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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30667

FusionGeneSummary for RBFOX3_C4orf22

check button Fusion gene summary
Fusion gene informationFusion gene name: RBFOX3_C4orf22
Fusion gene ID: 30667
HgeneTgene
Gene symbol

RBFOX3

C4orf22

Gene ID

146713

Gene nameRNA binding fox-1 homolog 3
SynonymsFOX-3|FOX3|HRNBP3|NEUN
Cytomap

17q25.3

Type of geneprotein-coding
DescriptionRNA binding protein fox-1 homolog 3RNA binding protein, fox-1 homolog 3fox-1 homolog Chexaribonucleotide binding protein 3neuN antigenneuronal nuclei antigen
Modification date20180523
UniProtAcc

A6NFN3

Q6V702

Ensembl transtripts involved in fusion geneENST00000453134, ENST00000583458, 
ENST00000415831, ENST00000582043, 
ENST00000580155, ENST00000584778, 
ENST00000578887, 
ENST00000358105, 
ENST00000508675, ENST00000512931, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 3=75
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBFOX3 [Title/Abstract] AND C4orf22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA120291RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000453134ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000453134ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000453134ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000583458ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000583458ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000583458ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000415831ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000415831ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000415831ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000582043ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000582043ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000582043ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000580155ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000580155ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000580155ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000584778ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000584778ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000584778ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000578887ENST00000358105RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000578887ENST00000508675RBFOX3chr17

77303842

-C4orf22chr4

81550834

-
intron-intronENST00000578887ENST00000512931RBFOX3chr17

77303842

-C4orf22chr4

81550834

-

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FusionProtFeatures for RBFOX3_C4orf22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBFOX3

A6NFN3

C4orf22

Q6V702

Pre-mRNA alternative splicing regulator. Regulatesalternative splicing of RBFOX2 to enhance the production of mRNAspecies that are targeted for nonsense-mediated decay (NMD).{ECO:0000250|UniProtKB:Q8BIF2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBFOX3_C4orf22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBFOX3_C4orf22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBFOX3_C4orf22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBFOX3_C4orf22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource