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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30751

FusionGeneSummary for RBM39_PRDM5

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM39_PRDM5
Fusion gene ID: 30751
HgeneTgene
Gene symbol

RBM39

PRDM5

Gene ID

9584

11107

Gene nameRNA binding motif protein 39PR/SET domain 5
SynonymsCAPER|CAPERalpha|FSAP59|HCC1|RNPC2BCS2|PFM2
Cytomap

20q11.22

4q27

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsfunctional spliceosome-associated protein 59hepatocellular carcinoma protein 1splicing factor HCC1PR domain zinc finger protein 5PR domain 5PR domain containing 5
Modification date2018051920180523
UniProtAcc

Q14498

Q9NQX1

Ensembl transtripts involved in fusion geneENST00000253363, ENST00000361162, 
ENST00000528062, ENST00000407261, 
ENST00000397370, ENST00000463098, 
ENST00000264808, ENST00000428209, 
ENST00000515109, ENST00000506065, 
ENST00000394435, 
Fusion gene scores* DoF score13 X 11 X 8=11443 X 2 X 3=18
# samples 153
** MAII scorelog2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBM39 [Title/Abstract] AND PRDM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRDM5

GO:0000122

negative regulation of transcription by RNA polymerase II

17636019

TgenePRDM5

GO:0045892

negative regulation of transcription, DNA-templated

17636019

TgenePRDM5

GO:0051567

histone H3-K9 methylation

17636019


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-BT-A2LD-01ARBM39chr20

34329863

-PRDM5chr4

121742500

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000253363ENST00000264808RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000253363ENST00000428209RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000253363ENST00000515109RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000253363ENST00000506065RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000253363ENST00000394435RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000361162ENST00000264808RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000361162ENST00000428209RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000361162ENST00000515109RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000361162ENST00000506065RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000361162ENST00000394435RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000528062ENST00000264808RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000528062ENST00000428209RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000528062ENST00000515109RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000528062ENST00000506065RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000528062ENST00000394435RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000407261ENST00000264808RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000407261ENST00000428209RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000407261ENST00000515109RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000407261ENST00000506065RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000407261ENST00000394435RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000397370ENST00000264808RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000397370ENST00000428209RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000397370ENST00000515109RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000397370ENST00000506065RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000397370ENST00000394435RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000463098ENST00000264808RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000463098ENST00000428209RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-3CDSENST00000463098ENST00000515109RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000463098ENST00000506065RBM39chr20

34329863

-PRDM5chr4

121742500

-
5UTR-intronENST00000463098ENST00000394435RBM39chr20

34329863

-PRDM5chr4

121742500

-

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FusionProtFeatures for RBM39_PRDM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM39

Q14498

PRDM5

Q9NQX1

Transcriptional coactivator for steroid nuclearreceptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (Bysimilarity). May be involved in pre-mRNA splicing process.{ECO:0000250}. Sequence-specific DNA-binding transcription factor.Represses transcription at least in part by recruitment of thehistone methyltransferase EHMT2/G9A and histone deacetylases suchas HDAC1. Regulates hematopoiesis-associated protein-coding andmicroRNA (miRNA) genes. May regulate the expression of proteinsinvolved in extracellular matrix development and maintenance,including fibrillar collagens, such as COL4A1 and COL11A1,connective tissue components, such as HAPLN1, and moleculesregulating cell migration and adhesion, including EDIL3 and TGFB2.May caused G2/M arrest and apoptosis in cancer cells.{ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019,ECO:0000269|PubMed:21664999}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM39_PRDM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM39_PRDM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBM39ESR2, ESR1, JUN, HNRNPA1, CDK9, KHDRBS2, SRRM1, SRRM2, HIST1H1C, CTNNBL1, TADA2A, UBC, MME, HDAC5, SND1, RPS2, RPS3, ACIN1, SNRNP200, CDK12, SF3B1, RBM25, PNN, U2AF2, PCBP3, TRA2B, LUC7L2, SRSF7, SRSF1, SAP18, SNRPD1, HNRNPU, XRCC5, XRCC6, IRF2BP2, RPS13, RPL27A, IRF2BPL, HDGF, SF3A2, SIRT7, TCF3, NR2C1, CUL3, CUL1, COPS5, CAND1, PGR, APP, SMU1, DDX3X, BCAS2, PLRG1, NHP2L1, USP39, PRPF19, RALY, TOP1, DDX21, GPATCH1, ILF3, RRP7A, SEPT7, TRMT112, UTP14A, S100A9, RRS1, RAN, SEPT2, RBM14, VTN, FLNA, RPS14, BARD1, MDC1, MAGOH, PRPF40A, CHERP, RBM23, PRPF3, PRPF38A, SAP30BP, HNRNPH2, NKAP, TOE1, TTC14, ZCCHC10, RNF113A, SRPK2, AICDA, SRPK1, CLK2, SRPK3, TARDBP, RPA3, RPA2, RPA1, WWOX, SPRTN, TP53, PHC2, GOLGA2, REL, SDCBP, SP100, MLX, ZBTB22, SRSF11, PPIG, SF3B4, KIAA0907, ARL6IP4, BANP, THAP1, C11orf57, HOMEZ, AK8, FAM200A, SREK1IP1, KRTAP12-2, RP9P, NXF1, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, HSPB1, PNISR, RBM14-RBM4, CDC5L, SNRNP70, RNPS1, SON, SREK1, SFN, NTRK1, CLK1, AHSA1, SEC16A, LAP3, KMT2E, SNW1, CRBN, ZNF746, EGFR, JMJD6, NCL, MTNR1A, INO80B, TRIM25, MCPH1PRDM5GFI1, EHMT2, HDAC1, CCDC77, FAM102B, FBXO11, ZNF687, THAP11, TNRC18, YBX2, ABT1, ZFP91, ZBTB4, BAG1, RPL26L1, WHSC1, RBM34, RPL10A, UPF1, RBM28, PRDM10, BRIX1, FTSJ3, PGK2, GLYR1, KIF1C, RPL8, NGRN, CASC3, RPL4, HIST2H2AB, SURF6, KIAA0020, GAR1, RPL18A, RPF2, ZFP62, SAP130, RPL36


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM39_PRDM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBM39_PRDM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRDM5C3280011BRITTLE CORNEA SYNDROME 21UNIPROT