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Fusion gene ID: 30690 |
FusionGeneSummary for RBM11_RBM11 |
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Fusion gene information | Fusion gene name: RBM11_RBM11 | Fusion gene ID: 30690 | Hgene | Tgene | Gene symbol | RBM11 | RBM11 | Gene ID | 54033 | 54033 |
Gene name | RNA binding motif protein 11 | RNA binding motif protein 11 | |
Synonyms | - | - | |
Cytomap | 21q11.2 | 21q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | splicing regulator RBM11putative RNA-binding protein 11 | splicing regulator RBM11putative RNA-binding protein 11 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P57052 | P57052 | |
Ensembl transtripts involved in fusion gene | ENST00000468643, ENST00000400577, | ENST00000468643, ENST00000400577, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 3 | 5 | |
** MAII score | log2(3/1*10)=4.90689059560852 | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RBM11 [Title/Abstract] AND RBM11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RBM11 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21984414 |
Hgene | RBM11 | GO:0034599 | cellular response to oxidative stress | 21984414 |
Tgene | RBM11 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21984414 |
Tgene | RBM11 | GO:0034599 | cellular response to oxidative stress | 21984414 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA484740 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - | ||
ChiTaRS3.1 | AA484725 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - | ||
ChiTaRS3.1 | AW969796 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000468643 | ENST00000468643 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - |
3UTR-3UTR | ENST00000468643 | ENST00000400577 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - |
3UTR-3UTR | ENST00000400577 | ENST00000468643 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - |
3UTR-3UTR | ENST00000400577 | ENST00000400577 | RBM11 | chr21 | 15600323 | + | RBM11 | chr21 | 15600400 | - |
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FusionProtFeatures for RBM11_RBM11 |
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Hgene | Tgene |
RBM11 | RBM11 |
Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}. | Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RBM11_RBM11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RBM11_RBM11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RBM11_RBM11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM11_RBM11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |