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Fusion gene ID: 30715 |
FusionGeneSummary for RBM19_CLK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM19_CLK2 | Fusion gene ID: 30715 | Hgene | Tgene | Gene symbol | RBM19 | CLK2 | Gene ID | 9904 | 9894 |
| Gene name | RNA binding motif protein 19 | telomere maintenance 2 | |
| Synonyms | Mrd1 | CLK2|TEL2|YHFS | |
| Cytomap | 12q24.13-q24.21 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable RNA-binding protein 19 | telomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y4C8 | P49760 | |
| Ensembl transtripts involved in fusion gene | ENST00000545145, ENST00000392561, ENST00000261741, ENST00000553232, | ENST00000361168, ENST00000368361, ENST00000355560, ENST00000497188, ENST00000536801, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RBM19 [Title/Abstract] AND CLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-VP-A87K-01A | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shit | ENST00000545145 | ENST00000361168 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| Frame-shit | ENST00000545145 | ENST00000368361 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| Frame-shit | ENST00000545145 | ENST00000355560 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| 5CDS-intron | ENST00000545145 | ENST00000497188 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| 5CDS-intron | ENST00000545145 | ENST00000536801 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| Frame-shit | ENST00000392561 | ENST00000361168 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| Frame-shit | ENST00000392561 | ENST00000368361 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| Frame-shit | ENST00000392561 | ENST00000355560 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| 5CDS-intron | ENST00000392561 | ENST00000497188 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| 5CDS-intron | ENST00000392561 | ENST00000536801 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| In-frame | ENST00000261741 | ENST00000361168 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| In-frame | ENST00000261741 | ENST00000368361 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| In-frame | ENST00000261741 | ENST00000355560 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| 5CDS-intron | ENST00000261741 | ENST00000497188 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| 5CDS-intron | ENST00000261741 | ENST00000536801 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| intron-3CDS | ENST00000553232 | ENST00000361168 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| intron-3CDS | ENST00000553232 | ENST00000368361 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| intron-3CDS | ENST00000553232 | ENST00000355560 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| intron-intron | ENST00000553232 | ENST00000497188 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
| intron-intron | ENST00000553232 | ENST00000536801 | RBM19 | chr12 | 114364859 | - | CLK2 | chr1 | 155240768 | - |
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FusionProtFeatures for RBM19_CLK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBM19 | CLK2 |
| Plays a role in embryo pre-implantation development.{ECO:0000250}. | Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RBM19_CLK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000361168_chr1_155240768_-_1247aa MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKSFIDTSRITVEFCKSFGDPAKPRAWS KHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQES EEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSSATPVLQERDSKGAGQEQGMPAG KKRPPEARAETEKPANQKEPTTCHTVKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGR YIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKTGPLSELHYPIDSLTKKPKGFAFITF MFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVF DHETKGSVAVRVALGETQLVQEVRRFLIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGITAIVEFL EPLEARKAFRHLATSKFHHVPLTLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEE EEEEESLPGCTLFIKNLNFDTTEEKLKEMPHPRRYHSSERGSRGSYREHTRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSTDDR