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Fusion gene ID: 30547 |
FusionGeneSummary for RASGRF1_HOMER2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RASGRF1_HOMER2 | Fusion gene ID: 30547 | Hgene | Tgene | Gene symbol | RASGRF1 | HOMER2 | Gene ID | 5923 | 9455 |
| Gene name | Ras protein specific guanine nucleotide releasing factor 1 | homer scaffold protein 2 | |
| Synonyms | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | ACPD|CPD|DFNA68|HOMER-2|VESL-2 | |
| Cytomap | 15q25.1 | 15q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q13972 | Q9NSB8 | |
| Ensembl transtripts involved in fusion gene | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | ENST00000450735, ENST00000304231, ENST00000399166, ENST00000426485, ENST00000500334, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 3 X 3=45 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RASGRF1 [Title/Abstract] AND HOMER2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A7AP-01A | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shit | ENST00000558480 | ENST00000450735 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000558480 | ENST00000304231 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000558480 | ENST00000399166 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000558480 | ENST00000426485 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| 5CDS-intron | ENST00000558480 | ENST00000500334 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000419573 | ENST00000450735 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000419573 | ENST00000304231 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000419573 | ENST00000399166 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| Frame-shit | ENST00000419573 | ENST00000426485 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| 5CDS-intron | ENST00000419573 | ENST00000500334 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000560334 | ENST00000450735 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000560334 | ENST00000304231 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000560334 | ENST00000399166 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000560334 | ENST00000426485 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-intron | ENST00000560334 | ENST00000500334 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000394745 | ENST00000450735 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000394745 | ENST00000304231 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000394745 | ENST00000399166 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-3CDS | ENST00000394745 | ENST00000426485 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
| intron-intron | ENST00000394745 | ENST00000500334 | RASGRF1 | chr15 | 79382565 | - | HOMER2 | chr15 | 83561593 | - |
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FusionProtFeatures for RASGRF1_HOMER2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RASGRF1 | HOMER2 |
| Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. | Postsynaptic density scaffolding protein. Binds andcross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1,RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 withER-associated ITPR1 receptors, it aids the coupling of surfacereceptors to intracellular calcium release. May also couple GRM1to PI3 kinase through its interaction with AGAP2. Isoforms can bedifferently regulated and may play an important role inmaintaining the plasticity at glutamatergic synapses(PubMed:9808459). Required for normal hearing (PubMed:25816005).Negatively regulates T cell activation through negative regulationof IL2 expression by inhibiting calcineurin-NFAT pathwayactivation through interaction with NFATC2 (PubMed:18218901).{ECO:0000269|PubMed:18218901, ECO:0000269|PubMed:25816005,ECO:0000269|PubMed:9808459}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RASGRF1_HOMER2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RASGRF1_HOMER2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RASGRF1 | MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2 | HOMER2 | RYR1, UBXN1, APP, VKORC1, KPNA2, RNF41, LZTS2, CSPP1, HOMER1, IFT57, SMURF1, HOMER3, DBN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RASGRF1_HOMER2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASGRF1_HOMER2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RASGRF1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | RASGRF1 | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
| Hgene | RASGRF1 | C0027092 | Myopia | 1 | CTD_human |
| Hgene | RASGRF1 | C0034951 | Refractive Errors | 1 | CTD_human |
| Tgene | HOMER2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | HOMER2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | HOMER2 | C4225240 | DEAFNESS, AUTOSOMAL DOMINANT 68 | 1 | UNIPROT |
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