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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30546

FusionGeneSummary for RASGRF1_HNRNPD

check button Fusion gene summary
Fusion gene informationFusion gene name: RASGRF1_HNRNPD
Fusion gene ID: 30546
HgeneTgene
Gene symbol

RASGRF1

HNRNPD

Gene ID

5923

3184

Gene nameRas protein specific guanine nucleotide releasing factor 1heterogeneous nuclear ribonucleoprotein D
SynonymsCDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1AUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

15q25.1

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-reheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date2018051920180523
UniProtAcc

Q13972

Q14103

Ensembl transtripts involved in fusion geneENST00000558480, ENST00000419573, 
ENST00000560334, ENST00000394745, 
ENST00000313899, ENST00000353341, 
ENST00000543098, ENST00000352301, 
ENST00000508119, ENST00000541060, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 10 X 3=300
# samples 312
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASGRF1 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA845763RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000558480ENST00000313899RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000558480ENST00000353341RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000558480ENST00000543098RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000558480ENST00000352301RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000558480ENST00000508119RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000558480ENST00000541060RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000419573ENST00000313899RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000419573ENST00000353341RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000419573ENST00000543098RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000419573ENST00000352301RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000419573ENST00000508119RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000419573ENST00000541060RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000560334ENST00000313899RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000560334ENST00000353341RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000560334ENST00000543098RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000560334ENST00000352301RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000560334ENST00000508119RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000560334ENST00000541060RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000394745ENST00000313899RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000394745ENST00000353341RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000394745ENST00000543098RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000394745ENST00000352301RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-intronENST00000394745ENST00000508119RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-
intron-5UTRENST00000394745ENST00000541060RASGRF1chr15

79296310

-HNRNPDchr4

83295087

-

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FusionProtFeatures for RASGRF1_HNRNPD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASGRF1

Q13972

HNRNPD

Q14103

Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASGRF1_HNRNPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASGRF1_HNRNPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASGRF1_HNRNPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

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RelatedDiseases for RASGRF1_HNRNPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASGRF1C0005586Bipolar Disorder1PSYGENET
HgeneRASGRF1C0013386Dyskinesia, Drug-Induced1CTD_human
HgeneRASGRF1C0027092Myopia1CTD_human
HgeneRASGRF1C0034951Refractive Errors1CTD_human