00000307630RCHY1chr4

76407481

+YWHAGchr7

75956368

-
intron-3UTRENST00000513257ENST00000307630RCHY1chr4

76407481

+YWHAGchr7

75956368

-
intron-3UTRENST00000514021ENST00000307630RCHY1chr4

76407481

+YWHAGchr7

75956368

-

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FusionProtFeatures for RCHY1_YWHAG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RCHY1

Q96PM5

YWHAG

P61981

Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner.{ECO:0000269|PubMed:16511572}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RCHY1_YWHAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RCHY1_YWHAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RCHY1_YWHAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RCHY1_YWHAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneYWHAGC0023893Liver Cirrhosis, Experimental1CTD_human