SSDRRVTDRRYCGSYRRNDTSRDRGDAYTDTDTRHSTETQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIY HVGDWLQERTEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISF ELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDTELTYNLEKKRDERSVKSTAVRVVDFGSATF DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYTVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKTFYRGRLDWDE >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000368361_chr1_155240768_-_1248aa MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKSFIDTSRITVEFCKSFGDPAKPRAWS KHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQES EEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSSATPVLQERDSKGAGQEQGMPAG KKRPPEARAETEKPANQKEPTTCHTVKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGR YIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKTGPLSELHYPIDSLTKKPKGFAFITF MFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVF DHETKGSVAVRVALGETQLVQEVRRFLIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGITAIVEFL EPLEARKAFRHLATSKFHHVPLTLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEE EEEEESLPGCTLFIKNLNFDTTEEKLKEMPHPRRYHSSERGSRGSYREHTRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSTDDR SSDRRVTDRRYCGSYRRNDTSRDRGDAYTDTDTRHSTETQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLI YHVGDWLQERTEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCIS FELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDTELTYNLEKKRDERSVKSTAVRVVDFGSAT FDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYTVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKTFYRGRLDWD >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000355560_chr1_155240768_-_1246aa MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKSFIDTSRITVEFCKSFGDPAKPRAWS KHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQES EEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSSATPVLQERDSKGAGQEQGMPAG KKRPPEARAETEKPANQKEPTTCHTVKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGR YIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKTGPLSELHYPIDSLTKKPKGFAFITF MFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVF DHETKGSVAVRVALGETQLVQEVRRFLIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGITAIVEFL EPLEARKAFRHLATSKFHHVPLTLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEE EEEEESLPGCTLFIKNLNFDTTEEKLKEMPHPRRYHSSERGSRGSYREHTRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSTDDRS SDRRVTDRRYCGSYRRNDTSRDRGDAYTDTDTRHSTETQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYH VGDWLQERTEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFE LLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDTELTYNLEKKRDERSVKSTAVRVVDFGSATFD HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYTVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKTFYRGRLDWDEN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000361168_chr1_155240768_-_3741nt ATGTCGCGACTGATCGTGAAGAATCTCCCGAATGGGATGAAGGAGGAGCGTTTCAGGCAGCTGTTTGCCGCCTTCGGCACGCTGACAGAC TGCAGCCTGAAGTTCACCAAAGATGGCAAGTTCCGCAAGTTTGGTTTTATTGGCTTCAAGTCCGAGGAAGAGGCCCAGAAGGCACAGAAG CATTTCAACAAGAGCTTCATCGACACATCCCGGATCACAGTGGAGTTCTGCAAGTCATTCGGGGACCCGGCCAAACCCAGAGCCTGGAGC AAACATGCCCAGAAACCAAGCCAGCCCAAGCAGCCTCCAAAAGACTCTACTACTCCAGAAATTAAGAAAGATGAGAAGAAGAAAAAGGTG GCAGGTCAACTGGAGAAGCTGAAGGAGGATACAGAGTTCCAGGAGTTTCTGTCAGTTCATCAGAGGCGGGCGCAGGCAGCCACTTGGGCG AATGATGGCCTGGATGCTGAGCCCTCGAAAGGGAAGAGCAAGCCGGCCAGTGACTACCTGAACTTCGACTCCGATTCTGGGCAGGAGAGT GAGGAGGAGGGAGCCGGGGAGGACCTGGAAGAAGAGGCAAGCCTCGAACCAAAGGCAGCTGTGCAGAAGGAGCTGTCGGACATGGATTAC CTGAAATCCAAGATGGTGAAGGCTGGGTCGTCCTCTTCCTCGGAGGAAGAGGAAAGTGAAGATGAAGCCGTGCACTGTGATGAAGGGAGT GAGGCCGAGGAAGAGGATTCCTCCGCCACCCCAGTCCTGCAGGAAAGAGACAGCAAGGGTGCAGGCCAAGAGCAAGGGATGCCAGCTGGG AAAAAGAGACCACCGGAGGCCAGAGCCGAGACAGAGAAACCAGCAAACCAGAAGGAACCCACCACCTGCCACACCGTGAAGCTGCGGGGA GCCCCGTTCAATGTCACAGAGAAAAATGTTATGGAATTCCTGGCACCCCTGAAACCAGTGGCCATTCGAATTGTGAGAAACGCTCATGGG AATAAAACAGGATACATCTTTGTGGATTTCAGCAATGAAGAGGAAGTGAAGCAAGCTCTGAAATGCAACCGGGAGTACATGGGTGGGCGC TACATCGAGGTGTTCAGGGAAAAGAACGTCCCCACCACCAAGGGTGCACCAAAGAATACCACCAAATCCTGGCAAGGCCGGATACTCGGG GAGAACGAAGAGGAGGAGGACCTGGCCGAATCCGGAAGGCTCTTTGTACGGAACCTGCCCTACACCAGCACCGAGGAGGATCTGGAGAAG CTCTTCTCCAAATATGGTCCCCTGTCTGAGCTCCACTACCCCATCGACAGCCTGACCAAGAAACCCAAGGGTTTTGCATTCATCACCTTC ATGTTCCCTGAGCACGCTGTGAAGGCCTACTCGGAGGTGGACGGGCAGGTATTCCAGGGCAGGATGCTCCACGTGTTACCATCTACCATC AAGAAGGAAGCCAGCGAGGATGCCAGTGCCCTGGGATCGTCGTCCTACAAGAAGAAGAAGGAGGCCCAGGACAAAGCCAACAGTGCCAGC TCTCACAACTGGAACACACTATTCATGGGGCCGAATGCCGTGGCCGATGCCATCGCACAGAAGTACAACGCCACCAAGAGTCAAGTGTTT GACCACGAGACCAAGGGCAGCGTGGCCGTGCGCGTGGCTCTGGGGGAAACCCAGCTCGTCCAGGAAGTGCGGCGTTTTCTCATAGACAAC GGGGTCAGCCTGGATTCCTTCAGCCAGGCTGCAGCAGAGCGAAGCAAGACTGTGATTCTGGTCAAGAACCTCCCGGCAGGCACCCTGGCG GCCCAGCTGCAGGAGACCTTCGGCCATTTTGGCAGCCTGGGCCGCGTGCTGCTGCCAGAGGGCGGAATCACTGCCATCGTGGAGTTCCTG GAGCCCCTGGAGGCCCGCAAGGCCTTCAGGCATCTGGCCTATTCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGC GTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTG CCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAG GAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAATGCCG CATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGCCGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGT CGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGGCGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGCAGTTATGATGATCGT TCGTCCGACCGGAGGGTGTATGACCGGCGATACTGTGGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGAC ACAGACTATCGGCATTCCTATGAATATCAGCGGGAGAACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGG AGGCGCAGCCGGACATTTAGCCGCTCATCTTCGCACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTAC CACGTCGGGGACTGGCTACAAGAGCGATATGAAATCGTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCAT CGCAGGGGTGGGGCTCGAGTTGCCCTGAAGATCATTAAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTAGAG AAAATCAATGAGAAAGACCCTGACAACAAGAACCTCTGTGTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTT GAGCTTCTGGGCCTTAGCACCTTCGATTTCCTCAAAGACAACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTCCAG CTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTAT GAGCTCACCTACAACCTAGAGAAGAAGCGAGATGAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACCTTT GACCATGAGCACCATAGCACCATTGTCTCCACTCGCCATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGAT GTGTGGAGTATAGGCTGCATCATCTTTGAATACTATGTGGGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATGATG GAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGAAAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAG AACACATCAGCTGGGCGCTATGTTCGTGAGAACTGCAAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTCTTC GATCTGATTGAAAGCATGCTAGAGTATGAACCAGCTAAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGG >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000368361_chr1_155240768_-_3744nt ATGTCGCGACTGATCGTGAAGAATCTCCCGAATGGGATGAAGGAGGAGCGTTTCAGGCAGCTGTTTGCCGCCTTCGGCACGCTGACAGAC TGCAGCCTGAAGTTCACCAAAGATGGCAAGTTCCGCAAGTTTGGTTTTATTGGCTTCAAGTCCGAGGAAGAGGCCCAGAAGGCACAGAAG CATTTCAACAAGAGCTTCATCGACACATCCCGGATCACAGTGGAGTTCTGCAAGTCATTCGGGGACCCGGCCAAACCCAGAGCCTGGAGC AAACATGCCCAGAAACCAAGCCAGCCCAAGCAGCCTCCAAAAGACTCTACTACTCCAGAAATTAAGAAAGATGAGAAGAAGAAAAAGGTG GCAGGTCAACTGGAGAAGCTGAAGGAGGATACAGAGTTCCAGGAGTTTCTGTCAGTTCATCAGAGGCGGGCGCAGGCAGCCACTTGGGCG AATGATGGCCTGGATGCTGAGCCCTCGAAAGGGAAGAGCAAGCCGGCCAGTGACTACCTGAACTTCGACTCCGATTCTGGGCAGGAGAGT GAGGAGGAGGGAGCCGGGGAGGACCTGGAAGAAGAGGCAAGCCTCGAACCAAAGGCAGCTGTGCAGAAGGAGCTGTCGGACATGGATTAC CTGAAATCCAAGATGGTGAAGGCTGGGTCGTCCTCTTCCTCGGAGGAAGAGGAAAGTGAAGATGAAGCCGTGCACTGTGATGAAGGGAGT GAGGCCGAGGAAGAGGATTCCTCCGCCACCCCAGTCCTGCAGGAAAGAGACAGCAAGGGTGCAGGCCAAGAGCAAGGGATGCCAGCTGGG AAAAAGAGACCACCGGAGGCCAGAGCCGAGACAGAGAAACCAGCAAACCAGAAGGAACCCACCACCTGCCACACCGTGAAGCTGCGGGGA GCCCCGTTCAATGTCACAGAGAAAAATGTTATGGAATTCCTGGCACCCCTGAAACCAGTGGCCATTCGAATTGTGAGAAACGCTCATGGG AATAAAACAGGATACATCTTTGTGGATTTCAGCAATGAAGAGGAAGTGAAGCAAGCTCTGAAATGCAACCGGGAGTACATGGGTGGGCGC TACATCGAGGTGTTCAGGGAAAAGAACGTCCCCACCACCAAGGGTGCACCAAAGAATACCACCAAATCCTGGCAAGGCCGGATACTCGGG GAGAACGAAGAGGAGGAGGACCTGGCCGAATCCGGAAGGCTCTTTGTACGGAACCTGCCCTACACCAGCACCGAGGAGGATCTGGAGAAG CTCTTCTCCAAATATGGTCCCCTGTCTGAGCTCCACTACCCCATCGACAGCCTGACCAAGAAACCCAAGGGTTTTGCATTCATCACCTTC ATGTTCCCTGAGCACGCTGTGAAGGCCTACTCGGAGGTGGACGGGCAGGTATTCCAGGGCAGGATGCTCCACGTGTTACCATCTACCATC AAGAAGGAAGCCAGCGAGGATGCCAGTGCCCTGGGATCGTCGTCCTACAAGAAGAAGAAGGAGGCCCAGGACAAAGCCAACAGTGCCAGC TCTCACAACTGGAACACACTATTCATGGGGCCGAATGCCGTGGCCGATGCCATCGCACAGAAGTACAACGCCACCAAGAGTCAAGTGTTT GACCACGAGACCAAGGGCAGCGTGGCCGTGCGCGTGGCTCTGGGGGAAACCCAGCTCGTCCAGGAAGTGCGGCGTTTTCTCATAGACAAC GGGGTCAGCCTGGATTCCTTCAGCCAGGCTGCAGCAGAGCGAAGCAAGACTGTGATTCTGGTCAAGAACCTCCCGGCAGGCACCCTGGCG GCCCAGCTGCAGGAGACCTTCGGCCATTTTGGCAGCCTGGGCCGCGTGCTGCTGCCAGAGGGCGGAATCACTGCCATCGTGGAGTTCCTG GAGCCCCTGGAGGCCCGCAAGGCCTTCAGGCATCTGGCCTATTCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGC GTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTG CCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAG GAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAATGCCG CATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGCCGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGT CGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGGCGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGCAGTTATGATGATCGT TCGTCCGACCGGAGGGTGTATGACCGGCGATACTGTGGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGAC ACAGACTATCGGCATTCCTATGAATATCAGCGGGAGAACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGG AGGCGCAGCCGGACATTTAGCCGCTCATCTTCGCAGCACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATC TACCACGTCGGGGACTGGCTACAAGAGCGATATGAAATCGTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGAC CATCGCAGGGGTGGGGCTCGAGTTGCCCTGAAGATCATTAAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTA GAGAAAATCAATGAGAAAGACCCTGACAACAAGAACCTCTGTGTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCC TTTGAGCTTCTGGGCCTTAGCACCTTCGATTTCCTCAAAGACAACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTC CAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGAC TATGAGCTCACCTACAACCTAGAGAAGAAGCGAGATGAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACC TTTGACCATGAGCACCATAGCACCATTGTCTCCACTCGCCATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGT GATGTGTGGAGTATAGGCTGCATCATCTTTGAATACTATGTGGGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATG ATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGAAAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGAT GAGAACACATCAGCTGGGCGCTATGTTCGTGAGAACTGCAAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTC TTCGATCTGATTGAAAGCATGCTAGAGTATGAACCAGCTAAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTT >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000355560_chr1_155240768_-_3738nt ATGTCGCGACTGATCGTGAAGAATCTCCCGAATGGGATGAAGGAGGAGCGTTTCAGGCAGCTGTTTGCCGCCTTCGGCACGCTGACAGAC TGCAGCCTGAAGTTCACCAAAGATGGCAAGTTCCGCAAGTTTGGTTTTATTGGCTTCAAGTCCGAGGAAGAGGCCCAGAAGGCACAGAAG CATTTCAACAAGAGCTTCATCGACACATCCCGGATCACAGTGGAGTTCTGCAAGTCATTCGGGGACCCGGCCAAACCCAGAGCCTGGAGC AAACATGCCCAGAAACCAAGCCAGCCCAAGCAGCCTCCAAAAGACTCTACTACTCCAGAAATTAAGAAAGATGAGAAGAAGAAAAAGGTG GCAGGTCAACTGGAGAAGCTGAAGGAGGATACAGAGTTCCAGGAGTTTCTGTCAGTTCATCAGAGGCGGGCGCAGGCAGCCACTTGGGCG AATGATGGCCTGGATGCTGAGCCCTCGAAAGGGAAGAGCAAGCCGGCCAGTGACTACCTGAACTTCGACTCCGATTCTGGGCAGGAGAGT GAGGAGGAGGGAGCCGGGGAGGACCTGGAAGAAGAGGCAAGCCTCGAACCAAAGGCAGCTGTGCAGAAGGAGCTGTCGGACATGGATTAC CTGAAATCCAAGATGGTGAAGGCTGGGTCGTCCTCTTCCTCGGAGGAAGAGGAAAGTGAAGATGAAGCCGTGCACTGTGATGAAGGGAGT GAGGCCGAGGAAGAGGATTCCTCCGCCACCCCAGTCCTGCAGGAAAGAGACAGCAAGGGTGCAGGCCAAGAGCAAGGGATGCCAGCTGGG AAAAAGAGACCACCGGAGGCCAGAGCCGAGACAGAGAAACCAGCAAACCAGAAGGAACCCACCACCTGCCACACCGTGAAGCTGCGGGGA GCCCCGTTCAATGTCACAGAGAAAAATGTTATGGAATTCCTGGCACCCCTGAAACCAGTGGCCATTCGAATTGTGAGAAACGCTCATGGG AATAAAACAGGATACATCTTTGTGGATTTCAGCAATGAAGAGGAAGTGAAGCAAGCTCTGAAATGCAACCGGGAGTACATGGGTGGGCGC TACATCGAGGTGTTCAGGGAAAAGAACGTCCCCACCACCAAGGGTGCACCAAAGAATACCACCAAATCCTGGCAAGGCCGGATACTCGGG GAGAACGAAGAGGAGGAGGACCTGGCCGAATCCGGAAGGCTCTTTGTACGGAACCTGCCCTACACCAGCACCGAGGAGGATCTGGAGAAG CTCTTCTCCAAATATGGTCCCCTGTCTGAGCTCCACTACCCCATCGACAGCCTGACCAAGAAACCCAAGGGTTTTGCATTCATCACCTTC ATGTTCCCTGAGCACGCTGTGAAGGCCTACTCGGAGGTGGACGGGCAGGTATTCCAGGGCAGGATGCTCCACGTGTTACCATCTACCATC AAGAAGGAAGCCAGCGAGGATGCCAGTGCCCTGGGATCGTCGTCCTACAAGAAGAAGAAGGAGGCCCAGGACAAAGCCAACAGTGCCAGC TCTCACAACTGGAACACACTATTCATGGGGCCGAATGCCGTGGCCGATGCCATCGCACAGAAGTACAACGCCACCAAGAGTCAAGTGTTT GACCACGAGACCAAGGGCAGCGTGGCCGTGCGCGTGGCTCTGGGGGAAACCCAGCTCGTCCAGGAAGTGCGGCGTTTTCTCATAGACAAC GGGGTCAGCCTGGATTCCTTCAGCCAGGCTGCAGCAGAGCGAAGCAAGACTGTGATTCTGGTCAAGAACCTCCCGGCAGGCACCCTGGCG GCCCAGCTGCAGGAGACCTTCGGCCATTTTGGCAGCCTGGGCCGCGTGCTGCTGCCAGAGGGCGGAATCACTGCCATCGTGGAGTTCCTG GAGCCCCTGGAGGCCCGCAAGGCCTTCAGGCATCTGGCCTATTCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGC GTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTG CCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAG GAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAATGCCG CATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGCCGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGT CGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGGCGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGTTATGATGATCGTTCG TCCGACCGGAGGGTGTATGACCGGCGATACTGTGGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGACACA GACTATCGGCATTCCTATGAATATCAGCGGGAGAACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGG CGCAGCCGGACATTTAGCCGCTCATCTTCGCACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTACCAC GTCGGGGACTGGCTACAAGAGCGATATGAAATCGTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGC AGGGGTGGGGCTCGAGTTGCCCTGAAGATCATTAAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTAGAGAAA ATCAATGAGAAAGACCCTGACAACAAGAACCTCTGTGTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTTGAG CTTCTGGGCCTTAGCACCTTCGATTTCCTCAAAGACAACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTCCAGCTG TGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAG CTCACCTACAACCTAGAGAAGAAGCGAGATGAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACCTTTGAC CATGAGCACCATAGCACCATTGTCTCCACTCGCCATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGATGTG TGGAGTATAGGCTGCATCATCTTTGAATACTATGTGGGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATGATGGAA AGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGAAAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAAC ACATCAGCTGGGCGCTATGTTCGTGAGAACTGCAAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTCTTCGAT CTGATTGAAAGCATGCTAGAGTATGAACCAGCTAAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGGGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000361168_chr1_155240768_-_4235nt CTTCCGGACAGGTCAGGCCAAGGTCTCAGCCACGTGACTGTGTTCCGGCTCGGTAAAGATGGCGGCGCCCAGGGCGGTAGCGTGAAACTT GGTGGAAGACGCTGACCAGTCGTGTTGGAATCAAAACAGCGGGGACCCTGCGCCATGTCGCGACTGATCGTGAAGAATCTCCCGAATGGG ATGAAGGAGGAGCGTTTCAGGCAGCTGTTTGCCGCCTTCGGCACGCTGACAGACTGCAGCCTGAAGTTCACCAAAGATGGCAAGTTCCGC AAGTTTGGTTTTATTGGCTTCAAGTCCGAGGAAGAGGCCCAGAAGGCACAGAAGCATTTCAACAAGAGCTTCATCGACACATCCCGGATC ACAGTGGAGTTCTGCAAGTCATTCGGGGACCCGGCCAAACCCAGAGCCTGGAGCAAACATGCCCAGAAACCAAGCCAGCCCAAGCAGCCT CCAAAAGACTCTACTACTCCAGAAATTAAGAAAGATGAGAAGAAGAAAAAGGTGGCAGGTCAACTGGAGAAGCTGAAGGAGGATACAGAG TTCCAGGAGTTTCTGTCAGTTCATCAGAGGCGGGCGCAGGCAGCCACTTGGGCGAATGATGGCCTGGATGCTGAGCCCTCGAAAGGGAAG AGCAAGCCGGCCAGTGACTACCTGAACTTCGACTCCGATTCTGGGCAGGAGAGTGAGGAGGAGGGAGCCGGGGAGGACCTGGAAGAAGAG GCAAGCCTCGAACCAAAGGCAGCTGTGCAGAAGGAGCTGTCGGACATGGATTACCTGAAATCCAAGATGGTGAAGGCTGGGTCGTCCTCT TCCTCGGAGGAAGAGGAAAGTGAAGATGAAGCCGTGCACTGTGATGAAGGGAGTGAGGCCGAGGAAGAGGATTCCTCCGCCACCCCAGTC CTGCAGGAAAGAGACAGCAAGGGTGCAGGCCAAGAGCAAGGGATGCCAGCTGGGAAAAAGAGACCACCGGAGGCCAGAGCCGAGACAGAG AAACCAGCAAACCAGAAGGAACCCACCACCTGCCACACCGTGAAGCTGCGGGGAGCCCCGTTCAATGTCACAGAGAAAAATGTTATGGAA TTCCTGGCACCCCTGAAACCAGTGGCCATTCGAATTGTGAGAAACGCTCATGGGAATAAAACAGGATACATCTTTGTGGATTTCAGCAAT GAAGAGGAAGTGAAGCAAGCTCTGAAATGCAACCGGGAGTACATGGGTGGGCGCTACATCGAGGTGTTCAGGGAAAAGAACGTCCCCACC ACCAAGGGTGCACCAAAGAATACCACCAAATCCTGGCAAGGCCGGATACTCGGGGAGAACGAAGAGGAGGAGGACCTGGCCGAATCCGGA AGGCTCTTTGTACGGAACCTGCCCTACACCAGCACCGAGGAGGATCTGGAGAAGCTCTTCTCCAAATATGGTCCCCTGTCTGAGCTCCAC TACCCCATCGACAGCCTGACCAAGAAACCCAAGGGTTTTGCATTCATCACCTTCATGTTCCCTGAGCACGCTGTGAAGGCCTACTCGGAG GTGGACGGGCAGGTATTCCAGGGCAGGATGCTCCACGTGTTACCATCTACCATCAAGAAGGAAGCCAGCGAGGATGCCAGTGCCCTGGGA TCGTCGTCCTACAAGAAGAAGAAGGAGGCCCAGGACAAAGCCAACAGTGCCAGCTCTCACAACTGGAACACACTATTCATGGGGCCGAAT GCCGTGGCCGATGCCATCGCACAGAAGTACAACGCCACCAAGAGTCAAGTGTTTGACCACGAGACCAAGGGCAGCGTGGCCGTGCGCGTG GCTCTGGGGGAAACCCAGCTCGTCCAGGAAGTGCGGCGTTTTCTCATAGACAACGGGGTCAGCCTGGATTCCTTCAGCCAGGCTGCAGCA GAGCGAAGCAAGACTGTGATTCTGGTCAAGAACCTCCCGGCAGGCACCCTGGCGGCCCAGCTGCAGGAGACCTTCGGCCATTTTGGCAGC CTGGGCCGCGTGCTGCTGCCAGAGGGCGGAATCACTGCCATCGTGGAGTTCCTGGAGCCCCTGGAGGCCCGCAAGGCCTTCAGGCATCTG GCCTATTCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAATGCCGCATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGC CGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGTCGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGG CGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGCAGTTATGATGATCGTTCGTCCGACCGGAGGGTGTATGACCGGCGATACTGT GGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGACACAGACTATCGGCATTCCTATGAATATCAGCGGGAG AACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGGCGCAGCCGGACATTTAGCCGCTCATCTTCGCAC AGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTACCACGTCGGGGACTGGCTACAAGAGCGATATGAAATC GTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAGGGGTGGGGCTCGAGTTGCCCTGAAGATCATT AAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTAGAGAAAATCAATGAGAAAGACCCTGACAACAAGAACCTC TGTGTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTTGAGCTTCTGGGCCTTAGCACCTTCGATTTCCTCAAA GACAACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTCCAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAG CTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAGCTCACCTACAACCTAGAGAAGAAGCGAGATGAG CGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACCTTTGACCATGAGCACCATAGCACCATTGTCTCCACTCGC CATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGATGTGTGGAGTATAGGCTGCATCATCTTTGAATACTAT GTGGGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATGATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATC CGAAAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAACACATCAGCTGGGCGCTATGTTCGTGAGAACTGC AAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTCTTCGATCTGATTGAAAGCATGCTAGAGTATGAACCAGCT AAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGGGCTGAGCCGCCCAACAAGTTGTGGGACTCCAGTCGG GATATCAGTCGGTGACGATCAGGCCCTGGGCCCCCCTGCATCTTTTATAGCAGTGGGTGTCCAGTCCAGGACACTGGTGCTTTTTTATAC AAGAGAACGAGCCAGAGTTCACTCCTTCCTCCTGGCTCTCTATATACCTGTGAATATGTGAAATAGTGTAAATATGAAAGAACTTGTACC TATCACTTCAACCCCTGCCTTGTACATAATACTATTCCATCCACACAGTTTCCACCCTCACCTGCCCCCTCATACGGAGTTGGATGGGGG CCGAGTGAGGTAACCAGGTGGCATCTACCCCATGTTTTATAAGGAATTTTGTACAGTCTTTGTGAAATAAAATAACGTGCTTCATTTGAC >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000368361_chr1_155240768_-_4238nt CTTCCGGACAGGTCAGGCCAAGGTCTCAGCCACGTGACTGTGTTCCGGCTCGGTAAAGATGGCGGCGCCCAGGGCGGTAGCGTGAAACTT GGTGGAAGACGCTGACCAGTCGTGTTGGAATCAAAACAGCGGGGACCCTGCGCCATGTCGCGACTGATCGTGAAGAATCTCCCGAATGGG ATGAAGGAGGAGCGTTTCAGGCAGCTGTTTGCCGCCTTCGGCACGCTGACAGACTGCAGCCTGAAGTTCACCAAAGATGGCAAGTTCCGC AAGTTTGGTTTTATTGGCTTCAAGTCCGAGGAAGAGGCCCAGAAGGCACAGAAGCATTTCAACAAGAGCTTCATCGACACATCCCGGATC ACAGTGGAGTTCTGCAAGTCATTCGGGGACCCGGCCAAACCCAGAGCCTGGAGCAAACATGCCCAGAAACCAAGCCAGCCCAAGCAGCCT CCAAAAGACTCTACTACTCCAGAAATTAAGAAAGATGAGAAGAAGAAAAAGGTGGCAGGTCAACTGGAGAAGCTGAAGGAGGATACAGAG TTCCAGGAGTTTCTGTCAGTTCATCAGAGGCGGGCGCAGGCAGCCACTTGGGCGAATGATGGCCTGGATGCTGAGCCCTCGAAAGGGAAG AGCAAGCCGGCCAGTGACTACCTGAACTTCGACTCCGATTCTGGGCAGGAGAGTGAGGAGGAGGGAGCCGGGGAGGACCTGGAAGAAGAG GCAAGCCTCGAACCAAAGGCAGCTGTGCAGAAGGAGCTGTCGGACATGGATTACCTGAAATCCAAGATGGTGAAGGCTGGGTCGTCCTCT TCCTCGGAGGAAGAGGAAAGTGAAGATGAAGCCGTGCACTGTGATGAAGGGAGTGAGGCCGAGGAAGAGGATTCCTCCGCCACCCCAGTC CTGCAGGAAAGAGACAGCAAGGGTGCAGGCCAAGAGCAAGGGATGCCAGCTGGGAAAAAGAGACCACCGGAGGCCAGAGCCGAGACAGAG AAACCAGCAAACCAGAAGGAACCCACCACCTGCCACACCGTGAAGCTGCGGGGAGCCCCGTTCAATGTCACAGAGAAAAATGTTATGGAA TTCCTGGCACCCCTGAAACCAGTGGCCATTCGAATTGTGAGAAACGCTCATGGGAATAAAACAGGATACATCTTTGTGGATTTCAGCAAT GAAGAGGAAGTGAAGCAAGCTCTGAAATGCAACCGGGAGTACATGGGTGGGCGCTACATCGAGGTGTTCAGGGAAAAGAACGTCCCCACC ACCAAGGGTGCACCAAAGAATACCACCAAATCCTGGCAAGGCCGGATACTCGGGGAGAACGAAGAGGAGGAGGACCTGGCCGAATCCGGA AGGCTCTTTGTACGGAACCTGCCCTACACCAGCACCGAGGAGGATCTGGAGAAGCTCTTCTCCAAATATGGTCCCCTGTCTGAGCTCCAC TACCCCATCGACAGCCTGACCAAGAAACCCAAGGGTTTTGCATTCATCACCTTCATGTTCCCTGAGCACGCTGTGAAGGCCTACTCGGAG GTGGACGGGCAGGTATTCCAGGGCAGGATGCTCCACGTGTTACCATCTACCATCAAGAAGGAAGCCAGCGAGGATGCCAGTGCCCTGGGA TCGTCGTCCTACAAGAAGAAGAAGGAGGCCCAGGACAAAGCCAACAGTGCCAGCTCTCACAACTGGAACACACTATTCATGGGGCCGAAT GCCGTGGCCGATGCCATCGCACAGAAGTACAACGCCACCAAGAGTCAAGTGTTTGACCACGAGACCAAGGGCAGCGTGGCCGTGCGCGTG GCTCTGGGGGAAACCCAGCTCGTCCAGGAAGTGCGGCGTTTTCTCATAGACAACGGGGTCAGCCTGGATTCCTTCAGCCAGGCTGCAGCA GAGCGAAGCAAGACTGTGATTCTGGTCAAGAACCTCCCGGCAGGCACCCTGGCGGCCCAGCTGCAGGAGACCTTCGGCCATTTTGGCAGC CTGGGCCGCGTGCTGCTGCCAGAGGGCGGAATCACTGCCATCGTGGAGTTCCTGGAGCCCCTGGAGGCCCGCAAGGCCTTCAGGCATCTG GCCTATTCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAATGCCGCATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGC CGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGTCGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGG CGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGCAGTTATGATGATCGTTCGTCCGACCGGAGGGTGTATGACCGGCGATACTGT GGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGACACAGACTATCGGCATTCCTATGAATATCAGCGGGAG AACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGGCGCAGCCGGACATTTAGCCGCTCATCTTCGCAG CACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTACCACGTCGGGGACTGGCTACAAGAGCGATATGAA ATCGTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAGGGGTGGGGCTCGAGTTGCCCTGAAGATC ATTAAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTAGAGAAAATCAATGAGAAAGACCCTGACAACAAGAAC CTCTGTGTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTTGAGCTTCTGGGCCTTAGCACCTTCGATTTCCTC AAAGACAACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTCCAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAAC AAGCTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAGCTCACCTACAACCTAGAGAAGAAGCGAGAT GAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACCTTTGACCATGAGCACCATAGCACCATTGTCTCCACT CGCCATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGATGTGTGGAGTATAGGCTGCATCATCTTTGAATAC TATGTGGGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATGATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATG ATCCGAAAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAACACATCAGCTGGGCGCTATGTTCGTGAGAAC TGCAAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTCTTCGATCTGATTGAAAGCATGCTAGAGTATGAACCA GCTAAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGGGCTGAGCCGCCCAACAAGTTGTGGGACTCCAGT CGGGATATCAGTCGGTGACGATCAGGCCCTGGGCCCCCCTGCATCTTTTATAGCAGTGGGTGTCCAGTCCAGGACACTGGTGCTTTTTTA TACAAGAGAACGAGCCAGAGTTCACTCCTTCCTCCTGGCTCTCTATATACCTGTGAATATGTGAAATAGTGTAAATATGAAAGAACTTGT ACCTATCACTTCAACCCCTGCCTTGTACATAATACTATTCCATCCACACAGTTTCCACCCTCACCTGCCCCCTCATACGGAGTTGGATGG GGGCCGAGTGAGGTAACCAGGTGGCATCTACCCCATGTTTTATAAGGAATTTTGTACAGTCTTTGTGAAATAAAATAACGTGCTTCATTT >In-frame_RBM19_ENST00000261741_chr12_114364859_-_CLK2_ENST00000355560_chr1_155240768_-_4226nt CTTCCGGACAGGTCAGGCCAAGGTCTCAGCCACGTGACTGTGTTCCGGCTCGGTAAAGATGGCGGCGCCCAGGGCGGTAGCGTGAAACTT GGTGGAAGACGCTGACCAGTCGTGTTGGAATCAAAACAGCGGGGACCCTGCGCCATGTCGCGACTGATCGTGAAGAATCTCCCGAATGGG ATGAAGGAGGAGCGTTTCAGGCAGCTGTTTGCCGCCTTCGGCACGCTGACAGACTGCAGCCTGAAGTTCACCAAAGATGGCAAGTTCCGC AAGTTTGGTTTTATTGGCTTCAAGTCCGAGGAAGAGGCCCAGAAGGCACAGAAGCATTTCAACAAGAGCTTCATCGACACATCCCGGATC ACAGTGGAGTTCTGCAAGTCATTCGGGGACCCGGCCAAACCCAGAGCCTGGAGCAAACATGCCCAGAAACCAAGCCAGCCCAAGCAGCCT CCAAAAGACTCTACTACTCCAGAAATTAAGAAAGATGAGAAGAAGAAAAAGGTGGCAGGTCAACTGGAGAAGCTGAAGGAGGATACAGAG TTCCAGGAGTTTCTGTCAGTTCATCAGAGGCGGGCGCAGGCAGCCACTTGGGCGAATGATGGCCTGGATGCTGAGCCCTCGAAAGGGAAG AGCAAGCCGGCCAGTGACTACCTGAACTTCGACTCCGATTCTGGGCAGGAGAGTGAGGAGGAGGGAGCCGGGGAGGACCTGGAAGAAGAG GCAAGCCTCGAACCAAAGGCAGCTGTGCAGAAGGAGCTGTCGGACATGGATTACCTGAAATCCAAGATGGTGAAGGCTGGGTCGTCCTCT TCCTCGGAGGAAGAGGAAAGTGAAGATGAAGCCGTGCACTGTGATGAAGGGAGTGAGGCCGAGGAAGAGGATTCCTCCGCCACCCCAGTC CTGCAGGAAAGAGACAGCAAGGGTGCAGGCCAAGAGCAAGGGATGCCAGCTGGGAAAAAGAGACCACCGGAGGCCAGAGCCGAGACAGAG AAACCAGCAAACCAGAAGGAACCCACCACCTGCCACACCGTGAAGCTGCGGGGAGCCCCGTTCAATGTCACAGAGAAAAATGTTATGGAA TTCCTGGCACCCCTGAAACCAGTGGCCATTCGAATTGTGAGAAACGCTCATGGGAATAAAACAGGATACATCTTTGTGGATTTCAGCAAT GAAGAGGAAGTGAAGCAAGCTCTGAAATGCAACCGGGAGTACATGGGTGGGCGCTACATCGAGGTGTTCAGGGAAAAGAACGTCCCCACC ACCAAGGGTGCACCAAAGAATACCACCAAATCCTGGCAAGGCCGGATACTCGGGGAGAACGAAGAGGAGGAGGACCTGGCCGAATCCGGA