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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30767

FusionGeneSummary for RBM47_IDO2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM47_IDO2
Fusion gene ID: 30767
HgeneTgene
Gene symbol

RBM47

IDO2

Gene ID

54502

169355

Gene nameRNA binding motif protein 47indoleamine 2,3-dioxygenase 2
SynonymsNET18INDOL1
Cytomap

4p14

8p11.21

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 47indoleamine 2,3-dioxygenase 2IDO-2indoleamine 2,3-dioxygenase-like 1 proteinindoleamine 2,3-dioxygenase-like protein 1indoleamine-pyrrole 2,3 dioxygenase-like 1indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Modification date2018051920180519
UniProtAcc

A0AV96

Q6ZQW0

Ensembl transtripts involved in fusion geneENST00000319592, ENST00000381793, 
ENST00000381795, ENST00000295971, 
ENST00000514014, ENST00000515809, 
ENST00000343295, ENST00000502986, 
ENST00000389060, 
Fusion gene scores* DoF score9 X 9 X 7=5675 X 5 X 5=125
# samples 135
** MAII scorelog2(13/567*10)=-2.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM47 [Title/Abstract] AND IDO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIDO2

GO:0019441

tryptophan catabolic process to kynurenine

17671174


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YL-A8SR-01BRBM47chr4

40546439

-IDO2chr8

39821127

+
TCGALDPRADTCGA-YL-A8SR-01BRBM47chr4

40516533

-IDO2chr8

39806668

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000319592ENST00000343295RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000319592ENST00000502986RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000319592ENST00000389060RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000381793ENST00000343295RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000381793ENST00000502986RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000381793ENST00000389060RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000381795ENST00000343295RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000381795ENST00000502986RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000381795ENST00000389060RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000295971ENST00000343295RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000295971ENST00000502986RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000295971ENST00000389060RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000514014ENST00000343295RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000514014ENST00000502986RBM47chr4

40546439

-IDO2chr8

39821127

+
5UTR-3UTRENST00000514014ENST00000389060RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000515809ENST00000343295RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000515809ENST00000502986RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000515809ENST00000389060RBM47chr4

40546439

-IDO2chr8

39821127

+
intron-3UTRENST00000319592ENST00000343295RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000319592ENST00000502986RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-intronENST00000319592ENST00000389060RBM47chr4

40516533

-IDO2chr8

39806668

+
5UTR-3UTRENST00000381793ENST00000343295RBM47chr4

40516533

-IDO2chr8

39806668

+
5UTR-3UTRENST00000381793ENST00000502986RBM47chr4

40516533

-IDO2chr8

39806668

+
5UTR-intronENST00000381793ENST00000389060RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000381795ENST00000343295RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000381795ENST00000502986RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-intronENST00000381795ENST00000389060RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000295971ENST00000343295RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000295971ENST00000502986RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-intronENST00000295971ENST00000389060RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000514014ENST00000343295RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000514014ENST00000502986RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-intronENST00000514014ENST00000389060RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000515809ENST00000343295RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-3UTRENST00000515809ENST00000502986RBM47chr4

40516533

-IDO2chr8

39806668

+
intron-intronENST00000515809ENST00000389060RBM47chr4

40516533

-IDO2chr8

39806668

+

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FusionProtFeatures for RBM47_IDO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM47

A0AV96

IDO2

Q6ZQW0

Catalyzes the first and rate limiting step of thecatabolism of the essential amino acid tryptophan along thekynurenine pathway (PubMed:17671174). Involved in immuneregulation. May not play a significant role in tryptophan-relatedtumoral resistance (PubMed:25691885).{ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:25691885}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM47_IDO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM47_IDO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBM47ELAVL1, C1orf94, HSFY1, RNF2, ATM, TRIM25IDO2DPP8, NRN1, ATF1, ERICH5, ULBP2, EME1, SMARCA1, KLF12, FAM171A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM47_IDO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBM47_IDO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBM47C3495559Juvenile arthritis1CTD_human