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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30612

FusionGeneSummary for RB1_HTR2C

check button Fusion gene summary
Fusion gene informationFusion gene name: RB1_HTR2C
Fusion gene ID: 30612
HgeneTgene
Gene symbol

RB1

HTR2C

Gene ID

5925

3358

Gene nameRB transcriptional corepressor 15-hydroxytryptamine receptor 2C
SynonymsOSRC|PPP1R130|RB|p105-Rb|pRb|pp1105-HT1C|5-HT2C|5-HTR2C|5HTR2C|HTR1C
Cytomap

13q14.2

Xq23

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas5-hydroxytryptamine receptor 2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled5-hydroxytryptamine receptor 1Cserotonin 5-HT-1C receptorserotonin 5-HT-2C receptor
Modification date2018052320180523
UniProtAcc

P06400

P28335

Ensembl transtripts involved in fusion geneENST00000267163, ENST00000484879, 
ENST00000371951, ENST00000276198, 
ENST00000371950, 
Fusion gene scores* DoF score16 X 9 X 8=11521 X 1 X 1=1
# samples 161
** MAII scorelog2(16/1152*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: RB1 [Title/Abstract] AND HTR2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

HgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

HgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735

TgeneHTR2C

GO:0006182

cGMP biosynthetic process

12970106

TgeneHTR2C

GO:0006874

cellular calcium ion homeostasis

19057895

TgeneHTR2C

GO:0007200

phospholipase C-activating G-protein coupled receptor signaling pathway

12970106

TgeneHTR2C

GO:0010513

positive regulation of phosphatidylinositol biosynthetic process

19057895

TgeneHTR2C

GO:0042493

response to drug

18703043

TgeneHTR2C

GO:0070374

positive regulation of ERK1 and ERK2 cascade

19057895


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-D6-6827-01ARB1chr13

48881542

+HTR2CchrX

114141152

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267163ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141152

+
In-frameENST00000267163ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141152

+
Frame-shiftENST00000267163ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000371951RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000276198RB1chr13

48881542

+HTR2CchrX

114141152

+
intron-3CDSENST00000484879ENST00000371950RB1chr13

48881542

+HTR2CchrX

114141152

+

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FusionProtFeatures for RB1_HTR2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RB1

P06400

HTR2C

P28335

Key regulator of entry into cell division that acts as atumor suppressor. Promotes G0-G1 transition when phosphorylated byCDK3/cyclin-C. Acts as a transcription repressor of E2F1 targetgenes. The underphosphorylated, active form of RB1 interacts withE2F1 and represses its transcription activity, leading to cellcycle arrest. Directly involved in heterochromatin formation bymaintaining overall chromatin structure and, in particular, thatof constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferasesSUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptionalrepression. Controls histone H4 'Lys-20' trimethylation. Inhibitsthe intrinsic kinase activity of TAF1. Mediates transcriptionalrepression by SMARCA4/BRG1 by recruiting a histone deacetylase(HDAC) complex to the c-FOS promoter. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependentrecruitment of a phospho-RB1-HDAC1 repressor complex. Upon calciuminflux, RB1 is dephosphorylated by calcineurin, which leads torelease of the repressor complex (By similarity). In case of viralinfections, interactions with SV40 large T antigen, HPV E7 proteinor adenovirus E1A protein induce the disassembly of RB1-E2F1complex thereby disrupting RB1's activity. {ECO:0000250,ECO:0000269|PubMed:15084261}. G-protein coupled receptor for 5-hydroxytryptamine(serotonin). Also functions as a receptor for various drugs andpsychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic aciddiethylamide (LSD). Ligand binding causes a conformation changethat triggers signaling via guanine nucleotide-binding proteins (Gproteins) and modulates the activity of down-stream effectors.Beta-arrestin family members inhibit signaling via G proteins andmediate activation of alternative signaling pathways. Signalingactivates a phosphatidylinositol-calcium second messenger systemthat modulates the activity of phosphatidylinositol 3-kinase anddown-stream signaling cascades and promotes the release of Ca(2+)ions from intracellular stores. Regulates neuronal activity viathe activation of short transient receptor potential calciumchannels in the brain, and thereby modulates the activation ofpro-opiomelacortin neurons and the release of CRH that thenregulates the release of corticosterone. Plays a role in theregulation of appetite and eating behavior, responses toanxiogenic stimuli and stress. Plays a role in insulin sensitivityand glucose homeostasis. {ECO:0000269|PubMed:12970106,ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895,ECO:0000269|PubMed:7895773}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+22710_1888929Compositional biasNote=Poly-Ala
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+22720_2988929Compositional biasNote=Poly-Pro
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46364_368183459MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46456_458183459MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46151_153151249MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46364_368151249MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46456_458151249MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57364_368183459MotifNPxxY motif%3B important for ligand-induced conformation changes and signaling
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57456_458183459MotifNote=PDZ-binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46324_328183459RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46324_328151249RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57324_328183459RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46194_213183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46236_311183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46334_348183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46372_458183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46151_170151249Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46194_213151249Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46236_311151249Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46334_348151249Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46372_458151249Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57194_213183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57236_311183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57334_348183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57372_458183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46214_235183459TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46312_333183459TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46349_371183459TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46171_193151249TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46214_235151249TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46312_333151249TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46349_371151249TransmembraneHelical%3B Name%3D7
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57214_235183459TransmembraneHelical%3B Name%3D5
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57312_333183459TransmembraneHelical%3B Name%3D6
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57349_371183459TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227870_87688929MotifNuclear localization signal
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227373_57988929RegionNote=Domain A
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227373_77188929RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227580_63988929RegionNote=Spacer
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227640_77188929RegionNote=Domain B
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46151_153183459MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57151_153183459MotifDRY motif%3B important for ligand-induced conformation changes
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46134_139183459RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46134_139151249RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57134_139183459RegionAgonist binding
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46111_127183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46151_170183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+4633_52183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+4679_89183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46111_127151249Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+4633_52151249Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+4679_89151249Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57111_127183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57151_170183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+5733_52183459Topological domainExtracellular
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+5779_89183459Topological domainCytoplasmic
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46128_150183459TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+46171_193183459TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+4653_78183459TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000276198+4690_110183459TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+46128_150151249TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+4653_78151249TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371950+4690_110151249TransmembraneHelical%3B Name%3D2
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57128_150183459TransmembraneHelical%3B Name%3D3
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+57171_193183459TransmembraneHelical%3B Name%3D4
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+5753_78183459TransmembraneHelical%3B Name%3D1
TgeneHTR2Cchr13:48881542chrX:114141152ENST00000371951+5790_110183459TransmembraneHelical%3B Name%3D2


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FusionGeneSequence for RB1_HTR2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RB1_ENST00000267163_chr13_48881542_+_HTR2C_ENST00000371951_chrX_114141152_+_363aa
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLVY
QFLSLXLDXGTKKRCSXTTRRACSTTQISFLLGPSXLSSYRXRLWXLRIAXPSTFCADKLXCYCTATPRNRLDXVWISXSAARGIRPRKR
TLQTLTKTRTHAEERRRRDVLGAPCRLSTMKEKLRKSLGLFSLCFXSCGAHFSLPIFCLFFVRSPVTKSSWKSFXMCLFGLAMFVQESIL
WCILCSTKFTEGHSPTICVAIIRXRKSLLSGRFQELPPLLCLGGSLMLTFIGIPMNRXSRKPVTMSPVXRCKLRIXSYQXIPPVWLAKGL

>In-frame_RB1_ENST00000267163_chr13_48881542_+_HTR2C_ENST00000276198_chrX_114141152_+_363aa
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLVY
QFLSLXLDXGTKKRCSXTTRRACSTTQISFLLGPSXLSSYRXRLWXLRIAXPSTFCADKLXCYCTATPRNRLDXVWISXSAARGIRPRKR
TLQTLTKTRTHAEERRRRDVLGAPCRLSTMKEKLRKSLGLFSLCFXSCGAHFSLPIFCLFFVRSPVTKSSWKSFXMCLFGLAMFVQESIL
WCILCSTKFTEGHSPTICVAIIRXRKSLLSGRFQELPPLLCLGGSLMLTFIGIPMNRXSRKPVTMSPVXRCKLRIXSYQXIPPVWLAKGL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RB1_ENST00000267163_chr13_48881542_+_HTR2C_ENST00000371951_chrX_114141152_+_1091nt
ATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCCGCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAG
GAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTCGTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTA
TGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCTTGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTAT
CAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGGTGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTC
TTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTATGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTT
TGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAAGTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGA
ACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAAAGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATG
AAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGTTTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTC
TTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTCTGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTC
TGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCTCCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCA
GGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGGAGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGA
AAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGAATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTA

>In-frame_RB1_ENST00000267163_chr13_48881542_+_HTR2C_ENST00000276198_chrX_114141152_+_1091nt
ATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCCGCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAG
GAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTCGTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTA
TGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCTTGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTAT
CAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGGTGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTC
TTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTATGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTT
TGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAAGTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGA
ACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAAAGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATG
AAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGTTTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTC
TTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTCTGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTC
TGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCTCCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCA
GGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGGAGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGA
AAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGAATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RB1_ENST00000267163_chr13_48881542_+_HTR2C_ENST00000371951_chrX_114141152_+_2321nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA

>In-frame_RB1_ENST00000267163_chr13_48881542_+_HTR2C_ENST00000276198_chrX_114141152_+_3875nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGTGTATCAGTTCCTATCCCTGTGATTGGACTGAGGGACGAAGAAAAGG
TGTTCGTGAACAACACGACGTGCGTGCTCAACGACCCAAATTTCGTTCTTATTGGGTCCTTCGTAGCTTTCTTCATACCGCTGACGATTA
TGGTGATTACGTATTGCCTGACCATCTACGTTCTGCGCCGACAAGCTTTGATGTTACTGCACGGCCACACCGAGGAACCGCCTGGACTAA
GTCTGGATTTCCTGAAGTGCTGCAAGAGGAATACGGCCGAGGAAGAGAACTCTGCAAACCCTAACCAAGACCAGAACGCACGCCGAAGAA
AGAAGAAGGAGAGACGTCCTAGGGGCACCATGCAGGCTATCAACAATGAAAGAAAAGCTTCGAAAGTCCTTGGGATTGTTTTCTTTGTGT
TTCTGATCATGTGGTGCCCATTTTTCATTACCAATATTCTGTCTGTTCTTTGTGAGAAGTCCTGTAACCAAAAGCTCATGGAAAAGCTTC
TGAATGTGTTTGTTTGGATTGGCTATGTTTGTTCAGGAATCAATCCTCTGGTGTATACTCTGTTCAACAAAATTTACCGAAGGGCATTCT
CCAACTATTTGCGTTGCAATTATAAGGTAGAGAAAAAGCCTCCTGTCAGGCAGATTCCAAGAGTTGCCGCCACTGCTTTGTCTGGGAGGG
AGCTTAATGTTAACATTTATCGGCATACCAATGAACCGGTGATCGAGAAAGCCAGTGACAATGAGCCCGGTATAGAGATGCAAGTTGAGA
ATTTAGAGTTACCAGTAAATCCCTCCAGTGTGGTTAGCGAAAGGATTAGCAGTGTGTGAGAAAGAACAGCACAGTCTTTTCCTACGGTAC
AAGCTACATATGTAGGAAAATTTTCTTCTTTAATTTTTCTGTTGGTCTTAACTAATGTAAATATTGCTGTCTGAAAAAGTGTTTTTACAT
ATAGCTTTGCAACCTTGTACTTTACAATCATGCCTACATTAGTGAGATTTAGGGTTCTATATTTACTGTTTATAATAGGTGGAGACTAAC
TTATTTTGATTGTTTGATGAATAAAATGTTTATTTTTGCTCTCCCTCCCTTCTTTCCTTCCTTTTTTCCTTTCTTCCTTCCTTTCTCTCT
TTCTTTTGTGCATATGGCAACGTTCATGTTCATCTCAGGTGGCATTTGCAGGTGACCAGAATGAGGCACATGACAGTGGTTATATTTCAA
CCACACCTAAATTAACAAATTCAGTGGACATTTGTTCTGGGTTAACAGTAAATATACACTTTACATTCTTGCTCTGCTCATCTACACATA
TAAACACAGTAAGATAGGTTCTGCTTTCTGATACATCTGTCAGTGAGTCAGAGGCAGAACCTAGTCTTGTTGTTCATATAGGGGCAAAAA
TTTGACATTGTCAGAATGTTGTGTTGGTATTTACTGCAATGTCTGTCCCTAAACATAGTGGTATTTTAACATAGCAGCTGGTTAACCGGG
ACTACAGAAGTGGAAGGATAATGAGATGTAATACACCAAATAGCTTTTCACTTCTTAAGGACAGTGTTCAAATTCTGATTATTACAACAA
GCAAACTGAAATTAGTGTTTTCATTCTGGTCCTTAGTAAATTCCTAATTCTATGATTAAACTGGGAAATGAGATCCCAGAGTTATTTCCC
AACCCAGGATTCAACATCAATTGGGTTTTGATCTCAGCATCCTGGAAATTTGTGTGCTTCACACAAAGTGAAATTAGTATTTTGAGCCTT
ATTAAAATATTTTCTTAATTATGGTACCTCTGTCTATAGGACTTAATTTAGCAGTCCATTTTTGAGTAAAACTTGTATTGGAAGTATAGA
TGGTAGAAACTTTGGAAGTTTTACTTGATTAAGGACTACAGAATTGGGCCCTTAGAATGTGAAAAAAAAAAGTAATTAAAAAGACACTTT
TACCGAACTCGGGATTACAGAAACACGGAGTTTCCATTTGGATTTTAAACAAAATTTATGTCATTTTCAGATCCTTCCAAACTCTCTAGT
GCAGGAAAAGGCTGCAGCTAATTTGTGAAAGTGGCAAGCTCTTCATTGCACTGCAGTTATTTACCAGAAGTTTAAATCTTTGTTAAAATA
TAGTGTTGTGTTACAATAAGTGTTGGCCATCATTTCATTCGTGGGCCTGCTGCTCTCTAAGAATTCAGTAGCATTTTAATAGTTTCTAAA
CCATGAAAAGTTTTCAAGCATTGCTAAAGTCAGGCCATTCAGTCTATGCTGTGTGCAGAGTATACAAGTGTTTCTAGTAACAGTATTTCC
ATACGTGCCCATTTCACACAACTGTGGATAAATTTTGGAAGAATTCATGATGCTAGTTCTTACGCTTGACAGTTACTTACACACCTGAGA
ATGTGCCTCTCAGTATCTTAAAATTGGTTAATGAAAAATCTGAATTTCTAAAACCCTTGGTCTGTGTTCTCAACACACAGTATAGATAAA
TCCAATAGTCTGCCACAAGGGCAGTGGAAGAGCTGCTGTATTTGAGGAAACTCATACAGTCTCTATTTGATTTGCAACACTGCCAAACAT
CAGTCAATTGCTTGAGCATGCCCAAATATAACATGAAAGTCAAGTCTACCTGCCTTGCCTGTTAGGTCTGTTGAAGTGCATGTTAAAATA
ATTATATGAAGCAGAATGAGATGATTTAATTCTTACCGAAATGAAAATGGCTGAAGAAACACAGCATGCATTTAGCATGAGTTCTGCACA
TACAGATGGTGTCCTGCATGTATGCCATGTATGTTGCATGAATCCATCGATTTGTATTAATGTAGGGCAGAATAGCTGATAGAAGAAGGA
CTGAAGAAAATCCTTCAGCAATCCTTAAAAAGACCATGCATTCAGATCTGAAGTAGTGTGAGTGTTAGAAAAAACTGGAAACATCTGATT
TCTGAACTATCAGGGCAAGCTCATAGCACATGTTTTACAAAGAAACAAAATATAAATCACAGATTTCCAAAAGTACTAGCAATAAGTTGA
ATGATAATAGCTCACAGCACATTTGTTAATGATTCTTGTGTCATCAAGTAGTAGTACTTAATAGTACCCAACCTGGTAATTATCCTCAAG
TTGTGTGCTATTCGTAAGTTCTGTGCAGTTTGGTATGAAACAAATATACTCATTTGGATATAAATCTTACCCTTCAATGTTAAATCTACA
AACTTTTATAAATGTTTTAAAGAAGTCCATGTGATAATTGTAAAGGTGATGAATTTACCATCAAACAAATCATTTTGATGTATTATTATA
TATGTATATCTGTGTAAGACACGTGCAACAGACTGCCTTATATTATTTTCTGTAATTCTTCTCCTTTGTCAAATGGTATTTTTTGTGAAT
GGTTGCAAAGTGTTGTCTTATTCCTAATTCCTGTATGTTATCCACTACAGGTTTTATGAGACTTCCTATTAATTTATTAAATTTATTAAA


