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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 30642

FusionGeneSummary for RBCK1_MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBCK1_MACROD2
Fusion gene ID: 30642
HgeneTgene
Gene symbol

RBCK1

MACROD2

Gene ID

10616

140733

Gene nameRANBP2-type and C3HC4-type zinc finger containing 1MACRO domain containing 2
SynonymsC20orf18|HOIL-1|HOIL1|PBMEI|PGBM1|RBCK2|RNF54|UBCE7IP3|XAP3|XAP4|ZRANB4C20orf133|C2orf133
Cytomap

20p13

20p12.1

Type of geneprotein-codingprotein-coding
DescriptionranBP-type and C3HC4-type zinc finger-containing protein 1HBV-associated factor 4RBCC protein interacting with PKC1RING finger protein 54RING-type E3 ubiquitin transferase HOIL-1heme-oxidized IRP2 ubiquitin ligase 1hepatitis B virus X-associated proO-acetyl-ADP-ribose deacetylase MACROD2MACRO domain-containing protein 2[Protein ADP-ribosylglutamate] hydrolase
Modification date2018052720180519
UniProtAcc

Q9BYM8

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000356286, ENST00000353660, 
ENST00000382181, ENST00000475269, 
ENST00000400245, ENST00000400247, 
ENST00000217246, ENST00000310348, 
ENST00000464883, ENST00000402914, 
ENST00000378058, ENST00000407045, 
Fusion gene scores* DoF score7 X 4 X 6=16819 X 14 X 11=2926
# samples 619
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2926*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBCK1 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBCK1

GO:0000209

protein polyubiquitination

12629548|17006537

HgeneRBCK1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

17449468

HgeneRBCK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19136968|21455173

HgeneRBCK1

GO:0050852

T cell receptor signaling pathway

20005846

HgeneRBCK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19136968

HgeneRBCK1

GO:0097039

protein linear polyubiquitination

21455173|21455180|21455181|23453807

TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-78-8660-01ARBCK1chr20

389423

+MACROD2chr20

14474125

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356286ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000356286ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000356286ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000353660ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000353660ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000353660ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-3CDSENST00000382181ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-3CDSENST00000382181ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5UTR-intronENST00000382181ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000475269ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
In-frameENST00000475269ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000475269ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-3CDSENST00000400245ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-3CDSENST00000400245ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
3UTR-intronENST00000400245ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000400247ENST00000217246RBCK1chr20

389423

+MACROD2chr20

14474125

+
Frame-shiftENST00000400247ENST00000310348RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000464883RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000402914RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000378058RBCK1chr20

389423

+MACROD2chr20

14474125

+
5CDS-intronENST00000400247ENST00000407045RBCK1chr20

389423

+MACROD2chr20

14474125

+

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FusionProtFeatures for RBCK1_MACROD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBCK1

Q9BYM8

MACROD2

A1Z1Q3

E3 ubiquitin-protein ligase, which accepts ubiquitinfrom specific E2 ubiquitin-conjugating enzymes, such asUBE2L3/UBCM4, and then transfers it to substrates. Functions as anE3 ligase for oxidized IREB2 and both heme and oxygen arenecessary for IREB2 ubiquitination. Promotes ubiquitination ofTAB2 and IRF3 and their degradation by the proteasome. Componentof the LUBAC complex which conjugates linear ('Met-1'-linked)polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBACconjugates linear polyubiquitin to IKBKG and RIPK1 and is involvedin activation of the canonical NF-kappa-B and the JNK signalingpathways. Linear ubiquitination mediated by the LUBAC complexinterferes with TNF-induced cell death and thereby preventsinflammation. LUBAC is proposed to be recruited to the TNF-R1signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linearpolyubiquitin to IKBKG and possibly other components contributingto the stability of the complex. Together with FAM105B/otulin, theLUBAC complex regulates the canonical Wnt signaling duringangiogenesis. Binds polyubiquitin of different linkage types.{ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537,ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448,ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846,ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180,ECO:0000269|PubMed:21455181}. Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins.{ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+217247_38890426Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+218247_38890449Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+010247_3880214Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+0106_90214Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+014247_388-154214Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+0146_9-154214Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+06247_388-7999Compositional biasNote=Glu-rich
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+066_9-7999Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+01059_2400214DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+01459_240-154214DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+0659_240-7999DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+217185_19190426RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+21790_9290426RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+21797_10290426RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+218185_19190449RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+21890_9290449RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+21897_10290449RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+010185_1910214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+01077_790214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+01090_920214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000378058+01097_1020214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+014185_191-154214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+01477_79-154214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+01490_92-154214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000402914+01497_102-154214RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+06185_191-7999RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+0677_79-7999RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+0690_92-7999RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000407045+0697_102-7999RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111233_26113469Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112233_2617511Coiled coilOntology_term=ECO:0000255
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+11155_11913469DomainUbiquitin-like
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+11255_1197511DomainUbiquitin-like
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111193_22213469Zinc fingerRanBP2-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111282_32713469Zinc fingerRING-type 1
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111362_41113469Zinc fingerNote=IBR-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+111437_46313469Zinc fingerRING-type 2
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112193_2227511Zinc fingerRanBP2-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112282_3277511Zinc fingerRING-type 1
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112362_4117511Zinc fingerNote=IBR-type
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+112437_4637511Zinc fingerRING-type 2
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+2176_990426Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+2186_990449Compositional biasNote=Poly-Lys
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+21759_24090426DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+21859_24090449DomainMacro
TgeneMACROD2chr20:389423chr20:14474125ENST00000217246+21777_7990426RegionNote=Substrate binding
TgeneMACROD2chr20:389423chr20:14474125ENST00000310348+21877_7990449RegionNote=Substrate binding


