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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 30608

FusionGeneSummary for RB1_DIAPH3

check button Fusion gene summary
Fusion gene informationFusion gene name: RB1_DIAPH3
Fusion gene ID: 30608
HgeneTgene
Gene symbol

RB1

DIAPH3

Gene ID

5925

81624

Gene nameRB transcriptional corepressor 1diaphanous related formin 3
SynonymsOSRC|PPP1R130|RB|p105-Rb|pRb|pp110AN|AUNA1|DIA2|DRF3|NSDAN|diap3|mDia2
Cytomap

13q14.2

13q21.2

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblasprotein diaphanous homolog 3diaphanous homolog 3
Modification date2018052320180527
UniProtAcc

P06400

Q9NSV4

Ensembl transtripts involved in fusion geneENST00000267163, ENST00000484879, 
ENST00000400324, ENST00000400330, 
ENST00000400319, ENST00000400320, 
ENST00000377908, ENST00000267215, 
ENST00000465066, 
Fusion gene scores* DoF score16 X 9 X 8=115210 X 10 X 7=700
# samples 1613
** MAII scorelog2(16/1152*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/700*10)=-2.42884329880387
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RB1 [Title/Abstract] AND DIAPH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

HgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

HgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-LI-A9QH-01ARB1chr13

48881542

+DIAPH3chr13

60707123

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267163ENST00000400324RB1chr13

48881542

+DIAPH3chr13

60707123

-
In-frameENST00000267163ENST00000400330RB1chr13

48881542

+DIAPH3chr13

60707123

-
5CDS-intronENST00000267163ENST00000400319RB1chr13

48881542

+DIAPH3chr13

60707123

-
5CDS-intronENST00000267163ENST00000400320RB1chr13

48881542

+DIAPH3chr13

60707123

-
5CDS-intronENST00000267163ENST00000377908RB1chr13

48881542

+DIAPH3chr13

60707123

-
5CDS-intronENST00000267163ENST00000267215RB1chr13

48881542

+DIAPH3chr13

60707123

-
5CDS-intronENST00000267163ENST00000465066RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-3CDSENST00000484879ENST00000400324RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-3CDSENST00000484879ENST00000400330RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-intronENST00000484879ENST00000400319RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-intronENST00000484879ENST00000400320RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-intronENST00000484879ENST00000377908RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-intronENST00000484879ENST00000267215RB1chr13

48881542

+DIAPH3chr13

60707123

-
intron-intronENST00000484879ENST00000465066RB1chr13

48881542

+DIAPH3chr13

60707123

-

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FusionProtFeatures for RB1_DIAPH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RB1

P06400

DIAPH3

Q9NSV4

Key regulator of entry into cell division that acts as atumor suppressor. Promotes G0-G1 transition when phosphorylated byCDK3/cyclin-C. Acts as a transcription repressor of E2F1 targetgenes. The underphosphorylated, active form of RB1 interacts withE2F1 and represses its transcription activity, leading to cellcycle arrest. Directly involved in heterochromatin formation bymaintaining overall chromatin structure and, in particular, thatof constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferasesSUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptionalrepression. Controls histone H4 'Lys-20' trimethylation. Inhibitsthe intrinsic kinase activity of TAF1. Mediates transcriptionalrepression by SMARCA4/BRG1 by recruiting a histone deacetylase(HDAC) complex to the c-FOS promoter. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependentrecruitment of a phospho-RB1-HDAC1 repressor complex. Upon calciuminflux, RB1 is dephosphorylated by calcineurin, which leads torelease of the repressor complex (By similarity). In case of viralinfections, interactions with SV40 large T antigen, HPV E7 proteinor adenovirus E1A protein induce the disassembly of RB1-E2F1complex thereby disrupting RB1's activity. {ECO:0000250,ECO:0000269|PubMed:15084261}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+22710_1888929Compositional biasNote=Poly-Ala
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+22720_2988929Compositional biasNote=Poly-Pro
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-0271013_1056601113Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-027497_554601113Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-0271013_105601183Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-027497_55401183Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-0261013_105601124Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-026497_55401124Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-0261013_105601148Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-026497_55401148Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-0281013_1056601194Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-028497_554601194Coiled coilOntology_term=ECO:0000255
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-027561_636601113Compositional biasNote=Pro-rich
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-027561_63601183Compositional biasNote=Pro-rich
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-026561_63601124Compositional biasNote=Pro-rich
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-026561_63601148Compositional biasNote=Pro-rich
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-028561_636601194Compositional biasNote=Pro-rich
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-0271057_1087601113DomainDAD
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-027114_476601113DomainGBD/FH3
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-027561_631601113DomainNote=FH1
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000267215-027636_1034601113DomainFH2
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-0271057_108701183DomainDAD
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-027114_47601183DomainGBD/FH3
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-027561_63101183DomainNote=FH1
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000377908-027636_103401183DomainFH2
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-0261057_108701124DomainDAD
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-026114_47601124DomainGBD/FH3
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-026561_63101124DomainNote=FH1
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400319-026636_103401124DomainFH2
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-0261057_108701148DomainDAD
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-026114_47601148DomainGBD/FH3
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-026561_63101148DomainNote=FH1
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400320-026636_103401148DomainFH2
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-0281057_1087601194DomainDAD
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-028114_476601194DomainGBD/FH3
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-028561_631601194DomainNote=FH1
TgeneDIAPH3chr13:48881542chr13:60707123ENST00000400324-028636_1034601194DomainFH2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+227870_87688929MotifNuclear localization signal
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+227373_57988929RegionNote=Domain A
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+227373_77188929RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+227580_63988929RegionNote=Spacer
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+227640_77188929RegionNote=Domain B


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FusionGeneSequence for RB1_DIAPH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RB1_ENST00000267163_chr13_48881542_+_DIAPH3_ENST00000400324_chr13_60707123_-_1222aa
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLHL
NIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKK
EMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKN
QHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRH
NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYN
MVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASEL
YKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGM
RMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKE
RREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCE
PEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKD
TKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKE
QYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEM
KTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDT

>In-frame_RB1_ENST00000267163_chr13_48881542_+_DIAPH3_ENST00000400330_chr13_60707123_-_1222aa
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLHL
NIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKK
EMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKN
QHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRH
NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYN
MVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASEL
YKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGM
RMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKE
RREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCE
PEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKD
TKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSIFVISAKE
QYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEM
KTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RB1_ENST00000267163_chr13_48881542_+_DIAPH3_ENST00000400324_chr13_60707123_-_3666nt
ATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCCGCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAG
GAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTCGTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTA
TGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCTTGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGCATTTA
AATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCAGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAAC
CTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTC
TTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATGAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAA
GAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAG
CTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGGAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAA
AGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAAT
CAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGCAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTA
TTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGC
ATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAGAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCAC
AATTCAGTTCAACTGCAAGTAGCTTGTATGCAGCTCATCAATGCCCTGGTTACATCTCCTGATGATTTGGATTTCAGGCTTCACATCAGA
AATGAATTTATGCGTTGTGGATTGAAAGAGATATTGCCAAATTTAAAATGCATTAAGAATGATGGCCTGGATATCCAACTTAAAGTCTTT
GATGAGCATAAAGAAGAAGATTTGTTTGAGTTATCCCATCGCCTTGAAGATATTAGAGCTGAACTTGATGAAGCATATGATGTTTACAAC
ATGGTGTGGAGCACAGTTAAAGAAACTAGAGCAGAGGGATATTTTATTTCTATTCTTCAGCATCTTTTGCTGATTCGAAATGATTATTTT
ATAAGGCAACAATACTTCAAATTAATTGATGAGTGTGTATCCCAGATTGTATTGCATAGAGATGGAATGGATCCAGACTTCACATATCGA
AAAAGACTAGATTTAGATTTAACCCAGTTTGTAGACATTTGCATAGATCAAGCAAAACTAGAAGAGTTTGAAGAGAAAGCATCAGAACTT
TACAAGAAATTTGAAAAAGAGTTTACCGACCACCAAGAAACTCAGGCTGAATTGCAGAAAAAAGAGGCAAAGATTAATGAGCTTCAAGCA
GAGCTACAAGCTTTTAAGTCTCAGTTTGGTGCCTTGCCAGCTGATTGTAATATTCCTTTGCCTCCCTCTAAAGAAGGTGGAACTGGCCAC
TCAGCACTTCCTCCTCCGCCTCCACTGCCTTCTGGTGGAGGGGTGCCGCCTCCACCTCCTCCCCCACCACCTCCTCCACTTCCAGGAATG
CGGATGCCATTCAGTGGTCCTGTGCCTCCACCACCTCCCCTGGGATTCCTTGGAGGACAAAATTCTCCTCCTCTACCAATCCTGCCATTT
GGGTTGAAACCAAAGAAAGAATTTAAACCTGAAATCAGCATGAGAAGATTGAATTGGTTAAAGATCAGACCTCATGAAATGACTGAAAAC
TGTTTCTGGATAAAAGTAAATGAAAATAAGTATGAAAACGTGGATTTGCTTTGTAAACTTGAGAATACATTTTGTTGCCAACAAAAAGAG
AGAAGAGAAGAGGAAGATATTGAAGAGAAGAAATCGATTAAGAAAAAAATTAAAGAACTTAAGTTTTTAGATTCTAAAATTGCCCAGAAC
CTTTCAATCTTCCTGAGCTCTTTTCGGGTGCCATATGAGGAAATCAGAATGATGATATTGGAAGTAGATGAAACACGGTTGGCAGAGTCT
ATGATTCAGAACTTAATAAAGCATCTTCCTGATCAAGAGCAATTAAATTCATTGTCTCAGTTCAAGAGTGAATATAGCAACTTATGTGAA
CCTGAGCAGTTTGTGGTTGTGATGAGCAATGTGAAGAGACTACGGCCACGGCTCAGTGCTATTCTCTTTAAGCTTCAGTTTGAAGAGCAG
GTGAACAACATCAAACCTGACATCATGGCTGTCAGTACTGCCTGCGAAGAGATAAAGAAGAGCAAAAGCTTTAGCAAGTTGCTGGAACTT
GTATTGCTAATGGGAAACTACATGAATGCTGGCTCCCGGAATGCTCAAACCTTCGGATTTAACCTTAGCTCTCTCTGTAAACTAAAGGAC
ACAAAATCAGCAGATCAGAAAACAACGCTACTTCATTTCCTGGTAGAAATATGTGAAGAGAAGTACCCTGATATACTGAATTTTGTGGAT
GATTTGGAACCTTTAGACAAAGCTAGTAAAGTCTCTGTAGAAACGCTGGAAAAGAATTTGAGGCAGATGGGAAGGCAGCTTCAACAGCTT
GAGAAGGAATTGGAAACCTTTCCCCCTCCTGAGGACTTGCATGACAAGTTTGTGACAAAGATGTCCAGATTTGTTATCAGTGCAAAAGAA
CAATATGAGACACTTTCGAAGTTACACGAAAACATGGAAAAGTTATACCAGAGTATAATAGGATACTATGCCATTGATGTGAAGAAGGTG
TCTGTGGAAGACTTTCTTACTGACCTGAATAACTTCAGAACCACATTCATGCAAGCAATAAAGGAGAATATCAAAAAAAGAGAAGCAGAG
GAAAAAGAAAAACGTGTCAGAATAGCTAAAGAATTAGCAGAGCGAGAAAGACTCGAACGCCAACAAAAGAAAAAGCGTTTATTAGAAATG
AAGACTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACA
CCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAG
TTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACT
CATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGC

>In-frame_RB1_ENST00000267163_chr13_48881542_+_DIAPH3_ENST00000400330_chr13_60707123_-_3666nt
ATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCCGCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAG
GAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTCGTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTA
TGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCTTGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGCATTTA
AATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCAGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAAC
CTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTC
TTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATGAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAA
GAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAG
CTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGGAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAA
AGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAAT
CAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGCAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTA
TTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGC
ATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAGAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCAC
AATTCAGTTCAACTGCAAGTAGCTTGTATGCAGCTCATCAATGCCCTGGTTACATCTCCTGATGATTTGGATTTCAGGCTTCACATCAGA
AATGAATTTATGCGTTGTGGATTGAAAGAGATATTGCCAAATTTAAAATGCATTAAGAATGATGGCCTGGATATCCAACTTAAAGTCTTT
GATGAGCATAAAGAAGAAGATTTGTTTGAGTTATCCCATCGCCTTGAAGATATTAGAGCTGAACTTGATGAAGCATATGATGTTTACAAC
ATGGTGTGGAGCACAGTTAAAGAAACTAGAGCAGAGGGATATTTTATTTCTATTCTTCAGCATCTTTTGCTGATTCGAAATGATTATTTT
ATAAGGCAACAATACTTCAAATTAATTGATGAGTGTGTATCCCAGATTGTATTGCATAGAGATGGAATGGATCCAGACTTCACATATCGA
AAAAGACTAGATTTAGATTTAACCCAGTTTGTAGACATTTGCATAGATCAAGCAAAACTAGAAGAGTTTGAAGAGAAAGCATCAGAACTT
TACAAGAAATTTGAAAAAGAGTTTACCGACCACCAAGAAACTCAGGCTGAATTGCAGAAAAAAGAGGCAAAGATTAATGAGCTTCAAGCA
GAGCTACAAGCTTTTAAGTCTCAGTTTGGTGCCTTGCCAGCTGATTGTAATATTCCTTTGCCTCCCTCTAAAGAAGGTGGAACTGGCCAC
TCAGCACTTCCTCCTCCGCCTCCACTGCCTTCTGGTGGAGGGGTGCCGCCTCCACCTCCTCCCCCACCACCTCCTCCACTTCCAGGAATG
CGGATGCCATTCAGTGGTCCTGTGCCTCCACCACCTCCCCTGGGATTCCTTGGAGGACAAAATTCTCCTCCTCTACCAATCCTGCCATTT
GGGTTGAAACCAAAGAAAGAATTTAAACCTGAAATCAGCATGAGAAGATTGAATTGGTTAAAGATCAGACCTCATGAAATGACTGAAAAC
TGTTTCTGGATAAAAGTAAATGAAAATAAGTATGAAAACGTGGATTTGCTTTGTAAACTTGAGAATACATTTTGTTGCCAACAAAAAGAG
AGAAGAGAAGAGGAAGATATTGAAGAGAAGAAATCGATTAAGAAAAAAATTAAAGAACTTAAGTTTTTAGATTCTAAAATTGCCCAGAAC
CTTTCAATCTTCCTGAGCTCTTTTCGGGTGCCATATGAGGAAATCAGAATGATGATATTGGAAGTAGATGAAACACGGTTGGCAGAGTCT
