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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 30643

FusionGeneSummary for RBCK1_MYO18A

check button Fusion gene summary
Fusion gene informationFusion gene name: RBCK1_MYO18A
Fusion gene ID: 30643
HgeneTgene
Gene symbol

RBCK1

MYO18A

Gene ID

10616

399687

Gene nameRANBP2-type and C3HC4-type zinc finger containing 1myosin XVIIIA
SynonymsC20orf18|HOIL-1|HOIL1|PBMEI|PGBM1|RBCK2|RNF54|UBCE7IP3|XAP3|XAP4|ZRANB4MAJN|MYSPDZ|SP-R210|SPR210
Cytomap

20p13

17q11.2

Type of geneprotein-codingprotein-coding
DescriptionranBP-type and C3HC4-type zinc finger-containing protein 1HBV-associated factor 4RBCC protein interacting with PKC1RING finger protein 54RING-type E3 ubiquitin transferase HOIL-1heme-oxidized IRP2 ubiquitin ligase 1hepatitis B virus X-associated prounconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210
Modification date2018052720180519
UniProtAcc

Q9BYM8

Q92614

Ensembl transtripts involved in fusion geneENST00000356286, ENST00000353660, 
ENST00000382181, ENST00000475269, 
ENST00000400245, ENST00000400247, 
ENST00000354329, ENST00000529578, 
ENST00000533112, ENST00000531253, 
ENST00000527372, 
Fusion gene scores* DoF score7 X 4 X 6=16815 X 13 X 10=1950
# samples 620
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1950*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBCK1 [Title/Abstract] AND MYO18A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBCK1

GO:0000209

protein polyubiquitination

12629548|17006537

HgeneRBCK1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

17449468

HgeneRBCK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19136968|21455173

HgeneRBCK1

GO:0050852

T cell receptor signaling pathway

20005846

HgeneRBCK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19136968

HgeneRBCK1

GO:0097039

protein linear polyubiquitination

21455173|21455180|21455181|23453807


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-23-1120-01ARBCK1chr20

389423

+MYO18Achr17

27401932

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356286ENST00000354329RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000356286ENST00000529578RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000356286ENST00000533112RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000356286ENST00000531253RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000356286ENST00000527372RBCK1chr20

389423

+MYO18Achr17

27401932

-
Frame-shiftENST00000353660ENST00000354329RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000353660ENST00000529578RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000353660ENST00000533112RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000353660ENST00000531253RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000353660ENST00000527372RBCK1chr20

389423

+MYO18Achr17

27401932

-
5UTR-3CDSENST00000382181ENST00000354329RBCK1chr20

389423

+MYO18Achr17

27401932

-
5UTR-5UTRENST00000382181ENST00000529578RBCK1chr20

389423

+MYO18Achr17

27401932

-
5UTR-5UTRENST00000382181ENST00000533112RBCK1chr20

389423

+MYO18Achr17

27401932

-
5UTR-5UTRENST00000382181ENST00000531253RBCK1chr20

389423

+MYO18Achr17

27401932

-
5UTR-5UTRENST00000382181ENST00000527372RBCK1chr20

389423

+MYO18Achr17

27401932

-
In-frameENST00000475269ENST00000354329RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000475269ENST00000529578RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000475269ENST00000533112RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000475269ENST00000531253RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000475269ENST00000527372RBCK1chr20

389423

+MYO18Achr17

27401932

-
3UTR-3CDSENST00000400245ENST00000354329RBCK1chr20

389423

+MYO18Achr17

27401932

-
3UTR-5UTRENST00000400245ENST00000529578RBCK1chr20

389423

+MYO18Achr17

27401932

-
3UTR-5UTRENST00000400245ENST00000533112RBCK1chr20

389423

+MYO18Achr17

27401932

-
3UTR-5UTRENST00000400245ENST00000531253RBCK1chr20

389423

+MYO18Achr17

27401932

-
3UTR-5UTRENST00000400245ENST00000527372RBCK1chr20

389423

+MYO18Achr17

27401932

-
Frame-shiftENST00000400247ENST00000354329RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000400247ENST00000529578RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000400247ENST00000533112RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000400247ENST00000531253RBCK1chr20

389423

+MYO18Achr17

27401932

-
5CDS-5UTRENST00000400247ENST00000527372RBCK1chr20

389423

+MYO18Achr17

27401932

-

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FusionProtFeatures for RBCK1_MYO18A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBCK1

Q9BYM8

MYO18A

Q92614

E3 ubiquitin-protein ligase, which accepts ubiquitinfrom specific E2 ubiquitin-conjugating enzymes, such asUBE2L3/UBCM4, and then transfers it to substrates. Functions as anE3 ligase for oxidized IREB2 and both heme and oxygen arenecessary for IREB2 ubiquitination. Promotes ubiquitination ofTAB2 and IRF3 and their degradation by the proteasome. Componentof the LUBAC complex which conjugates linear ('Met-1'-linked)polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBACconjugates linear polyubiquitin to IKBKG and RIPK1 and is involvedin activation of the canonical NF-kappa-B and the JNK signalingpathways. Linear ubiquitination mediated by the LUBAC complexinterferes with TNF-induced cell death and thereby preventsinflammation. LUBAC is proposed to be recruited to the TNF-R1signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linearpolyubiquitin to IKBKG and possibly other components contributingto the stability of the complex. Together with FAM105B/otulin, theLUBAC complex regulates the canonical Wnt signaling duringangiogenesis. Binds polyubiquitin of different linkage types.{ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537,ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448,ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846,ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180,ECO:0000269|PubMed:21455181}. May link Golgi membranes to the cytoskeleton andparticipate in the tensile force required for vesicle budding fromthe Golgi. Thereby, may play a role in Golgi membrane traffickingand could indirectly give its flattened shape to the Golgiapparatus (PubMed:19837035, PubMed:23345592). Alternatively, inconcert with LURAP1 and CDC42BPA/CDC42BPB, has been involved inmodulating lamellar actomyosin retrograde flow that is crucial tocell protrusion and migration (PubMed:18854160). May be involvedin the maintenance of the stromal cell architectures required forcell to cell contact (By similarity). Regulates trafficking,expression, and activation of innate immune receptors onmacrophages. Plays a role to suppress inflammatory responsivenessof macrophages via a mechanism that modulates CD14 trafficking(PubMed:25965346). Acts as a receptor of surfactant-associatedprotein A (SFTPA1/SP-A) and plays an important role ininternalization and clearance of SFTPA1-opsonized S.aureus byalveolar macrophages (PubMed:16087679, PubMed:21123169). Stronglyenhances natural killer cell cytotoxicity (PubMed:27467939).{ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679,ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592,ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+111233_26113469Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+112233_2617511Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+11155_11913469DomainUbiquitin-like
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+11255_1197511DomainUbiquitin-like
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+111193_22213469Zinc fingerRanBP2-type
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+111282_32713469Zinc fingerRING-type 1
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+111362_41113469Zinc fingerNote=IBR-type
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+111437_46313469Zinc fingerRING-type 2
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+112193_2227511Zinc fingerRanBP2-type
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+112282_3277511Zinc fingerRING-type 1
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+112362_4117511Zinc fingerNote=IBR-type
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+112437_4637511Zinc fingerRING-type 2
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-40421246_197120062055Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-39411246_197119912040Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-38401246_197119542003Coiled coilOntology_term=ECO:0000255
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-40426_2520062055Compositional biasNote=Lys-rich
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-39416_2519912040Compositional biasNote=Lys-rich
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-38406_2519542003Compositional biasNote=Lys-rich
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-40421188_121720062055DomainIQ
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-4042220_31120062055DomainPDZ
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-4042349_40120062055DomainMyosin N-terminal SH3-like
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-4042405_118520062055DomainMyosin motor
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-39411188_121719912040DomainIQ
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-3941220_31119912040DomainPDZ
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-3941349_40119912040DomainMyosin N-terminal SH3-like
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-3941405_118519912040DomainMyosin motor
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-38401188_121719542003DomainIQ
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-3840220_31119542003DomainPDZ
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-3840349_40119542003DomainMyosin N-terminal SH3-like
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-3840405_118519542003DomainMyosin motor
TgeneMYO18Achr20:389423chr17:27401932ENST00000527372-4042498_50520062055Nucleotide bindingATP
TgeneMYO18Achr20:389423chr17:27401932ENST00000531253-3941498_50519912040Nucleotide bindingATP
TgeneMYO18Achr20:389423chr17:27401932ENST00000533112-3840498_50519542003Nucleotide bindingATP


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FusionGeneSequence for RBCK1_MYO18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MYO18A_ENST00000354329_chr17_27401932_-_55aa

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MYO18A_ENST00000354329_chr17_27401932_-_55aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MYO18A_ENST00000354329_chr17_27401932_-_167nt
ATGGACGAGAAGACCAAGAAAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACA

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MYO18A_ENST00000354329_chr17_27401932_-_167nt
ATGGACGAGAAGACCAAGAAAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MYO18A_ENST00000354329_chr17_27401932_-_2132nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCCCCACCAGCTACTGGAAGTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCTCCAGACCGCGAT
ACTCCCACAGTTATCTGAGTGACAGCGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCCCTCTCA
CCCCAGGGCCTGTGGCTGCCTGGGCACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACA
CCCTGACCTTCTTCTGTCAGGGGCACTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGAGGAGTTTCTGAA
GAGAACTTTTTGCTCCTCTGTCTCAAAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGGCCTGGCACTGCA
TGGAGCCAGCACGTTGACCTCCCTCTCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTTGCTGGGTCCAT
GGGGAGGATTGGGGGAGGAGAAGCAGTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTTT
AATTTAAATACCCAACCTCTCCATCACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGG
GAATGTCATCTCCATCTTCACCCTTCAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTA
AGAATGAGGTGCGGAGGGGCTCTCCGGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGACCATCCGCACCTC
CAGCCCCCACCCCACCCTCTTTGTCTCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGCAGTTCAGGGCTG
ATCCAAGCACTGCCTCCCTCCTGCTCTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGACTTGTGA
TCAGAAAAACTGAAGATGGAAGTTTTGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCT
CCCTGCCCCCACACACTTATCCCAGACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCCCTGAGAACTCCA
CCAGACTTGGGAGCCCAAGTGCAGTGCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTACTCACTGGGCTG

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MYO18A_ENST00000354329_chr17_27401932_-_2107nt
GGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGAGGACGGGGTGGGGTCGCCCCAAACA
GGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTT
CCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGG
GCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCC
CGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGG
CGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGC
ACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCA
TTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGCCCCACCAGCTACTGGAA
GTCCCTTGCCCCTGATCGGTCAGATGATGAGCACGACCCTCTCGACAACACCTCCAGACCGCGATACTCCCACAGTTATCTGAGTGACAG
CGACACAGAGGCCAAGCTGACGGAGACTAACGCATAGCCCAGGGGAGTGGTTGGCAGCCCTCTCACCCCAGGGCCTGTGGCTGCCTGGGC
ACCTCTCCCAGGAAGTGGTGGGGCACCGGTCTCCCCCACCCGACTGCTGATCTGCATGGGAAACACCCTGACCTTCTTCTGTCAGGGGCA
CTTTCCAGGCTATGGGTGTCTGATGTCTCCACGTGGAAGAGGTGGGGGAAAGAGGAGTTTCTGAAGAGAACTTTTTGCTCCTCTGTCTCA
AAATGCCAGACTCTTGGCTTCTACCCTGTGTCACCGTGGGCAGTGGCAGGTGGCCTGGCACTGCATGGAGCCAGCACGTTGACCTCCCTC
TCAGCTCCCTGCTCAGGGACGGTGGACAGGTTGCCTACTGGGACACTCTAGGTTGCTGGGTCCATGGGGAGGATTGGGGGAGGAGAAGCA
GTGCCTTCCCTCTCGTGTGGGGTGGGGGCTCTCTCTTCTTGGTGCCTGCTGTCTTTCTACTTTTTAATTTAAATACCCAACCTCTCCATC
ACAGCTGCATCCCTGAGAGTGGGAGGGGGCTGTAGTGGTAGCTGGGGCTCCCAAGAACGACTCGGGAATGTCATCTCCATCTTCACCCTT
CAGAGAGCAGTCCTTTCTCTGTGCAGCTGGAGACGCTGGTGAGGAGAGCCGGGTCCAGGTTCTTAAGAATGAGGTGCGGAGGGGCTCTCC
GGTGCTGCTGGGCTGGGTTGAGCAAGCCTACGCAGACAAGTGTGTGTGTGGACCATCCGCACCTCCAGCCCCCACCCCACCCTCTTTGTC
TCAGCGTGTTATGTGCAATGACCTATTTAAGGTAAACCCATTCCAACTACAGCAGTTCAGGGCTGATCCAAGCACTGCCTCCCTCCTGCT
CTGTCCAGGTGGTCTGGACCATAAACTCAACTTGAGAGGGAAGGCTTGGGGTTGAGGACTTGTGATCAGAAAAACTGAAGATGGAAGTTT
TGGCCGGTGCTCATTAGACATGAGTCCTCACTCTGTGTCCTGAGCCCGTGTCATTCTTCCAACCTCCCTGCCCCCACACACTTATCCCAG
ACACAACACCATGTGGTCTGGAGGTCCCAGCCCCCACCCTAAAAAGGTTATCCCTGAGAACTCCACCAGACTTGGGAGCCCAAGTGCAGT
GCCTGGTGCTGCTCCCATCTGCCGCCCCCCTTCTCTCCTGCAATTGGTTTGTACTCACTGGGCTGTGCTCTCCCCTGTTTACCCGATGTA


