FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30648

FusionGeneSummary for RBFA_RBFA

check button Fusion gene summary
Fusion gene informationFusion gene name: RBFA_RBFA
Fusion gene ID: 30648
HgeneTgene
Gene symbol

RBFA

RBFA

Gene ID

79863

79863

Gene nameribosome binding factor Aribosome binding factor A
SynonymsC18orf22|HsT169C18orf22|HsT169
Cytomap

18q23

18q23

Type of geneprotein-codingprotein-coding
Descriptionputative ribosome-binding factor A, mitochondrialribosome binding factor A (putative)putative ribosome-binding factor A, mitochondrialribosome binding factor A (putative)
Modification date2018051920180519
UniProtAcc

Q8N0V3

Q8N0V3

Ensembl transtripts involved in fusion geneENST00000306735, ENST00000586847, 
ENST00000262197, 
ENST00000306735, 
ENST00000586847, ENST00000262197, 
Fusion gene scores* DoF score4 X 5 X 5=1001 X 1 X 1=1
# samples 73
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/1*10)=4.90689059560852
Context

PubMed: RBFA [Title/Abstract] AND RBFA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE222251RBFAchr18

77806102

-RBFAchr18

77805756

+
ChiTaRS3.1BE669569RBFAchr18

77806102

-RBFAchr18

77805756

+
ChiTaRS3.1BE551363RBFAchr18

77806102

-RBFAchr18

77805756

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306735ENST00000306735RBFAchr18

77806102

-RBFAchr18

77805756

+
5CDS-intronENST00000306735ENST00000586847RBFAchr18

77806102

-RBFAchr18

77805756

+
5CDS-intronENST00000306735ENST00000262197RBFAchr18

77806102

-RBFAchr18

77805756

+
intron-intronENST00000586847ENST00000306735RBFAchr18

77806102

-RBFAchr18

77805756

+
intron-intronENST00000586847ENST00000586847RBFAchr18

77806102

-RBFAchr18

77805756

+
intron-intronENST00000586847ENST00000262197RBFAchr18

77806102

-RBFAchr18

77805756

+
3UTR-intronENST00000262197ENST00000306735RBFAchr18

77806102

-RBFAchr18

77805756

+
3UTR-intronENST00000262197ENST00000586847RBFAchr18

77806102

-RBFAchr18

77805756

+
3UTR-intronENST00000262197ENST00000262197RBFAchr18

77806102

-RBFAchr18

77805756

+

Top

FusionProtFeatures for RBFA_RBFA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBFA

Q8N0V3

RBFA

Q8N0V3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RBFA_RBFA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RBFA_RBFA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RBFA_RBFA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RBFA_RBFA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource