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Fusion gene ID: 3053 |
FusionGeneSummary for ASXL1_EIF2S2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASXL1_EIF2S2 | Fusion gene ID: 3053 | Hgene | Tgene | Gene symbol | ASXL1 | EIF2S2 | Gene ID | 171023 | 8894 |
| Gene name | ASXL transcriptional regulator 1 | eukaryotic translation initiation factor 2 subunit beta | |
| Synonyms | BOPS|MDS | EIF2|EIF2B|EIF2beta|PPP1R67|eIF-2-beta | |
| Cytomap | 20q11.21 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | putative Polycomb group protein ASXL1additional sex combs like 1, transcriptional regulatoradditional sex combs like transcriptional regulator 1 | eukaryotic translation initiation factor 2 subunit 2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDaprotein phosphatase 1, regulatory subunit 67 | |
| Modification date | 20180526 | 20180519 | |
| UniProtAcc | Q8IXJ9 | P20042 | |
| Ensembl transtripts involved in fusion gene | ENST00000375687, ENST00000542461, ENST00000375689, ENST00000306058, ENST00000470145, | ENST00000374980, | |
| Fusion gene scores | * DoF score | 10 X 5 X 9=450 | 5 X 3 X 5=75 |
| # samples | 13 | 5 | |
| ** MAII score | log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ASXL1 [Title/Abstract] AND EIF2S2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ASXL1 | GO:0035522 | monoubiquitinated histone H2A deubiquitination | 20436459 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-DS-A7WH-01A | ASXL1 | chr20 | 30956926 | + | EIF2S2 | chr20 | 32693351 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375687 | ENST00000374980 | ASXL1 | chr20 | 30956926 | + | EIF2S2 | chr20 | 32693351 | - |
| In-frame | ENST00000542461 | ENST00000374980 | ASXL1 | chr20 | 30956926 | + | EIF2S2 | chr20 | 32693351 | - |
| In-frame | ENST00000375689 | ENST00000374980 | ASXL1 | chr20 | 30956926 | + | EIF2S2 | chr20 | 32693351 | - |
| In-frame | ENST00000306058 | ENST00000374980 | ASXL1 | chr20 | 30956926 | + | EIF2S2 | chr20 | 32693351 | - |
| 3UTR-3CDS | ENST00000470145 | ENST00000374980 | ASXL1 | chr20 | 30956926 | + | EIF2S2 | chr20 | 32693351 | - |
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FusionProtFeatures for ASXL1_EIF2S2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASXL1 | EIF2S2 |
| eIF-2 functions in the early steps of protein synthesisby forming a ternary complex with GTP and initiator tRNA. Thiscomplex binds to a 40S ribosomal subunit, followed by mRNA bindingto form a 43S preinitiation complex. Junction of the 60S ribosomalsubunit to form the 80S initiation complex is preceded byhydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDPbinary complex. In order for eIF-2 to recycle and catalyze anotherround of initiation, the GDP bound to eIF-2 must exchange with GTPby way of a reaction catalyzed by eIF-2B. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 2_9 | 84 | 1542 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr20:30956926 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 124_129 | 5 | 334 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr20:30956926 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 14_21 | 5 | 334 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr20:30956926 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 79_87 | 5 | 334 | Compositional bias | Note=Poly-Lys |
| Tgene | >EIF2S2 | chr20:30956926 | chr20:32693351 | ENST00000374980 | - | 0 | 9 | 281_305 | 5 | 334 | Zinc finger | C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 1457_1460 | 84 | 1542 | Compositional bias | Note=Poly-Ser |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 199_209 | 84 | 1542 | Compositional bias | Note=Poly-Ser |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 641_684 | 84 | 1542 | Compositional bias | Note=Gly-rich |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 160_164 | 84 | 1542 | Motif | Nuclear localization signal 1 |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 284_288 | 84 | 1542 | Motif | Note=LXXLL motif |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 409_413 | 84 | 1542 | Motif | Nuclear localization signal 2 |
| Hgene | >ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 1503_1540 | 84 | 1542 | Zinc finger | Note=PHD-type%3B atypical |
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FusionGeneSequence for ASXL1_EIF2S2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ASXL1_ENST00000375687_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_413aa MKDKQKKKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKMIFDPT MSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDL KIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKN PDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTC >In-frame_ASXL1_ENST00000542461_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_412aa MKDKQKKKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKMIFDPTM SKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLK IESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNP DMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCH >In-frame_ASXL1_ENST00000375689_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_409aa MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKMIFDPTMSKK KKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIES DVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMV AGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCR >In-frame_ASXL1_ENST00000306058_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_408aa MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKMIFDPTMSKKK KKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESD VQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVA GEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ASXL1_ENST00000375687_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_1239nt ATGAAGGACAAACAGAAGAAGAAGAAGGAGCGCACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACA CCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTA CATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACT ATGAGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACA AAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGAT GACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTT AAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTT AAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAAT CAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAAT CCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAAC TTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGAT GGTAATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGT CACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTT >In-frame_ASXL1_ENST00000542461_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_1236nt ATGAAGGACAAACAGAAGAAGAAGAAGGAGCGCACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACA CCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACAT TCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATG AGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAA GAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGAC TTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAG ATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAG TTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAG ACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCA GATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTT ACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGT AATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCAC ACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCC >In-frame_ASXL1_ENST00000375689_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_1227nt ATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATT CTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCA AGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATGAGCAAGAAG AAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAG CCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTC TTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGT GATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGAT GAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCT GCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTT GCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATC TGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAA CTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGA TCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAA >In-frame_ASXL1_ENST00000306058_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_1224nt ATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATT CTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGA GGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATGAGCAAGAAGAAA AAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCA GAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTT AATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGAT GTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAG GATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCT TGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCT GGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGT AAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTT GTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCA CCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ASXL1_ENST00000375687_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_3095nt CGGCAGACACGCACGCACCCGGGCGCCGAAGGGAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTGTCTCAGTCCCTCAGCAGA GCGGGAAAGCGGAGGCCGGAGCCGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCT GCCGCCGTGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTG CCCGCCCCTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCGCCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAGCCCCGCGC CACCGCCCCAGCCCGCCCAGCCCGGAGGTCCCGCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAA GGAGCGCACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGA GGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGG GTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAA GAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGA GGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAA AAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACC AACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACT AGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTC AGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAG GAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACA TCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGG AAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAAT CCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGC TGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTGTGGAGATGTGGCTGG ACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGTGGTTGGTCTGAAGTC CTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATGGGGTAAGGAGGTGCT TTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTTGGTTTGTCCTTCAGT TTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGACTGAGAAACTGAACAA TGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCCTCCCACGCGAGTGTG GTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTCCGTATGTGGGGATGG TTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCTTCCTCGTTGGCCACT AAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTCTCTTGGTGAGGAAGC GATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGTTTTCCTAGCCAACTT GTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGACCATGAGAAACCAAG AAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAGGCCATCTTCTGTGTC GGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCGACTTCGTACTAAGCA GCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGCCAAGTGTTGTCAAAC ACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCCACCAACTGCCACGAT GAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATATTTCTACATGAATAAAG >In-frame_ASXL1_ENST00000542461_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_3085nt CACGCACGCACCCGGGCGCCGAAGGGAAAGCCGCGTCTCGCCCTCCCGCCCCGCCGTCGGTCCTGTCTCAGTCCCTCAGCAGAGCGGGAA AGCGGAGGCCGGAGCCGTGACCTCTGACCCCGTGGTTATGCGGAGCCGCCGCATTCCTTAGCGATCGCGGGGCAGCCGCCGCTGCCGCCG TGGGCGACTGACGCAGCGCGGGCGCGTGGAGCCGCCGCCGCCCCTCCCCCACCGCCGCTCTCGCGCCAGCCGGTCCCCGCGTGCCCGCCC CTTCTCCCCGGCCGCACCCGAGACCTCGCGCGCCGCCGCTGCCACGCGCCCCCCCCACCGCCGCCGCCGCCCCAGCCCCGCGCCACCGCC CCAGCCCGCCCAGCCCGGAGGTCCCGCGTGGAGCTGCCGCCGCCGCCGGGGAGAAGGATGAAGGACAAACAGAAGAAGAAGAAGGAGCGC ACGTGGGCCGAGGCCGCGCGCCTGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAA GGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTAT AAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATGAGCAAGAAGAAAAAGAAGAAGAAGAAGCCTTTT ATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGAT TTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAA AAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCA GAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGAT GAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGAC TACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTC ATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCC AAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGATTCCAA CAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAATCCTGCAGAAG GACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCTGTCACGGGC AAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTGTGGAGATGTGGCTGGACAGGTTTGC CATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGTGGTTGGTCTGAAGTCCTTGCAAGAC GCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATGGGGTAAGGAGGTGCTTTTTTAAAAT CGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTTGGTTTGTCCTTCAGTTTTCTTTTCT ATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGACTGAGAAACTGAACAATGGCAGGCGC TTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCCTCCCACGCGAGTGTGGTGGGACCTT GAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTCCGTATGTGGGGATGGTTGCTACTAC CTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCTTCCTCGTTGGCCACTAAGAGGTCTT AGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTCTCTTGGTGAGGAAGCGATGTGTGTG CGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGTTTTCCTAGCCAACTTGTGTTCTGGG TTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGACCATGAGAAACCAAGAAATGCTGCT TGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAGGCCATCTTCTGTGTCGGTGCTGTGA TCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCGACTTCGTACTAAGCAGCTCAGGAGC AGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGCCAAGTGTTGTCAAACACCTTGGCTA AAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCCACCAACTGCCACGATGAACCCAACT GCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATATTTCTACATGAATAAAGCAAGGATCAG >In-frame_ASXL1_ENST00000375689_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_2841nt CAGACTGGGCTGTTTGCCTTCAGAAGCTGGACTGGAAATTGGTATTTTGAGGAGAACTGAATCCACTTTGCAAAGAATGTATGTTGGACA AAGACAAAGTATCTCTGTTGGGAGACGTTGTTCACTGAGGATTTAGCAAGGGAGAGCGTAACTTGAGTGTTTGAAGCCGTCTCGTTCAAC CGATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGA TTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATT CAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATGAGCAAGA AGAAAAAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGG AGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACT TCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAA GTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAG ATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCC CTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGG TTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATA TCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACC AACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCC GATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCA AAACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTT GTGGAGATGTGGCTGGACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAG TGGTTGGTCTGAAGTCCTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATAT GGGGTAAGGAGGTGCTTTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATT TGGTTTGTCCTTCAGTTTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGA CTGAGAAACTGAACAATGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGC CTCCCACGCGAGTGTGGTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTT CCGTATGTGGGGATGGTTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCC TTCCTCGTTGGCCACTAAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCT CTCTTGGTGAGGAAGCGATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCG TTTTCCTAGCCAACTTGTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATG ACCATGAGAAACCAAGAAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAA GGCCATCTTCTGTGTCGGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCC GACTTCGTACTAAGCAGCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGG CCAAGTGTTGTCAAACACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGC CACCAACTGCCACGATGAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATAT >In-frame_ASXL1_ENST00000306058_chr20_30956926_+_EIF2S2_ENST00000374980_chr20_32693351_-_2656nt ATGGGGGTTGTGAATTTTGTGTTCAGAGCGTCAGAGGACTTGCAGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATT CTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGA GGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGATGATTTTTGATCCTACTATGAGCAAGAAGAAA AAGAAGAAGAAGAAGCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCA GAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTT AATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGAT GTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAG GATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCT TGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCT GGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGT AAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTT GTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCA CCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACC GGCTTCCAGGCTGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTGTGGA GATGTGGCTGGACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGTGGTT GGTCTGAAGTCCTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATGGGGT AAGGAGGTGCTTTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTTGGTT TGTCCTTCAGTTTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGACTGAG AAACTGAACAATGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCCTCCC ACGCGAGTGTGGTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTCCGTA TGTGGGGATGGTTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCTTCCT CGTTGGCCACTAAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTCTCTT GGTGAGGAAGCGATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGTTTTC CTAGCCAACTTGTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGACCAT GAGAAACCAAGAAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAGGCCA TCTTCTGTGTCGGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCGACTT CGTACTAAGCAGCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGCCAAG TGTTGTCAAACACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCCACCA ACTGCCACGATGAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATATTTCTA |
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FusionGenePPI for ASXL1_EIF2S2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ASXL1 | BAP1, HIST1H1C, AKT1, CEBPA, APP, EZH2, EED, STAT3, SRPK1, FOXK2, OGT, HCFC1, FOXK1, UBC | EIF2S2 | PLEKHM1, CRMP1, KIAA1377, ZBTB16, APLP1, CCDC90B, TLE1, TP53, UNC119, EIF5, PRKDC, H2AFX, DCC, HDGF, CAND1, APP, EIF2S1, PAXIP1, CSNK2A1, CSNK2B, UPF1, MMS19, HMGA1, GCN1L1, RPA3, RPA2, RPA1, SUZ12, RNF2, MAST3, ESR1, KLHL20, MBD5, SERPINB5, HOXB5, ZCCHC7, EIF2S3, PRMT7, CDC123, ETFA, RNF26, CYP1A1, RPS6KB2, DDX56, ATAD3B, CDC5L, ETF1, FBL, MRTO4, MYL9, SUB1, KIF23, NCAPD3, NEMF, NOP56, NOP58, NSA2, RPL15, RPL37A, NTRK1, NCK1, XPO1, COPS7A, EXOSC4, EXOSC1, FAU, UBA52, EIF5A, RPS19, RPS12, RPS10, NPM1, RAN, ATP5C1, VAT1, PA2G4, STIP1, CYLD, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ASXL1 | chr20:30956926 | chr20:32693351 | ENST00000375687 | + | 4 | 13 | 300_658 | 84 | 1542 | NCOA1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASXL1_EIF2S2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASXL1_EIF2S2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ASXL1 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| Hgene | ASXL1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Hgene | ASXL1 | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |
| Hgene | ASXL1 | C0796232 | Bohring syndrome | 1 | CTD_human;ORPHANET |
| Tgene | EIF2S2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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