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Fusion gene ID: 30556 |
FusionGeneSummary for RASL11B_CSRNP3 |
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Fusion gene information | Fusion gene name: RASL11B_CSRNP3 | Fusion gene ID: 30556 | Hgene | Tgene | Gene symbol | RASL11B | CSRNP3 | Gene ID | 65997 | 80034 |
Gene name | RAS like family 11 member B | cysteine and serine rich nuclear protein 3 | |
Synonyms | - | FAM130A2|PPP1R73|TAIP-2|TAIP2 | |
Cytomap | 4q12 | 2q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-like protein family member 11B | cysteine/serine-rich nuclear protein 3TGF-beta induced apoptosis protein 2family with sequence similarity 130, member A2protein phosphatase 1, regulatory subunit 73 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9BPW5 | Q8WYN3 | |
Ensembl transtripts involved in fusion gene | ENST00000248706, ENST00000505041, | ENST00000314499, ENST00000464503, ENST00000342316, ENST00000409420, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 1=9 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RASL11B [Title/Abstract] AND CSRNP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CSRNP3 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T20253 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000248706 | ENST00000314499 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000248706 | ENST00000464503 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000248706 | ENST00000342316 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000248706 | ENST00000409420 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000505041 | ENST00000314499 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000505041 | ENST00000464503 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000505041 | ENST00000342316 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
3UTR-intron | ENST00000505041 | ENST00000409420 | RASL11B | chr4 | 53732076 | + | CSRNP3 | chr2 | 166377694 | + |
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FusionProtFeatures for RASL11B_CSRNP3 |
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Hgene | Tgene |
RASL11B | CSRNP3 |
Binds to the consensus sequence 5'-AGAGTG-3' and hastranscriptional activator activity. Plays a role in apoptosis (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RASL11B_CSRNP3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RASL11B_CSRNP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RASL11B_CSRNP3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASL11B_CSRNP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CSRNP3 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | CSRNP3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |