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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30690

FusionGeneSummary for RBM11_RBM11

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM11_RBM11
Fusion gene ID: 30690
HgeneTgene
Gene symbol

RBM11

RBM11

Gene ID

54033

54033

Gene nameRNA binding motif protein 11RNA binding motif protein 11
Synonyms--
Cytomap

21q11.2

21q11.2

Type of geneprotein-codingprotein-coding
Descriptionsplicing regulator RBM11putative RNA-binding protein 11splicing regulator RBM11putative RNA-binding protein 11
Modification date2018052320180523
UniProtAcc

P57052

P57052

Ensembl transtripts involved in fusion geneENST00000468643, ENST00000400577, 
ENST00000468643, ENST00000400577, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 35
** MAII scorelog2(3/1*10)=4.90689059560852log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBM11 [Title/Abstract] AND RBM11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBM11

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21984414

HgeneRBM11

GO:0034599

cellular response to oxidative stress

21984414

TgeneRBM11

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21984414

TgeneRBM11

GO:0034599

cellular response to oxidative stress

21984414


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA484740RBM11chr21

15600323

+RBM11chr21

15600400

-
ChiTaRS3.1AA484725RBM11chr21

15600323

+RBM11chr21

15600400

-
ChiTaRS3.1AW969796RBM11chr21

15600323

+RBM11chr21

15600400

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000468643ENST00000468643RBM11chr21

15600323

+RBM11chr21

15600400

-
3UTR-3UTRENST00000468643ENST00000400577RBM11chr21

15600323

+RBM11chr21

15600400

-
3UTR-3UTRENST00000400577ENST00000468643RBM11chr21

15600323

+RBM11chr21

15600400

-
3UTR-3UTRENST00000400577ENST00000400577RBM11chr21

15600323

+RBM11chr21

15600400

-

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FusionProtFeatures for RBM11_RBM11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM11

P57052

RBM11

P57052

Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}. Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM11_RBM11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM11_RBM11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM11_RBM11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBM11_RBM11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource