FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30662

FusionGeneSummary for RBFOX2_MPPED1

check button Fusion gene summary
Fusion gene informationFusion gene name: RBFOX2_MPPED1
Fusion gene ID: 30662
HgeneTgene
Gene symbol

RBFOX2

MPPED1

Gene ID

23543

758

Gene nameRNA binding fox-1 homolog 2metallophosphoesterase domain containing 1
SynonymsFOX2|Fox-2|HNRBP2|HRNBP2|RBM9|RTA|dJ106I20.3|fxh239AB|C22orf1|FAM1A
Cytomap

22q12.3

22q13.2

Type of geneprotein-codingprotein-coding
DescriptionRNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activitymetallophosphoesterase domain-containing protein 1adult brain protein 239
Modification date2018052320180519
UniProtAcc

O43251

O15442

Ensembl transtripts involved in fusion geneENST00000405409, ENST00000414461, 
ENST00000449924, ENST00000262829, 
ENST00000397303, ENST00000359369, 
ENST00000416721, ENST00000438146, 
ENST00000417669, ENST00000414469, 
ENST00000439548, ENST00000443721, 
ENST00000465861, ENST00000542779, 
ENST00000538182, 
Fusion gene scores* DoF score13 X 8 X 8=8322 X 2 X 2=8
# samples 142
** MAII scorelog2(14/832*10)=-2.57115670119613
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: RBFOX2 [Title/Abstract] AND MPPED1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBFOX2

GO:0030520

intracellular estrogen receptor signaling pathway

11875103

HgeneRBFOX2

GO:0045892

negative regulation of transcription, DNA-templated

11875103


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-S9-A7R7-01ARBFOX2chr22

36334895

-MPPED1chr22

43870616

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000405409ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000405409ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000405409ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000405409ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000405409ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000405409ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000405409ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000414461ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000414461ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000414461ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000414461ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000414461ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000414461ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000414461ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000449924ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000449924ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000449924ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000449924ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000449924ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000449924ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000449924ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000262829ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000262829ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000262829ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000262829ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000262829ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000262829ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000262829ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000397303ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000397303ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000397303ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000397303ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000397303ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000397303ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000397303ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-3CDSENST00000359369ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-3CDSENST00000359369ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-5UTRENST00000359369ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-5UTRENST00000359369ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-intronENST00000359369ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-intronENST00000359369ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5UTR-intronENST00000359369ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000416721ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-3CDSENST00000416721ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000416721ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-5UTRENST00000416721ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000416721ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000416721ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
intron-intronENST00000416721ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
Frame-shiftENST00000438146ENST00000417669RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
Frame-shiftENST00000438146ENST00000414469RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5CDS-5UTRENST00000438146ENST00000439548RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5CDS-5UTRENST00000438146ENST00000443721RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5CDS-intronENST00000438146ENST00000465861RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5CDS-intronENST00000438146ENST00000542779RBFOX2chr22

36334895

-MPPED1chr22

43870616

+
5CDS-intronENST00000438146ENST00000538182RBFOX2chr22

36334895

-MPPED1chr22

43870616

+

Top

FusionProtFeatures for RBFOX2_MPPED1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBFOX2

O43251

MPPED1

O15442

May have metallophosphoesterase activity (in vitro).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RBFOX2_MPPED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RBFOX2_MPPED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBFOX2RHOXF2, DAZAP2, DMRTB1, RBPMS, ESR1, ESR2, TOLLIP, POLR3D, ELAVL2, HNRNPAB, ZNF137P, MED7, NR2E3, CHAF1A, GTF2A1L, RBFOX2, BRD7, DEDD2, GLIS2, ELAVL1, CUL3, ATXN1, QKI, RBFOX1, ATN1, ATXN1L, RERE, VCP, SNRPC, SF3A1, U2AF2, RBM23, RBM22, DDX5, HNRNPK, SMN1, HNRNPF, HNRNPH2, RBM42, PTBP1, KHDRBS1, PSMF1, APH1A, RPA1, RPA2, RPA3, CAMK2B, DAB1, PSMA3, RNF8, MAGED1, VAC14, BOLL, C1orf94, NAF1, MAPK1IP1L, BMI1, TRMT61A, PRMT5, EIF4G3, MBNL1, RBPMS2, LARP4B, PUM1, PUM2, RBM38, HELZ, DPH2, GPATCH8, FNDC3B, FAM136A, PRRC2A, ATXN2, COPRS, JMJD4, CLNS1A, ANKRD40, RBMS1, RIOK1, MSI2, OTUD4, HOXA5, UBAP2, PLEKHB1, C19orf52, PJA1, FBXO7, BCS1L, PARL, UNK, NTRK1, CEP164, APC, MATR3, PHF12, GATAD1, RBMS2, NR3C1, TRIM25MPPED1DISC1, TK1, ANXA7, SPP1, CUL4B, CIAO1, CCT7, PHKA1, PHKA2, CCT6B, MMS19, NR2F6, NR2F1, NR2F2, CLUH, PHKB, UCKL1, NARF, TXNDC9, MPPED2, UCK1, DNPEP, PHKG2, USP33, UPRT, ZNF232, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RBFOX2_MPPED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RBFOX2_MPPED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBFOX2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneRBFOX2C0036095Salivary Gland Neoplasms1CTD_human