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Fusion gene ID: 30594 |
FusionGeneSummary for RAVER1_TMEM259 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAVER1_TMEM259 | Fusion gene ID: 30594 | Hgene | Tgene | Gene symbol | RAVER1 | TMEM259 | Gene ID | 125950 | 91304 |
| Gene name | ribonucleoprotein, PTB binding 1 | transmembrane protein 259 | |
| Synonyms | - | ASBABP1|C19orf6|MBRL|MEMBRALIN|R32184_3 | |
| Cytomap | 19p13.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribonucleoprotein PTB-binding 1protein raver-1 | membralinaspecific BCL2 ARE-binding protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q4ZIN3 | ||
| Ensembl transtripts involved in fusion gene | ENST00000293677, | ENST00000356663, ENST00000333175, | |
| Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 3 X 3 X 4=36 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAVER1 [Title/Abstract] AND TMEM259 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-FP-A8CX-01A | RAVER1 | chr19 | 10439318 | - | TMEM259 | chr19 | 1014472 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000293677 | ENST00000356663 | RAVER1 | chr19 | 10439318 | - | TMEM259 | chr19 | 1014472 | - |
| In-frame | ENST00000293677 | ENST00000333175 | RAVER1 | chr19 | 10439318 | - | TMEM259 | chr19 | 1014472 | - |
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FusionProtFeatures for RAVER1_TMEM259 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAVER1 | TMEM259 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May have a role in the ERAD pathway required forclearance of misfolded proteins in the endoplasmic reticulum (ER).Promotes survival of motor neurons, probably by protecting againstER stress. {ECO:0000250|UniProtKB:Q8CIV2}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000333175 | - | 0 | 10 | 302_322 | 75 | 409 | Transmembrane | Helical |
| Tgene | >TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000333175 | - | 0 | 10 | 346_366 | 75 | 409 | Transmembrane | Helical |
| Tgene | >TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000333175 | - | 0 | 10 | 426_446 | 75 | 409 | Transmembrane | Helical |
| Tgene | >TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000356663 | - | 0 | 11 | 302_322 | 75 | 621 | Transmembrane | Helical |
| Tgene | >TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000356663 | - | 0 | 11 | 346_366 | 75 | 621 | Transmembrane | Helical |
| Tgene | >TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000356663 | - | 0 | 11 | 426_446 | 75 | 621 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000333175 | - | 0 | 10 | 70_90 | 75 | 409 | Transmembrane | Helical |
| Tgene | TMEM259 | chr19:10439318 | chr19:1014472 | ENST00000356663 | - | 0 | 11 | 70_90 | 75 | 621 | Transmembrane | Helical |
