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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30776

FusionGeneSummary for RBM4B_GSE1

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM4B_GSE1
Fusion gene ID: 30776
HgeneTgene
Gene symbol

RBM4B

GSE1

Gene ID

83759

23199

Gene nameRNA binding motif protein 4BGse1 coiled-coil protein
SynonymsRBM30|RBM4L|ZCCHC15|ZCCHC21B|ZCRB3BCRHSP24|KIAA0182
Cytomap

11q13.2

16q24.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 4BRNA-binding motif protein 30zinc finger CCHC-type and RNA binding motif 3Bgenetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homolog
Modification date2018052320180519
UniProtAcc

Q9BQ04

Q14687

Ensembl transtripts involved in fusion geneENST00000525754, ENST00000310046, 
ENST00000531969, ENST00000529195, 
ENST00000524637, ENST00000531036, 
ENST00000405402, ENST00000253458, 
ENST00000393243, ENST00000471070, 
Fusion gene scores* DoF score4 X 3 X 3=367 X 7 X 5=245
# samples 47
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM4B [Title/Abstract] AND GSE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA337470RBM4Bchr11

66444255

-GSE1chr16

85709696

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000525754ENST00000405402RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000525754ENST00000253458RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000525754ENST00000393243RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000525754ENST00000471070RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000310046ENST00000405402RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000310046ENST00000253458RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000310046ENST00000393243RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000310046ENST00000471070RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000531969ENST00000405402RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000531969ENST00000253458RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000531969ENST00000393243RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000531969ENST00000471070RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000529195ENST00000405402RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000529195ENST00000253458RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000529195ENST00000393243RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000529195ENST00000471070RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000524637ENST00000405402RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000524637ENST00000253458RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000524637ENST00000393243RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000524637ENST00000471070RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000531036ENST00000405402RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000531036ENST00000253458RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-3UTRENST00000531036ENST00000393243RBM4Bchr11

66444255

-GSE1chr16

85709696

+
intron-intronENST00000531036ENST00000471070RBM4Bchr11

66444255

-GSE1chr16

85709696

+

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FusionProtFeatures for RBM4B_GSE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM4B

Q9BQ04

GSE1

Q14687

Required for the translational activation of PER1 mRNAin response to circadian clock. Binds directly to the 3'-UTR ofthe PER1 mRNA (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM4B_GSE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM4B_GSE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM4B_GSE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBM4B_GSE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource