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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 30568

FusionGeneSummary for RASSF3_TBK1

check button Fusion gene summary
Fusion gene informationFusion gene name: RASSF3_TBK1
Fusion gene ID: 30568
HgeneTgene
Gene symbol

RASSF3

TBK1

Gene ID

283349

29110

Gene nameRas association domain family member 3TANK binding kinase 1
SynonymsRASSF5FTDALS4|IIAE8|NAK|T2K
Cytomap

12q14.2

12q14.2

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3serine/threonine-protein kinase TBK1NF-kB-activating kinaseNF-kappa-B-activating kinase
Modification date2018051920180523
UniProtAcc

Q86WH2

Q9UHD2

Ensembl transtripts involved in fusion geneENST00000336061, ENST00000542104, 
ENST00000540088, 
ENST00000331710, 
Fusion gene scores* DoF score11 X 5 X 11=6054 X 4 X 5=80
# samples 136
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASSF3 [Title/Abstract] AND TBK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTBK1

GO:0006468

protein phosphorylation

27103069

TgeneTBK1

GO:0016239

positive regulation of macroautophagy

27103069

TgeneTBK1

GO:0018105

peptidyl-serine phosphorylation

25803835|27103069

TgeneTBK1

GO:0018107

peptidyl-threonine phosphorylation

27103069

TgeneTBK1

GO:0032727

positive regulation of interferon-alpha production

16127453

TgeneTBK1

GO:0032728

positive regulation of interferon-beta production

16127453

TgeneTBK1

GO:0045944

positive regulation of transcription by RNA polymerase II

16127453


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A4OQ-01ARASSF3chr12

65004523

+TBK1chr12

64873792

+
TCGARVREADTCGA-EF-5830-01ARASSF3chr12

65004523

+TBK1chr12

64889263

+
TCGALDSKCMTCGA-EE-A2MH-06ARASSF3chr12

65004523

+TBK1chr12

64889263

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336061ENST00000331710RASSF3chr12

65004523

+TBK1chr12

64873792

+
Frame-shiftENST00000542104ENST00000331710RASSF3chr12

65004523

+TBK1chr12

64873792

+
3UTR-3CDSENST00000540088ENST00000331710RASSF3chr12

65004523

+TBK1chr12

64873792

+
In-frameENST00000336061ENST00000331710RASSF3chr12

65004523

+TBK1chr12

64889263

+
In-frameENST00000542104ENST00000331710RASSF3chr12

65004523

+TBK1chr12

64889263

+
3UTR-3CDSENST00000540088ENST00000331710RASSF3chr12

65004523

+TBK1chr12

64889263

+

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FusionProtFeatures for RASSF3_TBK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASSF3

Q86WH2

TBK1

Q9UHD2

Serine/threonine kinase that plays an essential role inregulating inflammatory responses to foreign agents. Followingactivation of toll-like receptors by viral or bacterialcomponents, associates with TRAF3 and TANK and phosphorylatesinterferon regulatory factors (IRFs) IRF3 and IRF7 as well asDDX3X. This activity allows subsequent homodimerization andnuclear translocation of the IRFs leading to transcriptionalactivation of pro-inflammatory and antiviral genes including IFNAand IFNB. In order to establish such an antiviral state, TBK1 formseveral different complexes whose composition depends on the typeof cell and cellular stimuli. Thus, several scaffolding moleculesincluding FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can berecruited to the TBK1-containing-complexes. Under particularconditions, functions as a NF-kappa-B effector by phosphorylatingNF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocateNF-Kappa-B to the nucleus. Restricts bacterial proliferation byphosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterialautophagy (PubMed:21617041). Phosphorylates SMCR8 component of theC9orf72-SMCR8 complex, promoting autophagosome maturation(PubMed:27103069). Phosphorylates and activates AKT1(PubMed:21464307). Seems to play a role in energy balanceregulation by sustaining a state of chronic, low-gradeinflammation in obesity, wich leads to a negative impact oninsulin sensitivity. Attenuates retroviral budding byphosphorylating the endosomal sorting complex required fortransport-I (ESCRT-I) subunit VPS37C (PubMed:21270402).Phosphorylates Borna disease virus (BDV) P protein(PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections inthe central nervous system (PubMed:22851595).{ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893,ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549,ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513,ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837,ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125,ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416,ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307,ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631,ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971,ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807,ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTBK1chr12:65004523chr12:64889263ENST00000331710+1221658_713507730Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASSF3chr12:65004523chr12:64889263ENST00000336061+26187_23437239DomainSARAH
HgeneRASSF3chr12:65004523chr12:64889263ENST00000336061+2679_18637239DomainRas-associating
HgeneRASSF3chr12:65004523chr12:64889263ENST00000542104+15187_23437239DomainSARAH
HgeneRASSF3chr12:65004523chr12:64889263ENST00000542104+1579_18637239DomainRas-associating
TgeneTBK1chr12:65004523chr12:64889263ENST00000331710+1221407_657507730Coiled coil.
TgeneTBK1chr12:65004523chr12:64889263ENST00000331710+1221309_385507730DomainNote=Ubiquitin-like
TgeneTBK1chr12:65004523chr12:64889263ENST00000331710+12219_310507730DomainProtein kinase
TgeneTBK1chr12:65004523chr12:64889263ENST00000331710+122115_23507730Nucleotide bindingATP


