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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30548

FusionGeneSummary for RASGRF2_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: RASGRF2_MBP
Fusion gene ID: 30548
HgeneTgene
Gene symbol

RASGRF2

MBP

Gene ID

5924

5553

Gene nameRas protein specific guanine nucleotide releasing factor 2proteoglycan 2, pro eosinophil major basic protein
SynonymsGRF2|RAS-GRF2BMPG|MBP|MBP1|proMBP
Cytomap

5q14.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionras-specific guanine nucleotide-releasing factor 2ras guanine nucleotide exchange factor 2bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018051920180519
UniProtAcc

O14827

P02686

Ensembl transtripts involved in fusion geneENST00000265080, ENST00000502677, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score1 X 1 X 1=126 X 20 X 3=1560
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASGRF2 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA342507RASGRF2chr5

80291646

-MBPchr18

74702020

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000265080ENST00000382582RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000265080ENST00000355994RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000265080ENST00000397875RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000265080ENST00000397866RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000265080ENST00000397865RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000265080ENST00000527041RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000265080ENST00000359645RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000528160RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000397869RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000354542RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000526111RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000580402RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000579129RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000578193RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000397863RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000397860RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000265080ENST00000487778RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000382582RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000355994RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000397875RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000397866RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000397865RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000527041RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-3CDSENST00000502677ENST00000359645RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000528160RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000397869RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000354542RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000526111RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000580402RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000579129RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000578193RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000397863RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000397860RASGRF2chr5

80291646

-MBPchr18

74702020

-
intron-intronENST00000502677ENST00000487778RASGRF2chr5

80291646

-MBPchr18

74702020

-

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FusionProtFeatures for RASGRF2_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASGRF2

O14827

MBP

P02686

Functions as a calcium-regulated nucleotide exchangefactor activating both Ras and RAC1 through the exchange of boundGDP for GTP. Preferentially activates HRAS in vivo compared toRRAS based on their different types of prenylation. Functions insynaptic plasticity by contributing to the induction of long termpotentiation. {ECO:0000269|PubMed:15128856}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASGRF2_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASGRF2_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASGRF2_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASGRF2_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASGRF2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneRASGRF2C0024667Animal Mammary Neoplasms1CTD_human
HgeneRASGRF2C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human