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Fusion gene ID: 30872 |
FusionGeneSummary for RCHY1_YWHAG |
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Fusion gene information | Fusion gene name: RCHY1_YWHAG | Fusion gene ID: 30872 | Hgene | Tgene | Gene symbol | RCHY1 | YWHAG | Gene ID | 25898 | 7532 |
Gene name | ring finger and CHY zinc finger domain containing 1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | |
Synonyms | ARNIP|CHIMP|PIRH2|PRO1996|RNF199|ZCHY|ZNF363 | 14-3-3GAMMA|EIEE56|PPP1R170 | |
Cytomap | 4q21.1 | 7q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | RING finger and CHY zinc finger domain-containing protein 1CH-rich interacting match with PLAG1E3 ubiquitin-protein ligase Pirh2RING finger protein 199RING-type E3 ubiquitin transferase RCHY1androgen-receptor N-terminal-interacting proteinp53-induce | 14-3-3 protein gammaKCIP-1protein kinase C inhibitor protein 1protein phosphatase 1, regulatory subunit 170tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q96PM5 | P61981 | |
Ensembl transtripts involved in fusion gene | ENST00000324439, ENST00000451788, ENST00000380840, ENST00000512706, ENST00000513257, ENST00000514021, | ENST00000307630, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 2=98 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RCHY1 [Title/Abstract] AND YWHAG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RCHY1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 19483087 |
Hgene | RCHY1 | GO:0016567 | protein ubiquitination | 19043414|19483087 |
Hgene | RCHY1 | GO:0031398 | positive regulation of protein ubiquitination | 19483087 |
Hgene | RCHY1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 19483087 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ376661 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000324439 | ENST00000307630 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
intron-3UTR | ENST00000451788 | ENST00000307630 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
intron-3UTR | ENST00000380840 | ENST00000307630 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
intron-3UTR | ENST00000512706 | ENST00000307630 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
intron-3UTR | ENST00000513257 | ENST00000307630 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
intron-3UTR | ENST00000514021 | ENST00000307630 | RCHY1 | chr4 | 76407481 | + | YWHAG | chr7 | 75956368 | - |
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FusionProtFeatures for RCHY1_YWHAG |
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Hgene | Tgene |
RCHY1 | YWHAG |
Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner.{ECO:0000269|PubMed:16511572}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RCHY1_YWHAG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RCHY1_YWHAG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RCHY1_YWHAG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RCHY1_YWHAG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | YWHAG | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |