![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 30546 |
FusionGeneSummary for RASGRF1_HNRNPD |
![]() |
Fusion gene information | Fusion gene name: RASGRF1_HNRNPD | Fusion gene ID: 30546 | Hgene | Tgene | Gene symbol | RASGRF1 | HNRNPD | Gene ID | 5923 | 3184 |
Gene name | Ras protein specific guanine nucleotide releasing factor 1 | heterogeneous nuclear ribonucleoprotein D | |
Synonyms | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | AUF1|AUF1A|HNRPD|P37|hnRNPD0 | |
Cytomap | 15q25.1 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q13972 | Q14103 | |
Ensembl transtripts involved in fusion gene | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | ENST00000313899, ENST00000353341, ENST00000543098, ENST00000352301, ENST00000508119, ENST00000541060, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 10 X 10 X 3=300 |
# samples | 3 | 12 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/300*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RASGRF1 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA845763 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000558480 | ENST00000313899 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000558480 | ENST00000353341 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000558480 | ENST00000543098 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000558480 | ENST00000352301 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000558480 | ENST00000508119 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000558480 | ENST00000541060 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000419573 | ENST00000313899 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000419573 | ENST00000353341 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000419573 | ENST00000543098 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000419573 | ENST00000352301 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000419573 | ENST00000508119 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000419573 | ENST00000541060 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000560334 | ENST00000313899 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000560334 | ENST00000353341 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000560334 | ENST00000543098 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000560334 | ENST00000352301 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000560334 | ENST00000508119 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000560334 | ENST00000541060 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000394745 | ENST00000313899 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000394745 | ENST00000353341 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000394745 | ENST00000543098 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000394745 | ENST00000352301 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-intron | ENST00000394745 | ENST00000508119 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
intron-5UTR | ENST00000394745 | ENST00000541060 | RASGRF1 | chr15 | 79296310 | - | HNRNPD | chr4 | 83295087 | - |
Top |
FusionProtFeatures for RASGRF1_HNRNPD |
![]() |
Hgene | Tgene |
RASGRF1 | HNRNPD |
Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RASGRF1_HNRNPD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RASGRF1_HNRNPD |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RASGRF1_HNRNPD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | HNRNPD | Q14103 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein D0 | small molecule | approved|investigational |
Top |
RelatedDiseases for RASGRF1_HNRNPD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RASGRF1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | RASGRF1 | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
Hgene | RASGRF1 | C0027092 | Myopia | 1 | CTD_human |
Hgene | RASGRF1 | C0034951 | Refractive Errors | 1 | CTD_human |