FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30763

FusionGeneSummary for RBM47_APBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM47_APBB2
Fusion gene ID: 30763
HgeneTgene
Gene symbol

RBM47

APBB2

Gene ID

54502

323

Gene nameRNA binding motif protein 47amyloid beta precursor protein binding family B member 2
SynonymsNET18FE65L|FE65L1
Cytomap

4p14

4p14-p13

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 47amyloid-beta A4 precursor protein-binding family B member 2Fe65-like 1protein Fe65-like 1
Modification date2018051920180523
UniProtAcc

A0AV96

Q92870

Ensembl transtripts involved in fusion geneENST00000319592, ENST00000381793, 
ENST00000381795, ENST00000295971, 
ENST00000514014, ENST00000515809, 
ENST00000295974, ENST00000513140, 
ENST00000508593, ENST00000506352, 
ENST00000511572, ENST00000543538, 
ENST00000502841, ENST00000504305, 
Fusion gene scores* DoF score9 X 9 X 7=5675 X 5 X 6=150
# samples 138
** MAII scorelog2(13/567*10)=-2.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM47 [Title/Abstract] AND APBB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A8NI-01ARBM47chr4

40631413

-APBB2chr4

40832594

-
TCGARVLUADTCGA-44-A479-01ARBM47chr4

40546439

-APBB2chr4

41102767

-
TCGARVOVTCGA-24-2298-01ARBM47chr4

40631413

-APBB2chr4

40832594

-
TCGARVUCECTCGA-E6-A8L9-01ARBM47chr4

40631413

-APBB2chr4

40818276

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000319592ENST00000295974RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000319592ENST00000513140RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000319592ENST00000508593RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000319592ENST00000506352RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-intronENST00000319592ENST00000511572RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000319592ENST00000543538RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000319592ENST00000502841RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000319592ENST00000504305RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381793ENST00000295974RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381793ENST00000513140RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381793ENST00000508593RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381793ENST00000506352RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-intronENST00000381793ENST00000511572RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000381793ENST00000543538RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000381793ENST00000502841RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000381793ENST00000504305RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381795ENST00000295974RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381795ENST00000513140RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381795ENST00000508593RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000381795ENST00000506352RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-intronENST00000381795ENST00000511572RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000381795ENST00000543538RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000381795ENST00000502841RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000381795ENST00000504305RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000295971ENST00000295974RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000295971ENST00000513140RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000295971ENST00000508593RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-3CDSENST00000295971ENST00000506352RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-intronENST00000295971ENST00000511572RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000295971ENST00000543538RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000295971ENST00000502841RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000295971ENST00000504305RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000514014ENST00000295974RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000514014ENST00000513140RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000514014ENST00000508593RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000514014ENST00000506352RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-intronENST00000514014ENST00000511572RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000514014ENST00000543538RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000514014ENST00000502841RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000514014ENST00000504305RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000515809ENST00000295974RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000515809ENST00000513140RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000515809ENST00000508593RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-3CDSENST00000515809ENST00000506352RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-intronENST00000515809ENST00000511572RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000515809ENST00000543538RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000515809ENST00000502841RBM47chr4

40631413

-APBB2chr4

40832594

-
intron-5UTRENST00000515809ENST00000504305RBM47chr4

40631413

-APBB2chr4

40832594

-
5UTR-5UTRENST00000319592ENST00000295974RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000319592ENST00000513140RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000319592ENST00000508593RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000319592ENST00000506352RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000319592ENST00000511572RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000319592ENST00000543538RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000319592ENST00000502841RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000319592ENST00000504305RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381793ENST00000295974RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381793ENST00000513140RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381793ENST00000508593RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381793ENST00000506352RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381793ENST00000511572RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000381793ENST00000543538RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000381793ENST00000502841RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000381793ENST00000504305RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381795ENST00000295974RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381795ENST00000513140RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381795ENST00000508593RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381795ENST00000506352RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000381795ENST00000511572RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000381795ENST00000543538RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000381795ENST00000502841RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000381795ENST00000504305RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000295971ENST00000295974RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000295971ENST00000513140RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000295971ENST00000508593RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000295971ENST00000506352RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000295971ENST00000511572RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000295971ENST00000543538RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000295971ENST00000502841RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000295971ENST00000504305RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000514014ENST00000295974RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000514014ENST00000513140RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000514014ENST00000508593RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000514014ENST00000506352RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-5UTRENST00000514014ENST00000511572RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000514014ENST00000543538RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000514014ENST00000502841RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-intronENST00000514014ENST00000504305RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000515809ENST00000295974RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000515809ENST00000513140RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000515809ENST00000508593RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000515809ENST00000506352RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-5UTRENST00000515809ENST00000511572RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000515809ENST00000543538RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000515809ENST00000502841RBM47chr4

40546439

-APBB2chr4

41102767

-
intron-intronENST00000515809ENST00000504305RBM47chr4

40546439

-APBB2chr4

41102767

-
5UTR-3CDSENST00000319592ENST00000295974RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000319592ENST00000513140RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000319592ENST00000508593RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000319592ENST00000506352RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000319592ENST00000511572RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000319592ENST00000543538RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000319592ENST00000502841RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000319592ENST00000504305RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381793ENST00000295974RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381793ENST00000513140RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381793ENST00000508593RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381793ENST00000506352RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381793ENST00000511572RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381793ENST00000543538RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381793ENST00000502841RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381793ENST00000504305RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381795ENST00000295974RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381795ENST00000513140RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381795ENST00000508593RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000381795ENST00000506352RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381795ENST00000511572RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381795ENST00000543538RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381795ENST00000502841RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000381795ENST00000504305RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000295971ENST00000295974RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000295971ENST00000513140RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000295971ENST00000508593RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-3CDSENST00000295971ENST00000506352RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000295971ENST00000511572RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000295971ENST00000543538RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000295971ENST00000502841RBM47chr4

40631413

-APBB2chr4

40818276

-
5UTR-intronENST00000295971ENST00000504305RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000514014ENST00000295974RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000514014ENST00000513140RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000514014ENST00000508593RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000514014ENST00000506352RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000514014ENST00000511572RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000514014ENST00000543538RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000514014ENST00000502841RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000514014ENST00000504305RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000515809ENST00000295974RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000515809ENST00000513140RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000515809ENST00000508593RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-3CDSENST00000515809ENST00000506352RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000515809ENST00000511572RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000515809ENST00000543538RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000515809ENST00000502841RBM47chr4

40631413

-APBB2chr4

40818276

-
intron-intronENST00000515809ENST00000504305RBM47chr4

40631413

-APBB2chr4

40818276

-

Top

FusionProtFeatures for RBM47_APBB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM47

A0AV96

APBB2

Q92870

May modulate the internalization of amyloid-betaprecursor protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RBM47_APBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RBM47_APBB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBM47ELAVL1, C1orf94, HSFY1, RNF2, ATM, TRIM25APBB2APP, EGFR, HSPA8, TBC1D4, OSBPL2, APLP2, APBB1, AKAP1, GOPC, TUBA1A, APLP1, CBWD1, APOL2, RAP1GDS1, SYDE2, ATP7A, WDR41, TBC1D2B, FMN2, QTRT1, LDHAL6B, WISP3, NCK1, SORT1, SYNCRIP, MRPL1, GAN, TMEM30B, ADCYAP1, VAV1, HGFAC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RBM47_APBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RBM47_APBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBM47C3495559Juvenile arthritis1CTD_human
TgeneAPBB2C0043094Weight Gain1CTD_human