ATGATTCAGAACTTAATAAAGCATCTTCCTGATCAAGAGCAATTAAATTCATTGTCTCAGTTCAAGAGTGAATATAGCAACTTATGTGAA
CCTGAGCAGTTTGTGGTTGTGATGAGCAATGTGAAGAGACTACGGCCACGGCTCAGTGCTATTCTCTTTAAGCTTCAGTTTGAAGAGCAG
GTGAACAACATCAAACCTGACATCATGGCTGTCAGTACTGCCTGCGAAGAGATAAAGAAGAGCAAAAGCTTTAGCAAGTTGCTGGAACTT
GTATTGCTAATGGGAAACTACATGAATGCTGGCTCCCGGAATGCTCAAACCTTCGGATTTAACCTTAGCTCTCTCTGTAAACTAAAGGAC
ACAAAATCAGCAGATCAGAAAACAACGCTACTTCATTTCCTGGTAGAAATATGTGAAGAGAAGTACCCTGATATACTGAATTTTGTGGAT
GATTTGGAACCTTTAGACAAAGCTAGTAAAGTCTCTGTAGAAACGCTGGAAAAGAATTTGAGGCAGATGGGAAGGCAGCTTCAACAGCTT
GAGAAGGAATTGGAAACCTTTCCCCCTCCTGAGGACTTGCATGACAAGTTTGTGACAAAGATGTCCATATTTGTTATCAGTGCAAAAGAA
CAATATGAGACACTTTCGAAGTTACACGAAAACATGGAAAAGTTATACCAGAGTATAATAGGATACTATGCCATTGATGTGAAGAAGGTG
TCTGTGGAAGACTTTCTTACTGACCTGAATAACTTCAGAACCACATTCATGCAAGCAATAAAGGAGAATATCAAAAAAAGAGAAGCAGAG
GAAAAAGAAAAACGTGTCAGAATAGCTAAAGAATTAGCAGAGCGAGAAAGACTCGAACGCCAACAAAAGAAAAAGCGTTTATTAGAAATG
AAGACTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACA
CCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAG
TTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACT
CATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RB1_ENST00000267163_chr13_48881542_+_DIAPH3_ENST00000400324_chr13_60707123_-_4805nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGCATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCC
AGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCT
TTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAAT
GAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGA
AGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTG
GAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTG
GAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACG
CAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACA
GATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAA
GAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAGTAGCTTGTATGCAGCTCATCAAT
GCCCTGGTTACATCTCCTGATGATTTGGATTTCAGGCTTCACATCAGAAATGAATTTATGCGTTGTGGATTGAAAGAGATATTGCCAAAT
TTAAAATGCATTAAGAATGATGGCCTGGATATCCAACTTAAAGTCTTTGATGAGCATAAAGAAGAAGATTTGTTTGAGTTATCCCATCGC
CTTGAAGATATTAGAGCTGAACTTGATGAAGCATATGATGTTTACAACATGGTGTGGAGCACAGTTAAAGAAACTAGAGCAGAGGGATAT
TTTATTTCTATTCTTCAGCATCTTTTGCTGATTCGAAATGATTATTTTATAAGGCAACAATACTTCAAATTAATTGATGAGTGTGTATCC
CAGATTGTATTGCATAGAGATGGAATGGATCCAGACTTCACATATCGAAAAAGACTAGATTTAGATTTAACCCAGTTTGTAGACATTTGC
ATAGATCAAGCAAAACTAGAAGAGTTTGAAGAGAAAGCATCAGAACTTTACAAGAAATTTGAAAAAGAGTTTACCGACCACCAAGAAACT