AGGCTCTTTGTACGGAACCTGCCCTACACCAGCACCGAGGAGGATCTGGAGAAGCTCTTCTCCAAATATGGTCCCCTGTCTGAGCTCCAC TACCCCATCGACAGCCTGACCAAGAAACCCAAGGGTTTTGCATTCATCACCTTCATGTTCCCTGAGCACGCTGTGAAGGCCTACTCGGAG GTGGACGGGCAGGTATTCCAGGGCAGGATGCTCCACGTGTTACCATCTACCATCAAGAAGGAAGCCAGCGAGGATGCCAGTGCCCTGGGA TCGTCGTCCTACAAGAAGAAGAAGGAGGCCCAGGACAAAGCCAACAGTGCCAGCTCTCACAACTGGAACACACTATTCATGGGGCCGAAT GCCGTGGCCGATGCCATCGCACAGAAGTACAACGCCACCAAGAGTCAAGTGTTTGACCACGAGACCAAGGGCAGCGTGGCCGTGCGCGTG GCTCTGGGGGAAACCCAGCTCGTCCAGGAAGTGCGGCGTTTTCTCATAGACAACGGGGTCAGCCTGGATTCCTTCAGCCAGGCTGCAGCA GAGCGAAGCAAGACTGTGATTCTGGTCAAGAACCTCCCGGCAGGCACCCTGGCGGCCCAGCTGCAGGAGACCTTCGGCCATTTTGGCAGC CTGGGCCGCGTGCTGCTGCCAGAGGGCGGAATCACTGCCATCGTGGAGTTCCTGGAGCCCCTGGAGGCCCGCAAGGCCTTCAGGCATCTG GCCTATTCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAATGCCGCATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGC CGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGTCGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGG CGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGTTATGATGATCGTTCGTCCGACCGGAGGGTGTATGACCGGCGATACTGTGGC AGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGACACAGACTATCGGCATTCCTATGAATATCAGCGGGAGAAC AGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGGCGCAGCCGGACATTTAGCCGCTCATCTTCGCACAGC AGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTACCACGTCGGGGACTGGCTACAAGAGCGATATGAAATCGTT AGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAGGGGTGGGGCTCGAGTTGCCCTGAAGATCATTAAG AATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTAGAGAAAATCAATGAGAAAGACCCTGACAACAAGAACCTCTGT GTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTTGAGCTTCTGGGCCTTAGCACCTTCGATTTCCTCAAAGAC AACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTCCAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTG ACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAGCTCACCTACAACCTAGAGAAGAAGCGAGATGAGCGC AGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACCTTTGACCATGAGCACCATAGCACCATTGTCTCCACTCGCCAT TACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGATGTGTGGAGTATAGGCTGCATCATCTTTGAATACTATGTG GGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATGATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGA AAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAACACATCAGCTGGGCGCTATGTTCGTGAGAACTGCAAA CCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTCTTCGATCTGATTGAAAGCATGCTAGAGTATGAACCAGCTAAG CGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGGGCTGAGCCGCCCAACAAGTTGTGGGACTCCAGTCGGGAT ATCAGTCGGTGACGATCAGGCCCTGGGCCCCCCTGCATCTTTTATAGCAGTGGGTGTCCAGTCCAGGACACTGGTGCTTTTTTATACAAG AGAACGAGCCAGAGTTCACTCCTTCCTCCTGGCTCTCTATATACCTGTGAATATGTGAAATAGTGTAAATATGAAAGAACTTGTACCTAT CACTTCAACCCCTGCCTTGTACATAATACTATTCCATCCACACAGTTTCCACCCTCACCTGCCCCCTCATACGGAGTTGGATGGGGGCCG |
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FusionGenePPI for RBM19_CLK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RBM19 | FTSJ3, PTPN12, NXF1, FBXW11, HIST1H1A, NOL12, NIFK, ZC3H3, RPS8, BYSL, DDX27, DHX37, FBL, GRWD1, NOL10, RRP12, UTP18, TSR1, UTP15, IFI16, SRPK2, MEX3C, HIST1H1E, RPS14, HIST1H1T, GPATCH4, ZC3HAV1, ZCRB1, FGF3, FGF8, ZNF2, RPL7, RPL18, CDX1, H2AFY2, H2AFX, ZBTB48, RRS1, FOXA1, TRIM25 | CLK2 | CLK3, UBL5, FANCM, C19orf40, YWHAG, HSP90AA1, AKT1, SNRNP70, PNN, HNRNPM, LUC7L, TNPO3, CLK2, HUWE1, PSME3, SKIV2L2, ZCCHC8, BCLAF1, CPSF1, FIP1L1, RBBP6, WDR33, PPHLN1, RBM7, ACIN1, PABPC1, SETD2, PKP2, THRAP3, CPSF2, RBM39, SON, ZNF30, HNRNPF, CPSF4, CDKN2A, ECE1, TRIM27, SDCBP, SRPK2, U2AF1, UBE2I, ZRSR2, ZNF263, SRRM1, RNPS1, KLHL2, ZNF473, MRPL4, LUZP4, RSRP1, ZNF398, GMCL1, SNIP1, CPSF7, ZNF394, LNX1, PRPF38A, YTHDC1, BRCA1, EED, TRA2A, LUC7L2, TBC1D9B, NKTR, ZC3H18, CLK1, RBMXL1, SRSF8, ELAVL2, CLASRP, GPATCH8, ZNF638, C11orf57, SRSF12, MDK, SRSF10, NCOA5, EPB41L2, RSBN1L, C17orf85, GPALPP1, APOBEC3D, U2AF2, CDX1, ZC3H14, GSPT2, REPIN1, SRRT, JPH4, CASC3, PRPF4B, PTPN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RBM19_CLK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM19_CLK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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