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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 30563

FusionGeneSummary for RASSF3_ITGA7

check button Fusion gene summary
Fusion gene informationFusion gene name: RASSF3_ITGA7
Fusion gene ID: 30563
HgeneTgene
Gene symbol

RASSF3

ITGA7

Gene ID

283349

3679

Gene nameRas association domain family member 3integrin subunit alpha 7
SynonymsRASSF5-
Cytomap

12q14.2

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3integrin alpha-7integrin alpha 7 chain
Modification date2018051920180522
UniProtAcc

Q86WH2

Q13683

Ensembl transtripts involved in fusion geneENST00000336061, ENST00000542104, 
ENST00000540088, 		ENST00000553804, 
ENST00000257879, ENST00000347027, 
ENST00000452168, ENST00000394229, 
ENST00000257880, ENST00000394230, 
ENST00000555728, 
Fusion gene scores* DoF score11 X 5 X 11=6053 X 3 X 3=27
# samples 133
** MAII scorelog2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RASSF3 [Title/Abstract] AND ITGA7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-GN-A26D-06ARASSF3chr12

65004523

+ITGA7chr12

56079072

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336061ENST00000553804RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000257879RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000336061ENST00000347027RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000336061ENST00000452168RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000394229RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000257880RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000394230RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000336061ENST00000555728RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000542104ENST00000553804RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000257879RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000542104ENST00000347027RASSF3chr12

65004523

+ITGA7chr12

56079072

-
In-frameENST00000542104ENST00000452168RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000394229RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000257880RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000394230RASSF3chr12

65004523

+ITGA7chr12

56079072

-
Frame-shiftENST00000542104ENST00000555728RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000553804RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000257879RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000347027RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000452168RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000394229RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000257880RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000394230RASSF3chr12

65004523

+ITGA7chr12

56079072

-
3UTR-3CDSENST00000540088ENST00000555728RASSF3chr12

65004523

+ITGA7chr12

56079072

-

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FusionProtFeatures for RASSF3_ITGA7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASSF3

Q86WH2

ITGA7

Q13683


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251107_111110611138MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251107_11119681045MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251107_111110651142MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261107_111111051182MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251157_117610611138RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271157_117611421163RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251157_11769681045RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251157_117610651142RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261157_117611051182RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251157_116010611138RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251165_116810611138RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251173_117610611138RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271157_116011421163RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271165_116811421163RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271173_117611421163RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251157_11609681045RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251165_11689681045RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251173_11769681045RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251157_116010651142RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251165_116810651142RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251173_117610651142RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261157_116011051182RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261165_116811051182RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261173_117611051182RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251104_118110611138Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251104_11819681045Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251104_118110651142Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261104_118111051182Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-23251083_110310611138TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-23251083_11039681045TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-23251083_110310651142TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASSF3chr12:65004523chr12:56079072ENST00000336061+26187_23437239DomainSARAH
HgeneRASSF3chr12:65004523chr12:56079072ENST00000336061+2679_18637239DomainRas-associating
HgeneRASSF3chr12:65004523chr12:56079072ENST00000542104+15187_23437239DomainSARAH
HgeneRASSF3chr12:65004523chr12:56079072ENST00000542104+1579_18637239DomainRas-associating
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325372_38010611138Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325434_44210611138Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325492_50010611138Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527372_38011421163Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527434_44211421163Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527492_50011421163Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325372_3809681045Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325434_4429681045Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325492_5009681045Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325372_38010651142Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325434_44210651142Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325492_50010651142Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426372_38011051182Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426434_44211051182Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426492_50011051182Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325953_95810611138Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527953_95811421163Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325953_9589681045Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325953_95810651142Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426953_95811051182Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271107_111111421163MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325110_17510611138RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325185_23810611138RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325292_34910611138RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325350_41110611138RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-232535_10310611138RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325412_46710611138RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-2325471_53010611138RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527110_17511421163RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527185_23811421163RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527292_34911421163RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527350_41111421163RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-252735_10311421163RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527412_46711421163RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-2527471_53011421163RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325110_1759681045RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325185_2389681045RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325292_3499681045RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325350_4119681045RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-232535_1039681045RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325412_4679681045RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-2325471_5309681045RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325110_17510651142RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325185_23810651142RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325292_34910651142RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325350_41110651142RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-232535_10310651142RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325412_46710651142RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-2325471_53010651142RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426110_17511051182RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426185_23811051182RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426292_34911051182RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426350_41111051182RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-242635_10311051182RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426412_46711051182RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-2426471_53011051182RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879-232534_108210611138Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271104_118111421163Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-252734_108211421163Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168-232534_10829681045Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804-232534_108210651142Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-242634_108211051182Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880-25271083_110311421163TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728-24261083_110311051182TransmembraneHelical


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FusionGeneSequence for RASSF3_ITGA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000553804_chr12_56079072_-_114aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDA

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000347027_chr12_56079072_-_114aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDA

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000452168_chr12_56079072_-_114aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000553804_chr12_56079072_-_114aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000347027_chr12_56079072_-_114aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000452168_chr12_56079072_-_114aa
MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000553804_chr12_56079072_-_342nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCT
CGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCA

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000347027_chr12_56079072_-_342nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCT
CGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCA

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000452168_chr12_56079072_-_342nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCT
CGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000553804_chr12_56079072_-_342nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCT
CGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000347027_chr12_56079072_-_342nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCT
CGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCA

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000452168_chr12_56079072_-_342nt
ATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGC
AAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCT
CGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000553804_chr12_56079072_-_875nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCA
CCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCT
GAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGG
GCATCCAGGGCCAGGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGA
TGAAGAGGGTAGAGTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAAC
TCCTCCCACCCAACTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGG
TGTCCTGATGCAAAGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCG
GAAGTGCCTTAACCTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGT

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000347027_chr12_56079072_-_871nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCA
CCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCT
GAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGG
GCATCCAGGGCCAGGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGA
TGAAGAGGGTAGAGTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAAC
TCCTCCCACCCAACTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGG
TGTCCTGATGCAAAGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCG
GAAGTGCCTTAACCTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGT

>In-frame_RASSF3_ENST00000336061_chr12_65004523_+_ITGA7_ENST00000452168_chr12_56079072_-_871nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTT
CTTCACCGCCAGGACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCA
CCCCGAGGCCACCGTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCT
GAGGAACAACTGGGGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGG
GCATCCAGGGCCAGGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGA
TGAAGAGGGTAGAGTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAAC
TCCTCCCACCCAACTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGG
TGTCCTGATGCAAAGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCG
GAAGTGCCTTAACCTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGT

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000553804_chr12_56079072_-_952nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACC
GTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGG
GGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGGGCATCCAGGGCCA
GGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGATGAAGAGGGTAGA
GTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAACTCCTCCCACCCAA
CTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGGTGTCCTGATGCAA
AGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCGGAAGTGCCTTAAC
CTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGTTTGCTGCCATCAG

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000347027_chr12_56079072_-_948nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACC
GTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGG
GGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGGGCATCCAGGGCCA
GGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGATGAAGAGGGTAGA
GTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAACTCCTCCCACCCAA
CTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGGTGTCCTGATGCAA
AGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCGGAAGTGCCTTAAC
CTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGTTTGCTGCCATCAG

>In-frame_RASSF3_ENST00000542104_chr12_65004523_+_ITGA7_ENST00000452168_chr12_56079072_-_948nt
GCTGCATAAGGACTGCCCGGGGCTGCGCGCCGGGAACCTCGCGGGGCTGGCGGGCGCCGCACCCCCTCCCTGGCCGCCTGCGCCCCGGGG
AGGCCGCCCGCGCGCGACGGGACCGGCAGCATGAGCAGCGGCTACAGCAGCCTGGAGGAGGACGCCGAGGACTTCTTCTTCACCGCCAGG
ACCTCCTTCTTCAGGAGAGCGCCCCAGGGCAAGCCCCGCTCCGGCCAACAAATGGGATTCTTCAAACGGGCGAAGCACCCCGAGGCCACC
GTGCCCCAGTACCATGCGGTGAAGATTCCTCGGGAAGACCGACAGCAGTTCAAGGAGGAGAAGACGGGCACCATCCTGAGGAACAACTGG
GGCAGCCCCCGGCGGGAGGGCCCGGATGCACACCCCATCCTGGCTGCTGACGGGCATCCCGAGCTGGGCCCCGATGGGCATCCAGGGCCA
GGCACCGCCTAGGTTCCCATGTCCCAGCCTGGCCTGTGGCTGCCCTCCATCCCTTCCCCAGAGATGGCTCCTTGGGATGAAGAGGGTAGA
GTGGGCTGCTGGTGTCGCATCAAGATTTGGCAGGATCGGCTTCCTCAGGGGCACAGACCTCTCCCACCCACAAGAACTCCTCCCACCCAA
CTTCCCCTTAGAGTGCTGTGAGATGAGAGTGGGTAAATCAGGGACAGGGCCATGGGGTAGGGTGAGAAGGGCAGGGGTGTCCTGATGCAA
AGGTGGGGAGAAGGGATCCTAATCCCTTCCTCTCCCATTCACCCTGTGTAACAGGACCCCAAGGACCTGCCTCCCCGGAAGTGCCTTAAC
CTAGAGGGTCGGGGAGGAGGTTGTGTCACTGACTCAGGCTGCTCCTTCTCTAGTTTCCCCTCTCATCTGACCTTAGTTTGCTGCCATCAG


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FusionGenePPI for RASSF3_ITGA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RASSF3MDM2, APP, STK3, STK4, FBXW11, BTRC, MAP1S, CDC37, FGFR1OP2, MAP1B, MOB4, SIKE1, SLMAP, STRN, STRN3, STRN4, STRIP1, VAPA, VAPB, XPO1, LITAFITGA7FHL2, FHL3, CHRNA1, MYOC, ITGB1, TAZ, ATP1B3, SUSD4, LGALS8, TNFSF13B, ATP1B4, BTNL8, ART3, B3GNT2, PTCH1, TSPAN11, ST8SIA4, SLAMF1, PCDHGA5, DKKL1, DEFA1, PSG8, TMPRSS11B, CD1E, PCDH20, NCEH1, TMED6, IL17RC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASSF3_ITGA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASSF3_ITGA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneITGA7C0009375Colonic Neoplasms1CTD_human