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Fusion gene ID: 30545 |
FusionGeneSummary for RASGRF1_HCN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RASGRF1_HCN4 | Fusion gene ID: 30545 | Hgene | Tgene | Gene symbol | RASGRF1 | HCN4 | Gene ID | 5923 | 10021 |
| Gene name | Ras protein specific guanine nucleotide releasing factor 1 | hyperpolarization activated cyclic nucleotide gated potassium channel 4 | |
| Synonyms | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | SSS2 | |
| Cytomap | 15q25.1 | 15q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4hyperpolarization activated cyclic nucleotide-gated cation channel 4 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q13972 | Q9Y3Q4 | |
| Ensembl transtripts involved in fusion gene | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | ENST00000261917, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RASGRF1 [Title/Abstract] AND HCN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HCN4 | GO:0003254 | regulation of membrane depolarization | 12750403 |
| Tgene | HCN4 | GO:0006812 | cation transport | 12750403 |
| Tgene | HCN4 | GO:0071320 | cellular response to cAMP | 12750403|16407510|22748890 |
| Tgene | HCN4 | GO:0071321 | cellular response to cGMP | 22748890 |
| Tgene | HCN4 | GO:0071805 | potassium ion transmembrane transport | 16407510 |
| Tgene | HCN4 | GO:0098719 | sodium ion import across plasma membrane | 10228147 |
| Tgene | HCN4 | GO:1990573 | potassium ion import across plasma membrane | 10228147 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A3TO-01A | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000558480 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| Frame-shift | ENST00000419573 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| intron-3CDS | ENST00000560334 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
| In-frame | ENST00000394745 | ENST00000261917 | RASGRF1 | chr15 | 79264208 | - | HCN4 | chr15 | 73636149 | - |
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FusionProtFeatures for RASGRF1_HCN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RASGRF1 | HCN4 |
| Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. | Hyperpolarization-activated ion channel with very slowactivation and inactivation exhibiting weak selectivity forpotassium over sodium ions. Contributes to the native pacemakercurrents in heart (If) that regulate the rhythm of heart beat. Maycontribute to the native pacemaker currents in neurons (Ih). Maymediate responses to sour stimuli. {ECO:0000269|PubMed:10228147,ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510,ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RASGRF1_HCN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RASGRF1_ENST00000394745_chr15_79264208_-_HCN4_ENST00000261917_chr15_73636149_-_942aa ILLGPDHAAADGGKPDYHSCGHHLLQGXEHHTLDCLQCGVRHILPHRLGPQLPHRDRGGGQHRDHPGPAADXNEVPEKLVHGRFHFLHPR GLHLPHCGDTHRLGGLQDCPGPAHCPLHEDPQPLTPVTPLPPHSIYSPVGRDLPHDLRPGQRRGAHREPHRHDAPALPLGRLPAVPGTHA TGLPXRLLGVHQQHGEQLLGEAVLLRALQGHEPHAVHRLRAAGARGHVRRLAHHAQHDRGCHLLRHVHWPRHCPHPVPGLLPAPVPGKVQ AGGAVHVLSQAPARHPAAHPRLLRAPLPGQDVRRGEHPGRAKRAPAGGDHQLXLSEAGGLHATVCQCGPQLRDVHADQAAFRGLPAWGLH HPGRHHWQEDVLHPAWRGQRAHQGQQGDQAGRRLLLWRDLPADPGPAHSQREGRHLLPPLLAERGQLQXGAGGVPHDAKGLRDRGAGPPG PHWQEELHPPPQSPARPQLRRLQLPGEXDHPADCAAXPGDGPLRAPRPGCCLCHPNPHARHLDPADPGTTAGCRCHHFCGHSPHPPPSPA CCHLPPSPRIWAGQPRCRADAKAPETAAVPDPFCAGLRLARQQPVPGGHTVFILLPHPTAGWILCPRWTEPTPALIQLLPTPRGLWLPLG SHTISWRSRHHHSRVWPLPQGAGWLPVLLRLSPAHPAAARRPLPAGCPAISRATRGPGRPGTPGALPATPTLIQIPVIXPRAAGPASRGV VPRSGHWPTEHARDTPTAAXAAVPCGRGLWGGFPCRLYSPRRSQPPWPQPRPPKNLPECPAPGLWLPRILAPATCIQPPTTPGPPAPGHT PAHPRPPHPGPQAHLRVSASPASGRGADSPQSLPALLRGVHGCLPALPQGWGWQRGQWEQRGPRSPWEALWCHPRPARHSASEDILRFFA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RASGRF1_ENST00000394745_chr15_79264208_-_HCN4_ENST00000261917_chr15_73636149_-_2827nt ATTTTACTGGGACCTGACCATGCTGCTGCTGATGGTGGGAAACCTGATTATCATTCCTGTGGGCATCACCTTCTTCAAGGATGAGAACAC CACACCCTGGATTGTCTTCAATGTGGTGTCAGACACATTCTTCCTCATCGACTTGGTCCTCAACTTCCGCACAGGGATCGTGGTGGAGGA CAACACAGAGATCATCCTGGACCCGCAGCGGATTAAAATGAAGTACCTGAAAAGCTGGTTCATGGTAGATTTCATTTCCTCCATCCCCGT GGACTACATCTTCCTCATTGTGGAGACACGCATCGACTCGGAGGTCTACAAGACTGCCCGGGCCCTGCGCATTGTCCGCTTCACGAAGAT CCTCAGCCTCTTACGCCTGTTACGCCTCTCCCGCCTCATTCGATATATTCACCAGTGGGAAGAGATCTTCCACATGACCTACGACCTGGC CAGCGCCGTGGTGCGCATCGTGAACCTCATCGGCATGATGCTCCTGCTCTGCCACTGGGACGGCTGCCTGCAGTTCCTGGTACCCATGCT ACAGGACTTCCCTGACGACTGCTGGGTGTCCATCAACAACATGGTGAACAACTCCTGGGGGAAGCAGTACTCCTACGCGCTCTTCAAGGC CATGAGCCACATGCTGTGCATCGGCTACGGGCGGCAGGCGCCCGTGGGCATGTCCGACGTCTGGCTCACCATGCTCAGCATGATCGTGGG TGCCACCTGCTACGCCATGTTCATTGGCCACGCCACTGCCCTCATCCAGTCCCTGGACTCCTCCCGGCGCCAGTACCAGGAAAAGTACAA GCAGGTGGAGCAGTACATGTCCTTTCACAAGCTCCCGCCCGACACCCGGCAGCGCATCCACGACTACTACGAGCACCGCTACCAGGGCAA GATGTTCGACGAGGAGAGCATCCTGGGCGAGCTAAGCGAGCCCCTGCGGGAGGAGATCATCAACTTTAACTGTCGGAAGCTGGTGGCCTC CATGCCACTGTTTGCCAATGCGGACCCCAACTTCGTGACGTCCATGCTGACCAAGCTGCGTTTCGAGGTCTTCCAGCCTGGGGACTACAT CATCCGGGAAGGCACCATTGGCAAGAAGATGTACTTCATCCAGCATGGCGTGGTCAGCGTGCTCACCAAGGGCAACAAGGAGACCAAGCT GGCCGACGGCTCCTACTTTGGAGAGATCTGCCTGCTGACCCGGGGCCGGCGCACAGCCAGCGTGAGGGCCGACACCTACTGCCGCCTCTA CTCGCTGAGCGTGGACAACTTCAATGAGGTGCTGGAGGAGTACCCCATGATGCGAAGGGCCTTCGAGACCGTGGCGCTGGACCGCCTGGA CCGCATTGGCAAGAAGAACTCCATCCTCCTCCACAAAGTCCAGCACGACCTCAACTCCGGCGTCTTCAACTACCAGGAGAATGAGATCAT CCAGCAGATTGTGCAGCATGACCGGGAGATGGCCCACTGCGCGCACCGCGTCCAGGCTGCTGCCTCTGCCACCCCAACCCCCACGCCCGT CATCTGGACCCCGCTGATCCAGGCACCACTGCAGGCTGCCGCTGCCACCACTTCTGTGGCCATAGCCCTCACCCACCACCCTCGCCTGCC TGCTGCCATCTTCCGCCCTCCCCCAGGATCTGGGCTGGGCAACCTCGGTGCCGGGCAGACGCCAAGGCACCTGAAACGGCTGCAGTCCCT GATCCCTTCTGCGCTGGGCTCCGCCTCGCCCGCCAGCAGCCCGTCCCAGGTGGACACACCGTCTTCATCCTCCTTCCACATCCAACAGCT GGCTGGATTCTCTGCCCCCGCTGGACTGAGCCCACTCCTGCCCTCATCCAGCTCCTCCCCACCCCCCGGGGCCTGTGGCTCCCCCTCGGC TCCCACACCATCAGCTGGCGTAGCCGCCACCACCATAGCCGGGTTTGGCCACTTCCACAAGGCGCTGGGTGGCTCCCTGTCCTCCTCCGA CTCTCCCCTGCTCACCCCGCTGCAGCCAGGCGCCCGCTCCCCGCAGGCTGCCCAGCCATCTCCCGCGCCACCCGGGGCCCGGGGAGGCCT GGGACTCCCGGAGCACTTCCTGCCACCCCCACCCTCATCCAGATCCCCGTCATCTAGCCCCGGGCAGCTGGGCCAGCCTCCCGGGGAGTT GTCCCTAGGTCTGGCCACTGGCCCACTGAGCACGCCAGAGACACCCCCACGGCAGCCTGAGCCGCCGTCCCTTGTGGCAGGGGCCTCTGG GGGGGCTTCCCCTGTAGGCTTTACTCCCCGAGGAGGTCTCAGCCCCCCTGGCCACAGCCCAGGCCCCCCAAGAACCTTCCCGAGTGCCCC GCCCCGGGCCTCTGGCTCCCACGGATCCTTGCTCCTGCCACCTGCATCCAGCCCCCCACCACCCCAGGTCCCCCAGCGCCGGGGCACACC CCCGCTCACCCCCGGCCGCCTCACCCAGGACCTCAAGCTCATCTCCGCGTCTCAGCCAGCCCTGCCTCAGGACGGGGCGCAGACTCTCCG CAGAGCCTCCCCGCACTCCTCAGGGGAGTCCATGGCTGCCTTCCCGCTCTTCCCCAGGGCTGGGGGTGGCAGCGGGGGCAGTGGGAGCAG CGGGGGCCTCGGTCCCCCTGGGAGGCCCTATGGTGCCATCCCCGGCCAGCACGTCACTCTGCCTCGGAAGACATCCTCAGGTTCTTTGCC ACCCCCTCTGTCTTTGTTTGGGGCAAGAGCCACCTCTTCTGGGGGGCCCCCTCTGACTGCTGGACCCCAGAGGGAACCTGGGGCCAGGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RASGRF1_ENST00000394745_chr15_79264208_-_HCN4_ENST00000261917_chr15_73636149_-_8004nt