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Fusion gene ID: 30548 |
FusionGeneSummary for RASGRF2_MBP |
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Fusion gene information | Fusion gene name: RASGRF2_MBP | Fusion gene ID: 30548 | Hgene | Tgene | Gene symbol | RASGRF2 | MBP | Gene ID | 5924 | 5553 |
Gene name | Ras protein specific guanine nucleotide releasing factor 2 | proteoglycan 2, pro eosinophil major basic protein | |
Synonyms | GRF2|RAS-GRF2 | BMPG|MBP|MBP1|proMBP | |
Cytomap | 5q14.1 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-specific guanine nucleotide-releasing factor 2ras guanine nucleotide exchange factor 2 | bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O14827 | P02686 | |
Ensembl transtripts involved in fusion gene | ENST00000265080, ENST00000502677, | ENST00000382582, ENST00000355994, ENST00000397875, ENST00000397866, ENST00000397865, ENST00000527041, ENST00000359645, ENST00000528160, ENST00000397869, ENST00000354542, ENST00000526111, ENST00000580402, ENST00000579129, ENST00000578193, ENST00000397863, ENST00000397860, ENST00000487778, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 26 X 20 X 3=1560 |
# samples | 1 | 27 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(27/1560*10)=-2.53051471669878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RASGRF2 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA342507 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000265080 | ENST00000382582 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000265080 | ENST00000355994 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000265080 | ENST00000397875 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000265080 | ENST00000397866 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000265080 | ENST00000397865 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000265080 | ENST00000527041 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000265080 | ENST00000359645 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000528160 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000397869 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000354542 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000526111 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000580402 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000579129 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000578193 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000397863 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000397860 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000265080 | ENST00000487778 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000382582 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000355994 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000397875 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000397866 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000397865 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000527041 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-3CDS | ENST00000502677 | ENST00000359645 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000528160 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000397869 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000354542 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000526111 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000580402 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000579129 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000578193 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000397863 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000397860 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
intron-intron | ENST00000502677 | ENST00000487778 | RASGRF2 | chr5 | 80291646 | - | MBP | chr18 | 74702020 | - |
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FusionProtFeatures for RASGRF2_MBP |
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Hgene | Tgene |
RASGRF2 | MBP |
Functions as a calcium-regulated nucleotide exchangefactor activating both Ras and RAC1 through the exchange of boundGDP for GTP. Preferentially activates HRAS in vivo compared toRRAS based on their different types of prenylation. Functions insynaptic plasticity by contributing to the induction of long termpotentiation. {ECO:0000269|PubMed:15128856}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RASGRF2_MBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RASGRF2_MBP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RASGRF2_MBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASGRF2_MBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RASGRF2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | RASGRF2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | RASGRF2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | MBP | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | MBP | C0014072 | Experimental Autoimmune Encephalomyelitis | 3 | CTD_human |
Tgene | MBP | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | MBP | C0011303 | Demyelinating Diseases | 1 | CTD_human |
Tgene | MBP | C0027873 | Neuromyelitis Optica | 1 | CTD_human |