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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30649

FusionGeneSummary for RBFA_TXNL4A

check button Fusion gene summary
Fusion gene informationFusion gene name: RBFA_TXNL4A
Fusion gene ID: 30649
HgeneTgene
Gene symbol

RBFA

TXNL4A

Gene ID

79863

10907

Gene nameribosome binding factor Athioredoxin like 4A
SynonymsC18orf22|HsT169BMKS|DIB1|DIM1|SNRNP15|TXNL4|U5-15kD
Cytomap

18q23

18q23

Type of geneprotein-codingprotein-coding
Descriptionputative ribosome-binding factor A, mitochondrialribosome binding factor A (putative)thioredoxin-like protein 4ADIM1 protein homologspliceosomal U5 snRNP-specific 15 kDa proteinthioredoxin-like 4thioredoxin-like U5 snRNP protein U5-15kD
Modification date2018051920180523
UniProtAcc

Q8N0V3

P83876

Ensembl transtripts involved in fusion geneENST00000306735, ENST00000586847, 
ENST00000262197, 		ENST00000269601, 
ENST00000585474, ENST00000588162, 
ENST00000592957, ENST00000592837, 
ENST00000591711, ENST00000589926, 
Fusion gene scores* DoF score4 X 5 X 5=1001 X 2 X 2=4
# samples 72
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: RBFA [Title/Abstract] AND TXNL4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0BR-01ARBFAchr18

77798617

+TXNL4Achr18

77790577

-
TCGALDUCECTCGA-AJ-A2QM-01ARBFAchr18

77797506

+TXNL4Achr18

77737701

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306735ENST00000269601RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000306735ENST00000585474RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000306735ENST00000588162RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-5UTRENST00000306735ENST00000592957RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000306735ENST00000592837RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000306735ENST00000591711RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000306735ENST00000589926RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-intronENST00000586847ENST00000269601RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-intronENST00000586847ENST00000585474RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-intronENST00000586847ENST00000588162RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-5UTRENST00000586847ENST00000592957RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-intronENST00000586847ENST00000592837RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-intronENST00000586847ENST00000591711RBFAchr18

77798617

+TXNL4Achr18

77790577

-
intron-intronENST00000586847ENST00000589926RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000262197ENST00000269601RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000262197ENST00000585474RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000262197ENST00000588162RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-5UTRENST00000262197ENST00000592957RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000262197ENST00000592837RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000262197ENST00000591711RBFAchr18

77798617

+TXNL4Achr18

77790577

-
5CDS-intronENST00000262197ENST00000589926RBFAchr18

77798617

+TXNL4Achr18

77790577

-
In-frameENST00000306735ENST00000269601RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000306735ENST00000585474RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-intronENST00000306735ENST00000588162RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000306735ENST00000592957RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000306735ENST00000592837RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000306735ENST00000591711RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-intronENST00000306735ENST00000589926RBFAchr18

77797506

+TXNL4Achr18

77737701

-
Frame-shiftENST00000586847ENST00000269601RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000586847ENST00000585474RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-intronENST00000586847ENST00000588162RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000586847ENST00000592957RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000586847ENST00000592837RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000586847ENST00000591711RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-intronENST00000586847ENST00000589926RBFAchr18

77797506

+TXNL4Achr18

77737701

-
In-frameENST00000262197ENST00000269601RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000262197ENST00000585474RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-intronENST00000262197ENST00000588162RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000262197ENST00000592957RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000262197ENST00000592837RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000262197ENST00000591711RBFAchr18

77797506

+TXNL4Achr18

77737701

-
5CDS-intronENST00000262197ENST00000589926RBFAchr18

77797506

+TXNL4Achr18

77737701

-

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FusionProtFeatures for RBFA_TXNL4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBFA

Q8N0V3

TXNL4A

P83876

Essential role in pre-mRNA splicing as component of theU5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved inspliceosome assembly. {ECO:0000269|PubMed:10610776}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBFA_TXNL4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBFA_TXNL4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBFAKBTBD7, CMTM5, SCN2B, EPB41L3, METTL15, CDH5, ZZEF1, TRIM69, EXT2, SIRT1, HECTD3, KBTBD6, ZNF638, CD70TXNL4APQBP1, RHEBL1, HNRNPF, USP39, PRPF4, PRPF6, WDFY1, EXOC5, LZTS2, DDX23, TSSC4, SNRNP40, UNK, CBR1, GRIA2, GSTP1, ID1, KIFC3, KRAS, RET, TSNAX, SYNCRIP, USP43, NANOG, CD2BP2, SNRPN, SNRPF, SNRPG, PRPF3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBFA_TXNL4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBFA_TXNL4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource