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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30547

FusionGeneSummary for RASGRF1_HOMER2

check button Fusion gene summary
Fusion gene informationFusion gene name: RASGRF1_HOMER2
Fusion gene ID: 30547
HgeneTgene
Gene symbol

RASGRF1

HOMER2

Gene ID

5923

9455

Gene nameRas protein specific guanine nucleotide releasing factor 1homer scaffold protein 2
SynonymsCDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1ACPD|CPD|DFNA68|HOMER-2|VESL-2
Cytomap

15q25.1

15q25.2

Type of geneprotein-codingprotein-coding
Descriptionras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-rehomer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2
Modification date2018051920180523
UniProtAcc

Q13972

Q9NSB8

Ensembl transtripts involved in fusion geneENST00000558480, ENST00000419573, 
ENST00000560334, ENST00000394745, 
ENST00000450735, ENST00000304231, 
ENST00000399166, ENST00000426485, 
ENST00000500334, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 3 X 3=45
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RASGRF1 [Title/Abstract] AND HOMER2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A7AP-01ARASGRF1chr15

79382565

-HOMER2chr15

83561593

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000558480ENST00000450735RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000558480ENST00000304231RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000558480ENST00000399166RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000558480ENST00000426485RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
5CDS-intronENST00000558480ENST00000500334RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000419573ENST00000450735RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000419573ENST00000304231RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000419573ENST00000399166RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
Frame-shitENST00000419573ENST00000426485RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
5CDS-intronENST00000419573ENST00000500334RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000560334ENST00000450735RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000560334ENST00000304231RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000560334ENST00000399166RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000560334ENST00000426485RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-intronENST00000560334ENST00000500334RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000394745ENST00000450735RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000394745ENST00000304231RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000394745ENST00000399166RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-3CDSENST00000394745ENST00000426485RASGRF1chr15

79382565

-HOMER2chr15

83561593

-
intron-intronENST00000394745ENST00000500334RASGRF1chr15

79382565

-HOMER2chr15

83561593

-

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FusionProtFeatures for RASGRF1_HOMER2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASGRF1

Q13972

HOMER2

Q9NSB8

Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. Postsynaptic density scaffolding protein. Binds andcross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1,RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 withER-associated ITPR1 receptors, it aids the coupling of surfacereceptors to intracellular calcium release. May also couple GRM1to PI3 kinase through its interaction with AGAP2. Isoforms can bedifferently regulated and may play an important role inmaintaining the plasticity at glutamatergic synapses(PubMed:9808459). Required for normal hearing (PubMed:25816005).Negatively regulates T cell activation through negative regulationof IL2 expression by inhibiting calcineurin-NFAT pathwayactivation through interaction with NFATC2 (PubMed:18218901).{ECO:0000269|PubMed:18218901, ECO:0000269|PubMed:25816005,ECO:0000269|PubMed:9808459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASGRF1_HOMER2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASGRF1_HOMER2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RASGRF1MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2HOMER2RYR1, UBXN1, APP, VKORC1, KPNA2, RNF41, LZTS2, CSPP1, HOMER1, IFT57, SMURF1, HOMER3, DBN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASGRF1_HOMER2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASGRF1_HOMER2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASGRF1C0005586Bipolar Disorder1PSYGENET
HgeneRASGRF1C0013386Dyskinesia, Drug-Induced1CTD_human
HgeneRASGRF1C0027092Myopia1CTD_human
HgeneRASGRF1C0034951Refractive Errors1CTD_human
TgeneHOMER2C0036341Schizophrenia1PSYGENET
TgeneHOMER2C0236736Cocaine-Related Disorders1CTD_human
TgeneHOMER2C4225240DEAFNESS, AUTOSOMAL DOMINANT 681UNIPROT