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FusionGeneSequence for RASSF3_TBK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_260aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMT
EIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_260aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMT
EIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_260aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMT
EIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_260aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMT
EIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_780nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAGGATATCGACAGCAGATTATCTCCAGGTGGA
TCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGACAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACA
GAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAACAAATCCACAAATTTGATAAGCAAAAACTG
TATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGTTAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATA
AGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATTGAAGAAGAAGTATCAAAATATCAAGAATAT
ACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTCCAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCT
AACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAACCACATT

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_780nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAGGATATCGACAGCAGATTATCTCCAGGTGGA
TCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGACAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACA
GAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAACAAATCCACAAATTTGATAAGCAAAAACTG
TATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGTTAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATA
AGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATTGAAGAAGAAGTATCAAAATATCAAGAATAT
ACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTCCAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCT
AACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAACCACATT

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_780nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAGGATATCGACAGCAGATTATCTCCAGGTGGA
TCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGACAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACA
GAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAACAAATCCACAAATTTGATAAGCAAAAACTG
TATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGTTAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATA
AGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATTGAAGAAGAAGTATCAAAATATCAAGAATAT
ACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTCCAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCT
AACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAACCACATT

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_780nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAGGATATCGACAGCAGATTATCTCCAGGTGGA
TCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGACAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACA
GAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAACAAATCCACAAATTTGATAAGCAAAAACTG
TATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGTTAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATA
AGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATTGAAGAAGAAGTATCAAAATATCAAGAATAT
ACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTCCAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCT
AACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAACCACATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_1550nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGA
AACCAGTCTTCAGGATATCGACAGCAGATTATCTCCAGGTGGATCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGA
CAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACAGAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGC
TTATAATGAAGAACAAATCCACAAATTTGATAAGCAAAAACTGTATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGT
TAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATAAGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCA
GTGTTTTGATATTGAAGAAGAAGTATCAAAATATCAAGAATATACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTC
CAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCTAACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGA
GATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAACCACATTTTAGAAAGGTTTGGCTCTTTAACCATGGATGGTGGCCTTCGCAACGT
TGACTGTCTTTAGCTTTCTAATAGAAGTTTAAGAAAAGTTTCCGTTTGCACAAGAAAATAACGCTTGGGCATTAAATGAATGCCTTTATA
GATAGTCACTTGTTTCTACAATTCAGTATTTGATGTGGTCGTGTAAATATGTACAATATTGTAAATACATAAAAAATATACAAATTTTTG
GCTGCTGTGAAGATGTAATTTTATCTTTTAACATTTATAATTATATGAGGAAATTTGACCTCAGTGATCACGAGAAGAAAGCCATGACCG
ACCAATATGTTGACATACTGATCCTCTACTCTGAGTGGGGCTAAATAAGTTATTTTCTCTGACCGCCTACTGGAAATATTTTTAAGTGGA
ACCAAAATAGGCATCCTTACAAATCAGGAAGACTGACTTGACACGTTTGTAAATGGTAGAACGGTGGCTACTGTGAGTGGGGAGCAGAAC
CGCACCACTGTTATACTGGGATAACAATTTTTTTGAGAAGGATAAAGTGGCATTATTTTATTTTACAAGGTGCCCAGATCCCAGTTATCC
TTGTATCCATGTAATTTCAGATGAATTATTAAGCAAACATTTTAAAGTGAATTCATTATTAAAAACTATTCATTTTTTTCCTTTGGCCAT
AAATGTGTAATTGTCATTAAAATTCTAAGGTCATTTCAACTGTTTTAAGCTGTATATTTCTTTAATTCTGCTTACTATTTCATGGAAAAA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_1627nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAG
GATATCGACAGCAGATTATCTCCAGGTGGATCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGACAGAAATGTAGAA
AAACTACAAGTCCTGTTAAATTGCATGACAGAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAA
CAAATCCACAAATTTGATAAGCAAAAACTGTATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGTTAAAAAGTATGAG
GCATTTTTGAATAAGTCAGAAGAATGGATAAGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATT
GAAGAAGAAGTATCAAAATATCAAGAATATACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTCCAGTGGAATCAAA
CATACCATGACCCCAATTTATCCAAGTTCTAACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTG
GTTAAAGAACTTGCTGAAAATAACCACATTTTAGAAAGGTTTGGCTCTTTAACCATGGATGGTGGCCTTCGCAACGTTGACTGTCTTTAG
CTTTCTAATAGAAGTTTAAGAAAAGTTTCCGTTTGCACAAGAAAATAACGCTTGGGCATTAAATGAATGCCTTTATAGATAGTCACTTGT
TTCTACAATTCAGTATTTGATGTGGTCGTGTAAATATGTACAATATTGTAAATACATAAAAAATATACAAATTTTTGGCTGCTGTGAAGA
TGTAATTTTATCTTTTAACATTTATAATTATATGAGGAAATTTGACCTCAGTGATCACGAGAAGAAAGCCATGACCGACCAATATGTTGA
CATACTGATCCTCTACTCTGAGTGGGGCTAAATAAGTTATTTTCTCTGACCGCCTACTGGAAATATTTTTAAGTGGAACCAAAATAGGCA
TCCTTACAAATCAGGAAGACTGACTTGACACGTTTGTAAATGGTAGAACGGTGGCTACTGTGAGTGGGGAGCAGAACCGCACCACTGTTA
TACTGGGATAACAATTTTTTTGAGAAGGATAAAGTGGCATTATTTTATTTTACAAGGTGCCCAGATCCCAGTTATCCTTGTATCCATGTA
ATTTCAGATGAATTATTAAGCAAACATTTTAAAGTGAATTCATTATTAAAAACTATTCATTTTTTTCCTTTGGCCATAAATGTGTAATTG
TCATTAAAATTCTAAGGTCATTTCAACTGTTTTAAGCTGTATATTTCTTTAATTCTGCTTACTATTTCATGGAAAAAAATAAATTTCTCA

