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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 3071

FusionGeneSummary for ASXL2_PPWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASXL2_PPWD1
Fusion gene ID: 3071
HgeneTgene
Gene symbol

ASXL2

PPWD1

Gene ID

55252

23398

Gene nameASXL transcriptional regulator 2peptidylprolyl isomerase domain and WD repeat containing 1
SynonymsASXH2|SHAPNS-
Cytomap

2p23.3

5q12.3

Type of geneprotein-codingprotein-coding
Descriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2peptidylprolyl isomerase domain and WD repeat-containing protein 1spliceosome-associated cyclophilin
Modification date2018052320180523
UniProtAcc

Q76L83

Q96BP3

Ensembl transtripts involved in fusion geneENST00000435504, ENST00000336112, 
ENST00000272341, ENST00000404843, 
ENST00000497092, 		ENST00000261308, 
ENST00000535264, ENST00000538977, 
Fusion gene scores* DoF score13 X 7 X 8=7283 X 2 X 3=18
# samples 153
** MAII scorelog2(15/728*10)=-2.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASXL2 [Title/Abstract] AND PPWD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

HgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

HgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783

TgenePPWD1

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5J2-01AASXL2chr2

26029098

-PPWD1chr5

64863340

+
TCGALDACCTCGA-OR-A5J2-01AASXL2chr2

26029098

-PPWD1chr5

64872706

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000435504ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000435504ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5CDS-intronENST00000435504ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000336112ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
Frame-shiftENST00000336112ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5CDS-intronENST00000336112ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000272341ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000272341ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-intronENST00000272341ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
intron-3CDSENST00000404843ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
intron-3CDSENST00000404843ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
intron-intronENST00000404843ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000497092ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-3CDSENST00000497092ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64863340

+
5UTR-intronENST00000497092ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64863340

+
In-frameENST00000435504ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
In-frameENST00000435504ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
In-frameENST00000435504ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
Frame-shiftENST00000336112ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
Frame-shiftENST00000336112ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
Frame-shiftENST00000336112ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000272341ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000272341ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000272341ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-3CDSENST00000404843ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-3CDSENST00000404843ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
intron-3CDSENST00000404843ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000497092ENST00000261308ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000497092ENST00000535264ASXL2chr2

26029098

-PPWD1chr5

64872706

+
5UTR-3CDSENST00000497092ENST00000538977ASXL2chr2

26029098

-PPWD1chr5

64872706

+

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FusionProtFeatures for ASXL2_PPWD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL2

Q76L83

PPWD1

Q96BP3

Putative Polycomb group (PcG) protein. PcG proteins actby forming multiprotein complexes, which are required to maintainthe transcriptionally repressive state of homeotic genesthroughout development. PcG proteins are not required to initiaterepression, but to maintain it during later stages of development.They probably act via methylation of histones, rendering chromatinheritably changed in its expressibility (By similarity). Involvedin transcriptional regulation mediated by ligand-bound nuclearhormone receptors, such as peroxisome proliferator-activatedreceptor gamma (PPARG). Acts as coactivator for PPARG and enhancesits adipocyte differentiation-inducing activity; the functionseems to involve differential recruitment of acetylated andmethylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}. PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638). {ECO:0000269|PubMed:11991638,ECO:0000269|PubMed:20676357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411490_645323647DomainPPIase cyclophilin-type
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411345_386323647RepeatNote=WD 6
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411401_453323647RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-3131173_1176-176919Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313303_307-176919Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313654_684-176919Compositional biasNote=Ala-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313687_739-176919Compositional biasNote=Gly-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-31395_235-176919Compositional biasNote=Ser-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-1101173_1176-146919Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110303_307-146919Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110654_684-146919Compositional biasNote=Ala-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110687_739-146919Compositional biasNote=Gly-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-11095_235-146919Compositional biasNote=Ser-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-4131173_1176841436Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413303_307841436Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413654_684841436Compositional biasNote=Ala-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413687_739841436Compositional biasNote=Gly-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-41395_235841436Compositional biasNote=Ser-rich
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313174_178-176919MotifNuclear localization signal
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-313887_891-176919MotifNote=LXXLL motif 2
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110174_178-146919MotifNuclear localization signal
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-110887_891-146919MotifNote=LXXLL motif 2
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413174_178841436MotifNuclear localization signal
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-413887_891841436MotifNote=LXXLL motif 2
HgeneASXL2chr2:26029098chr5:64872706ENST00000272341-3131397_1434-176919Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26029098chr5:64872706ENST00000404843-1101397_1434-146919Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26029098chr5:64872706ENST00000435504-4131397_1434841436Zinc fingerNote=PHD-type%3B atypical
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+41112_17323647Compositional biasNote=Poly-Arg
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411124_162323647RepeatNote=WD 2
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411168_208323647RepeatNote=WD 3
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411213_252323647RepeatNote=WD 4
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+411271_309323647RepeatNote=WD 5
TgenePPWD1chr2:26029098chr5:64872706ENST00000261308+41180_118323647RepeatNote=WD 1


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FusionGeneSequence for ASXL2_PPWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000261308_chr5_64872706_+_408aa
MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKMFTELQ
QMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTI
EMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFP
VECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPT

>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000535264_chr5_64872706_+_408aa
MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKMFTELQ
QMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTI
EMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFP
VECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPT

>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000538977_chr5_64872706_+_408aa
MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKMFTELQ
QMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTI
EMKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKEEVMAATQAEGPKRVSDSAIIHTSMGDIHTKLFP
VECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000261308_chr5_64872706_+_1224nt
ATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAAAAATACCCCAATACACCCATGAGT
CATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTT
CACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGATGTTTACTGAACTGCAA
CAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAGAAGGTTGATGCTGTAAGATTAATT
AATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATAAATGTAGAGACAAACCGGTGTGTG
CGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAAAAGCATCGTGCTGCAACTACTATA
GAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACATCATTCAAAAAGAATAGATTTTAT
ATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAGAAACCTTCTAAAGAAGAAGTCATG
GCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGAGACATTCACACCAAACTTTTTCCT
GTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCATACATTTCACCGTATAATTAAGGGC
TTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAATTTGAAGATGAATTTCATTCAACA
TTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAGTTTTTCATAACGGTAGTACCAACG
CCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGGATCTCCAACGTCAAAGTCAATCCC

>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000535264_chr5_64872706_+_1224nt
ATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAAAAATACCCCAATACACCCATGAGT
CATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTT
CACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGATGTTTACTGAACTGCAA
CAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAGAAGGTTGATGCTGTAAGATTAATT
AATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATAAATGTAGAGACAAACCGGTGTGTG
CGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAAAAGCATCGTGCTGCAACTACTATA
GAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACATCATTCAAAAAGAATAGATTTTAT
ATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAGAAACCTTCTAAAGAAGAAGTCATG
GCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGAGACATTCACACCAAACTTTTTCCT
GTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCATACATTTCACCGTATAATTAAGGGC
TTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAATTTGAAGATGAATTTCATTCAACA
TTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAGTTTTTCATAACGGTAGTACCAACG
CCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGGATCTCCAACGTCAAAGTCAATCCC

>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000538977_chr5_64872706_+_1224nt
ATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAAAAATACCCCAATACACCCATGAGT
CATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTT
CACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGATGTTTACTGAACTGCAA
CAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAGAAGGTTGATGCTGTAAGATTAATT
AATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATAAATGTAGAGACAAACCGGTGTGTG
CGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAAAAGCATCGTGCTGCAACTACTATA
GAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACATCATTCAAAAAGAATAGATTTTAT
ATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAGAAACCTTCTAAAGAAGAAGTCATG
GCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGAGACATTCACACCAAACTTTTTCCT
GTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCATACATTTCACCGTATAATTAAGGGC
TTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAATTTGAAGATGAATTTCATTCAACA
TTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAGTTTTTCATAACGGTAGTACCAACG
CCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGGATCTCCAACGTCAAAGTCAATCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000261308_chr5_64872706_+_1671nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGATGTTTACTGAACTGCAACAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAG
AAGGTTGATGCTGTAAGATTAATTAATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATA
AATGTAGAGACAAACCGGTGTGTGCGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAA
AAGCATCGTGCTGCAACTACTATAGAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACA
TCATTCAAAAAGAATAGATTTTATATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAG
AAACCTTCTAAAGAAGAAGTCATGGCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGA
GACATTCACACCAAACTTTTTCCTGTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCAT
ACATTTCACCGTATAATTAAGGGCTTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAA
TTTGAAGATGAATTTCATTCAACATTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAG
TTTTTCATAACGGTAGTACCAACGCCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGG
ATCTCCAACGTCAAAGTCAATCCCAAAACAGATAAGCCCTATGAGGATGTCAGCATCATAAATATTACTGTCAAGTAAAATAAGATTTGT
TTTAATGTACTTGCAAATAAAAATACAATATTAAACAGATTATTTTACATTAGGAAGCTTAGGACTTGCTGAATATACAGATCATGTTTC

>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000535264_chr5_64872706_+_1544nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGATGTTTACTGAACTGCAACAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAG
AAGGTTGATGCTGTAAGATTAATTAATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATA
AATGTAGAGACAAACCGGTGTGTGCGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAA
AAGCATCGTGCTGCAACTACTATAGAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACA
TCATTCAAAAAGAATAGATTTTATATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAG
AAACCTTCTAAAGAAGAAGTCATGGCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGA
GACATTCACACCAAACTTTTTCCTGTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCAT
ACATTTCACCGTATAATTAAGGGCTTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAA
TTTGAAGATGAATTTCATTCAACATTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAG
TTTTTCATAACGGTAGTACCAACGCCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGG
ATCTCCAACGTCAAAGTCAATCCCAAAACAGATAAGCCCTATGAGGATGTCAGCATCATAAATATTACTGTCAAGTAAAATAAGATTTGT

>In-frame_ASXL2_ENST00000435504_chr2_26029098_-_PPWD1_ENST00000538977_chr5_64872706_+_1649nt
ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG
CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT
TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC
CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAA
AAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGAAGTGGGACTTCTCCT
CTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACT
TTGAAGATGTTTACTGAACTGCAACAGATGAGGCAACAGTTACCAGACATGGAATTTGGCCGACGAATGGCTGTAGAACGTGAGTTGGAG
AAGGTTGATGCTGTAAGATTAATTAATATAGTTTTTGATGAAACTGGACACTTCGTGCTGTATGGAACAATGCTGGGCATTAAAGTTATA
AATGTAGAGACAAACCGGTGTGTGCGGATTTTAGGCAAACAAGAAAATATTAGAGTGATGCAATTGGCTTTGTTCCAGGGGATAGCCAAA
AAGCATCGTGCTGCAACTACTATAGAAATGAAAGCTTCTGAAAATCCTGTTCTTCAGAATATTCAAGCTGACCCAACAATAGTCTGTACA
TCATTCAAAAAGAATAGATTTTATATGTTTACCAAACGAGAACCAGAAGATACGAAAAGTGCAGATTCTGATCGAGATGTTTTTAATGAG
AAACCTTCTAAAGAAGAAGTCATGGCAGCTACTCAAGCTGAAGGACCTAAACGAGTTTCGGACAGTGCCATTATCCACACCAGCATGGGA
GACATTCACACCAAACTTTTTCCTGTTGAGTGCCCTAAGACAGTGGAAAACTTCTGTGTTCACAGCAGAAATGGTTATTATAATGGGCAT
ACATTTCACCGTATAATTAAGGGCTTTATGATTCAGACTGGAGATCCAACAGGTACTGGTATGGGAGGAGAAAGCATATGGGGAGGAGAA
TTTGAAGATGAATTTCATTCAACATTACGACATGACAGGCCATACACACTCAGCATGGCTAACGCGGGATCAAATACTAATGGATCCCAG
TTTTTCATAACGGTAGTACCAACGCCTTGGCTTGATAATAAGCATACAGTATTTGGACGAGTGACTAAAGGAATGGAAGTTGTACAGAGG
ATCTCCAACGTCAAAGTCAATCCCAAAACAGATAAGCCCTATGAGGATGTCAGCATCATAAATATTACTGTCAAGTAAAATAAGATTTGT
TTTAATGTACTTGCAAATAAAAATACAATATTAAACAGATTATTTTACATTAGGAAGCTTAGGACTTGCTGAATATACAGATCATGTTTC


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FusionGenePPI for ASXL2_PPWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASXL2TRAF6, BAP1, APP, PRPF40A, HECW2, KDM1B, MBD6, FOXK1, MBD5, EXOSC2, KRBOX4, FOXK2, OGT, HCFC1, UBC, TRIM25PPWD1EED, ADRBK1, ACOX1, DDX6, PTPRF, PTBP3, NTRK1, SEC13, ZNF232


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASXL2_PPWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASXL2_PPWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASXL2C0005695Bladder Neoplasm1CTD_human
HgeneASXL2C0023467Leukemia, Myelocytic, Acute1CTD_human