CAGGCTGAATTGCAGAAAAAAGAGGCAAAGATTAATGAGCTTCAAGCAGAGCTACAAGCTTTTAAGTCTCAGTTTGGTGCCTTGCCAGCT
GATTGTAATATTCCTTTGCCTCCCTCTAAAGAAGGTGGAACTGGCCACTCAGCACTTCCTCCTCCGCCTCCACTGCCTTCTGGTGGAGGG
GTGCCGCCTCCACCTCCTCCCCCACCACCTCCTCCACTTCCAGGAATGCGGATGCCATTCAGTGGTCCTGTGCCTCCACCACCTCCCCTG
GGATTCCTTGGAGGACAAAATTCTCCTCCTCTACCAATCCTGCCATTTGGGTTGAAACCAAAGAAAGAATTTAAACCTGAAATCAGCATG
AGAAGATTGAATTGGTTAAAGATCAGACCTCATGAAATGACTGAAAACTGTTTCTGGATAAAAGTAAATGAAAATAAGTATGAAAACGTG
GATTTGCTTTGTAAACTTGAGAATACATTTTGTTGCCAACAAAAAGAGAGAAGAGAAGAGGAAGATATTGAAGAGAAGAAATCGATTAAG
AAAAAAATTAAAGAACTTAAGTTTTTAGATTCTAAAATTGCCCAGAACCTTTCAATCTTCCTGAGCTCTTTTCGGGTGCCATATGAGGAA
ATCAGAATGATGATATTGGAAGTAGATGAAACACGGTTGGCAGAGTCTATGATTCAGAACTTAATAAAGCATCTTCCTGATCAAGAGCAA
TTAAATTCATTGTCTCAGTTCAAGAGTGAATATAGCAACTTATGTGAACCTGAGCAGTTTGTGGTTGTGATGAGCAATGTGAAGAGACTA
CGGCCACGGCTCAGTGCTATTCTCTTTAAGCTTCAGTTTGAAGAGCAGGTGAACAACATCAAACCTGACATCATGGCTGTCAGTACTGCC
TGCGAAGAGATAAAGAAGAGCAAAAGCTTTAGCAAGTTGCTGGAACTTGTATTGCTAATGGGAAACTACATGAATGCTGGCTCCCGGAAT
GCTCAAACCTTCGGATTTAACCTTAGCTCTCTCTGTAAACTAAAGGACACAAAATCAGCAGATCAGAAAACAACGCTACTTCATTTCCTG
GTAGAAATATGTGAAGAGAAGTACCCTGATATACTGAATTTTGTGGATGATTTGGAACCTTTAGACAAAGCTAGTAAAGTCTCTGTAGAA
ACGCTGGAAAAGAATTTGAGGCAGATGGGAAGGCAGCTTCAACAGCTTGAGAAGGAATTGGAAACCTTTCCCCCTCCTGAGGACTTGCAT
GACAAGTTTGTGACAAAGATGTCCAGATTTGTTATCAGTGCAAAAGAACAATATGAGACACTTTCGAAGTTACACGAAAACATGGAAAAG
TTATACCAGAGTATAATAGGATACTATGCCATTGATGTGAAGAAGGTGTCTGTGGAAGACTTTCTTACTGACCTGAATAACTTCAGAACC
ACATTCATGCAAGCAATAAAGGAGAATATCAAAAAAAGAGAAGCAGAGGAAAAAGAAAAACGTGTCAGAATAGCTAAAGAATTAGCAGAG
CGAGAAAGACTCGAACGCCAACAAAAGAAAAAGCGTTTATTAGAAATGAAGACTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTG
GAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCT
CAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAAC
TCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAA
GCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTG
CTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTT
GAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCT
TTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGT
TCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATC
TTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATAT
TCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATAC
ATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAG
GCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAA
CAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTT
GAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGA
TCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCAAAGG

>In-frame_RB1_ENST00000267163_chr13_48881542_+_DIAPH3_ENST00000400330_chr13_60707123_-_4797nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGCATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCC
AGCATAAGAATTCCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGTGATTGCTCAGCAGCACCT
TTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAATGAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAAT
GAAGATAAAAAGGCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAATACTGCTTCTAAGACAGGA
AGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATTCATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTG
GAGTCTCTCCGAGTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGATTATTATTAGACATTTTG
GAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAGAAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACG
CAGTATGGCTTGGAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGACACCCCAATATGATGACA
GATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAAGAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAA
GAAAAAAAAATTGACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAGTAGCTTGTATGCAGCTCATCAAT
GCCCTGGTTACATCTCCTGATGATTTGGATTTCAGGCTTCACATCAGAAATGAATTTATGCGTTGTGGATTGAAAGAGATATTGCCAAAT
TTAAAATGCATTAAGAATGATGGCCTGGATATCCAACTTAAAGTCTTTGATGAGCATAAAGAAGAAGATTTGTTTGAGTTATCCCATCGC
CTTGAAGATATTAGAGCTGAACTTGATGAAGCATATGATGTTTACAACATGGTGTGGAGCACAGTTAAAGAAACTAGAGCAGAGGGATAT
TTTATTTCTATTCTTCAGCATCTTTTGCTGATTCGAAATGATTATTTTATAAGGCAACAATACTTCAAATTAATTGATGAGTGTGTATCC
CAGATTGTATTGCATAGAGATGGAATGGATCCAGACTTCACATATCGAAAAAGACTAGATTTAGATTTAACCCAGTTTGTAGACATTTGC
ATAGATCAAGCAAAACTAGAAGAGTTTGAAGAGAAAGCATCAGAACTTTACAAGAAATTTGAAAAAGAGTTTACCGACCACCAAGAAACT
CAGGCTGAATTGCAGAAAAAAGAGGCAAAGATTAATGAGCTTCAAGCAGAGCTACAAGCTTTTAAGTCTCAGTTTGGTGCCTTGCCAGCT
GATTGTAATATTCCTTTGCCTCCCTCTAAAGAAGGTGGAACTGGCCACTCAGCACTTCCTCCTCCGCCTCCACTGCCTTCTGGTGGAGGG
GTGCCGCCTCCACCTCCTCCCCCACCACCTCCTCCACTTCCAGGAATGCGGATGCCATTCAGTGGTCCTGTGCCTCCACCACCTCCCCTG
GGATTCCTTGGAGGACAAAATTCTCCTCCTCTACCAATCCTGCCATTTGGGTTGAAACCAAAGAAAGAATTTAAACCTGAAATCAGCATG
AGAAGATTGAATTGGTTAAAGATCAGACCTCATGAAATGACTGAAAACTGTTTCTGGATAAAAGTAAATGAAAATAAGTATGAAAACGTG
GATTTGCTTTGTAAACTTGAGAATACATTTTGTTGCCAACAAAAAGAGAGAAGAGAAGAGGAAGATATTGAAGAGAAGAAATCGATTAAG
AAAAAAATTAAAGAACTTAAGTTTTTAGATTCTAAAATTGCCCAGAACCTTTCAATCTTCCTGAGCTCTTTTCGGGTGCCATATGAGGAA
ATCAGAATGATGATATTGGAAGTAGATGAAACACGGTTGGCAGAGTCTATGATTCAGAACTTAATAAAGCATCTTCCTGATCAAGAGCAA
TTAAATTCATTGTCTCAGTTCAAGAGTGAATATAGCAACTTATGTGAACCTGAGCAGTTTGTGGTTGTGATGAGCAATGTGAAGAGACTA
CGGCCACGGCTCAGTGCTATTCTCTTTAAGCTTCAGTTTGAAGAGCAGGTGAACAACATCAAACCTGACATCATGGCTGTCAGTACTGCC
TGCGAAGAGATAAAGAAGAGCAAAAGCTTTAGCAAGTTGCTGGAACTTGTATTGCTAATGGGAAACTACATGAATGCTGGCTCCCGGAAT
GCTCAAACCTTCGGATTTAACCTTAGCTCTCTCTGTAAACTAAAGGACACAAAATCAGCAGATCAGAAAACAACGCTACTTCATTTCCTG
GTAGAAATATGTGAAGAGAAGTACCCTGATATACTGAATTTTGTGGATGATTTGGAACCTTTAGACAAAGCTAGTAAAGTCTCTGTAGAA
ACGCTGGAAAAGAATTTGAGGCAGATGGGAAGGCAGCTTCAACAGCTTGAGAAGGAATTGGAAACCTTTCCCCCTCCTGAGGACTTGCAT
GACAAGTTTGTGACAAAGATGTCCATATTTGTTATCAGTGCAAAAGAACAATATGAGACACTTTCGAAGTTACACGAAAACATGGAAAAG
TTATACCAGAGTATAATAGGATACTATGCCATTGATGTGAAGAAGGTGTCTGTGGAAGACTTTCTTACTGACCTGAATAACTTCAGAACC
ACATTCATGCAAGCAATAAAGGAGAATATCAAAAAAAGAGAAGCAGAGGAAAAAGAAAAACGTGTCAGAATAGCTAAAGAATTAGCAGAG
CGAGAAAGACTCGAACGCCAACAAAAGAAAAAGCGTTTATTAGAAATGAAGACTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTG
GAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCT
CAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAAC
TCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAA
GCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTG
CTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTAAAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTT
GAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTAAATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCT
TTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTACCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGT
TCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGAGCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATC
TTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACATTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATAT
TCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAATTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATAC
ATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCATTATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAG
GCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGTATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAA
CAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAGAGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTT
GAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAAACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGA
TCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATGTAATATTACCTCATTTGGGCATCATTACTCTGTTAATTCTATATCAAAGG