GGAGCCCTTTTTGGCCTACTTGGGGTGAGTCAACATAAGGAGTGCAGGCCACCTTAGCCTTTGCTTCTCAAAAGTCATGGGGCAATGAAG GACTTGGCCAAGGCTGTCCAGCAGTAGGCCAAGTTCAGGGATTGGCTCAGGCCCCTAATGGACTTCACTGCATCCAGGAATGGTAGGTGA TTATCTTTTCCGAGAGGCCACCTACCCAGATCCCAGTTGTGGACAGCCCATCCCAGCCCTCAGAGGCTCAGAGGCTCTCTGAGTGCCCTG CCCCAAAACACCCTAGGCAAGACATTATGCCAGAGCCTCAGCTCTAGGGCTGCCTGGAGCAGAGCTCCTGAATCACACTGGCTCCCCAGG GCTCCCCAGGAACCTCACCATTCCTCCCCCAATCCACACCTCTGCTGCCAGAGCAACGCAACGACCCAGAATACACCCGTTCCCTCTTCT GTTCCCTCCTCCTGCCCCCACCTCAGGCCTCACTGGGGCAGGGTACATCTTGCCTCTCTGCCCTGAACTTCTGAAACCTCAATGATCAGA TTCCCAGGGCTCTGAGAAAACAGAAGCAAACATCCCATCCAGGATGGATTTACCCCCTAAAAGTCACTGAGATCATTCCCAGGGGCCCAG CAGACAGTGTCCTTCCTTTCCCAGCAGCAGTGCCCTGCAGAACAAAGAGGCTGGTTCAGAGCCAGCTCTCAGCCCTATGGCCTTGGCTGA GTCCCTTAACCTTTCTGAGACTCAGTTTCCTACCTGTGACATTCCTGCAGTTATCCTGTAGGAATAAGAGTGCCTACGTCCTGGGGCAAC AGTGAGGGTTAAAAGATCAATCCTATCCTGTGTGCAACGTGGAGCAGACAGCCTCGATGAGACAAGCTATGGTTTGCAATGTTCTGGATG TATAACCTGTTTCCAGCCTGGCCTGAGGTGGAACCCTGTCATGAGGATGGTCGCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAATAAGC TCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCGCCACCTCTGTCCATCACCAAGACATCGTCACCGA GCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCTGGCCGCCCTCAGCTGCAACTCCAATGGCT ACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACACCAGCAAGCTCTATGTGTCCAGCAGCTTCACCAACAAGA TTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCAGAGCTCAGAAGTCTCCATGAGAGAGGAGT CAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAACTAAATCTCCAACAACACCCAAATCAGTCAAAAACAAAA ATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGAACTGGACAATAACCGCAGTGCCTTGTCGG CCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAACAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGTGCAG GGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAATCGTGTCTTGAACGTGCTCCGCCACTGGG TGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGTGATCGGCTTCCTGGAAGAAGTCATGCACGACCCGGAGC TCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCCAGGTGACAACCAGATCACGCTGGAGGAGA TCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGCCCTGGAGATCGCGGAGCAGCTGACCCTGCTAGATCACC TCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAAGAATGAAAGGACCCCTTATATCATGAAAA CCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCGCAATGAGGACATCAACGCCAGGGTGAGCGCCATCGAGA AGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGATCACCTCGTCCATGAACCGCAGTGCAATCT TCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGATTGATAAGCTCCAAAAGCTTGTGTCATCTGAGGGCAGAT TTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGATGTACCTCACCGACCTGGCCTTCATCGAGG AGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAGGATGATATCCCATATTATCCGAGAGATTCGCCAGTTTC AACAAACTGCCTACAAAATAGAGCACCAAGCAAAGATTTTACTGGGACCTGACCATGCTGCTGCTGATGGTGGGAAACCTGATTATCATT CCTGTGGGCATCACCTTCTTCAAGGATGAGAACACCACACCCTGGATTGTCTTCAATGTGGTGTCAGACACATTCTTCCTCATCGACTTG GTCCTCAACTTCCGCACAGGGATCGTGGTGGAGGACAACACAGAGATCATCCTGGACCCGCAGCGGATTAAAATGAAGTACCTGAAAAGC TGGTTCATGGTAGATTTCATTTCCTCCATCCCCGTGGACTACATCTTCCTCATTGTGGAGACACGCATCGACTCGGAGGTCTACAAGACT GCCCGGGCCCTGCGCATTGTCCGCTTCACGAAGATCCTCAGCCTCTTACGCCTGTTACGCCTCTCCCGCCTCATTCGATATATTCACCAG TGGGAAGAGATCTTCCACATGACCTACGACCTGGCCAGCGCCGTGGTGCGCATCGTGAACCTCATCGGCATGATGCTCCTGCTCTGCCAC TGGGACGGCTGCCTGCAGTTCCTGGTACCCATGCTACAGGACTTCCCTGACGACTGCTGGGTGTCCATCAACAACATGGTGAACAACTCC TGGGGGAAGCAGTACTCCTACGCGCTCTTCAAGGCCATGAGCCACATGCTGTGCATCGGCTACGGGCGGCAGGCGCCCGTGGGCATGTCC GACGTCTGGCTCACCATGCTCAGCATGATCGTGGGTGCCACCTGCTACGCCATGTTCATTGGCCACGCCACTGCCCTCATCCAGTCCCTG GACTCCTCCCGGCGCCAGTACCAGGAAAAGTACAAGCAGGTGGAGCAGTACATGTCCTTTCACAAGCTCCCGCCCGACACCCGGCAGCGC ATCCACGACTACTACGAGCACCGCTACCAGGGCAAGATGTTCGACGAGGAGAGCATCCTGGGCGAGCTAAGCGAGCCCCTGCGGGAGGAG ATCATCAACTTTAACTGTCGGAAGCTGGTGGCCTCCATGCCACTGTTTGCCAATGCGGACCCCAACTTCGTGACGTCCATGCTGACCAAG CTGCGTTTCGAGGTCTTCCAGCCTGGGGACTACATCATCCGGGAAGGCACCATTGGCAAGAAGATGTACTTCATCCAGCATGGCGTGGTC AGCGTGCTCACCAAGGGCAACAAGGAGACCAAGCTGGCCGACGGCTCCTACTTTGGAGAGATCTGCCTGCTGACCCGGGGCCGGCGCACA GCCAGCGTGAGGGCCGACACCTACTGCCGCCTCTACTCGCTGAGCGTGGACAACTTCAATGAGGTGCTGGAGGAGTACCCCATGATGCGA AGGGCCTTCGAGACCGTGGCGCTGGACCGCCTGGACCGCATTGGCAAGAAGAACTCCATCCTCCTCCACAAAGTCCAGCACGACCTCAAC TCCGGCGTCTTCAACTACCAGGAGAATGAGATCATCCAGCAGATTGTGCAGCATGACCGGGAGATGGCCCACTGCGCGCACCGCGTCCAG GCTGCTGCCTCTGCCACCCCAACCCCCACGCCCGTCATCTGGACCCCGCTGATCCAGGCACCACTGCAGGCTGCCGCTGCCACCACTTCT GTGGCCATAGCCCTCACCCACCACCCTCGCCTGCCTGCTGCCATCTTCCGCCCTCCCCCAGGATCTGGGCTGGGCAACCTCGGTGCCGGG CAGACGCCAAGGCACCTGAAACGGCTGCAGTCCCTGATCCCTTCTGCGCTGGGCTCCGCCTCGCCCGCCAGCAGCCCGTCCCAGGTGGAC ACACCGTCTTCATCCTCCTTCCACATCCAACAGCTGGCTGGATTCTCTGCCCCCGCTGGACTGAGCCCACTCCTGCCCTCATCCAGCTCC