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FusionGenePPI for RB1_HTR2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RB1CUX1, MCM7, HBP1, TRAP1, AATF, THOC1, LIN9, BRCA1, ABL1, BCR, NCOA6, BAG1, RBBP8, HDAC1, AR, MORF4L2, SERPINB2, TP73, GNB2L1, CBX1, PELP1, PIK3R3, PPARG, HDAC3, RBBP4, E2F1, MORF4L1, MRFAP1, RBBP7, CDK2, DNMT1, HDAC2, ARID4A, NFIX, SP1, SMARCA4, MYOD1, DNMT3A, EID1, BRF1, PRDM2, SUV39H1, CBX5, CBX4, RING1, VDR, KDM5A, CCND3, PML, CCND1, TAF1, PA2G4, TMPO, MYC, TGM2, POLA1, FRK, ATF2, SNW1, ARID3B, SNAPC1, SNAPC3, CCNT2, CDK9, RAF1, E2F4, E4F1, ENC1, RFC1, LMNA, CREG1, CEBPB, HMGB1, PHB, MDM2, JUN, PAX6, MNAT1, RBBP5, E2F2, TRIP11, UBTF, AHR, ARNT, CCNA1, TFDP1, TFDP2, RBBP9, TBP, USP4, L3MBTL1, L3MBTL2, AURKB, CDK4, ZBTB7A, SKP2, HMGA2, KDM5B, KDM4A, STAT3, KDM1A, LIN54, SKI, SKIL, KAT2B, FOXM1, YY1, DNAJA2, SMYD2, UHRF2, TAL1, TCF3, LMO2, LDB1, IRF3, NPM1, CEBPA, KAT5, TRIM27, CCNE1, CDK5, CCND2, PSMA7, CCNA2, CDK1, PSMD10, CDC27, ANAPC2, CDC16, FZR1, MAPK14, TP53, PPP1CA, CDK6, RNF40, UHRF1, UBR4, RBAK, SPI1, E2F3, CHEK2, CHEK1, CEBPD, MDM4, PAX2, PNO1, GTF2H1, PURA, CCNB1, RINT1, FOS, CDK14, PPIA, TOP2A, NOTCH1, RUNX2, ID2, CDK3, DGKZ, INS, HIST4H4, PRMT2, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, MAPK8, UBE2I, CEBPE, MRPS18B, CCNC, PRKCB, TFAP2A, PAX5, HIF1A, CDKN1A, CDKN1C, HDAC11, PLA2G12A, MAGEA11, NEFM, DYRK1A, DYRK1B, USP7, KDM2A, EP300, SIRT1, PAX8, KLK11, RFPL2, FAS, TFDP3, CTBP1, C3orf62, CDK13, NTRK1, RBBP6, GTF3C2, GRB2, RABGAP1L, CHN2, ANKS1A, CLNK, MED23, BAG6, UBL4A, HERC4, RPRD1B, RBM26, FOXA3, FOXK1, FOXK2, FOXO1, FOXO3, PPP1R26, NFATC2, BRD4, FAM208A, RFC5, PPAN, KIAA0430, HELZ, PCGF3, HSP90AA1, WEE1, TUBA1AHTR2CMPDZ, DLG4, LIN7C, APBA1, CALM1, SNTA1, TAPBP, FAM134A, KLRG2, CERS5, SLC35F1, FAM210B, UBE2Q1, C6orf47, HMOX2, ITPRIPL1, FAM134C, GPR50, LPCAT3, ARL10, PDXDC1, RBM14-RBM4, KNTC1, TMEM147, ITPA, ATP8, CERS6, CAV1, XPO7, IPO11, LGALS3, SLC35G2, ACP2, FITM2, ATP2B2, SLC39A1, LMBRD2, NT5C3A, EFR3A, GOLGA5, HEATR3, DPY19L4, SEC63, PDS5B, BTAF1, ALG8, TNPO3, RTN4, TBC1D15, RMND1, SLC19A2, SLC35F2, TVP23C, ATP5B, PTRH2, CAND2, CERS2, GPR89A, IPO9, LRRC8A, GLMN, ACTA2, RINT1, EXTL3, NCAPG, TM9SF3, SERINC1, FADS1, MRS2, IPO7, MBOAT7, ANGEL1, TMPPE, NCAPD2, KIAA0368, KIAA1524, SFXN5, C10orf35, TNPO2, ALG10, CAND1, C19orf25, MTX1, SYNGR2, GPRC5C, ASPH, ATP5F1, GNB2, EIF2B3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRB1chr13:48881542chrX:114141152ENST00000267163+227763_92888929LIMD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RB1_HTR2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRB1P06400DB00071Insulin PorkRetinoblastoma-associated proteinbiotechapproved
HgeneRB1P06400DB00030Insulin HumanRetinoblastoma-associated proteinbiotechapproved|investigational
TgeneHTR2CP28335DB00215Citalopram5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00246Ziprasidone5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00247Methysergide5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00248Cabergoline5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00321Amitriptyline5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00363Clozapine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00370Mirtazapine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00408Loxapine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00434Cyproheptadine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00458Imipramine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00540Nortriptyline5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00543Amoxapine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00623Fluphenazine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00696Ergotamine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00726Trimipramine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00777Propiomazine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00805Minaprine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB01224Quetiapine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB01267Paliperidone5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB04871Lorcaserin5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB06216Asenapine5-hydroxytryptamine receptor 2Csmall moleculeapproved
TgeneHTR2CP28335DB00574Fenfluramine5-hydroxytryptamine receptor 2Csmall moleculeapproved|illicit|investigational|withdrawn
TgeneHTR2CP28335DB01191Dexfenfluramine5-hydroxytryptamine receptor 2Csmall moleculeapproved|illicit|investigational|withdrawn
TgeneHTR2CP28335DB00193Tramadol5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00268Ropinirole5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00334Olanzapine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00413Pramipexole5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00589Lisuride5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00656Trazodone5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00714Apomorphine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00734Risperidone5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00934Maprotiline5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB01142Doxepin5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB01151Desipramine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB01200Bromocriptine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB01238Aripiprazole5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB06148Mianserin5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB06594Agomelatine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB09014Captodiame5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational
TgeneHTR2CP28335DB00477Chlorpromazine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|vet_approved
TgeneHTR2CP28335DB01242Clomipramine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|vet_approved
TgeneHTR2CP28335DB01392Yohimbine5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|vet_approved
TgeneHTR2CP28335DB01186Pergolide5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|vet_approved|withdrawn
TgeneHTR2CP28335DB01079Tegaserod5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|withdrawn
TgeneHTR2CP28335DB01239Chlorprothixene5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|withdrawn
TgeneHTR2CP28335DB06144Sertindole5-hydroxytryptamine receptor 2Csmall moleculeapproved|investigational|withdrawn
TgeneHTR2CP28335DB00420Promazine5-hydroxytryptamine receptor 2Csmall moleculeapproved|vet_approved
TgeneHTR2CP28335DB00472Fluoxetine5-hydroxytryptamine receptor 2Csmall moleculeapproved|vet_approved
TgeneHTR2CP28335DB01149Nefazodone5-hydroxytryptamine receptor 2Csmall moleculeapproved|withdrawn

