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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30817

FusionGeneSummary for RBMXL1_DAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: RBMXL1_DAP3
Fusion gene ID: 30817
HgeneTgene
Gene symbol

RBMXL1

DAP3

Gene ID

494115

58512

Gene nameRBMX like 1DLG associated protein 3
SynonymsRBM1DAP3|SAPAP3
Cytomap

1p22.2

1p34.3

Type of geneprotein-codingprotein-coding
DescriptionRNA binding motif protein, X-linked-like-1RNA binding motif protein, X-linked like 1heterogeneous nuclear ribonucleoprotein G-like 1disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3
Modification date2018052320180519
UniProtAcc

Q96E39

P51398

Ensembl transtripts involved in fusion geneENST00000321792, ENST00000399794, 
ENST00000413769, 		ENST00000471642, 
ENST00000368336, ENST00000343043, 
ENST00000496863, ENST00000535183, 
ENST00000421487, ENST00000465375, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 2=12
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBMXL1 [Title/Abstract] AND DAP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-TQ-A7RW-01ARBMXL1chr1

89458268

-DAP3chr1

155707948

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000321792ENST00000471642RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000321792ENST00000368336RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000321792ENST00000343043RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000321792ENST00000496863RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000321792ENST00000535183RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000321792ENST00000421487RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000321792ENST00000465375RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000399794ENST00000471642RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000399794ENST00000368336RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000399794ENST00000343043RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000399794ENST00000496863RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000399794ENST00000535183RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000399794ENST00000421487RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000399794ENST00000465375RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000413769ENST00000471642RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000413769ENST00000368336RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-3CDSENST00000413769ENST00000343043RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000413769ENST00000496863RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000413769ENST00000535183RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000413769ENST00000421487RBMXL1chr1

89458268

-DAP3chr1

155707948

+
5UTR-intronENST00000413769ENST00000465375RBMXL1chr1

89458268

-DAP3chr1

155707948

+

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FusionProtFeatures for RBMXL1_DAP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBMXL1

Q96E39

DAP3

P51398

RNA-binding protein which may be involved in pre-mRNAsplicing. {ECO:0000250}. Involved in mediating interferon-gamma-induced celldeath.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBMXL1_DAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBMXL1_DAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBMXL1ILF2, PPP1CB, PPP1CC, AKAP5, BCLAF1, MATR3, MCM2, MCM5, CRBN, SNRNP70, APOBEC3D, ELAVL2, SFPQ, FBXW11, SYNCRIP, CLK2, ZC3H18, FDXACB1, MTF1DAP3CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBMXL1_DAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBMXL1_DAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDAP3C1458155Mammary Neoplasms1CTD_human