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FusionGenePPI for RB1_DIAPH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RB1CUX1, MCM7, HBP1, TRAP1, AATF, THOC1, LIN9, BRCA1, ABL1, BCR, NCOA6, BAG1, RBBP8, HDAC1, AR, MORF4L2, SERPINB2, TP73, GNB2L1, CBX1, PELP1, PIK3R3, PPARG, HDAC3, RBBP4, E2F1, MORF4L1, MRFAP1, RBBP7, CDK2, DNMT1, HDAC2, ARID4A, NFIX, SP1, SMARCA4, MYOD1, DNMT3A, EID1, BRF1, PRDM2, SUV39H1, CBX5, CBX4, RING1, VDR, KDM5A, CCND3, PML, CCND1, TAF1, PA2G4, TMPO, MYC, TGM2, POLA1, FRK, ATF2, SNW1, ARID3B, SNAPC1, SNAPC3, CCNT2, CDK9, RAF1, E2F4, E4F1, ENC1, RFC1, LMNA, CREG1, CEBPB, HMGB1, PHB, MDM2, JUN, PAX6, MNAT1, RBBP5, E2F2, TRIP11, UBTF, AHR, ARNT, CCNA1, TFDP1, TFDP2, RBBP9, TBP, USP4, L3MBTL1, L3MBTL2, AURKB, CDK4, ZBTB7A, SKP2, HMGA2, KDM5B, KDM4A, STAT3, KDM1A, LIN54, SKI, SKIL, KAT2B, FOXM1, YY1, DNAJA2, SMYD2, UHRF2, TAL1, TCF3, LMO2, LDB1, IRF3, NPM1, CEBPA, KAT5, TRIM27, CCNE1, CDK5, CCND2, PSMA7, CCNA2, CDK1, PSMD10, CDC27, ANAPC2, CDC16, FZR1, MAPK14, TP53, PPP1CA, CDK6, RNF40, UHRF1, UBR4, RBAK, SPI1, E2F3, CHEK2, CHEK1, CEBPD, MDM4, PAX2, PNO1, GTF2H1, PURA, CCNB1, RINT1, FOS, CDK14, PPIA, TOP2A, NOTCH1, RUNX2, ID2, CDK3, DGKZ, INS, HIST4H4, PRMT2, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, MAPK8, UBE2I, CEBPE, MRPS18B, CCNC, PRKCB, TFAP2A, PAX5, HIF1A, CDKN1A, CDKN1C, HDAC11, PLA2G12A, MAGEA11, NEFM, DYRK1A, DYRK1B, USP7, KDM2A, EP300, SIRT1, PAX8, KLK11, RFPL2, FAS, TFDP3, CTBP1, C3orf62, CDK13, NTRK1, RBBP6, GTF3C2, GRB2, RABGAP1L, CHN2, ANKS1A, CLNK, MED23, BAG6, UBL4A, HERC4, RPRD1B, RBM26, FOXA3, FOXK1, FOXK2, FOXO1, FOXO3, PPP1R26, NFATC2, BRD4, FAM208A, RFC5, PPAN, KIAA0430, HELZ, PCGF3, HSP90AA1, WEE1, TUBA1ADIAPH3NCKIPSD, HDAC6, SIRT1, VCP, SMAD9, CDC42, RHOA, RAC1, CENPA, WWOX, ENO1, NXF1, HS2ST1, CCDC183, COMTD1, PNKD, ENPP6, SCN2B, CCNB1, CCNB2, OFD1, PCM1, SPICE1, NINL, NIN, XPO1, SNW1, CDH1, EPHA1, TPTE2, BCHE, VASN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRB1chr13:48881542chr13:60707123ENST00000267163+227763_92888929LIMD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RB1_DIAPH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRB1P06400DB00071Insulin PorkRetinoblastoma-associated proteinbiotechapproved
HgeneRB1P06400DB00030Insulin HumanRetinoblastoma-associated proteinbiotechapproved|investigational

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RelatedDiseases for RB1_DIAPH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRB1C0035335Retinoblastoma9CTD_human;HPO;UNIPROT
HgeneRB1C1458155Mammary Neoplasms3CTD_human
HgeneRB1C0149925Small cell carcinoma of lung2CTD_human;ORPHANET
HgeneRB1C2239176Liver carcinoma2CTD_human
HgeneRB1C0001624Adrenal Gland Neoplasms1CTD_human
HgeneRB1C0007117Basal cell carcinoma1CTD_human
HgeneRB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneRB1C0007786Brain Ischemia1CTD_human
HgeneRB1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneRB1C0024667Animal Mammary Neoplasms1CTD_human
HgeneRB1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneRB1C0027627Neoplasm Metastasis1CTD_human
HgeneRB1C0027659Neoplasms, Experimental1CTD_human
HgeneRB1C0029463Osteosarcoma1CTD_human;HPO
HgeneRB1C0030297Pancreatic Neoplasm1CTD_human
HgeneRB1C0036920Sezary Syndrome1CTD_human
HgeneRB1C0038325Stevens-Johnson Syndrome1CTD_human
HgeneRB1C0206686Adrenocortical carcinoma1CTD_human
HgeneRB1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneRB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human