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RelatedDiseases for RB1_HTR2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRB1C0035335Retinoblastoma9CTD_human;HPO;UNIPROT
HgeneRB1C1458155Mammary Neoplasms3CTD_human
HgeneRB1C0149925Small cell carcinoma of lung2CTD_human;ORPHANET
HgeneRB1C2239176Liver carcinoma2CTD_human
HgeneRB1C0001624Adrenal Gland Neoplasms1CTD_human
HgeneRB1C0007117Basal cell carcinoma1CTD_human
HgeneRB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneRB1C0007786Brain Ischemia1CTD_human
HgeneRB1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneRB1C0024667Animal Mammary Neoplasms1CTD_human
HgeneRB1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneRB1C0027627Neoplasm Metastasis1CTD_human
HgeneRB1C0027659Neoplasms, Experimental1CTD_human
HgeneRB1C0029463Osteosarcoma1CTD_human;HPO
HgeneRB1C0030297Pancreatic Neoplasm1CTD_human
HgeneRB1C0036920Sezary Syndrome1CTD_human
HgeneRB1C0038325Stevens-Johnson Syndrome1CTD_human
HgeneRB1C0206686Adrenocortical carcinoma1CTD_human
HgeneRB1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneRB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneHTR2CC0001973Alcoholic Intoxication, Chronic5PSYGENET
TgeneHTR2CC0005586Bipolar Disorder5PSYGENET
TgeneHTR2CC0011570Mental Depression5PSYGENET
TgeneHTR2CC0011581Depressive disorder5PSYGENET
TgeneHTR2CC0041696Unipolar Depression5PSYGENET
TgeneHTR2CC0525045Mood Disorders5PSYGENET
TgeneHTR2CC1269683Major Depressive Disorder5PSYGENET
TgeneHTR2CC0036341Schizophrenia4PSYGENET
TgeneHTR2CC0524620Metabolic Syndrome X3CTD_human
TgeneHTR2CC0028754Obesity2CTD_human
TgeneHTR2CC0043094Weight Gain2CTD_human
TgeneHTR2CC0085159Seasonal Affective Disorder2PSYGENET
TgeneHTR2CC0009171Cocaine Abuse1PSYGENET
TgeneHTR2CC0038587Substance Withdrawal Syndrome1CTD_human
TgeneHTR2CC0424295Hyperactive behavior1CTD_human