TCCCCACCCCCCGGGGCCTGTGGCTCCCCCTCGGCTCCCACACCATCAGCTGGCGTAGCCGCCACCACCATAGCCGGGTTTGGCCACTTC CACAAGGCGCTGGGTGGCTCCCTGTCCTCCTCCGACTCTCCCCTGCTCACCCCGCTGCAGCCAGGCGCCCGCTCCCCGCAGGCTGCCCAG CCATCTCCCGCGCCACCCGGGGCCCGGGGAGGCCTGGGACTCCCGGAGCACTTCCTGCCACCCCCACCCTCATCCAGATCCCCGTCATCT AGCCCCGGGCAGCTGGGCCAGCCTCCCGGGGAGTTGTCCCTAGGTCTGGCCACTGGCCCACTGAGCACGCCAGAGACACCCCCACGGCAG CCTGAGCCGCCGTCCCTTGTGGCAGGGGCCTCTGGGGGGGCTTCCCCTGTAGGCTTTACTCCCCGAGGAGGTCTCAGCCCCCCTGGCCAC AGCCCAGGCCCCCCAAGAACCTTCCCGAGTGCCCCGCCCCGGGCCTCTGGCTCCCACGGATCCTTGCTCCTGCCACCTGCATCCAGCCCC CCACCACCCCAGGTCCCCCAGCGCCGGGGCACACCCCCGCTCACCCCCGGCCGCCTCACCCAGGACCTCAAGCTCATCTCCGCGTCTCAG CCAGCCCTGCCTCAGGACGGGGCGCAGACTCTCCGCAGAGCCTCCCCGCACTCCTCAGGGGAGTCCATGGCTGCCTTCCCGCTCTTCCCC AGGGCTGGGGGTGGCAGCGGGGGCAGTGGGAGCAGCGGGGGCCTCGGTCCCCCTGGGAGGCCCTATGGTGCCATCCCCGGCCAGCACGTC ACTCTGCCTCGGAAGACATCCTCAGGTTCTTTGCCACCCCCTCTGTCTTTGTTTGGGGCAAGAGCCACCTCTTCTGGGGGGCCCCCTCTG ACTGCTGGACCCCAGAGGGAACCTGGGGCCAGGCCTGAGCCAGTGCGCTCCAAACTGCCATCCAATCTATGAGCTGGGCCCTTCCTTCCC TCTTCTTTCTTCTTTTCTCTCCCTTCCTTCTTCCTTCAGGTTTAACTGTGATTAGGAGATATACCAATAACAGTAATAATTATTTAAAAA ACCACACACACCAGAAAAACAAAAGACAGCAGAAAATAACCAGGTATTCTTAGAGCTATAGATTTTTGGTCACTTGCTTTTATAGACTAT TTTAATACTCAGCACTAGAGGGAGGGAGGGGGAGGGAGGAGGGAGCAGGCAGGTCCCAAATGCAAAAGCCAGAGAAAGGCAGATGGGGTC TCCGGGGCTGGGCAGGGGTGGGAGTGGCCAGTGTTGGCGGTTCTTAGAGCAGATGTGTCATTGTGTTCATTTAGAGAAACAGCTGCCATC AGCCCGTTAGCTGTAACTTGGAGCTCCACTCTGCCCCCAGAAAGGGGCTGCCCTGGGGTGTGCCCTGGGGAGCCTCAGAAGCCTGCGACC TTGGGAGAAAAGGGCCAGGGCCCTGAGGGCCTAGCATTTTTTCTACTGTAAACGTAGCAAGATCTGTATATGAATATGTATATGTATATG TATGTAAGATGTGTATATGTATAGCTATGTAGCGCTCTGTAGAGCCATGTAGATAGCCACTCACATGTGCGCACACGTGTGCGGTCTAGT TTAATCCCATGTTGACAGGATGCCCAGGTCACCTTACACCCAGCAACCCGCCTTGGCCCACAGGCTGTGCACTGCATGGTCTAGGGACGT TCTCTCTCCAGTCCTCAGGGAAGAGGACCCCAGGACTTCGCAGCAGGCCCCCTCTCTCCCCATCTCTGGTCTCAAAGCCAGTCCCAGCCT GACCTCTCACCACACGGAAGTGGAAGACTCCCCTTTCCTAGGGCCTCAAGCACACACCGCCACCTCTGGGGCCGTCAGTTTGCCCATCTG TACAGTGGGAGGTGAGCGGAACTTCTGTTTATTGAGTCTGCTCTGTGCCAAGCACTGGTTTCGCACTTTACACACATTAACTCCTTCAGT TTCACAAAGACCATGGGGTGGGTACTTTGATTCTCCCCATTTAGCAGAGGAAGAAACAGTTTTGGGTAATTTTTCCAGAATCATGTAACT AGGAGTGGCAGAGTGGGGACTGATTTGAGGTTCGAGTCCACGCCTCCTTGAGGCCCAAGTCTGTGTTCCTTCCATCAGAAAACTGTGTTG AGGGGGGCTGAGGTAGATGGTCCCCAAGCATGGTACAGAAGGAAGACACCAGATTTTGGCAGCAGTCAGGCCTGGGTTTGAATCCCAGCC CTGCCACTTCTTAGCTGTATGATCTTGGGCAAGTTATCTGACCTTTCTGTCACCTCATTTGTAAAATGGGAATAATTATGGTACTGCCTC ACAAGGACCTATGAGGACCAGATGAGAAAAATCTATATGTGAAATGCCCAGCCCAGCGCCTGGCACATACCATGGTAGGTGCTCAATAAA AAATCACATTTCTTCTGCCCCTCATATGCCCAGCCTATTGCTCCAGCAAACTATGTGAGAGCCCAGGGAGCTTTGGCTGAGGGCTCCAAG ACTTAAAATCTCAGGACTCAGGAGGTGGCTGGGCCTCCCTAAGGGCCCAAGGAAGGTGTGTGGCCAGAGGTGGGTGGGAGCCAGGCCTTG AGAAGTGGGAAGACTTCAACAGGGAGAGAGGGAGGGAATGGTGGGTGGGATGGAGTGTATGGTGGGGAGATTCCTGAGGTGGATGTGGAG TGGTGGATCAGGGCTTTGGGAGGGGATCCCCAGGCTGAGGGGTCAGAGGGACGGCCTTGGGTGATAGGGTAAGGGATTGTCTGGGCTTAG TCCTGGCAACTAGGAGCCATAAGCAGGTTCCAGATTGCGGGAACGAGAAAGCAGCTCAGATGCCTTTGGAGGCACCATCCTCCCTCCTCC CAGATGGGATCTTGCCAGAGCCAAGGTCAGGGGTCTGCCCCTGCCTATAGGGCCAGAGCAGGTATGGCTGCAATCCCCAAGTAATGAGAA GGGCTGGTCCCACATTATCCATCCAGAACCTTCCATGCTCCAAGCCAGAATGTTGGCAAGATCGGGTTTTGCCTTGAGCTATCCTGGGAT GTGAGACAAACCGATTTCTCCATAGATGGGCTGCAGGGAGTGGGAGGCAGTACTCCAGGAGAGAAGTGGGTGAAGGTTCCTGGGATCTTA GGTAAAGACTAGACGCCGCCTAGTACTGGTCTCTACTGTGCTGGCTCAGGAGTTCTGAGAACTGGAAGGACTTAGCCTCAACCTGAGTTC TGCACACACCCCTTCCCCTTAAGGAAGGCAGCTCTGAGAGGCAGCAGGACTTGATCCAAACCCACAGTCTTGTCCTGGAGGCAGCAGGGG TGAAGGTGGAGGGTCCAGGGCCATGAGGAGCCCCCTTGCCATCAGAGCCTGGCCTAACCACCCTCTTCTCTACTTACACACACATGCATT TTATAATAGCTCTGACCCAACCTGGCCACTCTGCAGAGACTGGGACAGACAGGTGCAGGCAATGGGCCCTCCCACACCCAGTCACCTACA |
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FusionGenePPI for RASGRF1_HCN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RASGRF1 | MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2 | HCN4 | HCN1, HCN3, HCN2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RASGRF1_HCN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASGRF1_HCN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RASGRF1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | RASGRF1 | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
| Hgene | RASGRF1 | C0027092 | Myopia | 1 | CTD_human |
| Hgene | RASGRF1 | C0034951 | Refractive Errors | 1 | CTD_human |
| Tgene | HCN4 | C1834144 | Sick Sinus Syndrome 2, Autosomal Dominant | 3 | CTD_human;UNIPROT |
| Tgene | HCN4 | C0004238 | Atrial Fibrillation | 1 | CTD_human;HPO |
| Tgene | HCN4 | C0525045 | Mood Disorders | 1 | PSYGENET |
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