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FusionGeneSequence for RBCK1_MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MACROD2_ENST00000217246_chr20_14474125_+_343aa
MDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVK
ENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGP
EEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETE

>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MACROD2_ENST00000310348_chr20_14474125_+_366aa
MDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVK
ENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGP
EEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETE
ELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQ

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MACROD2_ENST00000217246_chr20_14474125_+_343aa
MDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVK
ENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGP
EEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETE

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MACROD2_ENST00000310348_chr20_14474125_+_366aa
MDEKTKKANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVK
ENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGP
EEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETE
ELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MACROD2_ENST00000217246_chr20_14474125_+_1029nt
ATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTG
CTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCAT
ACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAA
GAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAAC
ACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAA
AAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCA
GAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAA
GAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGAC
CAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAA
GAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAA
AAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCA

>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MACROD2_ENST00000310348_chr20_14474125_+_1098nt
ATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTG
CTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCAT
ACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAA
GAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAAC
ACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAA
AAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCA
GAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAA
GAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGAC
CAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAA
GAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAA
AAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATG
AATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAA

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MACROD2_ENST00000217246_chr20_14474125_+_1029nt
ATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTG
CTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCAT
ACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAA
GAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAAC
ACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAA
AAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCA
GAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAA
GAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGAC
CAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAA
GAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAA
AAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCA

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MACROD2_ENST00000310348_chr20_14474125_+_1098nt
ATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTG
CTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCAT
ACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAA
GAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAAC
ACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAA
AAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCA
GAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAA
GAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGAC
CAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAA
GAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAA
AAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATG
AATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MACROD2_ENST00000217246_chr20_14474125_+_5055nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGT
AACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATA
GCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGA
TCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGG
CTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAG
TTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGT
GTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGAC
TGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGAT
GGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAAC
CAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAG
GACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAG
GAACAAAGAAATGGAACTAAATGACAATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTG
TGGAGGAGGGTGGGGGTGGGGGGAAGGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTT
TATCTGCAGAAAAAGAAAGAAAAAAAAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTAT
CCTTGTAATTTCTGTCTTTTCTCTTACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCT
GCTTTCTTGGTTATTTCACAAAGCTGGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAA
TTTTAGGAATCAATGAGCCCAGCAGCAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGA
AAAGGTCTGGACAATGAGGTGAAAATATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGA
ATTTTTTCCAGAGCAGAGTGCAGAGGCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGT
GCATCCTTCTTTGACACTGACTTTCAGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCT
GCATAACTGTAAAGGATGGCCCTTTGCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTAT
GAATATCAAAAGCTCCTCCTGAAATTGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGT
CTCATTTGAAATTACAGGAAATTAGAGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGT
TCAAGGCTGATTCAATGGTTGGTCCCCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCC
AAGATGCCAGTGGTATAGTGGGCACAAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGG
CCAGATGCCTACTTCCCACAGCCTCCCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAA
ATCCATCTTCCTTGTAAGGGCTTTAGAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCT
AAAATAAAAGGATGTTCTGCTTTCTAAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATG
ACTTTGGTTTTAGCCTTTCTGAATTTGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATAT
GCACTATATTCTAACAAATTTTTTTTAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTT
CTGTTGCTATTCCAGTTTGATATGGAAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCA
TTTTAAAGAATCCAAGAAACGATGTCATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCA
TTCTTGTGAAGTATTTGACAAGTGCAATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGA
GTTACAGTTGAAAAAAACATGAGGGAAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAAC
AGCCAGGATGGAAATTATCCAGCCCTGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGA
AGTGGAAGGAGGGAATTCTCTCTGCCTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAAT
ATCTTCAGCCCGACTCCTGAATTTGTTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTA
TTTGGCTATACAGTTTTATGCTTTAAAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGAT
CAAAGACACCTGAACACAGAAAACCTTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATT
TTCCCGCACATAAATTCTGGATGTCAATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAAT
AGCCCTATGTTAGTCATGTTTGCATACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAG
ACAAAGGGGCTTTTCCTCTAGCTGGTAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACT
GTCTGTGATACTGGGTCACATATTAATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAG
TTCTGCTTGATGCACTTGATTTGAAAAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATA
TGTTCAATATATTTTCTTGGGGAATAGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAA
TCAGAAAAAAAGTAATTTTCTTGATCAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCT
TCTGATATCTGGTATAAACTGCTAAATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTT
TGTTTCTTTTCATCTGTGCCATACACTAAAAAACAACTGTTGCCTTCATACTATATTTGTTAGAGCAGAATACAAATAAAATTTGTTTGA

>In-frame_RBCK1_ENST00000356286_chr20_389423_+_MACROD2_ENST00000310348_chr20_14474125_+_1803nt
CGCCTGCGGCCCAGCTCCTTCCCGCGGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGA
GGACGGGGTGGGGTCGCCCCAAACAGGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGA
GGTCCCGGATGAGGCGACAATTTTTCCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAA
GCCGCTCCCCTTGCGAAGAACTGGGGCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGG
GGGTCCTCCGGGACTTGGAACGCCCCGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCC
TGCGCCCAGTGCGGACCTGTCTCGGCGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTC
CCGACTGCCGCGGGGACAGCGAGGCACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCC
TCTCCCAGGCGACCCGGAGGTAGCATTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACC
AAGAAAGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGT
AACCTGAATGGCTGTGATACTGGACATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATA
GCCAGGGGCCATATTAATGGTTCCCACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGA
TCAGTTGCATTTCCCTGCATCTCAACAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGG
CTTGCCAAGAATCACCATGAGGTGGATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAG
TTTTTCTCCGTAGACGATAATAATGAAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGT
GTGGAAGAAATGGAAGAGCAGAGCCAAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGAC
TGTAAAGATGAAGATTTTGCAAAGGATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGAT
GGACAAGAGAATGATTCAACGAAGAATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAAC
CAAGAAGATGCCGTGATTGTGGAGCAACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAG
GACACACCTAGGATGCCTGGGAAAAGTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGAC
AAGGTAAATGACCCAACAGAGAGTCAACAAGAAGATCAACTAATAGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAA

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MACROD2_ENST00000217246_chr20_14474125_+_5030nt
GGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGAGGACGGGGTGGGGTCGCCCCAAACA
GGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTT
CCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGG
GCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCC
CGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGG
CGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGC
ACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCA
TTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTG
GAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGAC
ATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCC
ACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAA
CAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGG
ATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATG
AAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCC
AAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGG
ATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGA
ATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGC
AACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAA
GTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGCAGGGGCACAAGATGAAGCGAAGGAACAAAGAAATGGAACTAAATGAC
AATCCTCAGCATCGCAAGGCCTCTCCTGGCTCTGGGGGAGCTCGGGAAGATAGCAGCACACGCTGTGGAGGAGGGTGGGGGTGGGGGGAA
GGCAAGTCCCATGGAAGGACGGGGAATCCTTTACTCTAATTTCTCCAGCTGCATTTTGTTCCGTTTATCTGCAGAAAAAGAAAGAAAAAA
AAGAAAAAAAAAGTTTCCTTTAATTTGGTGGAGGGACCCATGTTGACGCATCTTTCAGGCATTATCCTTGTAATTTCTGTCTTTTCTCTT
ACAACTTTGCCCCAGGGTCACAGTGGCTTGATTGAACACTCACATGTGTATCCTGGCCCCTGTCTGCTTTCTTGGTTATTTCACAAAGCT
GGTCACACAGTGGTTTATTCAAAGGAAGGGGAGGAAGACAGTGGTTTGATAAGCTGCAGGATAAATTTTAGGAATCAATGAGCCCAGCAG
CAGTATAATCCCCAGACAGAGGAGGCAGGATAGAAAATGGGCAAAAGCCTCGGAAACCACTTGGAAAAGGTCTGGACAATGAGGTGAAAA
TATTTTCTTCAGGGTTCCCAAGGCACAATTTGTTCCAAGTGGCTAATGAGAAATATGGAAGCTGAATTTTTTCCAGAGCAGAGTGCAGAG
GCATAACAGAAGGGTGGGCCCTGGCAGCCATCTGGGTCTCTTCCTTCCTAACCATGGTGGCAGGTGCATCCTTCTTTGACACTGACTTTC
AGCAGAGCTTACTTGGTTCATGAGGTCTTCACATGGAGACTACCAGCAAGAGGTGACTCTCTGCTGCATAACTGTAAAGGATGGCCCTTT
GCTAGGTGTTACAGTTAAAAGCTAAGAAAAGGGGCAGTGCATTTAGGACCCAAACATATGCCTATGAATATCAAAAGCTCCTCCTGAAAT
TGCTGTGAGTTTTCCATAAAAGAATATCCTGTCTTCACCCAAGGCTTGACAGCCCACAGAGTGGTCTCATTTGAAATTACAGGAAATTAG
AGCTTTTGCTTGCAGTTCTGCCTTCCTGGCCTGTGTTTAAATGCTGTCACTTGTTTATGCCAAGTTCAAGGCTGATTCAATGGTTGGTCC
CCTCACCCAGAAAACCCTGAAGGGGAGGATACAGCTCTGAAGGGGGGCAGCAGTACTAAAAACCCAAGATGCCAGTGGTATAGTGGGCAC
AAGGGATGGCGACCATGAGGATGCCAGGCATCATCACCAATATCTATCCTAGAGCCAGTATAAGGCCAGATGCCTACTTCCCACAGCCTC
CCCGGGTTCCAAAGTCATGTCATTGTTTTCAGTGGAAACATATCGTTTGTTGCATATCTTCTTAAATCCATCTTCCTTGTAAGGGCTTTA
GAACTAAAACTTACTTATATTGTTTTTCCTTAACAGAGGGAGAAAAATAGTGGATTATTATTTCTAAAATAAAAGGATGTTCTGCTTTCT
AAATATCCCATCAAAATCTTCAGTTTTGCACTTTTTTGATGGAAAATTCATCTTATCTTCCTATGACTTTGGTTTTAGCCTTTCTGAATT
TGTTACCCCTTCTGGATGGCTTATTTGATATACTGGAATAGTTAACAAGCTATACTTCAGCATATGCACTATATTCTAACAAATTTTTTT
TAATAAAATCAAGACATCAGCAAGAATGACATTTACGTGACCTCATAATGTGGGATTATGGCCTTCTGTTGCTATTCCAGTTTGATATGG
AAGCATCTATATCCTCTATTGCCGTTAGATGTTGTTGCTTTTCAGAAAAGTAACGAAAAGGCTCATTTTAAAGAATCCAAGAAACGATGT
CATCCAAATATTGACAGTTTCTACATTTCATGCCATCTTTATAACTCAATTGAAAGTTGCCGTCATTCTTGTGAAGTATTTGACAAGTGC
AATCTGCTAGAAGCTCGTTTTTCTTGTGACTCCCAAATGTTAGTGCTACTTAGCCTCAGTAATGAGTTACAGTTGAAAAAAACATGAGGG
AAACAGAGGGACAGAGATTTTCTAATGAACAATGATGGAAGAGACCTAATGTCCTTGCTAGAAACAGCCAGGATGGAAATTATCCAGCCC
TGGCATTCTCCTTATCATCAATGACAGTCATTTTATTCATTTATTTCAAATGTGGGTGGGCTAGAAGTGGAAGGAGGGAATTCTCTCTGC
CTAAAAATTCTAGAAGAATGAAAGTAATCTTTGTATCCAGGAAACTAAGAGAATGAGGAATAAATATCTTCAGCCCGACTCCTGAATTTG
TTTATTCTTCCATCTATAATTAGATTGTGTTTTCATTTTTGCTTTGTCATGCTTTTTGGTTGTTATTTGGCTATACAGTTTTATGCTTTA
AAACAAATGATAAAGTTAATTTCCAATTCAATAGTGAAATATTAACAATCTAACTATAGCCAGATCAAAGACACCTGAACACAGAAAACC
TTTATTTGCTGGTGCTGCCATTGCACAGGCTGTACAATGAAATAGATTTGAAAAGCTGATTGATTTTCCCGCACATAAATTCTGGATGTC
AATTTCCAACCAAACTCCAATACAGCTATGTGGCATGAAGAGTTACAGGAGGGAGGGAGGAAAATAGCCCTATGTTAGTCATGTTTGCAT
ACAGAGGATCAAAGTAGGCCTTCACCATAATAGTTCTAATTAAAATGGTCCTCGCTGTAGGAGAGACAAAGGGGCTTTTCCTCTAGCTGG
TAACTATTCAGATGATGGACAAGTCTTCTTTCATAAAAGATTACAAAGAAGGCATCCGAATCACTGTCTGTGATACTGGGTCACATATTA
ATCACTGCAGCTAATTGTAAATCTTTCTATGAAACACTGAAAAGCCTCTTTGTGAATTAATACAGTTCTGCTTGATGCACTTGATTTGAA
AAGACATTTCTCTGTATGTGGCGCATGTCGGCTTTGCTTTGAAAAATAACAAAGTTAGCAGAATATGTTCAATATATTTTCTTGGGGAAT
AGGGTTTTTATTACATGATTCATTAAGGATTTGCCTTACCCTGACATTTGTGATATAAAGGAAAATCAGAAAAAAAGTAATTTTCTTGAT
CAAGATATGTTTTTACTTAATGCAAATAAATGTAGTCTGTTGCTTGCAAGGAAAAAAAAATGGCTTCTGATATCTGGTATAAACTGCTAA
ATAGGATAATACGTGCCTCTTTTGTTAAACCGGCATTTAAATGCTGGACTGCTTCTAAATCTGTTTGTTTCTTTTCATCTGTGCCATACA

