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Fusion gene ID: 30518 |
FusionGeneSummary for RASA2_SPSB4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RASA2_SPSB4 | Fusion gene ID: 30518 | Hgene | Tgene | Gene symbol | RASA2 | SPSB4 | Gene ID | 5922 | 92369 |
| Gene name | RAS p21 protein activator 2 | splA/ryanodine receptor domain and SOCS box containing 4 | |
| Synonyms | GAP1M | SSB-4|SSB4 | |
| Cytomap | 3q23 | 3q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras GTPase-activating protein 2GTPase-activating protein 1mGTPase-activating protein of RAS | SPRY domain-containing SOCS box protein 4SPRY domain-containing SOCS box protein SSB-4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q15283 | Q96A44 | |
| Ensembl transtripts involved in fusion gene | ENST00000452898, ENST00000286364, ENST00000509118, | ENST00000310546, ENST00000507895, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 5 X 2 X 4=40 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RASA2 [Title/Abstract] AND SPSB4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-NC-A5HL-01A | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000452898 | ENST00000310546 | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
| 5CDS-3UTR | ENST00000452898 | ENST00000507895 | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
| In-frame | ENST00000286364 | ENST00000310546 | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
| 5CDS-3UTR | ENST00000286364 | ENST00000507895 | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
| intron-3CDS | ENST00000509118 | ENST00000310546 | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
| intron-3UTR | ENST00000509118 | ENST00000507895 | RASA2 | chr3 | 141259451 | + | SPSB4 | chr3 | 140865984 | + |
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FusionProtFeatures for RASA2_SPSB4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RASA2 | SPSB4 |
| Inhibitory regulator of the Ras-cyclic AMP pathway.Binds inositol tetrakisphosphate (IP4). | Probable substrate recognition component of a SCF-likeECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-proteinligase complex which mediates the ubiquitination and subsequentproteasomal degradation of target proteins.{ECO:0000269|PubMed:15601820}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RASA2 | chr3:141259451 | chr3:140865984 | ENST00000286364 | + | 5 | 24 | 2_26 | 175 | 850 | Compositional bias | Note=Ala-rich |
| Hgene | RASA2 | chr3:141259451 | chr3:140865984 | ENST00000452898 | + | 5 | 24 | 2_26 | 175 | 851 | Compositional bias | Note=Ala-rich |
| Hgene | RASA2 | chr3:141259451 | chr3:140865984 | ENST00000286364 | + | 5 | 24 | 25_122 | 175 | 850 | Domain | C2 1 |
| Hgene | RASA2 | chr3:141259451 | chr3:140865984 | ENST00000452898 | + | 5 | 24 | 25_122 | 175 | 851 | Domain | C2 1 |
| Tgene | >SPSB4 | chr3:141259451 | chr3:140865984 | ENST00000310546 | + | 1 | 3 | 234_273 | 231 | 274 | Domain | SOCS box |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000286364 | + | 5 | 24 | 158_273 | 175 | 850 | Domain | C2 2 |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000286364 | + | 5 | 24 | 356_550 | 175 | 850 | Domain | Ras-GAP |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000286364 | + | 5 | 24 | 604_706 | 175 | 850 | Domain | PH |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000452898 | + | 5 | 24 | 158_273 | 175 | 851 | Domain | C2 2 |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000452898 | + | 5 | 24 | 356_550 | 175 | 851 | Domain | Ras-GAP |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000452898 | + | 5 | 24 | 604_706 | 175 | 851 | Domain | PH |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000286364 | + | 5 | 24 | 708_744 | 175 | 850 | Zinc finger | Btk-type |
| Hgene | >RASA2 | chr3:141259451 | chr3:140865984 | ENST00000452898 | + | 5 | 24 | 708_744 | 175 | 851 | Zinc finger | Btk-type |
| Tgene | SPSB4 | chr3:141259451 | chr3:140865984 | ENST00000310546 | + | 1 | 3 | 34_233 | 231 | 274 | Domain | B30.2/SPRY |
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FusionGeneSequence for RASA2_SPSB4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RASA2_ENST00000452898_chr3_141259451_+_SPSB4_ENST00000310546_chr3_140865984_+_218aa MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEE FYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHRAPA >In-frame_RASA2_ENST00000286364_chr3_141259451_+_SPSB4_ENST00000310546_chr3_140865984_+_218aa MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEE FYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHRAPA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RASA2_ENST00000452898_chr3_141259451_+_SPSB4_ENST00000310546_chr3_140865984_+_655nt ATGGCGGCGGCGGCGCCTGCTGCTGCGGCGGCTTCTTCCGAGGCGCCAGCGGCGAGTGCGACTGCAGAGCCCGAGGCCGGGGACCAGGAC AGTCGCGAGGTTCGAGTGTTGCAGAGCCTGCGGGGCAAGATCTGTGAAGCAAAAAATTTATTGCCATATCTTGGACCCCACAAAATGAGA GATTGTTTCTGTACCATAAATTTGGACCAGGAAGAAGTTTATCGTACCCAAGTTGTGGAAAAATCTTTAAGCCCATTTTTCAGTGAAGAA TTTTACTTTGAGATTCCAAGAACTTTCCAGTATTTGTCTTTCTATGTTTATGATAAGAATGTTTTACAAAGAGATCTCCGTATAGGAAAA GTAGCCATCAAAAAAGAAGACTTGTGTAATCACAGTGGCAAAGAAACTTGGTTTTCATTACAGCCTGTTGACTCCAATTCAGAGGTTCAG GGTAAAGTTCACCTTGAATTAAAACTGAATGAACTGATAACGGAGAATGGAACTGTATGCCAGCAGCTTGTTGTACACCGAGCCCCTGCC ACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCCTGCAGGACATCAGCTCCCTGCCCCTGCCTCAGTCTCT >In-frame_RASA2_ENST00000286364_chr3_141259451_+_SPSB4_ENST00000310546_chr3_140865984_+_655nt ATGGCGGCGGCGGCGCCTGCTGCTGCGGCGGCTTCTTCCGAGGCGCCAGCGGCGAGTGCGACTGCAGAGCCCGAGGCCGGGGACCAGGAC AGTCGCGAGGTTCGAGTGTTGCAGAGCCTGCGGGGCAAGATCTGTGAAGCAAAAAATTTATTGCCATATCTTGGACCCCACAAAATGAGA GATTGTTTCTGTACCATAAATTTGGACCAGGAAGAAGTTTATCGTACCCAAGTTGTGGAAAAATCTTTAAGCCCATTTTTCAGTGAAGAA TTTTACTTTGAGATTCCAAGAACTTTCCAGTATTTGTCTTTCTATGTTTATGATAAGAATGTTTTACAAAGAGATCTCCGTATAGGAAAA GTAGCCATCAAAAAAGAAGACTTGTGTAATCACAGTGGCAAAGAAACTTGGTTTTCATTACAGCCTGTTGACTCCAATTCAGAGGTTCAG GGTAAAGTTCACCTTGAATTAAAACTGAATGAACTGATAACGGAGAATGGAACTGTATGCCAGCAGCTTGTTGTACACCGAGCCCCTGCC ACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCCTGCAGGACATCAGCTCCCTGCCCCTGCCTCAGTCTCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RASA2_ENST00000452898_chr3_141259451_+_SPSB4_ENST00000310546_chr3_140865984_+_2032nt AGGCGGCAGGGCTGCGGCACGGGCCGGGCGGCACCATGGCGGCGGCGGCGCCTGCTGCTGCGGCGGCTTCTTCCGAGGCGCCAGCGGCGA GTGCGACTGCAGAGCCCGAGGCCGGGGACCAGGACAGTCGCGAGGTTCGAGTGTTGCAGAGCCTGCGGGGCAAGATCTGTGAAGCAAAAA ATTTATTGCCATATCTTGGACCCCACAAAATGAGAGATTGTTTCTGTACCATAAATTTGGACCAGGAAGAAGTTTATCGTACCCAAGTTG TGGAAAAATCTTTAAGCCCATTTTTCAGTGAAGAATTTTACTTTGAGATTCCAAGAACTTTCCAGTATTTGTCTTTCTATGTTTATGATA AGAATGTTTTACAAAGAGATCTCCGTATAGGAAAAGTAGCCATCAAAAAAGAAGACTTGTGTAATCACAGTGGCAAAGAAACTTGGTTTT CATTACAGCCTGTTGACTCCAATTCAGAGGTTCAGGGTAAAGTTCACCTTGAATTAAAACTGAATGAACTGATAACGGAGAATGGAACTG TATGCCAGCAGCTTGTTGTACACCGAGCCCCTGCCACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCCTG CAGGACATCAGCTCCCTGCCCCTGCCTCAGTCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACAGA CACACACCGCAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGCTCCCCAGGACAC TCAGTTCTTTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGCCAACAGTATCTACTGCCCTCGAGGCAGCCCTCC CAAGTCAGACACCTCCTTCGGAGCCACAGAGAGCCTGGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACCGT ATTGATCAGAGAGCCTGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAGACAGGG CCAGGGAGAAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTGACGCCGTGCCCCTCCTGGCCCATACGC CTTGCCAGGGCGGCAGGATTGTCACACCGTTTTAGGACTCTGTGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGGCA AGTGGACAGTGCAGTGTGGAGACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCCAC TGACTCACAGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAGGGAAGAGCATATCCTTACCAT TATTTTAAGTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAGTACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATTGT GACACCCAAGTCTGATGTGTCCTGGGTTGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGCTG TCACAAAGCTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGTGTGTGTGATGTGCTG TTTATTTATCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGATATGGGAGACACATTCTCTACCTGCTCCGAGCCTGGT CCTCTCGCAGGAATGCTGCTGCTGCCTCCGCCGCCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTTTT AACTGGAAATCATCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTTAATGTGAAT >In-frame_RASA2_ENST00000286364_chr3_141259451_+_SPSB4_ENST00000310546_chr3_140865984_+_2032nt AGGCGGCAGGGCTGCGGCACGGGCCGGGCGGCACCATGGCGGCGGCGGCGCCTGCTGCTGCGGCGGCTTCTTCCGAGGCGCCAGCGGCGA GTGCGACTGCAGAGCCCGAGGCCGGGGACCAGGACAGTCGCGAGGTTCGAGTGTTGCAGAGCCTGCGGGGCAAGATCTGTGAAGCAAAAA ATTTATTGCCATATCTTGGACCCCACAAAATGAGAGATTGTTTCTGTACCATAAATTTGGACCAGGAAGAAGTTTATCGTACCCAAGTTG TGGAAAAATCTTTAAGCCCATTTTTCAGTGAAGAATTTTACTTTGAGATTCCAAGAACTTTCCAGTATTTGTCTTTCTATGTTTATGATA AGAATGTTTTACAAAGAGATCTCCGTATAGGAAAAGTAGCCATCAAAAAAGAAGACTTGTGTAATCACAGTGGCAAAGAAACTTGGTTTT CATTACAGCCTGTTGACTCCAATTCAGAGGTTCAGGGTAAAGTTCACCTTGAATTAAAACTGAATGAACTGATAACGGAGAATGGAACTG TATGCCAGCAGCTTGTTGTACACCGAGCCCCTGCCACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCCTG CAGGACATCAGCTCCCTGCCCCTGCCTCAGTCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACAGA CACACACCGCAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGCTCCCCAGGACAC TCAGTTCTTTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGCCAACAGTATCTACTGCCCTCGAGGCAGCCCTCC CAAGTCAGACACCTCCTTCGGAGCCACAGAGAGCCTGGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACCGT ATTGATCAGAGAGCCTGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAGACAGGG CCAGGGAGAAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTGACGCCGTGCCCCTCCTGGCCCATACGC CTTGCCAGGGCGGCAGGATTGTCACACCGTTTTAGGACTCTGTGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGGCA AGTGGACAGTGCAGTGTGGAGACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCCAC TGACTCACAGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAGGGAAGAGCATATCCTTACCAT TATTTTAAGTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAGTACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATTGT GACACCCAAGTCTGATGTGTCCTGGGTTGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGCTG TCACAAAGCTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGTGTGTGTGATGTGCTG TTTATTTATCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGATATGGGAGACACATTCTCTACCTGCTCCGAGCCTGGT CCTCTCGCAGGAATGCTGCTGCTGCCTCCGCCGCCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTTTT AACTGGAAATCATCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTTAATGTGAAT |
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FusionGenePPI for RASA2_SPSB4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RASA2 | GAPVD1 | SPSB4 | NOS2, TCEB1, DDX4, PAWR, MET, CUL5, RNF7, TCEB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RASA2_SPSB4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASA2_SPSB4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RASA2 | C0025202 | melanoma | 2 | CTD_human |
| Tgene | SPSB4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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