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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30490

FusionGeneSummary for RARB_OSBPL10

check button Fusion gene summary
Fusion gene informationFusion gene name: RARB_OSBPL10
Fusion gene ID: 30490
HgeneTgene
Gene symbol

RARB

OSBPL10

Gene ID

5915

114884

Gene nameretinoic acid receptor betaoxysterol binding protein like 10
SynonymsHAP|MCOPS12|NR1B2|RARbeta1|RRB2ORP10|OSBP9
Cytomap

3p24.2

3p23

Type of geneprotein-codingprotein-coding
Descriptionretinoic acid receptor betaHBV-activated proteinRAR-betaRAR-epsilonhepatitis B virus activated proteinnuclear receptor subfamily 1 group B member 2retinoic acid receptor, beta polypeptideoxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10
Modification date2018052320180523
UniProtAcc

P10826

Q9BXB5

Ensembl transtripts involved in fusion geneENST00000404969, ENST00000437042, 
ENST00000330688, ENST00000462272, 
ENST00000458646, 		ENST00000396556, 
ENST00000438237, ENST00000467647, 
Fusion gene scores* DoF score3 X 2 X 3=186 X 3 X 4=72
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RARB [Title/Abstract] AND OSBPL10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-GF-A6C9-06ARARBchr3

25216066

+OSBPL10chr3

31921322

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000404969ENST00000396556RARBchr3

25216066

+OSBPL10chr3

31921322

-
Frame-shiftENST00000404969ENST00000438237RARBchr3

25216066

+OSBPL10chr3

31921322

-
5CDS-intronENST00000404969ENST00000467647RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000437042ENST00000396556RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000437042ENST00000438237RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-intronENST00000437042ENST00000467647RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000330688ENST00000396556RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000330688ENST00000438237RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-intronENST00000330688ENST00000467647RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000462272ENST00000396556RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000462272ENST00000438237RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-intronENST00000462272ENST00000467647RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000458646ENST00000396556RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-3CDSENST00000458646ENST00000438237RARBchr3

25216066

+OSBPL10chr3

31921322

-
intron-intronENST00000458646ENST00000467647RARBchr3

25216066

+OSBPL10chr3

31921322

-

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FusionProtFeatures for RARB_OSBPL10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RARB

P10826

OSBPL10

Q9BXB5

Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence or presence of hormone ligand, acts mainly as an activatorof gene expression due to weak binding to corepressors. In concertwith RARG, required for skeletal growth, matrix homeostasis andgrowth plate function. {ECO:0000269|PubMed:12554770}. Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RARB_OSBPL10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RARB_OSBPL10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RARBNCOA1, CEBPA, CEBPB, GATA3, RXRG, HR, RXRA, NCOR2, RXRB, PNRC1, MAP6, HACE1, SMAD2, PRKD2, CCNH, ITGB1BP2, MEOX2, ARID1A, SMARCE1, SMARCD3, PSMC5, RARAOSBPL10AP2B1, ALDOA, BBS1, GBAS, MMP2, CUL1, CLINT1, KEAP1, SAP18, SRRM2, WRNIP1, CLPB, USP11, OSBPL9, ZC3H18, PGAM5, IKBKG, VAPB, VAPA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RARB_OSBPL10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRARBP10826DB00210AdapaleneRetinoic acid receptor betasmall moleculeapproved
HgeneRARBP10826DB00459AcitretinRetinoic acid receptor betasmall moleculeapproved
HgeneRARBP10826DB00523AlitretinoinRetinoic acid receptor betasmall moleculeapproved|investigational
HgeneRARBP10826DB00799TazaroteneRetinoic acid receptor betasmall moleculeapproved|investigational
HgeneRARBP10826DB00755TretinoinRetinoic acid receptor betasmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for RARB_OSBPL10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRARBC0001418Adenocarcinoma1CTD_human
HgeneRARBC0007137Squamous cell carcinoma1CTD_human
HgeneRARBC0007873Uterine Cervical Neoplasm1CTD_human
HgeneRARBC0014175Endometriosis1CTD_human
HgeneRARBC0018671Head and Neck Neoplasms1CTD_human
HgeneRARBC0024121Lung Neoplasms1CTD_human
HgeneRARBC0038356Stomach Neoplasms1CTD_human
HgeneRARBC0149940Sciatic Neuropathy1CTD_human
HgeneRARBC1458155Mammary Neoplasms1CTD_human
HgeneRARBC3809803MICROPHTHALMIA, SYNDROMIC 121UNIPROT