>In-frame_RBCK1_ENST00000475269_chr20_389423_+_MACROD2_ENST00000310348_chr20_14474125_+_1778nt
GGCTCTGCGATGCGGCCCGCAGGGTGACCCGGGCGGGAGTCCGGGGACCCGCGATCAGCCCCGGAGGACGGGGTGGGGTCGCCCCAAACA
GGAGCGCCGGGACCGCTGGGACCCCGCACTCGGCGTCCGCCGCCGCCGGGTAGCCGGGCAGTGGAGGTCCCGGATGAGGCGACAATTTTT
CCGGCCCCCCCTCCCAGTCCCGCCCCACTTCCGGGGCCGCCACTTTCACTTTCTCTTCCGCCGAAGCCGCTCCCCTTGCGAAGAACTGGG
GCCTCCCGGGAGGAGAGAGGGCTTTGCCTTGAAACCCGGGACGCCAGGGGCGCTCCCGCAAGTGGGGGTCCTCCGGGACTTGGAACGCCC
CGGCTGGGTGGTGTCCGGGCGTCCTTTCCCCGCTTCTTCCCACCTCGGCTGGTCCCGTTTCCTCCTGCGCCCAGTGCGGACCTGTCTCGG
CGCCCGCTGCCCTCTCACCGCCCCACGCAGGATCCCGGCCTGGTCACCGGGCAGTGTGATGCTTCCCGACTGCCGCGGGGACAGCGAGGC
ACACACAGGGCTTGGGCCGCGCCGGAGGCCACACGGCCTGGCTGAGTTGCTCCTGGTCTCCCGCCTCTCCCAGGCGACCCGGAGGTAGCA
TTTCCCAGGAGGCACGGTCCCCCCCAGGGGGATGGGCACAGCCACGCCAGATGGACGAGAAGACCAAGAAAGCAAATGCCAGTCTTCTTG
GAGGAGGAGGTGTGGATGGCTGTATTCATAGAGCAGCCGGCCCCTGTTTGCTAGCTGAATGTCGTAACCTGAATGGCTGTGATACTGGAC
ATGCAAAAATCACATGTGGCTATGACCTTCCTGCAAAATATGTCATCCATACTGTAGGGCCAATAGCCAGGGGCCATATTAATGGTTCCC
ACAAGGAAGACCTTGCAAATTGCTATAAATCATCTCTGAAGCTCGTGAAAGAAAATAACATCCGATCAGTTGCATTTCCCTGCATCTCAA
CAGGCATTTATGGCTTTCCCAACGAGCCTGCTGCAGTCATTGCCCTCAACACCATTAAGGAATGGCTTGCCAAGAATCACCATGAGGTGG
ATCGGATCATTTTCTGTGTCTTCTTAGAAGTTGACTTCAAAATCTACAAAAAGAAAATGAATGAGTTTTTCTCCGTAGACGATAATAATG
AAGAAGAAGAGGATGTTGAAATGAAAGAAGATTCAGATGAGAACGGTCCAGAGGAGAAGCAAAGTGTGGAAGAAATGGAAGAGCAGAGCC
AAGATGCAGATGGTGTCAACACTGTCACTGTGCCCGGCCCTGCTTCAGAAGAGGCAGTTGAAGACTGTAAAGATGAAGATTTTGCAAAGG
ATGAAAATATTACAAAAGGCGGTGAAGTGACAGATCATTCTGTGCGTGACCAAGATCATCCCGATGGACAAGAGAATGATTCAACGAAGA
ATGAAATAAAAATTGAAACAGAATCGCAGAGCTCATATATGGAAACAGAAGAACTTTCATCAAACCAAGAAGATGCCGTGATTGTGGAGC
AACCAGAAGTGATTCCATTAACAGAGGACCAAGAAGAAAAAGAAGGTGAAAAAGCTCCAGGCGAGGACACACCTAGGATGCCTGGGAAAA
GTGAAGGCTCCAGTGACCTAGAAAATACTCCAGGTCCTGATGTTGAAATGAATAGTCAGGTTGACAAGGTAAATGACCCAACAGAGAGTC