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FusionGenePPI for RBCK1_MYO18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBCK1UBC, RBCK1, PRKCB, BACH1, UBE2D3, IKBKG, UBE2G1, UBE2L3, UBE2L6, UBE2N, UBE2U, UBE2D4, UBE2S, UBE2K, IREB2, TNF, RNF31, TRAF1, TRIM25, DDX58, NEDD4, NOD2, PSMD4, TAB2, TAB3, MAP3K7, TRAF6, RIPK1, NR2C2, PML, ESR1, SHARPIN, TNFAIP3, APP, NR1I2, UCHL5, USP2, USP7, USP15, USP21, USP32, USP49, PAN2, OTUB2, OTUD6A, BIRC3, OTULIN, MKRN2, TRIML1, UHRF2, PCGF2, RNF181, TRIM65, TRIM21, FKBPL, HSP90AA1, ARNT2, PARK2, PRKCA, NAA10, NDUFAF3, TSSK3, SYCE1, UBE2D1, UBE2D2, MAP3K1, LTBR, LDLRAD4, MALT1, SMURF1, PDLIM7, TLR3, TNFRSF1A, LMO2, RABGEF1, ARPC5MYO18AGRB2, ARAF, MARK4, CUL4B, ATXN1, PAN2, ENO1, SHMT2, MOV10, NXF1, YIF1B, DDRGK1, LIMS1, LRFN4, PYCR2, UPK3B, RCN1, SEPT1, SP6, CDKL4, FIG4, SLC30A6, SPC25, UQCRB, YEATS4, DDX46, DIEXF, PUF60, SMARCA4, ACTA1, ACTB, ACTG1, ACTN4, AP2A1, ANXA2, DST, CALM1, CAPZA1, CAPZA2, CAPZB, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CSNK1A1, DAB2, DAPK3, DBN1, DSG2, CTTN, FLII, FLNA, FLNB, FYN, GSN, HMGB2, ABLIM1, LMO7, MYO1B, MYH9, MYL6, MYO1C, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, PIK3C2A, PLEC, PPP1CA, PPP1CB, TWF1, RANGAP1, SPTAN1, SPTBN1, SPTBN2, SSFA2, ST5, SVIL, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, PICALM, SORBS2, LRRFIP2, TJP2, CDC42BPB, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, BASP1, DCTN2, MYL12A, DSTN, TRIOBP, AKAP2, SYNPO, CEP162, LIMCH1, SIPA1L3, MPRIP, COBL, SPECC1L, FBXO46, CORO1C, CCRN4L, PLEKHG3, RAI14, TES, TMOD3, LIMA1, BMP2K, MYO5C, CORO1B, KIAA1211, CGN, MICAL3, ARHGAP21, AFAP1, INF2, EFHD2, CYBRD1, MYO19, ARPC5L, KCTD10, LZTS2, STON2, SSH2, PHLDB2, NEXN, SPECC1, MISP, MYL6B, PPP1R18, TPRN, DDX51, CDK2, IQGAP1, PLK2, ANLN, GAN, MYL3, RPL15, PATL1, HBZ, NOX4, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+1111_22013469IRF3
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+1121_2207511IRF3
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+11169_13113469RNF31
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+11269_1317511RNF31
HgeneRBCK1chr20:389423chr17:27401932ENST00000353660+1111_27013469TAB2
HgeneRBCK1chr20:389423chr17:27401932ENST00000356286+1121_2707511TAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBCK1_MYO18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBCK1_MYO18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBCK1C0018800Cardiomegaly1CTD_human
HgeneRBCK1C4014605POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCY1ORPHANET;UNIPROT