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_1550nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGA
AACCAGTCTTCAGGATATCGACAGCAGATTATCTCCAGGTGGATCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGA
CAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACAGAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGC
TTATAATGAAGAACAAATCCACAAATTTGATAAGCAAAAACTGTATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGT
TAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATAAGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCA
GTGTTTTGATATTGAAGAAGAAGTATCAAAATATCAAGAATATACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTC
CAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCTAACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGA
GATGGAAGGGGTGGTTAAAGAACTTGCTGAAAATAACCACATTTTAGAAAGGTTTGGCTCTTTAACCATGGATGGTGGCCTTCGCAACGT
TGACTGTCTTTAGCTTTCTAATAGAAGTTTAAGAAAAGTTTCCGTTTGCACAAGAAAATAACGCTTGGGCATTAAATGAATGCCTTTATA
GATAGTCACTTGTTTCTACAATTCAGTATTTGATGTGGTCGTGTAAATATGTACAATATTGTAAATACATAAAAAATATACAAATTTTTG
GCTGCTGTGAAGATGTAATTTTATCTTTTAACATTTATAATTATATGAGGAAATTTGACCTCAGTGATCACGAGAAGAAAGCCATGACCG
ACCAATATGTTGACATACTGATCCTCTACTCTGAGTGGGGCTAAATAAGTTATTTTCTCTGACCGCCTACTGGAAATATTTTTAAGTGGA
ACCAAAATAGGCATCCTTACAAATCAGGAAGACTGACTTGACACGTTTGTAAATGGTAGAACGGTGGCTACTGTGAGTGGGGAGCAGAAC
CGCACCACTGTTATACTGGGATAACAATTTTTTTGAGAAGGATAAAGTGGCATTATTTTATTTTACAAGGTGCCCAGATCCCAGTTATCC
TTGTATCCATGTAATTTCAGATGAATTATTAAGCAAACATTTTAAAGTGAATTCATTATTAAAAACTATTCATTTTTTTCCTTTGGCCAT
AAATGTGTAATTGTCATTAAAATTCTAAGGTCATTTCAACTGTTTTAAGCTGTATATTTCTTTAATTCTGCTTACTATTTCATGGAAAAA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_TBK1_ENST00000331710_chr12_64889263_+_1627nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAG
GATATCGACAGCAGATTATCTCCAGGTGGATCACTGGCAGACGCATGGGCACATCAAGAAGGCACTCATCCGAAAGACAGAAATGTAGAA
AAACTACAAGTCCTGTTAAATTGCATGACAGAGATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAA
CAAATCCACAAATTTGATAAGCAAAAACTGTATTACCATGCCACAAAAGCTATGACGCACTTTACAGATGAATGTGTTAAAAAGTATGAG
GCATTTTTGAATAAGTCAGAAGAATGGATAAGAAAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATT
GAAGAAGAAGTATCAAAATATCAAGAATATACTAATGAGTTACAAGAAACTCTGCCTCAGAAAATGTTTACAGCTTCCAGTGGAATCAAA
CATACCATGACCCCAATTTATCCAAGTTCTAACACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTG
GTTAAAGAACTTGCTGAAAATAACCACATTTTAGAAAGGTTTGGCTCTTTAACCATGGATGGTGGCCTTCGCAACGTTGACTGTCTTTAG
CTTTCTAATAGAAGTTTAAGAAAAGTTTCCGTTTGCACAAGAAAATAACGCTTGGGCATTAAATGAATGCCTTTATAGATAGTCACTTGT
TTCTACAATTCAGTATTTGATGTGGTCGTGTAAATATGTACAATATTGTAAATACATAAAAAATATACAAATTTTTGGCTGCTGTGAAGA
TGTAATTTTATCTTTTAACATTTATAATTATATGAGGAAATTTGACCTCAGTGATCACGAGAAGAAAGCCATGACCGACCAATATGTTGA
CATACTGATCCTCTACTCTGAGTGGGGCTAAATAAGTTATTTTCTCTGACCGCCTACTGGAAATATTTTTAAGTGGAACCAAAATAGGCA
TCCTTACAAATCAGGAAGACTGACTTGACACGTTTGTAAATGGTAGAACGGTGGCTACTGTGAGTGGGGAGCAGAACCGCACCACTGTTA
TACTGGGATAACAATTTTTTTGAGAAGGATAAAGTGGCATTATTTTATTTTACAAGGTGCCCAGATCCCAGTTATCCTTGTATCCATGTA
ATTTCAGATGAATTATTAAGCAAACATTTTAAAGTGAATTCATTATTAAAAACTATTCATTTTTTTCCTTTGGCCATAAATGTGTAATTG
TCATTAAAATTCTAAGGTCATTTCAACTGTTTTAAGCTGTATATTTCTTTAATTCTGCTTACTATTTCATGGAAAAAAATAAATTTCTCA


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FusionGenePPI for RASSF3_TBK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RASSF3MDM2, APP, STK3, STK4, FBXW11, BTRC, MAP1S, CDC37, FGFR1OP2, MAP1B, MOB4, SIKE1, SLMAP, STRN, STRN3, STRN4, STRIP1, VAPA, VAPB, XPO1, LITAFTBK1CDC37, HSP90AA2P, TANK, TBKBP1, TRAF2, NFKB1, IKBKG, BTRC, REL, CUL1, ANKRD28, PPP6R2, PPP6R1, NFKB2, PPP6C, RELA, SKP1, NCK1, CYLD, IRF3, TRAF3, TNFAIP3, RB1CC1, TNF, TMEM173, CALCOCO2, TLR4, TLR9, TLR3, NCOA2, AZI2, OPTN, ATG9A, CDC42BPG, FMR1, FXR2, MIB1, MAVS, AGO2, HMMR, IKBKE, LETM1, MTPAP, RBBP5, TXLNA, TXLNG, TICAM1, MIB2, NEDD4, NLRP4, DTX4, TNIP1, TAX1BP1, TBK1, MBP, XIAP, PELI1, HERC2, IRF7, TRAIP, TRIM27, SRC, NFKBIA, HSP90AA1, APP, RNF11, YWHAE, TOMM70A, TRAF3IP2, DDX58, SYK, PROS1, STX11, LATS2, EXOC2, EGFR, CCDC8, MAP1LC3B, AKT1, SOCS3, SQSTM1, STX12, STX3, STX19, APBA3, BBOX1, TRIM10, IFIT3, USP2, NTRK1, MED4, SCLT1, SSX2IP, OFD1, CEP152, CNTROB, CEP128, CEP135, CEP44, CEP63, NINL, ODF2, SASS6, STIL, XPO1, ESR1, MCM2, TRIM26, TRAF1, DYRK2, TRIM14, CTNNBL1, PBXIP1, SMURF1, TRAF6, TRIM9, GSK3B, RNF128, PLK1, HIF1AN, TXLNB, DFNB31, HERPUD1, TRAF5, TRIM23


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTBK1chr12:65004523chr12:64889263ENST00000331710+1221621_629507730AZI2%2C TANK and TBKBP1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASSF3_TBK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASSF3_TBK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTBK1C4225325FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 42UNIPROT