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FusionGenePPI for RBCK1_MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBCK1UBC, RBCK1, PRKCB, BACH1, UBE2D3, IKBKG, UBE2G1, UBE2L3, UBE2L6, UBE2N, UBE2U, UBE2D4, UBE2S, UBE2K, IREB2, TNF, RNF31, TRAF1, TRIM25, DDX58, NEDD4, NOD2, PSMD4, TAB2, TAB3, MAP3K7, TRAF6, RIPK1, NR2C2, PML, ESR1, SHARPIN, TNFAIP3, APP, NR1I2, UCHL5, USP2, USP7, USP15, USP21, USP32, USP49, PAN2, OTUB2, OTUD6A, BIRC3, OTULIN, MKRN2, TRIML1, UHRF2, PCGF2, RNF181, TRIM65, TRIM21, FKBPL, HSP90AA1, ARNT2, PARK2, PRKCA, NAA10, NDUFAF3, TSSK3, SYCE1, UBE2D1, UBE2D2, MAP3K1, LTBR, LDLRAD4, MALT1, SMURF1, PDLIM7, TLR3, TNFRSF1A, LMO2, RABGEF1, ARPC5MACROD2TERF1, TERF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+1111_22013469IRF3
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+1121_2207511IRF3
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+11169_13113469RNF31
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+11269_1317511RNF31
HgeneRBCK1chr20:389423chr20:14474125ENST00000353660+1111_27013469TAB2
HgeneRBCK1chr20:389423chr20:14474125ENST00000356286+1121_2707511TAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBCK1_MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBCK1_MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBCK1C0018800Cardiomegaly1CTD_human
HgeneRBCK1C4014605POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCY1ORPHANET;UNIPROT
TgeneMACROD2C0004352Autistic Disorder1CTD_human
TgeneMACROD2C0023903Liver neoplasms1CTD_human
TgeneMACROD2C0236969Substance-Related Disorders1CTD_human