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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30647

FusionGeneSummary for RBFA_MRPS35

check button Fusion gene summary
Fusion gene informationFusion gene name: RBFA_MRPS35
Fusion gene ID: 30647
HgeneTgene
Gene symbol

RBFA

MRPS35

Gene ID

79863

60488

Gene nameribosome binding factor Amitochondrial ribosomal protein S35
SynonymsC18orf22|HsT169HDCMD11P|MDS023|MRP-S28|MRPS28
Cytomap

18q23

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionputative ribosome-binding factor A, mitochondrialribosome binding factor A (putative)28S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35
Modification date2018051920180523
UniProtAcc

Q8N0V3

P82673

Ensembl transtripts involved in fusion geneENST00000306735, ENST00000586847, 
ENST00000262197, 
ENST00000081029, 
ENST00000538315, 
Fusion gene scores* DoF score4 X 5 X 5=1009 X 4 X 6=216
# samples 79
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBFA [Title/Abstract] AND MRPS35 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A1L0-01ARBFAchr18

77796710

+MRPS35chr12

27890472

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000306735ENST00000081029RBFAchr18

77796710

+MRPS35chr12

27890472

+
Frame-shitENST00000306735ENST00000538315RBFAchr18

77796710

+MRPS35chr12

27890472

+
3UTR-3CDSENST00000586847ENST00000081029RBFAchr18

77796710

+MRPS35chr12

27890472

+
3UTR-3CDSENST00000586847ENST00000538315RBFAchr18

77796710

+MRPS35chr12

27890472

+
Frame-shitENST00000262197ENST00000081029RBFAchr18

77796710

+MRPS35chr12

27890472

+
Frame-shitENST00000262197ENST00000538315RBFAchr18

77796710

+MRPS35chr12

27890472

+

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FusionProtFeatures for RBFA_MRPS35


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBFA

Q8N0V3

MRPS35

P82673


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBFA_MRPS35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBFA_MRPS35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBFAKBTBD7, CMTM5, SCN2B, EPB41L3, METTL15, CDH5, ZZEF1, TRIM69, EXT2, SIRT1, HECTD3, KBTBD6, ZNF638, CD70MRPS35USP42, UBC, ICT1, CUL3, CAND1, MRPS5, MRPS22, MRPS18B, MRPS26, MRPL42, MRPS25, UQCRFS1P1, LAMTOR3, ILF3, EIF3C, LRPPRC, SLC1A5, RPLP1, ATP6V1C1, ABCC2, SOX2, CEP250, HAUS2, BTRC, NOL12, TRA2A, ZC3H3, TRMT10B, ZBTB38, MRPS31, DAP3, HNRNPA1, NTRK1, ATP1B1, MRPS23, MRPS2, PTCD3, MRPS7, MRPS9, EPHA2, HNRNPU, RAP1B, AURKA, PHF8, MRPL50, NANOG, POU5F1, TRUB2, C17orf89, COQ4, COQ5, DUSP11, DUSP5, MRPS34, ZBTB48, MRPS11, MRPS27, E4F1, RRS1, AURKAIP1, PDGFB, MRPS15, ZNF331, PPAN, ZNF169, ZNF2, SNRNP70, FGF8, ZNF707, ZFC3H1, RPS8, ZNF263, GLTSCR2, ZNF324B, CCDC59, RPL18, RBM42, ZC3HAV1, H2AFX, HNRNPDL, RPL6, CFAP20, COX15, DLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBFA_MRPS35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBFA_MRPS35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource