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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30556

FusionGeneSummary for RASL11B_CSRNP3

check button Fusion gene summary
Fusion gene informationFusion gene name: RASL11B_CSRNP3
Fusion gene ID: 30556
HgeneTgene
Gene symbol

RASL11B

CSRNP3

Gene ID

65997

80034

Gene nameRAS like family 11 member Bcysteine and serine rich nuclear protein 3
Synonyms-FAM130A2|PPP1R73|TAIP-2|TAIP2
Cytomap

4q12

2q24.3

Type of geneprotein-codingprotein-coding
Descriptionras-like protein family member 11Bcysteine/serine-rich nuclear protein 3TGF-beta induced apoptosis protein 2family with sequence similarity 130, member A2protein phosphatase 1, regulatory subunit 73
Modification date2018051920180519
UniProtAcc

Q9BPW5

Q8WYN3

Ensembl transtripts involved in fusion geneENST00000248706, ENST00000505041, 
ENST00000314499, ENST00000464503, 
ENST00000342316, ENST00000409420, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 1=9
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RASL11B [Title/Abstract] AND CSRNP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCSRNP3

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T20253RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000248706ENST00000314499RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000248706ENST00000464503RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000248706ENST00000342316RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000248706ENST00000409420RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000505041ENST00000314499RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000505041ENST00000464503RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000505041ENST00000342316RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+
3UTR-intronENST00000505041ENST00000409420RASL11Bchr4

53732076

+CSRNP3chr2

166377694

+

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FusionProtFeatures for RASL11B_CSRNP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASL11B

Q9BPW5

CSRNP3

Q8WYN3

Binds to the consensus sequence 5'-AGAGTG-3' and hastranscriptional activator activity. Plays a role in apoptosis (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASL11B_CSRNP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASL11B_CSRNP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASL11B_CSRNP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASL11B_CSRNP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCSRNP3C0000786Spontaneous abortion1CTD_human
TgeneCSRNP3C0236969Substance-Related Disorders1CTD_human