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FusionGeneSequence for RAVER1_TMEM259 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAVER1_ENST00000293677_chr19_10439318_-_TMEM259_ENST00000356663_chr19_1014472_-_815aa MPLRPGSLVPEGAGFPKMAADVSVTHRPPLSPKSGAEVEAGDAAERRAPEEELPPLDPEEIRKRLEHTERQFRNRRKILIRGLPGDVTNQ EVHDLLSDYELKYCFVDKYKGTAFVTLLNGEQAEAAINAFHQSRLRERELSVQLQPTDALLCVANLPPSLTQQQFEELVRPFGSLERCFL VYSERTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTDAGQLTPALLHSRCLCVDRLPPGFNDVDALCRALSAVHSPTFCQA LFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNS SIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLL DEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAI AFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWL FIQHSMIYFFHHYELPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSSLVAA AASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLERRPASPLGPAGGLPHAPQDSVPPSDSAASDTTPLGAAVGGPSPASMAPTEAPS >In-frame_RAVER1_ENST00000293677_chr19_10439318_-_TMEM259_ENST00000333175_chr19_1014472_-_603aa MPLRPGSLVPEGAGFPKMAADVSVTHRPPLSPKSGAEVEAGDAAERRAPEEELPPLDPEEIRKRLEHTERQFRNRRKILIRGLPGDVTNQ EVHDLLSDYELKYCFVDKYKGTAFVTLLNGEQAEAAINAFHQSRLRERELSVQLQPTDALLCVANLPPSLTQQQFEELVRPFGSLERCFL VYSERTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTDAGQLTPALLHSRCLCVDRLPPGFNDVDALCRALSAVHSPTFCQA LFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTMEMFGNS SIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLL DEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAVER1_ENST00000293677_chr19_10439318_-_TMEM259_ENST00000356663_chr19_1014472_-_2445nt ATGCCGCTCCGCCCCGGCTCGCTGGTCCCAGAAGGCGCCGGGTTTCCCAAGATGGCGGCGGACGTGTCCGTTACTCACCGGCCCCCGCTG AGCCCTAAGTCTGGGGCCGAAGTCGAAGCCGGCGATGCCGCGGAGCGCCGGGCGCCGGAAGAAGAGCTGCCGCCTCTAGATCCAGAAGAG ATCCGGAAACGCCTGGAACACACCGAGCGCCAGTTCCGTAACCGCCGCAAGATACTGATCCGGGGCCTCCCGGGGGACGTGACCAACCAG GAAGTACATGACCTGCTCAGTGACTATGAGCTCAAATACTGTTTTGTGGACAAATACAAAGGGACAGCCTTCGTGACCCTGCTGAATGGG GAGCAGGCCGAGGCCGCAATCAATGCTTTCCACCAGAGCCGCCTGCGGGAGCGTGAACTGTCGGTGCAGCTGCAGCCCACGGATGCCCTG CTGTGTGTGGCCAACCTGCCCCCCAGCCTCACACAGCAGCAGTTCGAGGAGCTGGTGCGGCCCTTCGGCAGCCTGGAGCGCTGCTTCCTG GTCTACAGTGAGCGCACTGGCCAATCCAAGGGCTATGGCTTTGCTGAGTACATGAAGAAGGACTCGGCTGCCCGTGCCAAGTCGGACCTG CTGGGCAAGCCGCTGGGACCACGCACCCTCTACGTGCACTGGACGGATGCCGGGCAACTGACGCCTGCCCTTCTCCACTCCCGCTGCCTC TGTGTGGACCGCCTGCCACCTGGCTTCAACGATGTGGACGCTCTGTGCCGGGCGCTGTCAGCTGTCCACAGCCCCACCTTCTGCCAGGCC CTGTTTGTGCTCTTCGTCCTGGCCTACATCCACATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCG CGTGAGGGCATCCTGCGTGTGGAAGTGCGGCACAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGC TTCCCGGGCCTGGCCGTGGAACCAGGCAGCAACCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGC TCCATCAAGTTTGAGCTGGACATCGAGCCCAAGGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTC CCCGAGACGCCCACCAAAGTGTGGCCGCAGGACGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACC CGCCAGCGCCTGAGCATCCCCGTCATGGTGGTCACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTG GATGAGTTCCTGGGCTACGATGACATCCTCATGTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTG GTGTCGGGCGAGCACTACCGCTTTGTGAGCATGTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTG AGCGTGTCCATGCTGCTGCGGTACTCACACCACCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATC GCCTTCCCCGCAGCGCCCCTGCTGACCGTCATCCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACC GCCTTCTACATCATCCTCATCGTGTGGCTCGCGGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGG TTCTTCTATCTCTACCACTTCGCCTTCTATGCCTATCACTACCGCTTCAATGGGCAGTATAGCAGCCTGGCCCTGGTCACCTCCTGGCTC TTCATCCAGCATTCCATGATCTACTTCTTCCACCACTACGAGCTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAG GCGCCGCCACTGGGCCCCGGGACCCCCACGGCGCTGCCCGATGACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCC GGCCAGCCCCCCGCCCTGGGCCCCGTCTCGCCTGGGGCCAGCGGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCG GCAGCCTCAGTGGCAGCAGCTGCCGGTGGTGACCTGGGTTGGATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGC CTGAGCGCCTCCCTCCTGGAGCGGCGTCCAGCCAGCCCGCTGGGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCG AGTGACTCCGCAGCTTCTGACACAACTCCCCTGGGGGCTGCGGTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCG >In-frame_RAVER1_ENST00000293677_chr19_10439318_-_TMEM259_ENST00000333175_chr19_1014472_-_1809nt ATGCCGCTCCGCCCCGGCTCGCTGGTCCCAGAAGGCGCCGGGTTTCCCAAGATGGCGGCGGACGTGTCCGTTACTCACCGGCCCCCGCTG AGCCCTAAGTCTGGGGCCGAAGTCGAAGCCGGCGATGCCGCGGAGCGCCGGGCGCCGGAAGAAGAGCTGCCGCCTCTAGATCCAGAAGAG ATCCGGAAACGCCTGGAACACACCGAGCGCCAGTTCCGTAACCGCCGCAAGATACTGATCCGGGGCCTCCCGGGGGACGTGACCAACCAG GAAGTACATGACCTGCTCAGTGACTATGAGCTCAAATACTGTTTTGTGGACAAATACAAAGGGACAGCCTTCGTGACCCTGCTGAATGGG GAGCAGGCCGAGGCCGCAATCAATGCTTTCCACCAGAGCCGCCTGCGGGAGCGTGAACTGTCGGTGCAGCTGCAGCCCACGGATGCCCTG CTGTGTGTGGCCAACCTGCCCCCCAGCCTCACACAGCAGCAGTTCGAGGAGCTGGTGCGGCCCTTCGGCAGCCTGGAGCGCTGCTTCCTG GTCTACAGTGAGCGCACTGGCCAATCCAAGGGCTATGGCTTTGCTGAGTACATGAAGAAGGACTCGGCTGCCCGTGCCAAGTCGGACCTG CTGGGCAAGCCGCTGGGACCACGCACCCTCTACGTGCACTGGACGGATGCCGGGCAACTGACGCCTGCCCTTCTCCACTCCCGCTGCCTC TGTGTGGACCGCCTGCCACCTGGCTTCAACGATGTGGACGCTCTGTGCCGGGCGCTGTCAGCTGTCCACAGCCCCACCTTCTGCCAGGCC CTGTTTGTGCTCTTCGTCCTGGCCTACATCCACATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCG CGTGAGGGCATCCTGCGTGTGGAAGTGCGGCACAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGC TTCCCGGGCCTGGCCGTGGAACCAGGCAGCAACCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGC TCCATCAAGTTTGAGCTGGACATCGAGCCCAAGGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTC CCCGAGACGCCCACCAAAGTGTGGCCGCAGGACGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACC CGCCAGCGCCTGAGCATCCCCGTCATGGTGGTCACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTG GATGAGTTCCTGGGCTACGATGACATCCTCATGTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTG GTGTCGGGCGAGCACTACCGCTTTGTGAGCATGTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTG AGCGTGTCCATGCTGCTGCGGTACTCACACCACCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATC GCCTTCCCCGCAGCGCCCCTGCTGACCGTCATCCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACC GCCTTCTACATCATCCTCATCGTGTGGCTCGCGGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAVER1_ENST00000293677_chr19_10439318_-_TMEM259_ENST00000356663_chr19_1014472_-_3229nt GCTTAGCCAACGGGGCAAGGGGGGCGGGAAGGAGGTGGGGTTTCTCCCAGCCAATCGACGGGCGCGCCCTCGTTGCCGCTCTATGCCGCT CCGCCCCGGCTCGCTGGTCCCAGAAGGCGCCGGGTTTCCCAAGATGGCGGCGGACGTGTCCGTTACTCACCGGCCCCCGCTGAGCCCTAA GTCTGGGGCCGAAGTCGAAGCCGGCGATGCCGCGGAGCGCCGGGCGCCGGAAGAAGAGCTGCCGCCTCTAGATCCAGAAGAGATCCGGAA ACGCCTGGAACACACCGAGCGCCAGTTCCGTAACCGCCGCAAGATACTGATCCGGGGCCTCCCGGGGGACGTGACCAACCAGGAAGTACA TGACCTGCTCAGTGACTATGAGCTCAAATACTGTTTTGTGGACAAATACAAAGGGACAGCCTTCGTGACCCTGCTGAATGGGGAGCAGGC CGAGGCCGCAATCAATGCTTTCCACCAGAGCCGCCTGCGGGAGCGTGAACTGTCGGTGCAGCTGCAGCCCACGGATGCCCTGCTGTGTGT GGCCAACCTGCCCCCCAGCCTCACACAGCAGCAGTTCGAGGAGCTGGTGCGGCCCTTCGGCAGCCTGGAGCGCTGCTTCCTGGTCTACAG TGAGCGCACTGGCCAATCCAAGGGCTATGGCTTTGCTGAGTACATGAAGAAGGACTCGGCTGCCCGTGCCAAGTCGGACCTGCTGGGCAA GCCGCTGGGACCACGCACCCTCTACGTGCACTGGACGGATGCCGGGCAACTGACGCCTGCCCTTCTCCACTCCCGCTGCCTCTGTGTGGA CCGCCTGCCACCTGGCTTCAACGATGTGGACGCTCTGTGCCGGGCGCTGTCAGCTGTCCACAGCCCCACCTTCTGCCAGGCCCTGTTTGT GCTCTTCGTCCTGGCCTACATCCACATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCGCGTGAGGG CATCCTGCGTGTGGAAGTGCGGCACAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGCTTCCCGGG CCTGGCCGTGGAACCAGGCAGCAACCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGCTCCATCAA GTTTGAGCTGGACATCGAGCCCAAGGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTCCCCGAGAC GCCCACCAAAGTGTGGCCGCAGGACGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACCCGCCAGCG CCTGAGCATCCCCGTCATGGTGGTCACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTGGATGAGTT CCTGGGCTACGATGACATCCTCATGTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTGGTGTCGGG CGAGCACTACCGCTTTGTGAGCATGTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTGAGCGTGTC CATGCTGCTGCGGTACTCACACCACCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATCGCCTTCCC CGCAGCGCCCCTGCTGACCGTCATCCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACCGCCTTCTA CATCATCCTCATCGTGTGGCTCGCGGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGGTTCTTCTA TCTCTACCACTTCGCCTTCTATGCCTATCACTACCGCTTCAATGGGCAGTATAGCAGCCTGGCCCTGGTCACCTCCTGGCTCTTCATCCA GCATTCCATGATCTACTTCTTCCACCACTACGAGCTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAGGCGCCGCC ACTGGGCCCCGGGACCCCCACGGCGCTGCCCGATGACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCCGGCCAGCC CCCCGCCCTGGGCCCCGTCTCGCCTGGGGCCAGCGGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCGGCAGCCTC AGTGGCAGCAGCTGCCGGTGGTGACCTGGGTTGGATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGCCTGAGCGC CTCCCTCCTGGAGCGGCGTCCAGCCAGCCCGCTGGGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCGAGTGACTC CGCAGCTTCTGACACAACTCCCCTGGGGGCTGCGGTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCGGAGGTGGG GTCCTGAGCCGCACAGCTGAGCCGCCTCTGACCCCTGCTGGCTGGGCCTGACCTTCCCGAGCCCGTGGGGGTGGGGGAGGCCAGCCACCT CCTTCCTCTGGGACTGCCCAGCCTGTGTCGGGGGCTTTCAGGGTTTCGTGGGGTTTGCCCGGAAGGCGGCTTTCCTCCCCCTGGTGTGAG GTCGCGCCCGAGGCTTGTACCCGCTAGTGAGGTGTTTGAGCTGGTCAGCAAGGAGAGGGGGTGGGGTTCCGCGGAAGGTTCTGGAGGGGT CTTGGTAGGTCTGCAGTGAACCGTCCTGAGGATGGAGTGGGGTCCCATGGTGCAGGTCTCTGAGCAAGGCGGAGGTGTGGAGGAGAGGCC GGCTTGGGGTGGGGCCTCGCGCCCTAGTGCCGGCCGGCCTCAGCCCGGCTCTGCCTGGTGCTCCCTGCAGTGCCTTCTCCATGGCCCCGC CCTCCCCGCGTGTGCGCCAGGCTTGGGGTCCCCGGGAGAGCAGAGCTTGCGCCTCGGGCATAGGGACGTGGGGTGCAGGCGCCAACATCA GTGGCAGCAGCCAGGGCCGTGGTCCAGTCCCACTCGGGGATGGAGTGGGCCGGCGGCCAAACCAGTCACTCGGGGAGGAATGCGGAGGAG >In-frame_RAVER1_ENST00000293677_chr19_10439318_-_TMEM259_ENST00000333175_chr19_1014472_-_3126nt GCTTAGCCAACGGGGCAAGGGGGGCGGGAAGGAGGTGGGGTTTCTCCCAGCCAATCGACGGGCGCGCCCTCGTTGCCGCTCTATGCCGCT CCGCCCCGGCTCGCTGGTCCCAGAAGGCGCCGGGTTTCCCAAGATGGCGGCGGACGTGTCCGTTACTCACCGGCCCCCGCTGAGCCCTAA GTCTGGGGCCGAAGTCGAAGCCGGCGATGCCGCGGAGCGCCGGGCGCCGGAAGAAGAGCTGCCGCCTCTAGATCCAGAAGAGATCCGGAA ACGCCTGGAACACACCGAGCGCCAGTTCCGTAACCGCCGCAAGATACTGATCCGGGGCCTCCCGGGGGACGTGACCAACCAGGAAGTACA TGACCTGCTCAGTGACTATGAGCTCAAATACTGTTTTGTGGACAAATACAAAGGGACAGCCTTCGTGACCCTGCTGAATGGGGAGCAGGC CGAGGCCGCAATCAATGCTTTCCACCAGAGCCGCCTGCGGGAGCGTGAACTGTCGGTGCAGCTGCAGCCCACGGATGCCCTGCTGTGTGT GGCCAACCTGCCCCCCAGCCTCACACAGCAGCAGTTCGAGGAGCTGGTGCGGCCCTTCGGCAGCCTGGAGCGCTGCTTCCTGGTCTACAG TGAGCGCACTGGCCAATCCAAGGGCTATGGCTTTGCTGAGTACATGAAGAAGGACTCGGCTGCCCGTGCCAAGTCGGACCTGCTGGGCAA GCCGCTGGGACCACGCACCCTCTACGTGCACTGGACGGATGCCGGGCAACTGACGCCTGCCCTTCTCCACTCCCGCTGCCTCTGTGTGGA CCGCCTGCCACCTGGCTTCAACGATGTGGACGCTCTGTGCCGGGCGCTGTCAGCTGTCCACAGCCCCACCTTCTGCCAGGCCCTGTTTGT GCTCTTCGTCCTGGCCTACATCCACATCGTCTTCTCCCGCTCGCCCATCAACTGCCTGGAGCATGTGCGTGACAAGTGGCCGCGTGAGGG CATCCTGCGTGTGGAAGTGCGGCACAACTCGAGCCGCGCGCCCGTCTTCCTACAGTTCTGTGACAGCGGCGGCCGCGGGAGCTTCCCGGG CCTGGCCGTGGAACCAGGCAGCAACCTGGACATGGAAGATGAGGAGGAGGAAGAGCTGACCATGGAGATGTTTGGGAACAGCTCCATCAA GTTTGAGCTGGACATCGAGCCCAAGGTGTTCAAGCCGCCGAGTAGCACAGAGGCCCTGAATGACAGCCAGGAGTTCCCCTTCCCCGAGAC GCCCACCAAAGTGTGGCCGCAGGACGAGTACATCGTGGAGTACTCACTAGAGTATGGCTTCCTTCGCCTGTCGCAGGCCACCCGCCAGCG CCTGAGCATCCCCGTCATGGTGGTCACCCTGGACCCCACGCGGGACCAGTGCTTCGGGGACCGCTTCAGCCGCCTGCTGCTGGATGAGTT CCTGGGCTACGATGACATCCTCATGTCCAGCGTGAAGGGCCTGGCCGAGAACGAGGAGAACAAGGGCTTCCTGCGGAATGTGGTGTCGGG CGAGCACTACCGCTTTGTGAGCATGTGGATGGCGCGGACGTCCTACCTGGCCGCCTTCGCCATCATGGTCATCTTCACGCTGAGCGTGTC CATGCTGCTGCGGTACTCACACCACCAGATCTTCGTCTTCATCGTGGACCTGCTGCAGATGCTGGAGATGAACATGGCCATCGCCTTCCC CGCAGCGCCCCTGCTGACCGTCATCCTGGCCCTCGTCGGGATGGAGGCCATCATGTCGGAGTTCTTCAACGACACCACCACCGCCTTCTA CATCATCCTCATCGTGTGGCTCGCGGACCAGTATGACGCCATCTGCTGCCACACCAGCACCAGCAAGCGGCATTGGCTGCGCATTCCATG ATCTACTTCTTCCACCACTACGAGCTGCCTGCCATCCTGCAGCAGGTCCGCATCCAGGAGATGCTGCTTCAGGCGCCGCCACTGGGCCCC GGGACCCCCACGGCGCTGCCCGATGACATGAACAACAACTCGGGCGCCCCGGCTACAGCCCCTGACTCTGCCGGCCAGCCCCCCGCCCTG GGCCCCGTCTCGCCTGGGGCCAGCGGGAGTCCCGGGCCTGTGGCAGCGGCGCCCAGCTCCCTGGTGGCCGCGGCAGCCTCAGTGGCAGCA GCTGCCGGTGGTGACCTGGGTTGGATGGCAGAGACCGCTGCCATCATCACAGACGCCTCCTTCCTGTCCGGCCTGAGCGCCTCCCTCCTG GAGCGGCGTCCAGCCAGCCCGCTGGGCCCTGCTGGGGGCCTCCCCCACGCCCCCCAGGACAGTGTCCCCCCGAGTGACTCCGCAGCTTCT GACACAACTCCCCTGGGGGCTGCGGTAGGCGGGCCTAGCCCGGCCTCCATGGCCCCAACGGAGGCGCCCTCGGAGGTGGGGTCCTGAGCC GCACAGCTGAGCCGCCTCTGACCCCTGCTGGCTGGGCCTGACCTTCCCGAGCCCGTGGGGGTGGGGGAGGCCAGCCACCTCCTTCCTCTG GGACTGCCCAGCCTGTGTCGGGGGCTTTCAGGGTTTCGTGGGGTTTGCCCGGAAGGCGGCTTTCCTCCCCCTGGTGTGAGGTCGCGCCCG AGGCTTGTACCCGCTAGTGAGGTGTTTGAGCTGGTCAGCAAGGAGAGGGGGTGGGGTTCCGCGGAAGGTTCTGGAGGGGTCTTGGTAGGT CTGCAGTGAACCGTCCTGAGGATGGAGTGGGGTCCCATGGTGCAGGTCTCTGAGCAAGGCGGAGGTGTGGAGGAGAGGCCGGCTTGGGGT GGGGCCTCGCGCCCTAGTGCCGGCCGGCCTCAGCCCGGCTCTGCCTGGTGCTCCCTGCAGTGCCTTCTCCATGGCCCCGCCCTCCCCGCG TGTGCGCCAGGCTTGGGGTCCCCGGGAGAGCAGAGCTTGCGCCTCGGGCATAGGGACGTGGGGTGCAGGCGCCAACATCAGTGGCAGCAG CCAGGGCCGTGGTCCAGTCCCACTCGGGGATGGAGTGGGCCGGCGGCCAAACCAGTCACTCGGGGAGGAATGCGGAGGAGCGCTCATTCC |
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FusionGenePPI for RAVER1_TMEM259 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAVER1 | TERF2, ELAVL1, SDHA, ABCC1, PHKB, MCAT, AK2, DYNLT1, FN1, VCAM1, RPA3, RPA2, RPA1, STAU1, AIRE, AURKB, CDC20, CDKN1A, CEP250, HAUS2, CEP72, CEP76, LGALS3BP, NEDD1, PPP2R1A, TP53, TUBG1, FUS, ABCE1, SCGN, FGL1, CAPZA2, CNOT7, CYP1A1, PFAS, DDX1, DIS3, EIF4H, GART, RTCB, XPO1, SCARNA22, B9D2, NINL, CNOT1, BAG6, CDC5L, RC3H1, EYA2, FKBP9, CNOT11, TOB1, CDC16, GADD45B, HNRNPLL, P4HA2, GORASP2, UBAP2 | TMEM259 | TMEM173, ADRB2, ERLIN2, SRPRB, ATP1B3, C8orf74, ZDHHC7, ST3GAL5, B3GALT2, FAM189A2, TNF, TMEM155, TMUB2, RNF185, YIPF3, TMEM199, TNFRSF19, GPR21, SCGB1D2, TMCO3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAVER1_TMEM259 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAVER1_TMEM259 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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